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Showing metabocard for Valproic acid (HMDB0001877)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-02-24 11:11:14 UTC
Update Date2023-02-21 17:15:54 UTC
HMDB IDHMDB0001877
Secondary Accession Numbers
  • HMDB01877
Metabolite Identification
Common NameValproic acid
DescriptionValproic acid (VPA) is considered to be a drug of first choice and one of the most frequently-prescribed antiepileptic drugs worldwide for the therapy of generalized and focal epilepsies, including special epileptic. It is a broad-spectrum antiepileptic drug and is usually well tolerated. Rarely, serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulopathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy, but there is still a lack of knowledge about the incidence and occurrence of these special side effects. VPA has been approved for stabilization of manic episodes in patients with bipolar disorder. It is also used to treat migraine headaches and schizophrenia. As the use of VPA increases, the number of both accidental and intentional exposures increases. This is paralleled by more reports of VPA-induced toxicity. VPA is relatively contraindicated in pregnancy due to its teratogenicity. It is a known folate antagonist, which can cause neural tube defects. Thus, folic acid supplements may alleviate teratogenic problems. Women who become pregnant whilst taking valproate should be counselled as to its risks. VPA is an inhibitor of the enzyme histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells. Patients treated with valproic acid in addition to highly active antiretroviral therapy (HAART) showed a median 75% reduction in latent HIV infection. VPA is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) in the human brain. Valproic Acid dissociates to the valproate ion in the gastrointestinal tract. (PMID: 18201150 , 17496767 ).
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0001877 (Valproic acid)

  Mrv1652305271900322D          

 10  9  0  0  0  0            999 V2000
   -1.4289    0.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.2475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.2475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.4850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.0725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.2475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.9900    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  8  1  0  0  0  0
  4  5  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
M  END
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3D MOL for HMDB0001877 (Valproic acid)

HMDB0001877
     RDKit          3D
Valproic acid
 26 25  0  0  0  0  0  0  0  0999 V2000
    2.8499    0.8540   -1.0200 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3193    0.8024   -0.7455 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1139    0.0535    0.5130 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2394   -0.1274    1.0553 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2765   -0.8441    0.2942 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7223   -0.3553   -1.0171 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2739    1.0578   -0.9997 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0697   -0.9172    2.3476 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4283   -0.4966    3.4548 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5144   -2.1555    2.2455 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0298    1.7250   -1.6600 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3777    0.8543   -0.0664 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1522   -0.0566   -1.5789 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9293    0.3514   -1.6656 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9117    1.8218   -0.6652 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6334   -0.9428    0.4140 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7187    0.5697    1.3330 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6515    0.8535    1.4496 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9117   -1.9136    0.1146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2029   -1.0397    0.9168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -0.9810   -1.2601 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1123   -0.4796   -1.8891 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2482    1.0928   -0.4758 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5305    1.7497   -0.5851 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4326    1.3395   -2.0665 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2147   -2.8160    1.5563 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  4  8  1  0
  8  9  2  0
  8 10  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  0
  3 17  1  0
  4 18  1  0
  5 19  1  0
  5 20  1  0
  6 21  1  0
  6 22  1  0
  7 23  1  0
  7 24  1  0
  7 25  1  0
 10 26  1  0
M  END
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3D SDF for HMDB0001877 (Valproic acid)

  Mrv1652305271900322D          

 10  9  0  0  0  0            999 V2000
   -1.4289    0.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.2475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.2475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.4850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.0725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.2475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.9900    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  8  1  0  0  0  0
  4  5  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0001877

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCC(CCC)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

> <INCHI_KEY>
NIJJYAXOARWZEE-UHFFFAOYSA-N

> <FORMULA>
C8H16O2

> <MOLECULAR_WEIGHT>
144.2114

> <EXACT_MASS>
144.115029756

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
26

> <JCHEM_AVERAGE_POLARIZABILITY>
16.996878483662726

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-propylpentanoic acid

> <ALOGPS_LOGP>
2.54

> <JCHEM_LOGP>
2.7984510709999997

> <ALOGPS_LOGS>
-1.79

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
5.144389811177235

> <JCHEM_POLAR_SURFACE_AREA>
37.3

> <JCHEM_REFRACTIVITY>
40.2491

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.36e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
valproic acid

