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Showing metabocard for Phenylpyruvic acid (HMDB0000205)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:14:36 UTC
HMDB IDHMDB0000205
Secondary Accession Numbers
Metabolite Identification
Common NamePhenylpyruvic acid
Description
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000205 (Phenylpyruvic acid)

  Mrv1652309032023562D          

 12 12  0  0  0  0            999 V2000
   -0.7698    0.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4843    0.5013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1988    0.0887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1989   -0.7361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4844   -1.1486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7698   -0.7361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0554    0.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6590    0.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6590   -0.7360    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3735    0.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3734    1.3264    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0879    0.0889    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8 10  1  0  0  0  0
  8  9  2  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
M  END
Download

3D MOL for HMDB0000205 (Phenylpyruvic acid)

HMDB0000205
     RDKit          3D
Phenylpyruvic acid
 20 20  0  0  0  0  0  0  0  0999 V2000
   -3.7055    0.6146   -0.7101 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2873   -0.1343    0.1973 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2209   -0.8193    0.9541 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8654   -0.2629    0.4283 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3960   -1.0014    1.3262 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9153    0.4963   -0.4150 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4899    0.2517   -0.0479 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050   -0.7689   -0.6376 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5155   -1.0423   -0.3345 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1174   -0.2315    0.6162 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4545    0.8032    1.2397 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1380    1.0361    0.8990 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8502   -0.2536    1.5146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1819    1.5768   -0.4289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0497    0.1254   -1.4569 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7257   -1.3958   -1.3784 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0885   -1.8418   -0.7912 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1421   -0.4007    0.8919 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9784    1.4023    1.9748 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6171    1.8461    1.3862 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
  3 13  1  0
  6 14  1  0
  6 15  1  0
  8 16  1  0
  9 17  1  0
 10 18  1  0
 11 19  1  0
 12 20  1  0
M  END
Download

3D SDF for HMDB0000205 (Phenylpyruvic acid)

  Mrv1652309032023562D          

 12 12  0  0  0  0            999 V2000
   -0.7698    0.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4843    0.5013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1988    0.0887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1989   -0.7361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4844   -1.1486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7698   -0.7361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0554    0.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6590    0.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6590   -0.7360    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3735    0.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3734    1.3264    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0879    0.0889    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8 10  1  0  0  0  0
  8  9  2  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000205

> <DATABASE_NAME>
hmdb

> <SMILES>
OC(=O)C(=O)CC1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C9H8O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,12)

> <INCHI_KEY>
BTNMPGBKDVTSJY-UHFFFAOYSA-N

> <FORMULA>
C9H8O3

> <MOLECULAR_WEIGHT>
164.158

> <EXACT_MASS>
164.047344122

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
20

> <JCHEM_AVERAGE_POLARIZABILITY>
15.750874725076514

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2-oxo-3-phenylpropanoic acid

> <JCHEM_LOGP>
1.9002137729999997

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
16.097510920786018

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.332859227478436

> <JCHEM_PKA_STRONGEST_BASIC>
-9.757724229361303

> <JCHEM_POLAR_SURFACE_AREA>
54.37

> <JCHEM_REFRACTIVITY>
42.711600000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
phenylpyruvic acid

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0000205 (Phenylpyruvic acid)

HMDB0000205
     RDKit          3D
Phenylpyruvic acid
 20 20  0  0  0  0  0  0  0  0999 V2000
   -3.7055    0.6146   -0.7101 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2873   -0.1343    0.1973 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2209   -0.8193    0.9541 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8654   -0.2629    0.4283 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3960   -1.0014    1.3262 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9153    0.4963   -0.4150 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4899    0.2517   -0.0479 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050   -0.7689   -0.6376 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5155   -1.0423   -0.3345 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1174   -0.2315    0.6162 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4545    0.8032    1.2397 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1380    1.0361    0.8990 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8502   -0.2536    1.5146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1819    1.5768   -0.4289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0497    0.1254   -1.4569 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7257   -1.3958   -1.3784 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0885   -1.8418   -0.7912 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1421   -0.4007    0.8919 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9784    1.4023    1.9748 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6171    1.8461    1.3862 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12  7  1  0
  3 13  1  0
  6 14  1  0
  6 15  1  0
  8 16  1  0
  9 17  1  0
 10 18  1  0
 11 19  1  0
 12 20  1  0
M  END
Download

PDB for HMDB0000205 (Phenylpyruvic acid)

