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Showing metabocard for Pyridoxal (HMDB0001545)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:47 UTC
HMDB IDHMDB0001545
Secondary Accession Numbers
  • HMDB01545
Metabolite Identification
Common NamePyridoxal
DescriptionPyridoxal is a pyridinecarbaldehyde that is pyridine-4-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 5 respectively. Pyridoxal, also known as pyridoxaldehyde, belongs to the class of organic compounds known as pyridoxals and derivatives. Pyridoxals and derivatives are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2, 3, 4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively. Pyridoxal is one form of vitamin B6. Pyridoxal exists in all living species, ranging from bacteria to humans. In humans, pyridoxal is involved in glycine and serine metabolism. Pyridoxal has been detected, but not quantified in several different foods, such as sourdoughs, lichee, arctic blackberries, watercress, and cottonseeds. Some medically relevant bacteria, such as those in the genera Granulicatella and Abiotrophia, require pyridoxal for growth. This nutritional requirement can lead to the culture phenomenon of satellite growth. In in vitro culture, these pyridoxal-dependent bacteria may only grow in areas surrounding colonies of bacteria from other genera ("satellitism") that are capable of producing pyridoxal. Pridoxal has a role as a cofactor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite.
Structure
Data?1676999747
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0001545 (Pyridoxal)

  Mrv1652309042000242D          

 12 12  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
M  END
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3D MOL for HMDB0001545 (Pyridoxal)

HMDB0001545
     RDKit          3D
Pyridoxal
 21 21  0  0  0  0  0  0  0  0999 V2000
   -3.0457    1.1173   -0.4227 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924    0.8083   -0.3262 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6474    1.6878   -0.6640 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6675    1.4148   -0.5792 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1385    0.2032   -0.1358 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.1198   -0.0347 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3808    0.9193   -0.4291 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1819   -0.7434    0.2270 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6798   -2.0263    0.6969 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0736   -2.9412    1.0456 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1626   -0.4489    0.1345 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1452   -1.3258    0.4718 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6074    0.3062   -0.9266 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4699    1.3633    0.5719 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1327    2.0110   -1.0809 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4212    2.1507   -0.8614 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7550   -1.0566   -0.6179 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8248   -0.3892    1.0262 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6119    1.5109    0.3455 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7678   -2.2013    0.7484 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1325   -2.2405    0.8108 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
  8 11  2  0
 11 12  1  0
 11  2  1  0
  1 13  1  0
  1 14  1  0
  1 15  1  0
  4 16  1  0
  6 17  1  0
  6 18  1  0
  7 19  1  0
  9 20  1  0
 12 21  1  0
M  END
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3D SDF for HMDB0001545 (Pyridoxal)

  Mrv1652309042000242D          

 12 12  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0001545

> <DATABASE_NAME>
hmdb

> <SMILES>
CC1=NC=C(CO)C(C=O)=C1O

> <INCHI_IDENTIFIER>
InChI=1S/C8H9NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,4,10,12H,3H2,1H3

> <INCHI_KEY>
RADKZDMFGJYCBB-UHFFFAOYSA-N

> <FORMULA>
C8H9NO3

> <MOLECULAR_WEIGHT>
167.162

> <EXACT_MASS>
167.058243159

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
21

> <JCHEM_AVERAGE_POLARIZABILITY>
16.280640988280627

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde

> <ALOGPS_LOGP>
0.02

> <JCHEM_LOGP>
0.17853081366666687

> <ALOGPS_LOGS>
-1.16

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.658014655901226

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.971193899104745

> <JCHEM_PKA_STRONGEST_BASIC>
4.110818751313327

> <JCHEM_POLAR_SURFACE_AREA>
70.42

> <JCHEM_REFRACTIVITY>
43.8734

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.17e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
pyridoxal

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0001545 (Pyridoxal)

HMDB0001545
     RDKit          3D
Pyridoxal
 21 21  0  0  0  0  0  0  0  0999 V2000
   -3.0457    1.1173   -0.4227 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924    0.8083   -0.3262 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6474    1.6878   -0.6640 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6675    1.4148   -0.5792 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1385    0.2032   -0.1358 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.1198   -0.0347 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3808    0.9193   -0.4291 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1819   -0.7434    0.2270 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6798   -2.0263    0.6969 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0736   -2.9412    1.0456 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1626   -0.4489    0.1345 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1452   -1.3258    0.4718 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6074    0.3062   -0.9266 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4699    1.3633    0.5719 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1327    2.0110   -1.0809 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4212    2.1507   -0.8614 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7550   -1.0566   -0.6179 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8248   -0.3892    1.0262 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6119    1.5109    0.3455 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7678   -2.2013    0.7484 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1325   -2.2405    0.8108 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  2  0
  8 11  2  0
 11 12  1  0
 11  2  1  0
  1 13  1  0
  1 14  1  0
  1 15  1  0
  4 16  1  0
  6 17  1  0
  6 18  1  0
  7 19  1  0
  9 20  1  0
 12 21  1  0
M  END
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PDB for HMDB0001545 (Pyridoxal)

