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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (66) Show 66 proteins XML

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2009-03-24 16:16:27 UTC

Update Date

2022-03-07 02:51:13 UTC

HMDB ID

HMDB0011760

Secondary Accession Numbers

HMDB11760

Metabolite Identification

Common Name

Cer(d18:0/16:0)

Description

Cer(d18:0/16:0), also known as N-hexadecanoyl-sphinganine, is a ceramide (Cer). Ceramides are members of the class of compounds known as sphingolipids (SPs), or glycosylceramides. SPs are lipids containing a backbone of sphingoid bases (e.g. sphingosine or sphinganine) that are often covalently bound to a fatty acid derivative through N-acylation. SPs are found in cell membranes, particularly in peripheral nerve cells and the cells found in the central nervous system (including the brain and spinal cord). Sphingolipids are extremely versatile molecules that have functions controlling fundamental cellular processes such as cell division, differentiation, and cell death. Impairments associated with sphingolipid metabolism are associated with many common human diseases such as diabetes, various cancers, microbial infections, diseases of the cardiovascular and respiratory systems, Alzheimer’s disease and other neurological syndromes. The biosynthesis and catabolism of sphingolipids involves a large number of intermediate metabolites where many different enzymes are involved. Simple sphingolipids, which include the sphingoid bases and ceramides, make up the early products of the sphingolipid synthetic pathways, while complex sphingolipids may be formed by the addition of head groups to the ceramide template (Wikipedia). In humans, ceramides are phosphorylated to ceramide phosphates (CerPs) through the action of a specific ceramide kinase (CerK). Ceramide phosphates are important metabolites of ceramides as they act as a mediators of the inflammatory response. Ceramides are also one of the hydrolysis byproducts of sphingomyelins (SMs) through the action of the enzyme sphingomyelin phosphodiesterase, which has been identified in the subcellular fractions of human epidermis (PMID: 25935 ) and many other tissues. Ceramides can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID: 14998372 ). Ceramides are key in the biosynthesis of glycosphingolipids and gangliosides. In terms of its appearance and structure, Cer(d18:0/16:0) is a colorless solid that consists of a saturated 18-carbon sphingoid base with an attached saturated hexadecanoyl fatty acid side chain. In most mammalian SPs, the 18-carbon sphingoid bases are predominant (PMID: 9759481 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI


  Mrv0541 02241201532D          

 38 37  0  0  1  0            999 V2000
   19.1778   -3.3315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.4587   -2.9270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.7488   -3.3474    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   17.0298   -2.9429    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   16.3199   -3.3634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6009   -2.9589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8911   -3.3794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1720   -2.9749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4621   -3.3954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7431   -2.9909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0333   -3.4114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3142   -3.0069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6044   -3.4273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8853   -3.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1755   -3.4433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4564   -3.0388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7466   -3.4593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0276   -3.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0206   -2.1179    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.7581   -4.1724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3176   -3.4752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7554   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4698   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1843   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8988   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6133   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3278   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0423   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7567   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4712   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1857   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.9001   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6146   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.3291   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0436   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0436   -5.4099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0409   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3264   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  1  0  0  0  0
  4  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  8  1  0  0  0  0
 10  9  1  0  0  0  0
 11 10  1  0  0  0  0
 12 11  1  0  0  0  0
 13 12  1  0  0  0  0
 14 13  1  0  0  0  0
 15 14  1  0  0  0  0
 16 15  1  0  0  0  0
 17 16  1  0  0  0  0
 18 17  1  0  0  0  0
  4 19  1  1  0  0  0
  3 20  1  6  0  0  0
 21 18  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 20  1  0  0  0  0
 35 36  2  0  0  0  0
 37 22  1  0  0  0  0
 38 37  1  0  0  0  0
M  END

