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Showing metabocard for Isobutyrylglycine (HMDB0000730)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:07 UTC
HMDB IDHMDB0000730
Secondary Accession Numbers
  • HMDB00730
Metabolite Identification
Common NameIsobutyrylglycine
DescriptionIsobutyrylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine. Isobutyrylglycine is identified in large amount in urine of patients with isobutyryl-CoA dehydrogenase deficiency. Isobutyryl-CoA dehydrogenase deficiency is a disorder caused by the deficiency of isobutyryl-CoA dehydrogenase that is involved in the catabolism of the branched-chain amino acid valine (PMID 15505379 ). Moreover, Isobutyrylglycine is found to be associated with ethylmalonic encephalopathy and propionic acidemia, which are also inborn errors of metabolism. Isobutyrylglycine is a biomarker for the consumption of cheese.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000730 (Isobutyrylglycine)

Isobutyrylglycine.mol
  Mrv1652305271900172D          

 10  9  0  0  0  0            999 V2000
   -1.4289   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  2  0  0  0  0
  1  5  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  2  6  1  0  0  0  0
M  END
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3D MOL for HMDB0000730 (Isobutyrylglycine)

HMDB0000730
     RDKit          3D
Isobutyrylglycine
 21 20  0  0  0  0  0  0  0  0999 V2000
   -2.5996    0.9205   -0.9317 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5855   -0.1342   -0.5644 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1025   -0.9407    0.6105 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3069    0.5115   -0.2681 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1863    1.7727   -0.3414 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8442   -0.2165    0.1091 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147    0.3716    0.4080 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1218   -0.6573    0.7711 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8507   -1.8886    0.8006 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3971   -0.2113    1.0832 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1134    1.7192   -1.5454 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3303    0.4317   -1.6275 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0744    1.2986   -0.0197 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4273   -0.8461   -1.3959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5155   -1.9228    0.2995 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9577   -0.3922    1.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3241   -1.0870    1.3814 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7621   -1.2543    0.1740 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4496    0.9258   -0.5130 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0862    1.0993    1.2382 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8971    0.5001    0.6096 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  0
  3 15  1  0
  3 16  1  0
  3 17  1  0
  6 18  1  0
  7 19  1  0
  7 20  1  0
 10 21  1  0
M  END
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3D SDF for HMDB0000730 (Isobutyrylglycine)

Isobutyrylglycine.mol
  Mrv1652305271900172D          

 10  9  0  0  0  0            999 V2000
   -1.4289   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.2062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.0312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  2  0  0  0  0
  1  5  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  2  6  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000730

> <DATABASE_NAME>
hmdb

> <SMILES>
CC(C)C(=O)NCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)

> <INCHI_KEY>
DCICDMMXFIELDF-UHFFFAOYSA-N

> <FORMULA>
C6H11NO3

> <MOLECULAR_WEIGHT>
145.1564

> <EXACT_MASS>
145.073893223

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
21

> <JCHEM_AVERAGE_POLARIZABILITY>
14.569462707724016

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-(2-methylpropanamido)acetic acid

> <ALOGPS_LOGP>
-0.11

> <JCHEM_LOGP>
-0.08510682866666647

> <ALOGPS_LOGS>
-0.91

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
15.762853347112124

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.0629876465018375

> <JCHEM_PKA_STRONGEST_BASIC>
-1.8019866084514846

> <JCHEM_POLAR_SURFACE_AREA>
66.4

> <JCHEM_REFRACTIVITY>
34.6486

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.79e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
isobutyrylglycine

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0000730 (Isobutyrylglycine)

HMDB0000730
     RDKit          3D
Isobutyrylglycine
 21 20  0  0  0  0  0  0  0  0999 V2000
   -2.5996    0.9205   -0.9317 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5855   -0.1342   -0.5644 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1025   -0.9407    0.6105 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3069    0.5115   -0.2681 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1863    1.7727   -0.3414 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8442   -0.2165    0.1091 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147    0.3716    0.4080 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1218   -0.6573    0.7711 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8507   -1.8886    0.8006 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3971   -0.2113    1.0832 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1134    1.7192   -1.5454 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3303    0.4317   -1.6275 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0744    1.2986   -0.0197 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4273   -0.8461   -1.3959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5155   -1.9228    0.2995 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9577   -0.3922    1.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3241   -1.0870    1.3814 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7621   -1.2543    0.1740 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4496    0.9258   -0.5130 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0862    1.0993    1.2382 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8971    0.5001    0.6096 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  0
  3 15  1  0
  3 16  1  0
  3 17  1  0
  6 18  1  0
  7 19  1  0
  7 20  1  0
 10 21  1  0
M  END
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PDB for HMDB0000730 (Isobutyrylglycine)

