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Showing metabocard for Galactitol (HMDB0000107)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:14:31 UTC
HMDB IDHMDB0000107
Secondary Accession Numbers
  • HMDB00107
Metabolite Identification
Common NameGalactitol
DescriptionGalactitol or dulcitol is a sugar alcohol that is a metabolic breakdown product of galactose. Galactose is derived from lactose in food (such as dairy products). When lactose is broken down by the enzyme lactase it produces glucose and galactose. Galactitol has a slightly sweet taste. It is produced from galactose in a reaction catalyzed by aldose reductase. When present in sufficiently high levels, galactitol can act as a metabotoxin, a neurotoxin, and a hepatotoxin. A neurotoxin is a compound that disrupts or attacks neural cells and neural tissue. A hepatotoxin as a compound that disrupts or attacks liver tissue or liver cells. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of galactitol are associated with at least two inborn errors of metabolism, including galactosemia and galactosemia type II. Galactosemia is a rare genetic metabolic disorder that affects an individual's ability to metabolize the sugar galactose properly. Excess lactose consumption in individuals with galactose intolerance or galactosemia activates aldose reductase to produce galactitol, thus depleting NADPH and leading to lowered glutathione reductase activity. As a result, hydrogen peroxide or other free radicals accumulate causing serious oxidative damage to various cells and tissues. In individuals with galactosemia, the enzymes needed for the further metabolism of galactose (galactose-1-phosphate uridyltransferase) are severely diminished or missing entirely, leading to toxic levels of galactose 1-phosphate, galactitol, and galactonate. High levels of galactitol in infants are specifically associated with hepatomegaly (an enlarged liver), cirrhosis, renal failure, cataracts, vomiting, seizure, hypoglycemia, lethargy, brain damage, and ovarian failure.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000107 (Galactitol)

  Mrv1652303202019002D          

 12 11  0  0  1  0            999 V2000
   13.6187   -7.7492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9043   -9.8116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.3332   -9.8116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1899   -7.7492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.7620   -8.9867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7610   -8.5741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.6187   -8.5741    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9043   -8.9867    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   14.3332   -8.9867    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.1899   -8.5741    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   15.0475   -8.5741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4755   -8.9867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  7  1  1  1  0  0  0
  8  2  1  6  0  0  0
  9  3  1  1  0  0  0
 10  4  1  6  0  0  0
  5 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
M  END
Download

3D MOL for HMDB0000107 (Galactitol)

HMDB0000107
     RDKit          3D
Galactitol
 26 25  0  0  0  0  0  0  0  0999 V2000
   -3.9342    0.3703    0.0737 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6187    0.8099   -0.0664 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7779   -0.3824   -0.4129 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.8250   -1.3518    0.5552 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3361   -0.0203   -0.6970 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2501    0.9608   -1.6747 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4111    0.3464    0.5526 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3255   -0.6494    1.5224 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8687    0.6531    0.3357 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0961    1.6352   -0.6265 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7032   -0.5624    0.0614 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4154   -1.0954   -1.1865 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1472   -0.3675   -0.5628 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2987    1.2674    0.9011 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5521    1.5543   -0.8917 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1823   -0.8001   -1.3725 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7147   -2.2276    0.1348 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1168   -0.9422   -1.1096 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1073    0.5552   -2.5716 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0518    1.2540    1.0504 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4993   -1.5222    1.0923 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2403    1.0484    1.3376 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5534    2.4243   -0.3702 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7715   -0.2730    0.1602 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5168   -1.3235    0.8570 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2781   -1.3613   -1.6246 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  6
  4 17  1  0
  5 18  1  6
  6 19  1  0
  7 20  1  1
  8 21  1  0
  9 22  1  1
 10 23  1  0
 11 24  1  0
 11 25  1  0
 12 26  1  0
M  END
Download

3D SDF for HMDB0000107 (Galactitol)

  Mrv1652303202019002D          

 12 11  0  0  1  0            999 V2000
   13.6187   -7.7492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9043   -9.8116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.3332   -9.8116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1899   -7.7492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.7620   -8.9867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7610   -8.5741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.6187   -8.5741    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9043   -8.9867    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   14.3332   -8.9867    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.1899   -8.5741    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   15.0475   -8.5741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4755   -8.9867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  7  1  1  1  0  0  0
  8  2  1  6  0  0  0
  9  3  1  1  0  0  0
 10  4  1  6  0  0  0
  5 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000107

> <DATABASE_NAME>
hmdb

> <SMILES>
OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO

> <INCHI_IDENTIFIER>
InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6-

> <INCHI_KEY>
FBPFZTCFMRRESA-GUCUJZIJSA-N

> <FORMULA>
C6H14O6

> <MOLECULAR_WEIGHT>
182.1718

> <EXACT_MASS>
182.07903818

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
26

> <JCHEM_AVERAGE_POLARIZABILITY>
17.246117178806152

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol

> <ALOGPS_LOGP>
-2.68

> <JCHEM_LOGP>
-3.7300188486666666

> <ALOGPS_LOGS>
0.10

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.37874915684328

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.585200956788803

> <JCHEM_PKA_STRONGEST_BASIC>
-2.974211614825128

> <JCHEM_POLAR_SURFACE_AREA>
121.38000000000001

> <JCHEM_REFRACTIVITY>
38.403600000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.29e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
galactitol

