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Showing metabocard for 5-Hydroxytryptophol (HMDB0001855)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-02-21 08:10:09 UTC
Update Date2023-02-21 17:15:50 UTC
HMDB IDHMDB0001855
Secondary Accession Numbers
  • HMDB01855
Metabolite Identification
Common Name5-Hydroxytryptophol
Description5-Hydroxytryptophol is a relatively minor metabolite of serotonin that is excreted primarily as the glucuronide conjugate in human urine. 5-Hydroxytryptophol becomes more important quantitatively during alcohol intoxication, when a shift in the metabolism of serotonin occurs from 5-hydroxyindole acetic acid toward increased (15-fold higher) formation of 5-hydroxytryptophol due to the inhibition of aldehyde dehydrogenase by ethanol-derived acetaldehyde. Urinary excretion of 5-hydroxytryptophol has also been shown to be markedly increased for several hours following intake of foods rich in serotonin, such as bananas. Wide interspecies variation has been reported in the metabolism serotonin to 5-hydroxytryptophol; 5-Hydroxytryptophol makes up 35% of the excreted serotonin metabolites in the rat on average and 10 to 20% in several other species. Human UDP-glucuronosyltransferase 1A6 (UGT1A6) plays a predominant role in the glucuronidation of 5-hydroxytryptophol by human liver microsomes. (PMID 15258112 ).
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0001855 (5-Hydroxytryptophol)

  Mrv1652305271900002D          

 13 14  0  0  0  0            999 V2000
   13.3305  -10.3384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3378   -9.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0537   -9.1061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7653   -9.5236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7594  -10.3486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0421  -10.7560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5517   -9.2742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.0318   -9.9450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5423  -10.6090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6233   -9.0984    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.8121   -8.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2644   -7.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5248   -7.0917    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9  5  1  0  0  0  0
  2 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
M  END
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3D MOL for HMDB0001855 (5-Hydroxytryptophol)

HMDB0001855
     RDKit          3D
5-Hydroxytryptophol
 24 25  0  0  0  0  0  0  0  0999 V2000
    4.3117    0.0388    0.4054 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1236    0.8159    0.2739 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0280   -0.1003   -0.1663 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7264    0.5603   -0.3255 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4277    1.8480   -0.6896 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9301    2.0050   -0.6756 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5021    0.8547   -0.3150 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8286    0.4828   -0.1618 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1702   -0.8120    0.2180 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1603   -1.7169    0.4401 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4503   -3.0188    0.8189 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8315   -1.3246    0.2822 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4969   -0.0432   -0.0945 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1183   -0.6937    1.0783 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9481    1.4149    1.1559 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3455    1.5020   -0.6057 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9130   -0.8895    0.6388 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3120   -0.6930   -1.0625 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0795    2.6595   -0.9590 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4895    2.8533   -0.8980 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6388    1.1786   -0.3259 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2064   -1.1242    0.3375 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5921   -3.7730    0.1776 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0370   -2.0246    0.4529 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13  4  1  0
 13  7  1  0
  1 14  1  0
  2 15  1  0
  2 16  1  0
  3 17  1  0
  3 18  1  0
  5 19  1  0
  6 20  1  0
  8 21  1  0
  9 22  1  0
 11 23  1  0
 12 24  1  0
M  END
Download

3D SDF for HMDB0001855 (5-Hydroxytryptophol)

  Mrv1652305271900002D          

 13 14  0  0  0  0            999 V2000
   13.3305  -10.3384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3378   -9.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0537   -9.1061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7653   -9.5236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7594  -10.3486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0421  -10.7560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5517   -9.2742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.0318   -9.9450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5423  -10.6090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6233   -9.0984    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.8121   -8.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2644   -7.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5248   -7.0917    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9  5  1  0  0  0  0
  2 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0001855

> <DATABASE_NAME>
hmdb

> <SMILES>
OCCC1=CNC2=CC=C(O)C=C12

> <INCHI_IDENTIFIER>
InChI=1S/C10H11NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,5-6,11-13H,3-4H2

> <INCHI_KEY>
KQROHCSYOGBQGJ-UHFFFAOYSA-N

> <FORMULA>
C10H11NO2

> <MOLECULAR_WEIGHT>
177.1998

> <EXACT_MASS>
177.078978601

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
24

> <JCHEM_AVERAGE_POLARIZABILITY>
18.85673974074358

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-(2-hydroxyethyl)-1H-indol-5-ol

> <ALOGPS_LOGP>
0.91

> <JCHEM_LOGP>
1.2897539250000003

> <ALOGPS_LOGS>
-1.91

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.891538341234408

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.556124438991318

> <JCHEM_PKA_STRONGEST_BASIC>
-2.427895964995842

> <JCHEM_POLAR_SURFACE_AREA>
56.25

> <JCHEM_REFRACTIVITY>
50.6963

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.18e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
hydroxytryptophol

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0001855 (5-Hydroxytryptophol)

