| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
---|
Predicted GC-MS | Predicted GC-MS Spectrum - 7-Ketocholesterol GC-MS (Non-derivatized) - 70eV, Positive | splash10-007c-1129000000-5b8ecb213c1fedcf460f | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 7-Ketocholesterol GC-MS (1 TMS) - 70eV, Positive | splash10-0a4l-5345900000-53b849b3490f56e462a4 | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 7-Ketocholesterol GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 7-Ketocholesterol GC-MS (TMS_1_2) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 7-Ketocholesterol GC-MS (TBDMS_1_1) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 7-Ketocholesterol GC-MS (TBDMS_1_2) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
---|
Experimental LC-MS/MS | LC-MS/MS Spectrum - 7-Ketocholesterol Quattro_QQQ 10V, N/A-QTOF (Annotated) | splash10-0a4i-0009000000-82ed6dc62b49ac0340e6 | 2012-07-24 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 7-Ketocholesterol Quattro_QQQ 25V, N/A-QTOF (Annotated) | splash10-0a5a-5910100000-41a560da8a3cd10710d8 | 2012-07-24 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 7-Ketocholesterol Quattro_QQQ 40V, N/A-QTOF (Annotated) | splash10-05o1-9400000000-eef0253b6691ce201b6f | 2012-07-24 | HMDB team, MONA | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 10V, Positive-QTOF | splash10-0f89-0009400000-481f8105e35cf4435f7f | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 20V, Positive-QTOF | splash10-0kh9-2119100000-c9cd12d1521349134488 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 40V, Positive-QTOF | splash10-0a4i-5239000000-47c89b87f9de84a00976 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 10V, Negative-QTOF | splash10-0002-0009000000-f17e421c0d9bfb620553 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 20V, Negative-QTOF | splash10-0002-0009000000-3111ceac8df5c3a579c9 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 40V, Negative-QTOF | splash10-0159-1109000000-c1d906850e839a591b34 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 10V, Negative-QTOF | splash10-0002-0009000000-dc23ba87137530d83f68 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 20V, Negative-QTOF | splash10-0002-0009000000-2bf9ac3307f36d45ebaf | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 40V, Negative-QTOF | splash10-0002-0029000000-2f6d508f6d435a2fcb5a | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 10V, Positive-QTOF | splash10-0udi-0003900000-b8b5c49aa579e5ab22cd | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 20V, Positive-QTOF | splash10-0pvl-9267300000-d5cf69b5970c813ef95a | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 7-Ketocholesterol 40V, Positive-QTOF | splash10-059f-5951000000-e4fc61af27eb197f149f | 2021-09-25 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
---|
Experimental 1D NMR | 1H NMR Spectrum (1D, 500 MHz, CDCl3, experimental) | 2012-12-04 | Wishart Lab | View Spectrum | Experimental 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CDCl3, experimental) | 2012-12-05 | Wishart Lab | View Spectrum |
| Show more...
---|
General References | - Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C, Marie JC, Pouzet C, Samadi M, Elbim C, O'dowd Y, Bens M, Vandewalle A, Gougerot-Pocidalo MA, Lizard G, Ogier-Denis E: NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells. Mol Cell Biol. 2004 Dec;24(24):10703-17. [PubMed:15572675 ]
- Schweizer RA, Zurcher M, Balazs Z, Dick B, Odermatt A: Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. J Biol Chem. 2004 Apr 30;279(18):18415-24. Epub 2004 Feb 18. [PubMed:14973125 ]
- Miguet-Alfonsi C, Prunet C, Monier S, Bessede G, Lemaire-Ewing S, Berthier A, Menetrier F, Neel D, Gambert P, Lizard G: Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. Biochem Pharmacol. 2002 Aug 1;64(3):527-41. [PubMed:12147305 ]