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0       1.334   3.850   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0       2.667   1.540   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      -1.334   2.310   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      -2.667   0.000   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       2.667  -3.080   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    7                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6   11                                                  
CONECT    6    5    7    9                                                  
CONECT    7    6    2    8                                                  
CONECT    8    7                                                            
CONECT    9    6   10                                                       
CONECT   10    9                                                            
CONECT   11    5   12                                                       
CONECT   12   11                                                            
MASTER        0    0    0    0    0    0    0    0   12    0   24    0
END
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3D PDB for HMDB0001545 (Pyridoxal)

COMPND    HMDB0001545
HETATM    1  C1  UNL     1      -3.046   1.117  -0.423  1.00  0.00           C  
HETATM    2  C2  UNL     1      -1.592   0.808  -0.326  1.00  0.00           C  
HETATM    3  N1  UNL     1      -0.647   1.688  -0.664  1.00  0.00           N  
HETATM    4  C3  UNL     1       0.668   1.415  -0.579  1.00  0.00           C  
HETATM    5  C4  UNL     1       1.138   0.203  -0.136  1.00  0.00           C  
HETATM    6  C5  UNL     1       2.580  -0.120  -0.035  1.00  0.00           C  
HETATM    7  O1  UNL     1       3.381   0.919  -0.429  1.00  0.00           O  
HETATM    8  C6  UNL     1       0.182  -0.743   0.227  1.00  0.00           C  
HETATM    9  C7  UNL     1       0.680  -2.026   0.697  1.00  0.00           C  
HETATM   10  O2  UNL     1      -0.074  -2.941   1.046  1.00  0.00           O  
HETATM   11  C8  UNL     1      -1.163  -0.449   0.135  1.00  0.00           C  
HETATM   12  O3  UNL     1      -2.145  -1.326   0.472  1.00  0.00           O  
HETATM   13  H1  UNL     1      -3.607   0.306  -0.927  1.00  0.00           H  
HETATM   14  H2  UNL     1      -3.470   1.363   0.572  1.00  0.00           H  
HETATM   15  H3  UNL     1      -3.133   2.011  -1.081  1.00  0.00           H  
HETATM   16  H4  UNL     1       1.421   2.151  -0.861  1.00  0.00           H  
HETATM   17  H5  UNL     1       2.755  -1.057  -0.618  1.00  0.00           H  
HETATM   18  H6  UNL     1       2.825  -0.389   1.026  1.00  0.00           H  
HETATM   19  H7  UNL     1       3.612   1.511   0.345  1.00  0.00           H  
HETATM   20  H8  UNL     1       1.768  -2.201   0.748  1.00  0.00           H  
HETATM   21  H9  UNL     1      -2.133  -2.240   0.811  1.00  0.00           H  
CONECT    1    2   13   14   15
CONECT    2    3    3   11
CONECT    3    4
CONECT    4    5    5   16
CONECT    5    6    8
CONECT    6    7   17   18
CONECT    7   19
CONECT    8    9   11   11
CONECT    9   10   10   20
CONECT   11   12
CONECT   12   21
END
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SMILES for HMDB0001545 (Pyridoxal)

CC1=NC=C(CO)C(C=O)=C1O
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INCHI for HMDB0001545 (Pyridoxal)

