Record Information |
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Version | 5.0 |
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Status | Detected but not Quantified |
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Creation Date | 2005-11-16 15:48:42 UTC |
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Update Date | 2023-02-21 17:15:27 UTC |
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HMDB ID | HMDB0001122 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | N-Methylformamide |
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Description | N-Methylformamide, also known as HCONHCH3 or NMF, belongs to the class of organic compounds known as carboximidic acids. These are organic acids with the general formula RC(=N)-OH (R=H, organic group). N-Methylformamide has been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make N-methylformamide a potential biomarker for the consumption of these foods. Based on a literature review a significant number of articles have been published on N-Methylformamide. |
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Structure | InChI=1S/C2H5NO/c1-3-2-4/h2H,1H3,(H,3,4) |
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Synonyms | Value | Source |
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HCONHCH3 | ChEBI | Methylformamide | ChEBI | Monomethylformamide | ChEBI | N-Methyl-formamide | ChEBI | N-Monomethylformamide | ChEBI | NMF | ChEBI | N-Methylformamide | KEGG |
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Chemical Formula | C2H5NO |
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Average Molecular Weight | 59.0672 |
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Monoisotopic Molecular Weight | 59.037113787 |
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IUPAC Name | N-methylformamide |
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Traditional Name | methylformamide |
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CAS Registry Number | 123-39-7 |
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SMILES | CNC=O |
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InChI Identifier | InChI=1S/C2H5NO/c1-3-2-4/h2H,1H3,(H,3,4) |
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InChI Key | ATHHXGZTWNVVOU-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as carboximidic acids. These are organic acids with the general formula RC(=N)-OH (R=H, organic group). |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Carboximidic acids and derivatives |
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Sub Class | Carboximidic acids |
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Direct Parent | Carboximidic acids |
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Alternative Parents | |
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Substituents | - Organic 1,3-dipolar compound
- Propargyl-type 1,3-dipolar organic compound
- Carboximidic acid
- Organic nitrogen compound
- Organic oxygen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Organooxygen compound
- Organonitrogen compound
- Imine
- Aliphatic acyclic compound
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | Not Available |
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Role | Not Available |
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Physical Properties |
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State | Liquid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | -3.8 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 1000 mg/mL at 25 °C | Not Available | LogP | -0.97 | HANSCH,C ET AL. (1995) |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedMetabolite | SMILES | Kovats RI Value | Column Type | Reference |
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N-Methylformamide | CNC=O | 1519.7 | Standard polar | 33892256 | N-Methylformamide | CNC=O | 726.5 | Standard non polar | 33892256 | N-Methylformamide | CNC=O | 754.9 | Semi standard non polar | 33892256 |
DerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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N-Methylformamide,1TMS,isomer #1 | CN(C=O)[Si](C)(C)C | 858.6 | Semi standard non polar | 33892256 | N-Methylformamide,1TMS,isomer #1 | CN(C=O)[Si](C)(C)C | 853.8 | Standard non polar | 33892256 | N-Methylformamide,1TMS,isomer #1 | CN(C=O)[Si](C)(C)C | 1041.1 | Standard polar | 33892256 | N-Methylformamide,1TBDMS,isomer #1 | CN(C=O)[Si](C)(C)C(C)(C)C | 1028.0 | Semi standard non polar | 33892256 | N-Methylformamide,1TBDMS,isomer #1 | CN(C=O)[Si](C)(C)C(C)(C)C | 1048.7 | Standard non polar | 33892256 | N-Methylformamide,1TBDMS,isomer #1 | CN(C=O)[Si](C)(C)C(C)(C)C | 1182.6 | Standard polar | 33892256 |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - N-Methylformamide EI-B (Non-derivatized) | splash10-057i-9000000000-60a7888b3706e6c01b2b | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - N-Methylformamide EI-B (Non-derivatized) | splash10-057i-9000000000-60a7888b3706e6c01b2b | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - N-Methylformamide GC-MS (Non-derivatized) - 70eV, Positive | splash10-0a59-9000000000-3d1c6f14cce05319e765 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - N-Methylformamide GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 10V, Positive-QTOF | splash10-03di-9000000000-efef2ef9adab060d9968 | 2016-06-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 20V, Positive-QTOF | splash10-03e9-9000000000-d4d4c6894b8830773c2a | 2016-06-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 40V, Positive-QTOF | splash10-001i-9000000000-ef803f2a719044681087 | 2016-06-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 10V, Negative-QTOF | splash10-0a6r-9000000000-dbaf66b4271f4f119f54 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 20V, Negative-QTOF | splash10-0a6u-9000000000-82e7cd4cf5be3df7dced | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 40V, Negative-QTOF | splash10-004l-9000000000-1e7aed11b63f593cd587 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 10V, Negative-QTOF | splash10-0a4i-9000000000-0d3d5066ba65a1714c21 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 20V, Negative-QTOF | splash10-0a4i-9000000000-439ede5503e5f8b2f4fc | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 40V, Negative-QTOF | splash10-0006-9000000000-90726b17dc36e29c5299 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 10V, Positive-QTOF | splash10-03di-9000000000-14d0958d7f503100d058 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 20V, Positive-QTOF | splash10-01ox-9000000000-8ff4d86e2c774ca6af18 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - N-Methylformamide 40V, Positive-QTOF | splash10-0006-9000000000-ff7f2c935a022bb6caf6 | 2021-09-25 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted 1D NMR | 13C NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-16 | Wishart Lab | View Spectrum |
IR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-) | 2023-02-03 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+) | 2023-02-03 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+) | 2023-02-03 | FELIX lab | View Spectrum |
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General References | - Shieh DB, Chen CC, Shih TS, Tai HM, Wei YH, Chang HY: Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide. Chem Biol Interact. 2007 Feb 20;165(3):211-9. Epub 2006 Dec 20. [PubMed:17254560 ]
- Mraz J, Cimlova J, Stransky V, Nohova H, Kicova R, Simek P: N-Methylcarbamoyl-lysine adduct in globin: a new metabolic product and potential biomarker of N, N-dimethylformamide in humans. Toxicol Lett. 2006 Apr 10;162(2-3):211-8. Epub 2005 Nov 14. [PubMed:16289959 ]
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