Record Information |
---|
Version | 5.0 |
---|
Status | Detected and Quantified |
---|
Creation Date | 2006-08-16 13:07:24 UTC |
---|
Update Date | 2022-03-07 02:49:09 UTC |
---|
HMDB ID | HMDB0001315 |
---|
Secondary Accession Numbers | |
---|
Metabolite Identification |
---|
Common Name | Phosphorus |
---|
Description | Phosphorus, in its common form, is a waxy white (or yellowish) solid that has a characteristic disagreeable smell similar to that of garlic. Pure forms of the element are colourless and transparent. This nonmetal is not soluble in water, but is soluble in carbon disulfide. The white allotrope ignites spontaneously in air; however, both white and red phosphorus burn in air to produce phosphorus pentoxide. Phosphorus is a key element in all known forms of life. Physiologically, it exists as an ion in the body. Inorganic phosphorus in the form of the phosphate PO43- plays a major role in biological molecules such as DNA and RNA where it forms part of the structural framework of these molecules. Living cells also utilize phosphate to transport cellular energy via adenosine triphosphate (ATP). Nearly every cellular process that uses energy gets it in the form of ATP. ATP is also important for phosphorylation, a key regulatory event in cells. Phospholipids are the main structural components of all cellular membranes. Calcium phosphate salts are used by animals to stiffen their bones. An average person contains a little less than 1 kg of phosphorus, about three quarters of which is present in bones and teeth in the form of apatite. A well-fed adult in the industrialized world consumes and excretes about 1-3 g of phosphorus per day in the form of phosphate. Phosphorus is an essential mineral macronutrient, which is studied extensively in soil conservation in order to understand plant uptake from soil systems. Due to its reactivity to air and many other oxygen containing substances, phosphorus is not found free in nature, but it is widely distributed in many different minerals. Phosphorus is found to be associated with glycerol intolerance syndrome, which is an inborn error of metabolism. |
---|
Structure | |
---|
Synonyms | Value | Source |
---|
15P | ChEBI | Fosforo | ChEBI | P | ChEBI | Phosphor | ChEBI | Phosphore | ChEBI | Hittorf'S phosphorus | HMDB | Phosphorous | HMDB | Phosphorus-30 | HMDB | Red phosphorus | HMDB | Violet phosphorus | HMDB | White phosphorus | HMDB | Phosphorus 31 | HMDB | Phosphorus, red | HMDB | Phosphorus-31 | HMDB | Phosphorus, white | HMDB | Phosphorus, black | HMDB | Yellow phosphorus | HMDB | Phosphorus, yellow | HMDB | Black phosphorus | HMDB | Phosphorus | ChEBI |
|
---|
Chemical Formula | P |
---|
Average Molecular Weight | 30.9738 |
---|
Monoisotopic Molecular Weight | 30.973761512 |
---|
IUPAC Name | phosphanylidyne |
---|
Traditional Name | phosphanylidyne |
---|
CAS Registry Number | 7723-14-0 |
---|
SMILES | [P] |
---|
InChI Identifier | InChI=1S/P |
---|
InChI Key | OAICVXFJPJFONN-UHFFFAOYSA-N |
---|
Chemical Taxonomy |
---|
Description | Belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. |
---|
Kingdom | Inorganic compounds |
---|
Super Class | Homogeneous non-metal compounds |
---|
Class | Homogeneous other non-metal compounds |
---|
Sub Class | Not Available |
---|
Direct Parent | Homogeneous other non-metal compounds |
---|
Alternative Parents | Not Available |
---|
Substituents | - Homogeneous other non metal
|
---|
Molecular Framework | Not Available |
---|
External Descriptors | |
---|
Ontology |
---|
Physiological effect | |
---|
Disposition | Biological locationRoute of exposureSourceExogenousFood- Food (HMDB: HMDB0001315)
Animal originVegetableFruitHerb and spiceNutCereal and cereal productPulseGourdSoyTeaBeverageAquatic originEggConfectioneryMilk and milk productOther milk productFermented milkFermented milk productUnfermented milk- Milk (Other mammals) (FooDB: FOOD00690)
- Milk (Human) (FooDB: FOOD00666)
- Milk (Cow) (FooDB: FOOD00618)
- Cow milk, pasteurized, vitamin A + D added, 0% fat (FooDB: FOOD00889)
- Cow milk, pasteurized, vitamin A + D added, 1% fat (FooDB: FOOD00890)
- Cow milk, pasteurized, vitamin A + D added, 2% fat (FooDB: FOOD00891)
- Cow milk, pasteurized, vitamin D added, 3.25% fat (FooDB: FOOD00892)
Fat and oilCocoa and cocoa productBaking goodBaby foodUnclassified food or beverageDishCoffee and coffee productSnack
|
---|
Process | |
---|
Role | |
---|
Physical Properties |
---|
State | Solid |
---|
Experimental Molecular Properties | Property | Value | Reference |
---|
Melting Point | 44.1 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
|
---|
Experimental Chromatographic Properties | Not Available |
---|
Predicted Molecular Properties | |
---|
Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredictor | Adduct Type | CCS Value (Å2) | Reference |
---|
DeepCCS | [M+H]+ | 110.045 | 30932474 | DeepCCS | [M-H]- | 108.292 | 30932474 | DeepCCS | [M-2H]- | 143.458 | 30932474 | DeepCCS | [M+Na]+ | 116.778 | 30932474 |
Predicted Kovats Retention IndicesUnderivatizedMetabolite | SMILES | Kovats RI Value | Column Type | Reference |
---|
Phosphorus | [P] | 769.0 | Standard polar | 33892256 | Phosphorus | [P] | 259.8 | Standard non polar | 33892256 | Phosphorus | [P] | 185.9 | Semi standard non polar | 33892256 |
