Record Information |
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Version | 5.0 |
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Status | Detected and Quantified |
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Creation Date | 2005-11-16 15:48:42 UTC |
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Update Date | 2023-05-30 20:56:02 UTC |
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HMDB ID | HMDB0000087 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Dimethylamine |
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Description | Dimethylamine (DMA) is an organic secondary amine. It is a colorless, liquefied and flammable gas with an ammonia and fish-like odor. Dimethylamine is abundantly present in human urine. Main sources of urinary DMA have been reported to include trimethylamine N-oxide, a common food component, and asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis. ADMA is excreted in the urine in part unmetabolized and in part after hydrolysis to DMA by dimethylarginine dimethylaminohydrolase (DDAH). Statistically significant increases in urinary DMA have been found in individuals after the consumption of fish and seafoods. The highest values were obtained for individuals that consumed coley, squid and whiting with cod, haddock, sardine, skate and swordfish (PMID: 18282650 ). It has also been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821 ). As a pure chemical substance Dimethylamine is used as dehairing agent in tanning, in dyes, in rubber accelerators, in soaps and cleaning compounds and as an agricultural fungicide. In the body, DMA also undergoes nitrosation under weak acid conditions to give dimethlynitrosamine. Study has shown that DMA is a metabolite of Arthrobacter and Micrococcus (PMID: 11422368 ; PMID: 7191 ). |
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Structure | InChI=1S/C2H7N/c1-3-2/h3H,1-2H3 |
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Synonyms | Value | Source |
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DMA | ChEBI | HNMe2 | ChEBI | Me2nh | ChEBI | N,N-Dimethylamine | ChEBI | (CH3)2nh | Kegg | Dimethylamine anhydrous | HMDB | Dimethylamine anhydrous (dot) | HMDB | Dimethylamine aqueous solution | HMDB | Dimethylamine hydrobromide | HMDB | Dimethylamine solution | HMDB | N-Methyl-methanamine | HMDB | N-Methylmethanamine | HMDB | N-Methylmethanamine (acd/name 4.0) | HMDB | Dimethylamine nitrate | HMDB | Dimethylamine perchlorate | HMDB | Dimethylamine sulfate | HMDB | Dimethylamine hydrochloride | HMDB | Dimethylamine phosphate (3:1) | HMDB | Dimethylamine, conjugate acid | HMDB | Dimethylammonium chloride | HMDB | Dimethylamine sulfate (1:1) | HMDB | Dimethylammonium formate | HMDB | Dimethylamine monosulfate | HMDB |
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Chemical Formula | C2H7N |
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Average Molecular Weight | 45.0837 |
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Monoisotopic Molecular Weight | 45.057849229 |
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IUPAC Name | dimethylamine |
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Traditional Name | dimethylamine |
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CAS Registry Number | 124-40-3 |
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SMILES | CNC |
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InChI Identifier | InChI=1S/C2H7N/c1-3-2/h3H,1-2H3 |
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InChI Key | ROSDSFDQCJNGOL-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen. |
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Kingdom | Organic compounds |
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Super Class | Organic nitrogen compounds |
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Class | Organonitrogen compounds |
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Sub Class | Amines |
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Direct Parent | Dialkylamines |
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Alternative Parents | |
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Substituents | - Secondary aliphatic amine
- Organopnictogen compound
- Hydrocarbon derivative
- Aliphatic acyclic compound
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | |
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Disposition | |
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Process | |
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Role | |
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Physical Properties |
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State | Liquid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | -92.2 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 1630 mg/mL at 40 °C | Not Available | LogP | -0.38 | HANSCH,C ET AL. (1995) |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedMetabolite | SMILES | Kovats RI Value | Column Type | Reference |