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: Isobutyrylglycine.mol                             
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  C   UNK     0      -2.667  -0.385   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       0.000  -0.385   0.000  0.00  0.00           N+0
HETATM    3  C   UNK     0      -1.334   0.385   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -2.667  -1.925   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      -4.001   0.385   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       1.334   0.385   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       1.334   1.925   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       2.667  -0.385   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.001   0.385   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.667  -1.925   0.000  0.00  0.00           C+0
CONECT    1    3    4    5                                                  
CONECT    2    3    6                                                       
CONECT    3    2    1                                                       
CONECT    4    1                                                            
CONECT    5    1                                                            
CONECT    6    7    8    2                                                  
CONECT    7    6                                                            
CONECT    8    6    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8                                                            
MASTER        0    0    0    0    0    0    0    0   10    0   18    0
END
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3D PDB for HMDB0000730 (Isobutyrylglycine)

COMPND    HMDB0000730
HETATM    1  C1  UNL     1      -2.600   0.921  -0.932  1.00  0.00           C  
HETATM    2  C2  UNL     1      -1.586  -0.134  -0.564  1.00  0.00           C  
HETATM    3  C3  UNL     1      -2.103  -0.941   0.610  1.00  0.00           C  
HETATM    4  C4  UNL     1      -0.307   0.512  -0.268  1.00  0.00           C  
HETATM    5  O1  UNL     1      -0.186   1.773  -0.341  1.00  0.00           O  
HETATM    6  N1  UNL     1       0.844  -0.216   0.109  1.00  0.00           N  
HETATM    7  C5  UNL     1       2.115   0.372   0.408  1.00  0.00           C  
HETATM    8  C6  UNL     1       3.122  -0.657   0.771  1.00  0.00           C  
HETATM    9  O2  UNL     1       2.851  -1.889   0.801  1.00  0.00           O  
HETATM   10  O3  UNL     1       4.397  -0.211   1.083  1.00  0.00           O  
HETATM   11  H1  UNL     1      -2.113   1.719  -1.545  1.00  0.00           H  
HETATM   12  H2  UNL     1      -3.330   0.432  -1.628  1.00  0.00           H  
HETATM   13  H3  UNL     1      -3.074   1.299  -0.020  1.00  0.00           H  
HETATM   14  H4  UNL     1      -1.427  -0.846  -1.396  1.00  0.00           H  
HETATM   15  H5  UNL     1      -2.515  -1.923   0.300  1.00  0.00           H  
HETATM   16  H6  UNL     1      -2.958  -0.392   1.100  1.00  0.00           H  
HETATM   17  H7  UNL     1      -1.324  -1.087   1.381  1.00  0.00           H  
HETATM   18  H8  UNL     1       0.762  -1.254   0.174  1.00  0.00           H  
HETATM   19  H9  UNL     1       2.450   0.926  -0.513  1.00  0.00           H  
HETATM   20  H10 UNL     1       2.086   1.099   1.238  1.00  0.00           H  
HETATM   21  H11 UNL     1       4.897   0.500   0.610  1.00  0.00           H  
CONECT    1    2   11   12   13
CONECT    2    3    4   14
CONECT    3   15   16   17
CONECT    4    5    5    6
CONECT    6    7   18
CONECT    7    8   19   20
CONECT    8    9    9   10
CONECT   10   21
END
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SMILES for HMDB0000730 (Isobutyrylglycine)

CC(C)C(=O)NCC(O)=O
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INCHI for HMDB0000730 (Isobutyrylglycine)