InChI=1S/C8H9NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,4,10,12H,3H2,1H3
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
3-HYDROXY-5-(hydroxymethyl)-2-methylisonicotinaldehydeChEBI
PyridoxaldehydeChEBI
3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehydeHMDB
Chemical FormulaC8H9NO3
Average Molecular Weight167.162
Monoisotopic Molecular Weight167.058243159
IUPAC Name3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
Traditional Namepyridoxal
CAS Registry Number66-72-8
SMILES
CC1=NC=C(CO)C(C=O)=C1O
InChI Identifier
InChI=1S/C8H9NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,4,10,12H,3H2,1H3
InChI KeyRADKZDMFGJYCBB-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as pyridoxals and derivatives. Pyridoxals and derivatives are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2,3,4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPyridine carboxaldehydes
Direct ParentPyridoxals and derivatives
Alternative Parents
Substituents
  • Pyridoxal
  • Aryl-aldehyde
  • Hydroxypyridine
  • Methylpyridine
  • Vinylogous acid
  • Heteroaromatic compound
  • Azacycle
  • Hydrocarbon derivative
  • Aldehyde
  • Alcohol
  • Organic oxygen compound
  • Aromatic alcohol
  • Organic nitrogen compound
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organopnictogen compound
  • Organic oxide
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effect
Health effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Industrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point165 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility500 mg/mLNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available130.4http://allccs.zhulab.cn/database/detail?ID=AllCCS00000472
[M+H]+Not Available132.1http://allccs.zhulab.cn/database/detail?ID=AllCCS00000472
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Urine
Tissue Locations
  • Erythrocyte
  • Fibroblasts
  • Kidney
  • Placenta
Pathways
Normal Concentrations
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.036 +/- 0.031 uMAdult (>18 years old)BothSickle cell disease-SS (SCD-SS) details
Cerebrospinal Fluid (CSF)Detected and Quantified0.015 uMChildren (1-13 years old)FemaleEpilepsy, early-onset, vitamin B6-dependent details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer		 details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer		 details
Associated Disorders and Diseases
Disease References
Sickle cell anemia
  1. Nelson MC, Zemel BS, Kawchak DA, Barden EM, Frongillo EA Jr, Coburn SP, Ohene-Frempong K, Stallings VA: Vitamin B6 status of children with sickle cell disease. J Pediatr Hematol Oncol. 2002 Aug-Sep;24(6):463-9. [PubMed:12218594 ]
Epilepsy, early-onset, vitamin B6-dependent
  1. Darin N, Reid E, Prunetti L, Samuelsson L, Husain RA, Wilson M, El Yacoubi B, Footitt E, Chong WK, Wilson LC, Prunty H, Pope S, Heales S, Lascelles K, Champion M, Wassmer E, Veggiotti P, de Crecy-Lagard V, Mills PB, Clayton PT: Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy. Am J Hum Genet. 2016 Dec 1;99(6):1325-1337. doi: 10.1016/j.ajhg.2016.10.011. [PubMed:27912044 ]
Colorectal cancer
  1. Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
  2. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Associated OMIM IDs
  • 603903 (Sickle cell anemia)
  • 617290 (Epilepsy, early-onset, vitamin B6-dependent)
  • 114500 (Colorectal cancer)
DrugBank IDDB00147
Phenol Explorer Compound IDNot Available
FooDB IDFDB011169
KNApSAcK IDC00007509
Chemspider ID1021
KEGG Compound IDC00250
BioCyc IDPYRIDOXAL
BiGG ID34393
Wikipedia LinkPyridoxal
METLIN ID6312
PubChem Compound1050
PDB IDNot Available
ChEBI ID17310
Food Biomarker OntologyNot Available
VMH IDPYDX
MarkerDB IDMDB00000335
Good Scents IDNot Available
References
Synthesis ReferenceFujimoto, Yasuo. Pyridoxal. Jpn. Tokkyo Koho (1971), 2 pp.
Material Safety Data Sheet (MSDS)Download (PDF)
General References

Enzymes

Enzyme Details
1. Aldehyde oxidase
General function:
Involved in oxidoreductase activity
Specific function:
Not Available
Gene Name:
AOX1
Uniprot ID:
Q06278
Molecular weight:
147916.735
Reactions
Pyridoxal + Oxygen + Water → 4-Pyridoxic acid + Hydrogen peroxidedetails
Enzyme Details
2. Pyridoxine-5'-phosphate oxidase
General function:
Involved in pyridoxamine-phosphate oxidase activity
Specific function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Gene Name:
PNPO
Uniprot ID:
Q9NVS9
Molecular weight:
29987.79
Reactions
Pyridoxamine + Water + Oxygen → Pyridoxal + Ammonia + Hydrogen peroxidedetails
Pyridoxine + Oxygen → Pyridoxal + Hydrogen peroxidedetails
Enzyme Details
3. Glycine dehydrogenase [decarboxylating], mitochondrial
General function:
Involved in lyase activity
Specific function:
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Gene Name:
GLDC
Uniprot ID:
P23378
Molecular weight:
112728.805
Enzyme Details
4. Pyridoxal kinase
General function:
Involved in pyridoxal kinase activity
Specific function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name:
PDXK
Uniprot ID:
O00764
Molecular weight:
35102.105
Reactions
Adenosine triphosphate + Pyridoxal → ADP + Pyridoxal 5'-phosphatedetails
References
  1. Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, Reinhardt J, Ferandin Y, Galons H, Wan Y, Gray N, Meijer L, Jiang T, Liang DC: Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem. 2005 Sep 2;280(35):31220-9. Epub 2005 Jun 28. [PubMed:15985434 ]
  2. Adams JB, George F, Audhya T: Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63. [PubMed:16494569 ]
  3. Newman JA, Das SK, Sedelnikova SE, Rice DW: The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parallel emergence of enzyme activity during evolution. J Mol Biol. 2006 Oct 20;363(2):520-30. Epub 2006 Aug 12. [PubMed:16978644 ]
Enzyme Details
5. Pyridoxal phosphate phosphatase
General function:
Involved in catalytic activity
Specific function:
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
Gene Name:
PDXP
Uniprot ID:
Q96GD0
Molecular weight:
31697.735
Reactions
Pyridoxal 5'-phosphate + Water → Pyridoxal + Phosphatedetails
Enzyme Details
6. Pyridoxal phosphate phosphatase PHOSPHO2
General function:
Involved in phosphatase activity
Specific function:
Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
Gene Name:
PHOSPHO2
Uniprot ID:
Q8TCD6
Molecular weight:
27768.72
Reactions
Pyridoxal 5'-phosphate + Water → Pyridoxal + Phosphatedetails