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Dimethylamine | CNC | 621.1 | Standard polar | 33892256 | Dimethylamine | CNC | 382.2 | Standard non polar | 33892256 | Dimethylamine | CNC | 410.2 | Semi standard non polar | 33892256 |
DerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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Dimethylamine,1TMS,isomer #1 | CN(C)[Si](C)(C)C | 667.3 | Semi standard non polar | 33892256 | Dimethylamine,1TMS,isomer #1 | CN(C)[Si](C)(C)C | 661.6 | Standard non polar | 33892256 | Dimethylamine,1TMS,isomer #1 | CN(C)[Si](C)(C)C | 754.3 | Standard polar | 33892256 | Dimethylamine,1TBDMS,isomer #1 | CN(C)[Si](C)(C)C(C)(C)C | 884.0 | Semi standard non polar | 33892256 | Dimethylamine,1TBDMS,isomer #1 | CN(C)[Si](C)(C)C(C)(C)C | 867.1 | Standard non polar | 33892256 | Dimethylamine,1TBDMS,isomer #1 | CN(C)[Si](C)(C)C(C)(C)C | 912.7 | Standard polar | 33892256 |
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Spectra |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - Dimethylamine EI-B (Non-derivatized) | splash10-0006-9000000000-cfb8e10b3b28eba99793 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Dimethylamine EI-B (Non-derivatized) | splash10-0006-9000000000-cfb8e10b3b28eba99793 | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Dimethylamine GC-MS (Non-derivatized) - 70eV, Positive | splash10-0002-9000000000-398c710ba4ea34342a91 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Dimethylamine GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Dimethylamine GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | MS | Mass Spectrum (Electron Ionization) | splash10-0006-9000000000-8ae4e0d1cb5c91c730c0 | 2014-09-20 | Not Available | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine EI-B (HITACHI M-80B) , Positive-QTOF | splash10-0006-9000000000-8b085007dc085a460422 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive-QTOF | splash10-0002-9000000000-103f1d373ec0d015b807 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive-QTOF | splash10-0002-9000000000-df28f146170e28bfcb5e | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive-QTOF | splash10-0002-9000000000-cd82fdde4d83a74d83f1 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive-QTOF | splash10-00wc-9100000000-aeb1521c62f5010e11aa | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive-QTOF | splash10-017i-9101000000-c269a0887eed5daf0e28 | 2012-08-31 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ , positive-QTOF | splash10-0002-9000000000-103f1d373ec0d015b807 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ , positive-QTOF | splash10-0002-9000000000-df28f146170e28bfcb5e | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ , positive-QTOF | splash10-0002-9000000000-17646ed4f7c44ba14045 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ , positive-QTOF | splash10-00wc-9100000000-aeb1521c62f5010e11aa | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Dimethylamine LC-ESI-QQ , positive-QTOF | splash10-017i-9101000000-c269a0887eed5daf0e28 | 2017-09-14 | HMDB team, MONA | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 10V, Positive-QTOF | splash10-0002-9000000000-933c4b104db02265ac4a | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 20V, Positive-QTOF | splash10-0002-9000000000-e85cf853d2e7110d18c1 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 40V, Positive-QTOF | splash10-014j-9000000000-2032c41c4ca525ff4e1c | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 10V, Negative-QTOF | splash10-0006-9000000000-32c57cc32d61a2feae23 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 20V, Negative-QTOF | splash10-0006-9000000000-36fe99d2cc96e560f509 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 40V, Negative-QTOF | splash10-0006-9000000000-8914e111239eacc36328 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 10V, Negative-QTOF | splash10-0006-9000000000-46fb6b0f3d2dcd71d159 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 20V, Negative-QTOF | splash10-0006-9000000000-46fb6b0f3d2dcd71d159 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 40V, Negative-QTOF | splash10-0006-9000000000-46fb6b0f3d2dcd71d159 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 10V, Positive-QTOF | splash10-0002-9000000000-e97e92727205304cdb09 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 20V, Positive-QTOF | splash10-0002-9000000000-e97e92727205304cdb09 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Dimethylamine 40V, Positive-QTOF | splash10-0006-9000000000-9cf36baccac69593c69f | 2021-09-23 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Experimental 1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, experimental) | 2012-12-04 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 100 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 200 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 300 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 400 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 600 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 700 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 800 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 900 MHz, D2O, predicted) | 2021-09-29 | Wishart Lab | View Spectrum | Experimental 1D NMR | 13C NMR Spectrum (1D, 400 MHz, H2O, experimental) | 2021-10-10 | Wishart Lab | View Spectrum | Experimental 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | 2012-12-04 | Wishart Lab | View Spectrum |