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  C   UNK     0      -1.437   0.166   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.771   0.936   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -4.104   0.166   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -4.105  -1.374   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.771  -2.144   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.437  -1.374   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -0.103   0.936   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.230   0.166   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       1.230  -1.374   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       2.564   0.936   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       2.564   2.476   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0       3.897   0.166   0.000  0.00  0.00           O+0
CONECT    1    2    6    7                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    1                                                       
CONECT    7    1    8                                                       
CONECT    8    7   10    9                                                  
CONECT    9    8                                                            
CONECT   10    8   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10                                                            
MASTER        0    0    0    0    0    0    0    0   12    0   24    0
END
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3D PDB for HMDB0000205 (Phenylpyruvic acid)

COMPND    HMDB0000205
HETATM    1  O1  UNL     1      -3.705   0.615  -0.710  1.00  0.00           O  
HETATM    2  C1  UNL     1      -3.287  -0.134   0.197  1.00  0.00           C  
HETATM    3  O2  UNL     1      -4.221  -0.819   0.954  1.00  0.00           O  
HETATM    4  C2  UNL     1      -1.865  -0.263   0.428  1.00  0.00           C  
HETATM    5  O3  UNL     1      -1.396  -1.001   1.326  1.00  0.00           O  
HETATM    6  C3  UNL     1      -0.915   0.496  -0.415  1.00  0.00           C  
HETATM    7  C4  UNL     1       0.490   0.252  -0.048  1.00  0.00           C  
HETATM    8  C5  UNL     1       1.205  -0.769  -0.638  1.00  0.00           C  
HETATM    9  C6  UNL     1       2.515  -1.042  -0.334  1.00  0.00           C  
HETATM   10  C7  UNL     1       3.117  -0.231   0.616  1.00  0.00           C  
HETATM   11  C8  UNL     1       2.455   0.803   1.240  1.00  0.00           C  
HETATM   12  C9  UNL     1       1.138   1.036   0.899  1.00  0.00           C  
HETATM   13  H1  UNL     1      -4.850  -0.254   1.515  1.00  0.00           H  
HETATM   14  H2  UNL     1      -1.182   1.577  -0.429  1.00  0.00           H  
HETATM   15  H3  UNL     1      -1.050   0.125  -1.457  1.00  0.00           H  
HETATM   16  H4  UNL     1       0.726  -1.396  -1.378  1.00  0.00           H  
HETATM   17  H5  UNL     1       3.089  -1.842  -0.791  1.00  0.00           H  
HETATM   18  H6  UNL     1       4.142  -0.401   0.892  1.00  0.00           H  
HETATM   19  H7  UNL     1       2.978   1.402   1.975  1.00  0.00           H  
HETATM   20  H8  UNL     1       0.617   1.846   1.386  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   13
CONECT    4    5    5    6
CONECT    6    7   14   15
CONECT    7    8    8   12
CONECT    8    9   16
CONECT    9   10   10   17
CONECT   10   11   18
CONECT   11   12   12   19
CONECT   12   20
END
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SMILES for HMDB0000205 (Phenylpyruvic acid)

OC(=O)C(=O)CC1=CC=CC=C1
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INCHI for HMDB0000205 (Phenylpyruvic acid)