> <JCHEM_VEBER_RULE>
1

$$$$
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3D-SDF for HMDB0001877 (Valproic acid)

HMDB0001877
     RDKit          3D
Valproic acid
 26 25  0  0  0  0  0  0  0  0999 V2000
    2.8499    0.8540   -1.0200 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3193    0.8024   -0.7455 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1139    0.0535    0.5130 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2394   -0.1274    1.0553 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2765   -0.8441    0.2942 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7223   -0.3553   -1.0171 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2739    1.0578   -0.9997 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0697   -0.9172    2.3476 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4283   -0.4966    3.4548 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5144   -2.1555    2.2455 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0298    1.7250   -1.6600 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3777    0.8543   -0.0664 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1522   -0.0566   -1.5789 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9293    0.3514   -1.6656 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9117    1.8218   -0.6652 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6334   -0.9428    0.4140 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7187    0.5697    1.3330 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6515    0.8535    1.4496 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9117   -1.9136    0.1146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2029   -1.0397    0.9168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -0.9810   -1.2601 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1123   -0.4796   -1.8891 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2482    1.0928   -0.4758 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5305    1.7497   -0.5851 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4326    1.3395   -2.0665 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2147   -2.8160    1.5563 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  4  8  1  0
  8  9  2  0
  8 10  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  0
  3 17  1  0
  4 18  1  0
  5 19  1  0
  5 20  1  0
  6 21  1  0
  6 22  1  0
  7 23  1  0
  7 24  1  0
  7 25  1  0
 10 26  1  0
M  END
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PDB for HMDB0001877 (Valproic acid)

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  C   UNK     0      -2.667   0.308   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.334  -0.462   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.000   0.308   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.334  -0.462   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.667   0.308   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000  -2.772   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.000  -4.312   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.334  -2.002   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       4.001  -0.462   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0       2.667   1.848   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    8    5                                                  
CONECT    5    4    9   10                                                  
CONECT    6    7    8                                                       
CONECT    7    6                                                            
CONECT    8    4    6                                                       
CONECT    9    5                                                            
CONECT   10    5                                                            
MASTER        0    0    0    0    0    0    0    0   10    0   18    0
END
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3D PDB for HMDB0001877 (Valproic acid)

COMPND    HMDB0001877
HETATM    1  C1  UNL     1       2.850   0.854  -1.020  1.00  0.00           C  
HETATM    2  C2  UNL     1       1.319   0.802  -0.745  1.00  0.00           C  
HETATM    3  C3  UNL     1       1.114   0.054   0.513  1.00  0.00           C  
HETATM    4  C4  UNL     1      -0.239  -0.127   1.055  1.00  0.00           C  
HETATM    5  C5  UNL     1      -1.277  -0.844   0.294  1.00  0.00           C  
HETATM    6  C6  UNL     1      -1.722  -0.355  -1.017  1.00  0.00           C  
HETATM    7  C7  UNL     1      -2.274   1.058  -1.000  1.00  0.00           C  
HETATM    8  C8  UNL     1      -0.070  -0.917   2.348  1.00  0.00           C  
HETATM    9  O1  UNL     1      -0.428  -0.497   3.455  1.00  0.00           O  
HETATM   10  O2  UNL     1       0.514  -2.156   2.246  1.00  0.00           O  
HETATM   11  H1  UNL     1       3.030   1.725  -1.660  1.00  0.00           H  
HETATM   12  H2  UNL     1       3.378   0.854  -0.066  1.00  0.00           H  
HETATM   13  H3  UNL     1       3.152  -0.057  -1.579  1.00  0.00           H  
HETATM   14  H4  UNL     1       0.929   0.351  -1.666  1.00  0.00           H  
HETATM   15  H5  UNL     1       0.912   1.822  -0.665  1.00  0.00           H  
HETATM   16  H6  UNL     1       1.633  -0.943   0.414  1.00  0.00           H  
HETATM   17  H7  UNL     1       1.719   0.570   1.333  1.00  0.00           H  
HETATM   18  H8  UNL     1      -0.652   0.853   1.450  1.00  0.00           H  
HETATM   19  H9  UNL     1      -0.912  -1.914   0.115  1.00  0.00           H  
HETATM   20  H10 UNL     1      -2.203  -1.040   0.917  1.00  0.00           H  
HETATM   21  H11 UNL     1      -2.665  -0.981  -1.260  1.00  0.00           H  
HETATM   22  H12 UNL     1      -1.112  -0.480  -1.889  1.00  0.00           H  
HETATM   23  H13 UNL     1      -3.248   1.093  -0.476  1.00  0.00           H  
HETATM   24  H14 UNL     1      -1.530   1.750  -0.585  1.00  0.00           H  
HETATM   25  H15 UNL     1      -2.433   1.340  -2.067  1.00  0.00           H  
HETATM   26  H16 UNL     1       0.215  -2.816   1.556  1.00  0.00           H  
CONECT    1    2   11   12   13
CONECT    2    3   14   15
CONECT    3    4   16   17
CONECT    4    5    8   18
CONECT    5    6   19   20
CONECT    6    7   21   22
CONECT    7   23   24   25
CONECT    8    9    9   10
CONECT   10   26
END
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SMILES for HMDB0001877 (Valproic acid)