HMDB0001855
     RDKit          3D
5-Hydroxytryptophol
 24 25  0  0  0  0  0  0  0  0999 V2000
    4.3117    0.0388    0.4054 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1236    0.8159    0.2739 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0280   -0.1003   -0.1663 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7264    0.5603   -0.3255 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4277    1.8480   -0.6896 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9301    2.0050   -0.6756 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5021    0.8547   -0.3150 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8286    0.4828   -0.1618 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1702   -0.8120    0.2180 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1603   -1.7169    0.4401 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4503   -3.0188    0.8189 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8315   -1.3246    0.2822 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4969   -0.0432   -0.0945 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1183   -0.6937    1.0783 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9481    1.4149    1.1559 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3455    1.5020   -0.6057 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9130   -0.8895    0.6388 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3120   -0.6930   -1.0625 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0795    2.6595   -0.9590 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4895    2.8533   -0.8980 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6388    1.1786   -0.3259 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2064   -1.1242    0.3375 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5921   -3.7730    0.1776 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0370   -2.0246    0.4529 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 13  4  1  0
 13  7  1  0
  1 14  1  0
  2 15  1  0
  2 16  1  0
  3 17  1  0
  3 18  1  0
  5 19  1  0
  6 20  1  0
  8 21  1  0
  9 22  1  0
 11 23  1  0
 12 24  1  0
M  END
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PDB for HMDB0001855 (5-Hydroxytryptophol)

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  C   UNK     0      24.884 -19.298   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      24.897 -17.754   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      26.234 -16.998   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      27.562 -17.777   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      27.551 -19.317   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      26.212 -20.078   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      29.030 -17.312   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      29.926 -18.564   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0      29.012 -19.803   0.000  0.00  0.00           N+0
HETATM   10  O   UNK     0      23.563 -16.984   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      29.516 -15.851   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      28.494 -14.699   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      28.980 -13.238   0.000  0.00  0.00           O+0
CONECT    1    2    6                                                       
CONECT    2    1    3   10                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    7                                                  
CONECT    5    4    6    9                                                  
CONECT    6    5    1                                                       
CONECT    7    4    8   11                                                  
CONECT    8    7    9                                                       
CONECT    9    8    5                                                       
CONECT   10    2                                                            
CONECT   11    7   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12                                                            
MASTER        0    0    0    0    0    0    0    0   13    0   28    0
END
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3D PDB for HMDB0001855 (5-Hydroxytryptophol)

COMPND    HMDB0001855
HETATM    1  O1  UNL     1       4.312   0.039   0.405  1.00  0.00           O  
HETATM    2  C1  UNL     1       3.124   0.816   0.274  1.00  0.00           C  
HETATM    3  C2  UNL     1       2.028  -0.100  -0.166  1.00  0.00           C  
HETATM    4  C3  UNL     1       0.726   0.560  -0.325  1.00  0.00           C  
HETATM    5  C4  UNL     1       0.428   1.848  -0.690  1.00  0.00           C  
HETATM    6  N1  UNL     1      -0.930   2.005  -0.676  1.00  0.00           N  
HETATM    7  C5  UNL     1      -1.502   0.855  -0.315  1.00  0.00           C  
HETATM    8  C6  UNL     1      -2.829   0.483  -0.162  1.00  0.00           C  
HETATM    9  C7  UNL     1      -3.170  -0.812   0.218  1.00  0.00           C  
HETATM   10  C8  UNL     1      -2.160  -1.717   0.440  1.00  0.00           C  
HETATM   11  O2  UNL     1      -2.450  -3.019   0.819  1.00  0.00           O  
HETATM   12  C9  UNL     1      -0.831  -1.325   0.282  1.00  0.00           C  
HETATM   13  C10 UNL     1      -0.497  -0.043  -0.095  1.00  0.00           C  
HETATM   14  H1  UNL     1       4.118  -0.694   1.078  1.00  0.00           H  
HETATM   15  H2  UNL     1       2.948   1.415   1.156  1.00  0.00           H  
HETATM   16  H3  UNL     1       3.346   1.502  -0.606  1.00  0.00           H  
HETATM   17  H4  UNL     1       1.913  -0.890   0.639  1.00  0.00           H  
HETATM   18  H5  UNL     1       2.312  -0.693  -1.062  1.00  0.00           H  
HETATM   19  H6  UNL     1       1.079   2.659  -0.959  1.00  0.00           H  
HETATM   20  H7  UNL     1      -1.490   2.853  -0.898  1.00  0.00           H  
HETATM   21  H8  UNL     1      -3.639   1.179  -0.326  1.00  0.00           H  
HETATM   22  H9  UNL     1      -4.206  -1.124   0.338  1.00  0.00           H  
HETATM   23  H10 UNL     1      -2.592  -3.773   0.178  1.00  0.00           H  
HETATM   24  H11 UNL     1      -0.037  -2.025   0.453  1.00  0.00           H  
CONECT    1    2   14
CONECT    2    3   15   16
CONECT    3    4   17   18
CONECT    4    5    5   13
CONECT    5    6   19
CONECT    6    7   20
CONECT    7    8    8   13
CONECT    8    9   21
CONECT    9   10   10   22
CONECT   10   11   12
CONECT   11   23
CONECT   12   13   13   24
END
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SMILES for HMDB0001855 (5-Hydroxytryptophol)