InChI=1S/C9H8O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,12)
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View in JSmolView Stereo Labels
Synonyms
Chemical FormulaC9H8O3
Average Molecular Weight164.158
Monoisotopic Molecular Weight164.047344122
IUPAC Name2-oxo-3-phenylpropanoic acid
Traditional Namephenylpyruvic acid
CAS Registry Number156-06-9
SMILES
OC(=O)C(=O)CC1=CC=CC=C1
InChI Identifier
InChI=1S/C9H8O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,12)
InChI KeyBTNMPGBKDVTSJY-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phenylpyruvic acid derivatives. Phenylpyruvic acid derivatives are compounds containing a phenylpyruvic acid moiety, which consists of a phenyl group substituted at the second position by an pyruvic acid.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylpyruvic acid derivatives
Direct ParentPhenylpyruvic acid derivatives
Alternative Parents
Substituents
  • Phenylpyruvate
  • 3-phenylpropanoic-acid
  • Keto acid
  • Alpha-keto acid
  • Alpha-hydroxy ketone
  • Ketone
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effect
Health effect
Disposition
Biological locationSource
Process
Naturally occurring process
Role
Industrial applicationBiological role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point154 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility112 mg/mLNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Mitochondria
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
Abnormal Concentrations
Associated Disorders and Diseases
Disease References
Phenylketonuria
  1. Langenbeck U, Behbehani A, Luthe H: Renal transport of aromatic acids in patients with phenylketonuria. J Inherit Metab Dis. 1981;4(2):69-70. [PubMed:6790852 ]
  2. Monch E, Kneer J, Jakobs C, Arnold M, Diehl H, Batzler U: Examination of urine metabolites in the newborn period and during protein loading tests at 6 months of age--Part 1. Eur J Pediatr. 1990;149 Suppl 1:S17-24. [PubMed:2091926 ]
  3. Swarna M, Jyothy A, Usha Rani P, Reddy PP: Amino acid disorders in mental retardation: a two-decade study from Andhra Pradesh. Biochem Genet. 2004 Apr;42(3-4):85-98. [PubMed:15168722 ]
  4. Rampini S, Vollmin JA, Bosshard HR, Muller M, Curtius HC: Aromatic acids in urine of healthy infants, persistent hyperphenylalaninemia, and phenylketonuria, before and after phenylalanine load. Pediatr Res. 1974 Jul;8(7):704-9. [PubMed:4837567 ]
  5. G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de). METAGENE consortium.
Primary biliary cirrhosis
  1. Turchany JM, Leung PS, Iwayama T, Jefferson DM, Ishida J, Yamaguchi M, Munoz S, Danner DJ, Dickson ER, Gershwin ME: Comparative metabolism and structure of BCKD-E2 in primary biliary cirrhosis. J Autoimmun. 1993 Aug;6(4):459-66. [PubMed:8216688 ]
Associated OMIM IDs
DrugBank IDDB03884
Phenol Explorer Compound IDNot Available
FooDB IDFDB008272
KNApSAcK IDC00000751
Chemspider ID972
KEGG Compound IDC00166
BioCyc IDPHENYL-PYRUVATE
BiGG ID34111
Wikipedia LinkPhenylpyruvic_acid
METLIN ID328
PubChem Compound997
PDB IDNot Available
ChEBI ID30851
Food Biomarker OntologyNot Available
VMH IDPHPYR
MarkerDB IDMDB00000098
Good Scents IDNot Available
References
Synthesis ReferenceLi, Hongbin; Luo, Yuzhong. Preparation of phenyl-pyruvic acid by dicarbonylation of benzyl halide. Faming Zhuanli Shenqing Gongkai Shuomingshu (1996), 5 pp.
Material Safety Data Sheet (MSDS)Not Available
General References

Enzymes

Enzyme Details
1. Macrophage migration inhibitory factor
General function:
Involved in cell surface binding
Specific function:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Gene Name:
MIF
Uniprot ID:
P14174
Molecular weight:
12476.19
Reactions
Phenylpyruvic acid → Enol-phenylpyruvatedetails
Phenylpyruvic acid → Enol-phenylpyruvatedetails
Enzyme Details
2. Tyrosine aminotransferase
General function:
Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Gene Name:
TAT
Uniprot ID:
P17735
Molecular weight:
50398.895
Reactions
Phenylalanine + Oxoglutaric acid → Phenylpyruvic acid + Glutamic aciddetails
Enzyme Details
3. Aspartate aminotransferase, cytoplasmic
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Plays a key role in amino acid metabolism (By similarity).
Gene Name:
GOT1
Uniprot ID:
P17174
Molecular weight:
46247.14
Reactions
Phenylalanine + Oxoglutaric acid → Phenylpyruvic acid + Glutamic aciddetails
Enzyme Details
4. Aspartate aminotransferase, mitochondrial
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:
GOT2
Uniprot ID:
P00505
Molecular weight:
47517.285
Reactions
Phenylalanine + Oxoglutaric acid → Phenylpyruvic acid + Glutamic aciddetails
Enzyme Details
5. Kynurenine--oxoglutarate transaminase 1
General function:
Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Gene Name:
CCBL1
Uniprot ID:
Q16773
Molecular weight:
47874.765
Reactions
Glutamine + Phenylpyruvic acid → 2-Keto-glutaramic acid + Phenylalaninedetails
Enzyme Details
6. UDP-glucuronosyltransferase 1-1
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular weight:
59590.91
Reactions
Phenylpyruvic acid → 3,4,5-trihydroxy-6-[(2-oxo-3-phenylpropanoyl)oxy]oxane-2-carboxylic aciddetails
Enzyme Details
7. 4-hydroxyphenylpyruvate dioxygenase
General function:
Involved in 4-hydroxyphenylpyruvate dioxygenase activity
Specific function:
Key enzyme in the degradation of tyrosine.
Gene Name:
HPD
Uniprot ID:
P32754
Molecular weight:
40497.105
Reactions
Phenylpyruvic acid + Oxygen → ortho-Hydroxyphenylacetic acid + Carbon dioxidedetails
Enzyme Details
8. L-amino-acid oxidase
General function:
Involved in oxidoreductase activity
Specific function:
Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).
Gene Name:
IL4I1
Uniprot ID:
Q96RQ9
Molecular weight:
65327.26
Reactions
Phenylalanine + Water + Oxygen → Phenylpyruvic acid + Ammonia + Hydrogen peroxidedetails