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0000107 (Galactitol)

HMDB0000107
     RDKit          3D
Galactitol
 26 25  0  0  0  0  0  0  0  0999 V2000
   -3.9342    0.3703    0.0737 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6187    0.8099   -0.0664 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7779   -0.3824   -0.4129 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.8250   -1.3518    0.5552 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3361   -0.0203   -0.6970 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2501    0.9608   -1.6747 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4111    0.3464    0.5526 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3255   -0.6494    1.5224 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8687    0.6531    0.3357 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0961    1.6352   -0.6265 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7032   -0.5624    0.0614 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4154   -1.0954   -1.1865 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1472   -0.3675   -0.5628 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2987    1.2674    0.9011 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5521    1.5543   -0.8917 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1823   -0.8001   -1.3725 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7147   -2.2276    0.1348 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1168   -0.9422   -1.1096 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1073    0.5552   -2.5716 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0518    1.2540    1.0504 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4993   -1.5222    1.0923 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2403    1.0484    1.3376 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5534    2.4243   -0.3702 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7715   -0.2730    0.1602 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5168   -1.3235    0.8570 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2781   -1.3613   -1.6246 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  6
  4 17  1  0
  5 18  1  6
  6 19  1  0
  7 20  1  1
  8 21  1  0
  9 22  1  1
 10 23  1  0
 11 24  1  0
 11 25  1  0
 12 26  1  0
M  END
Download

PDB for HMDB0000107 (Galactitol)

HEADER    PROTEIN                                 20-MAR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   20-MAR-20         0                                  
HETATM    1  O   UNK     0      25.422 -14.465   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      24.088 -18.315   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      26.755 -18.315   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      22.754 -14.465   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      29.422 -16.775   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0      20.087 -16.005   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0      25.422 -16.005   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      24.088 -16.775   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      26.755 -16.775   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      22.754 -16.005   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      28.089 -16.005   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      21.421 -16.775   0.000  0.00  0.00           C+0
CONECT    1    7                                                            
CONECT    2    8                                                            
CONECT    3    9                                                            
CONECT    4   10                                                            
CONECT    5   11                                                            
CONECT    6   12                                                            
CONECT    7    1    8    9                                                  
CONECT    8    2    7   10                                                  
CONECT    9    3    7   11                                                  
CONECT   10    4    8   12                                                  
CONECT   11    5    9                                                       
CONECT   12    6   10                                                       
MASTER        0    0    0    0    0    0    0    0   12    0   22    0
END
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3D PDB for HMDB0000107 (Galactitol)

COMPND    HMDB0000107
HETATM    1  O1  UNL     1      -3.934   0.370   0.074  1.00  0.00           O  
HETATM    2  C1  UNL     1      -2.619   0.810  -0.066  1.00  0.00           C  
HETATM    3  C2  UNL     1      -1.778  -0.382  -0.413  1.00  0.00           C  
HETATM    4  O2  UNL     1      -1.825  -1.352   0.555  1.00  0.00           O  
HETATM    5  C3  UNL     1      -0.336  -0.020  -0.697  1.00  0.00           C  
HETATM    6  O3  UNL     1      -0.250   0.961  -1.675  1.00  0.00           O  
HETATM    7  C4  UNL     1       0.411   0.346   0.553  1.00  0.00           C  
HETATM    8  O4  UNL     1       0.326  -0.649   1.522  1.00  0.00           O  
HETATM    9  C5  UNL     1       1.869   0.653   0.336  1.00  0.00           C  
HETATM   10  O5  UNL     1       2.096   1.635  -0.627  1.00  0.00           O  
HETATM   11  C6  UNL     1       2.703  -0.562   0.061  1.00  0.00           C  
HETATM   12  O6  UNL     1       2.415  -1.095  -1.186  1.00  0.00           O  
HETATM   13  H1  UNL     1      -4.147  -0.367  -0.563  1.00  0.00           H  
HETATM   14  H2  UNL     1      -2.299   1.267   0.901  1.00  0.00           H  
HETATM   15  H3  UNL     1      -2.552   1.554  -0.892  1.00  0.00           H  
HETATM   16  H4  UNL     1      -2.182  -0.800  -1.372  1.00  0.00           H  
HETATM   17  H5  UNL     1      -1.715  -2.228   0.135  1.00  0.00           H  
HETATM   18  H6  UNL     1       0.117  -0.942  -1.110  1.00  0.00           H  
HETATM   19  H7  UNL     1      -0.107   0.555  -2.572  1.00  0.00           H  
HETATM   20  H8  UNL     1      -0.052   1.254   1.050  1.00  0.00           H  
HETATM   21  H9  UNL     1       0.499  -1.522   1.092  1.00  0.00           H  
HETATM   22  H10 UNL     1       2.240   1.048   1.338  1.00  0.00           H  
HETATM   23  H11 UNL     1       1.553   2.424  -0.370  1.00  0.00           H  
HETATM   24  H12 UNL     1       3.772  -0.273   0.160  1.00  0.00           H  
HETATM   25  H13 UNL     1       2.517  -1.324   0.857  1.00  0.00           H  
HETATM   26  H14 UNL     1       3.278  -1.361  -1.625  1.00  0.00           H  
CONECT    1    2   13
CONECT    2    3   14   15
CONECT    3    4    5   16
CONECT    4   17
CONECT    5    6    7   18
CONECT    6   19
CONECT    7    8    9   20
CONECT    8   21
CONECT    9   10   11   22
CONECT   10   23
CONECT   11   12   24   25
CONECT   12   26
END
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SMILES for HMDB0000107 (Galactitol)

OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO
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INCHI for HMDB0000107 (Galactitol)

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6-
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
(2R,3S,4R,5S)-Hexane-1,2,3,4,5,6-hexolChEBI
D-DulcitolChEBI
D-GalactitolChEBI
DulcitolChEBI
DulcoseChEBI
EuonymitChEBI
L-GalactitolChEBI
MelampyrinChEBI
MelampyritChEBI
Ambap5938HMDB
DulciteHMDB
HexitolHMDB
MelampyriteHMDB
MelampyrumHMDB
meso-GalactitolHMDB
Chemical FormulaC6H14O6
Average Molecular Weight182.1718
Monoisotopic Molecular Weight182.07903818
IUPAC Name(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol
Traditional Namegalactitol
CAS Registry Number608-66-2
SMILES
OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI Identifier
InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6-
InChI KeyFBPFZTCFMRRESA-GUCUJZIJSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentSugar alcohols
Alternative Parents
Substituents
  • Sugar alcohol
  • Monosaccharide
  • Secondary alcohol
  • Polyol
  • Hydrocarbon derivative
  • Primary alcohol
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Health effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Biological roleIndirect biological roleIndustrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point189.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility31 mg/mL at 15 °CYALKOWSKY,SH & DANNENFELSER,RM (1992)
LogP-3.10HANSCH,C ET AL. (1995)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available130.2http://allccs.zhulab.cn/database/detail?ID=AllCCS00000371
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Amniotic Fluid
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Saliva
  • Urine
Tissue Locations
  • Brain
  • Erythrocyte
  • Eye Lens
Pathways
Normal Concentrations
Abnormal Concentrations
Associated Disorders and Diseases
Disease References
Alzheimer's disease
  1. Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302. [PubMed:8595727 ]
Irritable bowel syndrome
  1. Ponnusamy K, Choi JN, Kim J, Lee SY, Lee CH: Microbial community and metabolomic comparison of irritable bowel syndrome faeces. J Med Microbiol. 2011 Jun;60(Pt 6):817-27. doi: 10.1099/jmm.0.028126-0. Epub 2011 Feb 17. [PubMed:21330412 ]
Galactosemia
  1. Jakobs C, Schweitzer S, Dorland B: Galactitol in galactosemia. Eur J Pediatr. 1995;154(7 Suppl 2):S50-2. [PubMed:7671965 ]
  2. Ning C, Segal S: Plasma galactose and galactitol concentration in patients with galactose-1-phosphate uridyltransferase deficiency galactosemia: determination by gas chromatography/mass spectrometry. Metabolism. 2000 Nov;49(11):1460-6. [PubMed:11092512 ]
  3. Jakobs C, Warner TG, Sweetman L, Nyhan WL: Stable isotope dilution analysis of galactitol in amniotic fluid: an accurate approach to the prenatal diagnosis of galactosemia. Pediatr Res. 1984 Aug;18(8):714-8. [PubMed:6433315 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB006453
KNApSAcK IDC00001160
Chemspider ID11357
KEGG Compound IDC01697
BioCyc IDNot Available
BiGG ID38183
Wikipedia LinkGalactitol
METLIN ID5148
PubChem Compound11850
PDB IDNot Available
ChEBI ID16813
Food Biomarker OntologyNot Available
VMH IDGALT
MarkerDB IDNot Available
Good Scents IDrw1306661
References
Synthesis ReferenceMuniruzzaman, Syed; Itoh, Hiromichi; Yoshino, Akira; Katayama, Takeshi; Izumori, Ken. Biotransformation of lactose to galactitol. Journal of Fermentation and Bioengineering (1994), 77(1), 32-5.
Material Safety Data Sheet (MSDS)Not Available
General References

Enzymes

Enzyme Details
1. Aldose reductase
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Gene Name:
AKR1B1
Uniprot ID:
P15121
Molecular weight:
35853.125
Reactions
beta-D-Galactose + NADH + Hydrogen Ion → Galactitol + NADdetails
beta-D-Galactose + NADPH + Hydrogen Ion → Galactitol + NADPdetails
Enzyme Details
2. Aldo-keto reductase family 1 member B10
General function:
Not Available
Specific function:
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
Gene Name:
AKR1B10
Uniprot ID:
O60218
Molecular weight:
Not Available
Reactions
beta-D-Galactose + NADH + Hydrogen Ion → Galactitol + NADdetails
beta-D-Galactose + NADPH + Hydrogen Ion → Galactitol + NADPdetails