OCCC1=CNC2=CC=C(O)C=C12
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INCHI for HMDB0001855 (5-Hydroxytryptophol)

InChI=1S/C10H11NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,5-6,11-13H,3-4H2
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
5-HTOLHMDB
5-Hydroxy-1H-indole-3-ethanolHMDB
5-Hydroxy-1H-indole-3-ethanol(9ci)HMDB
5-Hydroxy-3-indoleHMDB
5-Hydroxy-3-indoleacetic acidHMDB
5-Hydroxy-indole-acetic acidHMDB
5-Hydroxyindoacetic acidHMDB
5-HydroxyindolHMDB
5-HydroxyindolacetateHMDB
5-Hydroxyindolacetic acidHMDB
5-Hydroxyindole-3-ethanolHMDB
5-Hydroxyindole-acetic acidHMDB
Hydroxyindoleacetic acidHMDB
HydroxytryptopholHMDB, MeSH
Chemical FormulaC10H11NO2
Average Molecular Weight177.1998
Monoisotopic Molecular Weight177.078978601
IUPAC Name3-(2-hydroxyethyl)-1H-indol-5-ol
Traditional Namehydroxytryptophol
CAS Registry Number154-02-9
SMILES
OCCC1=CNC2=CC=C(O)C=C12
InChI Identifier
InChI=1S/C10H11NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,5-6,11-13H,3-4H2
InChI KeyKQROHCSYOGBQGJ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassIndoles and derivatives
Sub ClassHydroxyindoles
Direct ParentHydroxyindoles
Alternative Parents
Substituents
  • 3-alkylindole
  • Hydroxyindole
  • Indole
  • 1-hydroxy-2-unsubstituted benzenoid
  • Substituted pyrrole
  • Benzenoid
  • Heteroaromatic compound
  • Pyrrole
  • Azacycle
  • Organic oxygen compound
  • Alcohol
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect
Health effect
Disposition
Biological locationRoute of exposureSource
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available134.491http://allccs.zhulab.cn/database/detail?ID=AllCCS00000343
[M+H]+Not Available138.754http://allccs.zhulab.cn/database/detail?ID=AllCCS00000343
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.0009 +/- 0.0003 uMAdult (>18 years old)BothNormal details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.004 +/- 0.22 uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.107 +/- 0.019 uMNot SpecifiedNot SpecifiedNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal		 details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
Cerebrospinal Fluid (CSF)Detected and Quantified0.11 +/- 0.013 uMAdult (>18 years old)FemaleSchizophrenia details
Cerebrospinal Fluid (CSF)Detected and Quantified0.12 +/- 0.09 uMChildren (1-13 years old)Not SpecifiedLeukemia details
Cerebrospinal Fluid (CSF)Detected and Quantified0.009 +/- 0.01 uMNot SpecifiedNot SpecifiedNeurological disorders (2 - 18 years old) details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0846 +/- 0.0179 uMAdult (>18 years old)Not SpecifiedParkinson's Disease details
Associated Disorders and Diseases
Disease References
Leukemia
  1. Curtius HC, Wolfensberger M, Redweik U, Leimbacher W, Maibach RA, Isler W: Mass fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in human cerebrospinal fluid. J Chromatogr. 1975 Oct 29;112:523-31. [PubMed:1184685 ]
Schizophrenia
  1. Harnryd C, Bjerkenstedt L, Grimm VE, Sedvall G: Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment. Psychopharmacology (Berl). 1979 Aug 8;64(2):131-4. [PubMed:115032 ]
Parkinson's disease
  1. Dizdar N, Kagedal B, Lindvall B: Treatment of Parkinson's disease with NADH. Acta Neurol Scand. 1994 Nov;90(5):345-7. [PubMed:7887134 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022711
KNApSAcK IDC00045185
Chemspider ID8708
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID5730
PubChem Compound9061
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDCE1918
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceDa Prada, M.; Bartholini, G.; Pletscher, A. Formation of 5-hydroxytryptophol by blood platelets after thrombin and reserpine. Experientia (1965), 21(3), 135-6.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Curtius HC, Wolfensberger M, Redweik U, Leimbacher W, Maibach RA, Isler W: Mass fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in human cerebrospinal fluid. J Chromatogr. 1975 Oct 29;112:523-31. [PubMed:1184685 ]
  2. Krishnaswamy S, Hao Q, Von Moltke LL, Greenblatt DJ, Court MH: Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Drug Metab Dispos. 2004 Aug;32(8):862-9. [PubMed:15258112 ]