IR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-) | 2023-02-03 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+) | 2023-02-03 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+) | 2023-02-03 | FELIX lab | View Spectrum |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | - Blood
- Cerebrospinal Fluid (CSF)
- Feces
- Saliva
- Sweat
- Urine
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Tissue Locations | |
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Pathways | |
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Normal Concentrations |
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Blood | Detected and Quantified | 20.18 (3.33-53.22) uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 1.43 +/- 0.23 uM | Adult (>18 years old) | Female | Normal | | details | Blood | Detected and Quantified | 3.3 +/- 1.5 uM | Adult (>18 years old) | Both | Normal | | details | Blood | Detected and Quantified | 48.36 +/- 7.32 uM | Adult (>18 years old) | Both | Normal | | details | Cerebrospinal Fluid (CSF) | Detected and Quantified | 2.0 +/- 1.0 uM | Adult (>18 years old) | Both | Normal | | details | Feces | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Both | Normal | | details | Feces | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Not Specified | Normal | | details | Feces | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Both | Normal | | details | Saliva | Detected and Quantified | 13 (1-50) uM | Adult (>18 years old) | Male | Normal | | details | Saliva | Detected and Quantified | 13 (1-44) uM | Adult (>18 years old) | Male | Normal | | details | Saliva | Detected and Quantified | 16 (1-57) uM | Adult (>18 years old) | Male | Normal | | details | Saliva | Detected and Quantified | 11 (2-27) uM | Adult (>18 years old) | Female | Normal | | details | Saliva | Detected and Quantified | 1-65 uM | Adult (>18 years old) | Male | normal | | details | Saliva | Detected and Quantified | 1-30 uM | Adult (>18 years old) | Male | normal | | details | Saliva | Detected and Quantified | 7.82 +/- 3.13 uM | Adult (>18 years old) | Both | Normal | | details | Saliva | Detected and Quantified | 136 (9.00-262) uM | Adult (>18 years old) | Both | Normal | | details | Sweat | Detected and Quantified | < 10 uM | Adult (60 years old) | Male | Normal | | details | Sweat | Detected and Quantified | < 10 uM | Adult (40 years old) | Male | Normal | | details | Urine | Detected and Quantified | 17.059 +/- 6.3921 umol/mmol creatinine | Children (1 - 13 years old) | Not Specified | Normal | | details | Urine | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Male | Normal | | details | Urine | Detected and Quantified | 0.00050 +/- 0.00055 umol/mmol creatinine | Newborn (0-30 days old) | Both | Normal | | details | Urine | Detected and Quantified | 19.2 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 0.22 umol/mmol creatinine | Newborn (0-30 days old) | Both | Normal | | details | Urine | Detected and Quantified | 30.8 (20.3-59.2) umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 36.13 umol/mmol creatinine | Adult (>18 years old) | Male | Normal | | details | Urine | Detected and Quantified | 34.4 +/- 9.3 umol/mmol creatinine | Adult (>18 years old) | Male | Normal | | details | Urine | Detected and Quantified | 39.3 +/- 8.3 umol/mmol creatinine | Adult (>18 years old) | Female | Normal | | details | Urine | Detected and Quantified | 25.2 +/- 1.2 umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Male | Normal | | details | Urine | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Male | Normal | | details | Urine | Detected and Quantified | 56.97 +/- 42.793 umol/mmol creatinine | Children (1 - 13 years old) | Not Specified | Normal | | details | Urine | Detected and Quantified | 48.1 +/- 47.6 umol/mmol creatinine | Children (1-13 years old) | Male | Normal | | details | Urine | Detected and Quantified | 30.35 (16.30 – 50.36) umol/mmol creatinine | Adult (>18 years old) | Both | Normal | | details | Urine | Detected and Quantified | 25.0 (22.0-28.0) umol/mmol creatinine | Adult (>18 years old) | Both | Normal | - Geigy Scientific ...