InChI=1S/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
IsobutanoylglycineChEBI
N-IsobutanoylglycineChEBI
N-(1-Methylpropyl)glycineHMDB
N-IsobutyrylglycineHMDB
IsobutyrylglycineChEBI
Chemical FormulaC6H11NO3
Average Molecular Weight145.1564
Monoisotopic Molecular Weight145.073893223
IUPAC Name2-(2-methylpropanamido)acetic acid
Traditional Nameisobutyrylglycine
CAS Registry Number15926-18-8
SMILES
CC(C)C(=O)NCC(O)=O
InChI Identifier
InChI=1S/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)
InChI KeyDCICDMMXFIELDF-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as n-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentN-acyl-alpha amino acids
Alternative Parents
Substituents
  • N-acyl-alpha-amino acid
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Health effect
Disposition
Biological locationSource
Process
Naturally occurring process
Role
Biological roleIndustrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point82.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-MetCCS_train_neg132.06730932474
[M-H]-Not Available132.067http://allccs.zhulab.cn/database/detail?ID=AllCCS00000030
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
Abnormal Concentrations
Associated Disorders and Diseases
Disease References
Propionic acidemia
  1. Riemersma M, Hazebroek MR, Helderman-van den Enden ATJM, Salomons GS, Ferdinandusse S, Brouwers MCGJ, van der Ploeg L, Heymans S, Glatz JFC, van den Wijngaard A, Krapels IPC, Bierau J, Brunner HG: Propionic acidemia as a cause of adult-onset dilated cardiomyopathy. Eur J Hum Genet. 2017 Nov;25(11):1195-1201. doi: 10.1038/ejhg.2017.127. Epub 2017 Aug 30. [PubMed:28853722 ]
Ethylmalonic encephalopathy
  1. Nowaczyk MJ, Lehotay DC, Platt BA, Fisher L, Tan R, Phillips H, Clarke JT: Ethylmalonic and methylsuccinic aciduria in ethylmalonic encephalopathy arise from abnormal isoleucine metabolism. Metabolism. 1998 Jul;47(7):836-9. [PubMed:9667231 ]
  2. Lehnert W, Ruitenbeek W: Ethylmalonic aciduria associated with progressive neurological disease and partial cytochrome c oxidase deficiency. J Inherit Metab Dis. 1993;16(3):557-9. [PubMed:7609451 ]
  3. G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de). METAGENE consortium.
Glutaric aciduria II
  1. Gregersen N, Kolvraa S, Rasmussen K, Christensen E, Brandt NJ, Ebbesen F, Hansen FH: Biochemical studies in a patient with defects in the metabolism of acyl-CoA and sarcosine: another possible case of glutaric aciduria type II. J Inherit Metab Dis. 1980;3(3):67-72. [PubMed:6158623 ]
  2. G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de). METAGENE consortium.
Isobutyryl-CoA Dehydrogenase Deficiency
  1. Oglesbee D, He M, Majumder N, Vockley J, Ahmad A, Angle B, Burton B, Charrow J, Ensenauer R, Ficicioglu CH, Keppen LD, Marsden D, Tortorelli S, Hahn SH, Matern D: Development of a newborn screening follow-up algorithm for the diagnosis of isobutyryl-CoA dehydrogenase deficiency. Genet Med. 2007 Feb;9(2):108-16. doi: 10.1097GIM.0b013e31802f78d6. [PubMed:17304052 ]
Short Chain Acyl-Coa Dehydrogenase Deficiency
  1. Oglesbee D, He M, Majumder N, Vockley J, Ahmad A, Angle B, Burton B, Charrow J, Ensenauer R, Ficicioglu CH, Keppen LD, Marsden D, Tortorelli S, Hahn SH, Matern D: Development of a newborn screening follow-up algorithm for the diagnosis of isobutyryl-CoA dehydrogenase deficiency. Genet Med. 2007 Feb;9(2):108-16. doi: 10.1097GIM.0b013e31802f78d6. [PubMed:17304052 ]
Associated OMIM IDs
  • 606054 (Propionic acidemia)
  • 602473 (Ethylmalonic encephalopathy)
  • 231680 (Glutaric aciduria II)
  • 611283 (Isobutyryl-CoA Dehydrogenase Deficiency)
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022208
KNApSAcK IDC00052325
Chemspider ID9030891
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID5698
PubChem Compound10855600
PDB IDNot Available
ChEBI ID70979
Food Biomarker OntologyNot Available
VMH IDCE4969
MarkerDB IDMDB00000239
Good Scents IDNot Available
References
Synthesis ReferenceKatz, J.; Lieberman, I.; Barker, H. A. Formation of propionyl-, butyryl-, and other acylglycines by enzymes of Clostridium kluyveri. Journal of Biological Chemistry (1953), 200 431-41.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Sass JO, Sander S, Zschocke J: Isobutyryl-CoA dehydrogenase deficiency: isobutyrylglycinuria and ACAD8 gene mutations in two infants. J Inherit Metab Dis. 2004;27(6):741-5. [PubMed:15505379 ]
  2. Goodman SI, McCabe ER, Fennessey PV, Mace JW: Multiple acyl-CoA dehydrogenase deficiency (glutaric aciduria type II) with transient hypersarcosinemia and sarcosinuria; possible inherited deficiency of an electron transfer flavoprotein. Pediatr Res. 1980 Jan;14(1):12-7. [PubMed:7360517 ]

Enzymes

Enzyme Details
1. Glycine N-acyltransferase
General function:
Involved in glycine N-acyltransferase activity
Specific function:
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
Gene Name:
GLYAT
Uniprot ID:
Q6IB77
Molecular weight:
18506.33
Enzyme Details
2. Glycine N-acyltransferase-like protein 1
General function:
Involved in glycine N-acyltransferase activity
Specific function:
Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.
Gene Name:
GLYATL1
Uniprot ID:
Q969I3
Molecular weight:
35100.895
Enzyme Details
3. Glycine N-acyltransferase-like protein 2
General function:
Involved in glycine N-acyltransferase activity
Specific function:
Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.
Gene Name:
GLYATL2
Uniprot ID:
Q8WU03
Molecular weight:
34277.055
Enzyme Details
4. Glycine N-acyltransferase-like protein 3
General function:
Involved in glycine N-acyltransferase activity
Specific function:
Acyltransferase which transfers the acyl group to the N- terminus of glycine
Gene Name:
GLYATL3
Uniprot ID:
Q5SZD4
Molecular weight:
32703.3