- Dulak J, Jozkowicz A, Dichtl W, Alber H, Schwarzacher SP, Pachinger O, Weidinger F: Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation. Atherosclerosis. 2001 Dec;159(2):325-32. [PubMed:11730812 ]
- Miguet C, Monier S, Bettaieb A, Athias A, Bessede G, Laubriet A, Lemaire S, Neel D, Gambert P, Lizard G: Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. Cell Death Differ. 2001 Jan;8(1):83-99. [PubMed:11313706 ]
- Lyons MA, Brown AJ: Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. Lipids. 2001 Jul;36(7):701-11. [PubMed:11521968 ]
- Berthier A, Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Pais de Barros JP, Monier S, Gambert P, Lizard G, Neel D: 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways. FEBS J. 2005 Jun;272(12):3093-104. [PubMed:15955068 ]
- Monier S, Samadi M, Prunet C, Denance M, Laubriet A, Athias A, Berthier A, Steinmetz E, Jurgens G, Negre-Salvayre A, Bessede G, Lemaire-Ewing S, Neel D, Gambert P, Lizard G: Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. Biochem Biophys Res Commun. 2003 Apr 11;303(3):814-24. [PubMed:12670484 ]
- Lizard G, Moisant M, Cordelet C, Monier S, Gambert P, Lagrost L: Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. J Pathol. 1997 Nov;183(3):330-8. [PubMed:9422990 ]
- Tuomainen TP, Diczfalusy U, Kaikkonen J, Nyyssonen K, Salonen JT: Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. Free Radic Biol Med. 2003 Oct 15;35(8):922-8. [PubMed:14556856 ]
- Scopesi F, Zunin P, Mazzella M, Testa M, Boggia R, Evangelisti F, Serra G: 7-ketocholesterol in human and adapted milk formulas. Clin Nutr. 2002 Oct;21(5):379-84. [PubMed:12381334 ]
- Zhang Y, Yu C, Liu J, Spencer TA, Chang CC, Chang TY: Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. J Biol Chem. 2003 Mar 28;278(13):11642-7. Epub 2003 Jan 17. [PubMed:12533546 ]
- Shimozawa M, Naito Y, Manabe H, Uchiyama K, Kuroda M, Katada K, Yoshida N, Yoshikawa T: 7-Ketocholesterol enhances the expression of adhesion molecules on human aortic endothelial cells by increasing the production of reactive oxygen species. Redox Rep. 2004;9(6):370-5. [PubMed:15720835 ]
- Ghelli A, Porcelli AM, Zanna C, Rugolo M: 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells. Arch Biochem Biophys. 2002 Jun 15;402(2):208-17. [PubMed:12051665 ]
- Martinet W, De Bie M, Schrijvers DM, De Meyer GR, Herman AG, Kockx MM: 7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2296-301. Epub 2004 Sep 30. [PubMed:15458974 ]
- Hayden JM, Brachova L, Higgins K, Obermiller L, Sevanian A, Khandrika S, Reaven PD: Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. J Lipid Res. 2002 Jan;43(1):26-35. [PubMed:11792719 ]
- Jessup W, Brown AJ: Novel routes for metabolism of 7-ketocholesterol. Rejuvenation Res. 2005 Spring;8(1):9-12. [PubMed:15798369 ]
- Huang RF, Yaong HC, Chen SC, Lu YF: In vitro folate supplementation alleviates oxidative stress, mitochondria-associated death signalling and apoptosis induced by 7-ketocholesterol. Br J Nutr. 2004 Dec;92(6):887-94. [PubMed:15613250 ]
- Kahn E, Vejux A, Lizard G, Bessede G, Frouin F, Prunet C, Bernengo JC, Brau F, Todd-Pokropek A, Gambert P: Analysis of the fluorescence of monodansylcadaverine-positive cytoplasmic structures during 7-ketocholesterol-induced cell death. Anal Quant Cytol Histol. 2004 Feb;26(1):47-56. [PubMed:15032081 ]
- Kahn E, Vejux A, Dumas D, Montange T, Frouin F, Robert V, Riedinger JM, Stoltz JF, Gambert P, Todd-Pokropek A, Lizard G: FRET multiphoton spectral imaging microscopy of 7-ketocholesterol and Nile Red in U937 monocytic cells loaded with 7-ketocholesterol. Anal Quant Cytol Histol. 2004 Dec;26(6):304-13. [PubMed:15678612 ]
- Lyons MA, Brown AJ: 7-Ketocholesterol. Int J Biochem Cell Biol. 1999 Mar-Apr;31(3-4):369-75. [PubMed:10224662 ]
| Show more...
---|