- West Cadwell, N.J...
- Basel, Switzerlan...
| details | Urine | Detected and Quantified | 20-60 umol/mmol creatinine | Newborn (0-30 days old) | Both | Normal | | details | Urine | Detected and Quantified | 71.95 (44.20-116.10) umol/mmol creatinine | Newborn (0-30 days old) | Both | Normal | | details |
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Abnormal Concentrations |
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Blood | Detected and Quantified | 3.5 (1.4) uM | Adult (>18 years old) | Female | Early preeclampsia | | details | Blood | Detected and Quantified | 4.0 (2.7) uM | Adult (>18 years old) | Female | Pregnancy | | details | Blood | Detected and Quantified | 228.46 +/- 35.49 uM | Adult (>18 years old) | Both | uremia | | details | Blood | Detected and Quantified | 29.1 +/- 12.1 uM | Adult (>18 years old) | Both | Kidney disease | | details | Blood | Detected and Quantified | 3.2 (1.7) uM | Adult (>18 years old) | Female | Late-onset preeclampsia | | details | Blood | Detected and Quantified | 4.4 (2.1) uM | Adult (>18 years old) | Female | Pregnancy | | details | Blood | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Both | Pancreatic cancer | | details | Blood | Detected and Quantified | 33.6 (19.0) uM | Adult (>18 years old) | Female | Down syndrome pregnancy | | details | Blood | Detected and Quantified | 49.1 (30.6) uM | Adult (>18 years old) | Female | Pregnancy | | details | Urine | Detected and Quantified | 17.5908 +/- 6.4589 umol/mmol creatinine | Children (1 - 13 years old) | Not Specified | Eosinophilic esophagitis | | details | Urine | Detected and Quantified | 15.4394 +/- 7.28 umol/mmol creatinine | Children (1 - 13 years old) | Not Specified | Gastroesophageal reflux disease | | details | Urine | Detected and Quantified | 25.4 (8.22-42.7) umol/mmol creatinine | Adult (>18 years old) | Both | Diabetes | | details | Urine | Detected but not Quantified | Not Quantified | Adult (>18 years old) | Both | Autosomal dominant polycystic kidney disease (ADPKD) | | details | Urine | Detected and Quantified | 52 umol/mmol creatinine | Adult (>18 years old) | Female | Rhabdomyolysis | | details | Urine | Detected and Quantified | 56.531 +/- 42.872 umol/mmol creatinine | Children (1 - 13 years old) | Not Specified | Eosinophilic esophagitis | | details | Urine | Detected and Quantified | 78.9 +/- 29.2 umol/mmol creatinine | Children (1-13 years old) | Male | Duchenne Muscular Dystrophy | | details | Urine | Detected and Quantified | 35.268 (6.543 - 159.703) umol/mmol creatinine | Adult (>18 years old) | Both | Bladder infections | | details | Urine | Detected and Quantified | 32.42 (4.89 – 61.25) umol/mmol creatinine | Adult (>18 years old) | Both | Type 1 diabetes Mellitus | | details |
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Associated Disorders and Diseases |
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Disease References | Kidney disease |
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- Teerlink T, Hennekes MW, Mulder C, Brulez HF: Determination of dimethylamine in biological samples by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Apr 11;691(2):269-76. [PubMed:9174262 ]
| Uremia |
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- Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24. [PubMed:22626821 ]
| Early preeclampsia |
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- Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28. [PubMed:22494326 ]
| Pregnancy |
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- Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28. [PubMed:22494326 ]
- Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13. [PubMed:23159745 ]
- Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester Down syndrome prediction. Am J Obstet Gynecol. 2013 May;208(5):371.e1-8. doi: 10.1016/j.ajog.2012.12.035. Epub 2013 Jan 8. [PubMed:23313728 ]
| Late-onset preeclampsia |