CCCC(CCC)C(O)=O
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INCHI for HMDB0001877 (Valproic acid)

InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC8H16O2
Average Molecular Weight144.2114
Monoisotopic Molecular Weight144.115029756
IUPAC Name2-propylpentanoic acid
Traditional Namevalproic acid
CAS Registry Number99-66-1
SMILES
CCCC(CCC)C(O)=O
InChI Identifier
InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChI KeyNIJJYAXOARWZEE-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as methyl-branched fatty acids. These are fatty acids with an acyl chain that has a methyl branch. Usually, they are saturated and contain only one or more methyl group. However, branches other than methyl may be present.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassFatty acids and conjugates
Direct ParentMethyl-branched fatty acids
Alternative Parents
Substituents
  • Methyl-branched fatty acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Health effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Industrial applicationBiological roleIndirect biological role
Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling Point222 °CNot Available
Water Solubility2 mg/mL at 20 °CNot Available
LogP2.75SANGSTER (1993)
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane (predicted from logP)
Biospecimen Locations
  • Blood
Tissue Locations
  • Brain
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified208.0 (3.5-416.0) uMAdult (>18 years old)Both
Normal		 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00313
Phenol Explorer Compound IDNot Available
FooDB IDFDB022722
KNApSAcK IDNot Available
Chemspider ID3009
KEGG Compound IDC07185
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkValproic_Acid
METLIN ID2986
PubChem Compound3121
PDB IDNot Available
ChEBI ID39867
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References

Only showing the first 10 proteins. There are 25 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Cytochrome P450 3A4
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
Enzyme Details
2. Cytochrome P450 2C9
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
Enzyme Details
3. Cytochrome P450 2C19
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
Enzyme Details
4. Cytochrome P450 2E1
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
Enzyme Details
5. Cytochrome P450 3A43
General function:
Involved in monooxygenase activity
Specific function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular weight:
57756.285
Enzyme Details
6. Cytochrome P450 1B1
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Molecular weight:
60845.33
Enzyme Details
7. Cytochrome P450 2C18
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular weight:
55710.075
Enzyme Details
8. Cytochrome P450 2F1
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Gene Name:
CYP2F1
Uniprot ID:
P24903
Molecular weight:
55500.64
Enzyme Details
9. Cytochrome P450 4X1
General function:
Involved in monooxygenase activity
Specific function:
Not Available
Gene Name:
CYP4X1
Uniprot ID:
Q8N118
Molecular weight:
58874.62
Enzyme Details
10. Cytochrome P450 2B6
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81

Only showing the first 10 proteins. There are 25 proteins in total.

Show all enzymes and transporters