|
---|
Spectra |
---|
| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
---|
Predicted GC-MS | Predicted GC-MS Spectrum - Phosphorus GC-MS (Non-derivatized) - 70eV, Positive | splash10-001i-9000000000-88317f9b56fea79262a0 | 2016-09-22 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Phosphorus GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Phosphorus GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
---|
Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 10V, Positive-QTOF | splash10-000i-9000000000-0ff3e41d21c9c6b5734b | 2016-09-12 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 20V, Positive-QTOF | splash10-000i-9000000000-0ff3e41d21c9c6b5734b | 2016-09-12 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 40V, Positive-QTOF | splash10-000i-9000000000-0ff3e41d21c9c6b5734b | 2016-09-12 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 10V, Negative-QTOF | splash10-001i-9000000000-e5f6a63c9b1574340f61 | 2016-09-12 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 20V, Negative-QTOF | splash10-001i-9000000000-e5f6a63c9b1574340f61 | 2016-09-12 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 40V, Negative-QTOF | splash10-001i-9000000000-e5f6a63c9b1574340f61 | 2016-09-12 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 10V, Positive-QTOF | splash10-001i-9000000000-b25ebf44fa1deb41a771 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 20V, Positive-QTOF | splash10-001i-9000000000-b25ebf44fa1deb41a771 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Phosphorus 40V, Positive-QTOF | splash10-001i-9000000000-b25ebf44fa1deb41a771 | 2021-09-22 | Wishart Lab | View Spectrum |
|
---|
Biological Properties |
---|
Cellular Locations | - Cytoplasm (predicted from logP)
|
---|
Biospecimen Locations | - Blood
- Cerebrospinal Fluid (CSF)
- Saliva
- Urine
|
---|
Tissue Locations | - Brain
- Kidney
- Liver
- Parathyroid Gland
|
---|
Pathways | |
---|
Normal Concentrations |
---|
| |
Blood | Detected and Quantified | 11900.0 (10100.0-14300.0) uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 2030.0(1390.0-2600.0) uM | Newborn (0-30 days old) | Both | Normal | | details | Blood | Detected and Quantified | 1640.0 (1280.0-2000.0) uM | Children (1-13 years old) | Both | Normal | | details | Blood | Detected and Quantified | 1540.0 (1050.0-2050.0) uM | Adolescent (13-18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 1035.0 (710.0-1360.0) uM | Adult (>18 years old) | Male | Normal | | details | Blood | Detected and Quantified | 1065.0 (770.0-1360.0) uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 800.0-1500.0 uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 800.0-1500.0 uM | Adult (>18 years old) | Male | Normal | | details | Cerebrospinal Fluid (CSF) | Detected and Quantified | 520.0 (371.0-668.0) uM | Adult (>18 years old) | Both | Normal | | details | Saliva | Detected and Quantified | 5743.571 +/- 2085.636 uM | Adult (>18 years old) | Not Specified | Normal | | details | Saliva | Detected and Quantified | 4184.187 +/- 1468.985 uM | Adult (>18 years old) | Not Specified | Normal | | details | Saliva | Detected and Quantified | 5001.00698 +/- 1417.329 uM | Adolescent (13-18 years old) | Not Specified | Normal | | details | Saliva | Detected and Quantified | 3373.823 +/- 894.305 uM | Adolescent (13-18 years old) | Not Specified | Normal | | details | Saliva | Detected and Quantified | 3470 +/- 940 uM | Adult (>18 years old) | Not Specified | Normal | | details | Saliva | Detected and Quantified | 2020 +/- 5040 uM | Adult (>18 years old) | Not Specified | Normal | | details | Saliva | Detected and Quantified | 4702.78 +/- 2433.64 uM | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 1799 (221-4936) umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 1666.67-4333.33 umol/mmol creatinine | Adult (>18 years old) | Not Specified | Normal | | details | Urine | Detected and Quantified | 2993.4 (0.0-1710.5) umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 1315.7 +/- 592.1 umol/mmol creatinine | Children (1-13 years old) | Both | Normal | | details | Urine | Detected and Quantified | 4655.740 (2327.870-8978.928) umol/mmol creatinine | Adult (>18 years old) | Not Available | Normal | | details | Urine | Detected and Quantified | 1893.333 +/- 493.333 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details |
|
---|
Abnormal Concentrations |
---|
| |
Blood | Detected and Quantified | 676.518 uM | Adult (>18 years old) | Male | 27-hydroxylase deficiency | | details | Blood | Detected and Quantified | 2200.00 (1400.00-3000.00) uM | Adult (>18 years old) | Both | Glycerol intolerance syndrome | | details | Blood | Detected and Quantified | 50250.00 (500.00-100000.00) uM | Children (1-13 years old) | Both | Glycerol intolerance syndrom | | details | Urine | Detected and Quantified | 2660.423 (1330.212-35583.159) umol/mmol creatinine | Adult (>18 years old) | Not Available | Fructose intolerance, hereditary | | details |
|
---|
Associated Disorders and Diseases |
---|
Disease References | Glycerol intolerance syndrome |
---|
- G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de). METAGENE consortium.