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- Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13. [PubMed:23159745 ]
| Pancreatic cancer |
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- Zhang L, Jin H, Guo X, Yang Z, Zhao L, Tang S, Mo P, Wu K, Nie Y, Pan Y, Fan D: Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by (1)H nuclear magnetic resonance-based metabonomic profiles. Clin Biochem. 2012 Sep;45(13-14):1064-9. doi: 10.1016/j.clinbiochem.2012.05.012. Epub 2012 May 19. [PubMed:22613268 ]
| Diabetes mellitus type 2 |
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- Zhang AQ, Mitchell SC, Smith RL: Dimethylamine in human urine. Clin Chim Acta. 1995 Jan 16;233(1-2):81-8. [PubMed:7758205 ]
| Rhabdomyolysis |
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- Bairaktari E, Seferiadis K, Liamis G, Psihogios N, Tsolas O, Elisaf M: Rhabdomyolysis-related renal tubular damage studied by proton nuclear magnetic resonance spectroscopy of urine. Clin Chem. 2002 Jul;48(7):1106-9. [PubMed:12089184 ]
| Diabetes mellitus type 1 |
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- (). Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037 . .
| Autosomal dominant polycystic kidney disease |
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- Gronwald W, Klein MS, Zeltner R, Schulze BD, Reinhold SW, Deutschmann M, Immervoll AK, Boger CA, Banas B, Eckardt KU, Oefner PJ: Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Kidney Int. 2011 Jun;79(11):1244-53. doi: 10.1038/ki.2011.30. Epub 2011 Mar 9. [PubMed:21389975 ]
| Bladder infections |
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- Tricker AR, Pfundstein B, Kalble T, Preussmann R: Secondary amine precursors to nitrosamines in human saliva, gastric juice, blood, urine and faeces. Carcinogenesis. 1992 Apr;13(4):563-8. [PubMed:1576707 ]
| Eosinophilic esophagitis |
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- Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
| Duchenne Muscular Dystrophy |
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- Horster I, Weigt-Usinger K, Carmann C, Chobanyan-Jurgens K, Kohler C, Schara U, Kayacelebi AA, Beckmann B, Tsikas D, Lucke T: The L-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids. Amino Acids. 2015 Sep;47(9):1853-63. doi: 10.1007/s00726-015-2018-x. Epub 2015 Jun 12. [PubMed:26066683 ]
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Associated OMIM IDs | - 260350 (Pancreatic cancer)
- 125853 (Diabetes mellitus type 2)
- 222100 (Diabetes mellitus type 1)
- 601313 (Autosomal dominant polycystic kidney disease)
- 610247 (Eosinophilic esophagitis)
- 310200 (Duchenne Muscular Dystrophy)
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External Links |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | FDB012589 |
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KNApSAcK ID | Not Available |
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Chemspider ID | 654 |
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KEGG Compound ID | C00543 |
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BioCyc ID | DIMETHYLAMINE |
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BiGG ID | Not Available |
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Wikipedia Link | Dimethylamine |
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METLIN ID | 3758 |
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PubChem Compound | 674 |
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PDB ID | Not Available |
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ChEBI ID | 17170 |
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Food Biomarker Ontology | Not Available |
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VMH ID | DMA |
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MarkerDB ID | MDB00000046 |
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Good Scents ID | Not Available |
