Record Information |
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Version | 5.0 |
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Status | Detected and Quantified |
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Creation Date | 2006-08-13 11:32:55 UTC |
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Update Date | 2022-03-07 02:49:20 UTC |
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HMDB ID | HMDB0004118 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Antimony |
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Description | Antimony metal and many of its compounds have been known since ancient times, and its toxicity has periodically been a matter of comment. Antimony (stibium) is an element and a metalloid, with atomic number 51 and atomic weight 121.75. It is in Group Va of the Periodic Table along with arsenic, bismuth, nitrogen and phosphorus. Contact with antimony occurs in a variety of ways, and as it is a common element in the surface of the earth it may accompany exposures to many different materials. Antimony has been identified in at least 114 different ores, and has even been found in meteorites. A recurrent problem in assessing its toxicity industrially is that arsenic and lead are often found with it, and other toxic materials, for example sulfur dioxide, may also be produced in the course of the process, and separation of exposures may be difficult or impossible. Contact with antimony has also occurred from is use as a medicinal substance, from natural exposures, and from domestic sources. Antimony has been a constituent not only of printing-metal but also of lead acid batteries, pigments, an opacifier under glazes and enamels (the white oxide), and in the present day it has been used widely as a flame retardant in fabrics and in brake linings of motor cars. Large scale industrial production, largely of antimony oxide, began in the early 19th century. Physiologically, this metal/element exists as an ion in the body. The toxicology of antimony and its compounds is known from three sources: its medicinal use over centuries, studies of process workers in more recent times, and more recent still, studies of its presence in modern city environments and in domestic environments. Gross exposure to antimony compounds over long periods, usually the sulfide (SbS3) or the oxide (Sb2O3) has occurred in antimony miners and in antimony process workers. There have been relatively few of these, and few studies of possible symptoms have been made. Antimony sulfide imported from, at different times, China, South Africa, and South America was processed in the North-East of England from about 1870 to 2003. The process workers in North-East England have been studied at different times, notably by Sir Thomas Oliver in 1933, and by the Newcastle upon Tyne University Department of Occupational Medicine on later occasions. Studies which have been made of the working environment, and in particular of the risk of lung cancer in process workers, have underlined the high levels of exposure to antimony compounds and to other toxic materials. However, the working conditions in antimony processing have improved markedly over the last 30 years, and the workforce had been much reduced in numbers following automation of the process. Prior to the cessation of the industry in the UK it had become a white coat operation with relatively few people exposed to high concentrations of antimony. Antimony, which is normally present in domestic environments, has also been studied as a possible cause of cot death syndrome (SIDS) but extensive investigations have not confirmed this. The full importance of environmental antimony has still to be determined, and evidence of specific effects has not yet been presented. (PMID: 16307078 ). |
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Structure | |
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Synonyms | Value | Source |
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ANTIMONY (III) ion | ChEBI | Antimony, ion (SB(3+)) | ChEBI | SB(3+) | ChEBI | Antimony black | HMDB | Antimony element | HMDB | Sb | HMDB | Stibium | HMDB |
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Chemical Formula | Sb |
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Average Molecular Weight | 121.76 |
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Monoisotopic Molecular Weight | 120.903818044 |
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IUPAC Name | antimony(3+) ion |
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Traditional Name | antimony(3+) ion |
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CAS Registry Number | 7440-36-0 |
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SMILES | [Sb+3] |
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InChI Identifier | InChI=1S/Sb/q+3 |
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InChI Key | FAWGZAFXDJGWBB-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of inorganic compounds known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom. |
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Kingdom | Inorganic compounds |
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Super Class | Homogeneous metal compounds |
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Class | Homogeneous metalloid compounds |
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Sub Class | Not Available |
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Direct Parent | Homogeneous metalloid compounds |
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Alternative Parents | Not Available |
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Substituents | |
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Molecular Framework | Not Available |
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External Descriptors | |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | Not Available |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 630 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatized |
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Spectra |
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| MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Antimony 10V, Positive-QTOF | splash10-004i-0900000000-f838159747de83d607aa | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Antimony 20V, Positive-QTOF | splash10-004i-0900000000-f838159747de83d607aa | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Antimony 40V, Positive-QTOF | splash10-004i-0900000000-f838159747de83d607aa | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Antimony 10V, Negative-QTOF | splash10-004i-0900000000-c291a29e512d9d5b8686 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Antimony 20V, Negative-QTOF | splash10-004i-0900000000-c291a29e512d9d5b8686 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Antimony 40V, Negative-QTOF | splash10-004i-0900000000-c291a29e512d9d5b8686 | 2016-08-03 | Wishart Lab | View Spectrum |
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Biological Properties |
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Cellular Locations | Not Available |
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Biospecimen Locations | - Blood
- Cerebrospinal Fluid (CSF)
- Urine
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Tissue Locations | Not Available |
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Pathways | |
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Normal Concentrations |
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Blood | Detected and Quantified | 0.0050-0.030 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.0038 +/- 0.002 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.0038 +/- 0.002 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0-0.049 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 0.005-0.016 uM | Adult (>18 years old) | Both | Normal | | details | Cerebrospinal Fluid (CSF) | Detected and Quantified | 0.002+/-0.009 (0.0007-0.003) uM | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 0.0000529 (0.0000492-0.0000557) umol/mmol creatinine | Adult (>18 years old) | Not Specified | Normal | | details | Urine | Detected and Quantified | 0.00008728 (0.0000780-0.0000975) umol/mmol creatinine | Children (1-13 years old) | Not Specified | Normal | | details | Urine | Detected and Quantified | 0.00005 +/- 0.00002 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 0-0.008 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 0.00007 (0.00005-0.00009) umol/mmol creatinine | Not Available | Both | Normal | | details | Urine | Detected and Quantified | 0.00007 (0.00005-0.00010) umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details |
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Abnormal Concentrations |
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Blood | Detected and Quantified | 0.0055 +/- 0.0038 uM | Adult (>18 years old) | Both | Multiple Sclerosis | | details | Blood | Detected and Quantified | 0.0055 +/- 0.0039 uM | Adult (>18 years old) | Both | multiple sclerosis | | details | Blood | Detected and Quantified | 0.030 - 0.082 uM | Adult (>18 years old) | Not Specified | Antimony Exposure | | details |
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Associated Disorders and Diseases |
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Disease References | Multiple sclerosis |
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- Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. [PubMed:16244395 ]
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Associated OMIM IDs | |
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External Links |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | FDB003762 |
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KNApSAcK ID | Not Available |
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Chemspider ID | 94667 |
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KEGG Compound ID | Not Available |
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BioCyc ID | Not Available |
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BiGG ID | Not Available |
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Wikipedia Link | Antimony |
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METLIN ID | Not Available |
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PubChem Compound | 104894 |
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PDB ID | SB |
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ChEBI ID | 49867 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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MarkerDB ID | MDB00013450 |
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Good Scents ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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Material Safety Data Sheet (MSDS) | Download (PDF) |
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General References | - McCallum RI: Occupational exposure to antimony compounds. J Environ Monit. 2005 Dec;7(12):1245-50. Epub 2005 Oct 26. [PubMed:16307078 ]
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