| Cerebrotendinous xanthomatosis |
---|
- Agrawal NK, Garg S: Cerebrotendinous xanthomatosis: a rare disorder with a rare presentation. BMJ Case Rep. 2012 Sep 21;2012. pii: bcr-2012-006202. doi: 10.1136/bcr-2012-006202. [PubMed:23001091 ]
| Fructose intolerance, hereditary |
---|
- Steinmann B, Gitzelmann R: The diagnosis of hereditary fructose intolerance. Helv Paediatr Acta. 1981 Sep;36(4):297-316. [PubMed:6268573 ]
|
|
---|
Associated OMIM IDs | - 213700 (Cerebrotendinous xanthomatosis)
- 229600 (Fructose intolerance, hereditary)
|
---|
External Links |
---|
DrugBank ID | Not Available |
---|
Phenol Explorer Compound ID | Not Available |
---|
FooDB ID | FDB013348 |
---|
KNApSAcK ID | Not Available |
---|
Chemspider ID | 4575369 |
---|
KEGG Compound ID | C06262 |
---|
BioCyc ID | Not Available |
---|
BiGG ID | Not Available |
---|
Wikipedia Link | Phosphorus |
---|
METLIN ID | Not Available |
---|
PubChem Compound | 5462309 |
---|
PDB ID | Not Available |
---|
ChEBI ID | 28659 |
---|
Food Biomarker Ontology | Not Available |
---|
VMH ID | Not Available |
---|
MarkerDB ID | Not Available |
---|
Good Scents ID | Not Available |
---|
References |
---|
Synthesis Reference | Not Available |
---|
Material Safety Data Sheet (MSDS) | Not Available |
---|
General References | - Siqueira WL, de Oliveira E, Mustacchi Z, Nicolau J: Electrolyte concentrations in saliva of children aged 6-10 years with Down syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jul;98(1):76-9. [PubMed:15243474 ]
- Slatopolsky E, Gonzalez E, Martin K: Pathogenesis and treatment of renal osteodystrophy. Blood Purif. 2003;21(4-5):318-26. [PubMed:12944733 ]
- Goodman WG: Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. Pediatr Nephrol. 2003 Dec;18(12):1206-10. Epub 2003 Oct 28. [PubMed:14586685 ]
- Urena P, Frazao JM: Calcimimetic agents: review and perspectives. Kidney Int Suppl. 2003 Jun;(85):S91-6. [PubMed:12753275 ]
- Pawlowska J, Matusik H, Socha P, Ismail H, Ryzko J, Karczmarewicz E, Jankowska I, Teisseyre M, Lorenc R: Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis. Transplant Proc. 2004 Jun;36(5):1479-80. [PubMed:15251362 ]
- Obata T, Someya Y, Suhara T, Ota Y, Hirakawa K, Ikehira H, Tanada S, Okubo Y: Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study. Psychiatry Clin Neurosci. 2004 Feb;58(1):48-53. [PubMed:14678457 ]
- Gandhy M, Damle SG: Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children. J Indian Soc Pedod Prev Dent. 2003 Dec;21(4):135-8. [PubMed:14765611 ]
- Casari S, Rossi V, Varenna M, Gasparini M, Parafioriti A, Failoni S, Sinigaglia L: A case of oncogenic osteomalacia detected by 111In-pentetreotide total body scan. Clin Exp Rheumatol. 2003 Jul-Aug;21(4):493-6. [PubMed:12942704 ]
- Ahn JH, Yoo CI, Lee CR, Lee JH, Lee H, Kim CY, Park JK, Sakai T, Yoon CS, Kim Y: Calcification mimicking manganese-induced increased signal intensities in T1-weighted MR images in a patient taking herbal medicine: case report. Neurotoxicology. 2003 Dec;24(6):835-8. [PubMed:14637378 ]
- Emmett M: A comparison of clinically useful phosphorus binders for patients with chronic kidney failure. Kidney Int Suppl. 2004 Sep;(90):S25-32. [PubMed:15296504 ]
|
---|