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References |
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Synthesis Reference | Zones, Stacey I.; Burton, Allen W. Production of methylamine and dimethylamine using STI zeolite catalysts. U.S. Pat. Appl. Publ. (2007), 6pp. |
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Material Safety Data Sheet (MSDS) | Download (PDF) |
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General References | - Nicholson JK, Foxall PJ, Spraul M, Farrant RD, Lindon JC: 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. Anal Chem. 1995 Mar 1;67(5):793-811. [PubMed:7762816 ]
- Sweatman BC, Farrant RD, Holmes E, Ghauri FY, Nicholson JK, Lindon JC: 600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances. J Pharm Biomed Anal. 1993 Aug;11(8):651-64. [PubMed:8257730 ]
- Lee SH, Kim SO, Chung BC: Gas chromatographic-mass spectrometric determination of urinary oxoacids using O-(2,3,4,5,6-pentafluorobenzyl)oxime-trimethylsilyl ester derivatization and cation-exchange chromatography. J Chromatogr B Biomed Sci Appl. 1998 Nov 20;719(1-2):1-7. [PubMed:9869358 ]
- Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. [PubMed:12097436 ]
- Zeisel SH, daCosta KA, Youssef M, Hensey S: Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship. J Nutr. 1989 May;119(5):800-4. [PubMed:2723829 ]
- Lee L, Archer MC, Bruce WR: Absence of volatile nitrosamines in human feces. Cancer Res. 1981 Oct;41(10):3992-4. [PubMed:7285009 ]
- Sharif NA, Crider JY, Davis TL: AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonists. J Pharm Pharmacol. 2000 Dec;52(12):1529-39. [PubMed:11197083 ]
- Hughes R, Dart J, Kilvington S: Activity of the amidoamine myristamidopropyl dimethylamine against keratitis pathogens. J Antimicrob Chemother. 2003 Jun;51(6):1415-8. Epub 2003 Apr 25. [PubMed:12716783 ]
- Le Moyec L, Racine S, Le Toumelin P, Adnet F, Larue V, Cohen Y, Leroux Y, Cupa M, Hantz E: Aminoglycoside and glycopeptide renal toxicity in intensive care patients studied by proton magnetic resonance spectroscopy of urine. Crit Care Med. 2002 Jun;30(6):1242-5. [PubMed:12072675 ]
- Mulder C, Wahlund LO, Blomberg M, de Jong S, van Kamp GJ, Scheltens P, Teerlink T: Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid. J Neural Transm (Vienna). 2002 Sep;109(9):1203-8. [PubMed:12203047 ]
- Messana I, Forni F, Ferrari F, Rossi C, Giardina B, Zuppi C: Proton nuclear magnetic resonance spectral profiles of urine in type II diabetic patients. Clin Chem. 1998 Jul;44(7):1529-34. [PubMed:9665433 ]
- Lichtenberger LM, Gardner JW, Barreto JC, Morriss FH Jr: Evidence for a role of volatile amines in the development of neonatal hypergastrinemia. J Pediatr Gastroenterol Nutr. 1991 Nov;13(4):342-6. [PubMed:1779307 ]
- Zhang AQ, Mitchell SC, Smith RL: Dimethylamine in human urine. Clin Chim Acta. 1995 Jan 16;233(1-2):81-8. [PubMed:7758205 ]
- Choi SY, Chung MJ, Sung NJ: Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate. Food Chem Toxicol. 2002 Jul;40(7):949-57. [PubMed:12065217 ]
- Kilvington S, Hughes R, Byas J, Dart J: Activities of therapeutic agents and myristamidopropyl dimethylamine against Acanthamoeba isolates. Antimicrob Agents Chemother. 2002 Jun;46(6):2007-9. [PubMed:12019127 ]
- Mitchell SC, Zhang AQ, Smith RL: Dimethylamine and diet. Food Chem Toxicol. 2008 May;46(5):1734-8. doi: 10.1016/j.fct.2008.01.010. Epub 2008 Jan 15. [PubMed:18282650 ]
- Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24. [PubMed:22626821 ]
- Meskys R, Harris RJ, Casaite V, Basran J, Scrutton NS: Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter spp.: implications for glycine betaine catabolism. Eur J Biochem. 2001 Jun;268(12):3390-8. [PubMed:11422368 ]
- Tate RL 3rd, Alexander M: Microbial formation and degradation of dimethylamine. Appl Environ Microbiol. 1976 Mar;31(3):399-403. [PubMed:7191 ]
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