HMDB0011760
     RDKit          3D
Cer(d18:0/16:0)
107106  0  0  0  0  0  0  0  0999 V2000
  -13.6377   -1.7585    1.5194 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.2485   -0.5678    2.3329 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.3426    0.3499    1.5470 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.9910    0.8773    0.2855 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.0329    1.8184   -0.4584 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7990    1.0726   -0.8359 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8158    1.9963   -1.5413 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5677    1.2365   -1.9710 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9017    0.5692   -0.8185 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6759   -0.1820   -1.1329 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4870    0.5545   -1.6462 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0400    1.5923   -0.6088 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8172    0.9540    0.7066 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8277   -0.1079    0.8702 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3924    0.2355    0.6759 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5759   -1.0441    0.9725 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2622   -2.1072    0.9021 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2294   -0.9957    1.2959 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0922   -0.9775    1.6173 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7423   -2.4191    1.6947 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0725   -3.1134    2.7107 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0649   -0.1090    0.9053 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7715    1.2327    0.9027 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3443   -0.6050   -0.4572 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3927    0.1880   -1.2429 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6696    0.1313   -0.5055 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8702    0.7776   -1.0651 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3627    0.2773   -2.3860 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6868   -1.1694   -2.4006 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7254   -1.6721   -1.4800 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1117   -1.1415   -1.6639 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0259   -1.7985   -0.6655 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7539   -1.5549    0.7517 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7666   -0.2024    1.3269 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0089    0.6039    1.2821 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4900    1.0006   -0.0753 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7972    1.8034    0.0346 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8055    0.8897    0.7024 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.9583   -2.5882    2.1935 H   0  0  0  0  0  0  0  0  0  0  0  0
  -14.4766   -1.4334    0.8457 H   0  0  0  0  0  0  0  0  0  0  0  0
  -12.7713   -2.0337    0.8909 H   0  0  0  0  0  0  0  0  0  0  0  0
  -14.0963    0.0598    2.6764 H   0  0  0  0  0  0  0  0  0  0  0  0
  -12.6808   -0.9268    3.2410 H   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4313   -0.2708    1.3226 H   0  0  0  0  0  0  0  0  0  0  0  0
  -12.0686    1.1970    2.2220 H   0  0  0  0  0  0  0  0  0  0  0  0
  -13.8590    1.5027    0.5961 H   0  0  0  0  0  0  0  0  0  0  0  0
  -13.2797    0.0684   -0.4027 H   0  0  0  0  0  0  0  0  0  0  0  0
  -11.8584    2.7390    0.1237 H   0  0  0  0  0  0  0  0  0  0  0  0
  -12.5809    2.1632   -1.3855 H   0  0  0  0  0  0  0  0  0  0  0  0
  -11.0541    0.2328   -1.4649 H   0  0  0  0  0  0  0  0  0  0  0  0
  -10.2773    0.7995    0.1199 H   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3043    2.4531   -2.4212 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5808    2.8152   -0.8379 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8770    1.9804   -2.4167 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9241    0.5107   -2.7418 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5895   -0.1477   -0.2798 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6892    1.3487   -0.0271 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9477   -1.0483   -1.8339 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3919   -0.7497   -0.1940 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7075    1.0883   -2.5870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6963   -0.1861   -1.8606 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1784    2.1787   -0.9635 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8886    2.3097   -0.5195 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7947    0.6252    1.1662 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5059    1.7980    1.4158 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0942   -1.0551    0.2976 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9112   -0.4872    1.9424 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1231    0.9603    1.4729 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0766    0.5994   -0.2835 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2412   -2.3623    1.4721 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -0.6948    2.7631 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8126   -2.3096    1.8696 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5690   -2.9535    0.7547 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5134   -2.5208    3.2512 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0258   -0.1823    1.5278 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1705    1.7152    1.6337 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7565   -1.6614   -0.4673 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4003   -0.6687   -1.0392 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4275   -0.2864   -2.2513 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9879    1.2430   -1.2822 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4674    0.5157    0.5385 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9268   -0.9512   -0.2981 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6863    1.8856   -1.1132 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7242    0.7040   -0.3198 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3486    0.8151   -2.5649 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7242    0.5111   -3.2363 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.0840   -1.3724   -3.4473 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8129   -1.8499   -2.3383 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4001   -1.5921   -0.3928 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8076   -2.7858   -1.6433 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.4537   -1.5085   -2.6762 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.2214   -0.0600   -1.6882 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.7462   -2.9503   -0.7876 H   0  0  0  0  0  0  0  0  0  0  0  0
   11.0681   -1.8294   -0.9554 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.5341   -2.1556    1.3383 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7621   -2.0342    1.0503 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.5123   -0.3339    2.4334 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.9311    0.4467    0.9603 H   0  0  0  0  0  0  0  0  0  0  0  0
   11.8473    0.0922    1.8527 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.8130    1.5756    1.8364 H   0  0  0  0  0  0  0  0  0  0  0  0
   11.7113    0.1996   -0.7711 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.7361    1.6788   -0.5902 H   0  0  0  0  0  0  0  0  0  0  0  0
   12.6044    2.6771    0.6768 H   0  0  0  0  0  0  0  0  0  0  0  0
   13.1077    2.0464   -0.9929 H   0  0  0  0  0  0  0  0  0  0  0  0
   13.5877   -0.1357    0.3138 H   0  0  0  0  0  0  0  0  0  0  0  0
   14.8355    1.2123    0.4033 H   0  0  0  0  0  0  0  0  0  0  0  0
   13.6780    0.9407    1.7912 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
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 12 13  1  0
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 15 16  1  0
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 19 20  1  0
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 35100  1  0
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 38105  1  0
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 38107  1  0
M  END


  Mrv0541 02241201532D          

 38 37  0  0  1  0            999 V2000
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   18.4587   -2.9270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.7488   -3.3474    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   17.0298   -2.9429    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
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   15.6009   -2.9589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8911   -3.3794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1720   -2.9749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4621   -3.3954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7431   -2.9909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0333   -3.4114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3142   -3.0069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  0  0  0  0
  3  2  1  0  0  0  0
  4  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  8  1  0  0  0  0
 10  9  1  0  0  0  0
 11 10  1  0  0  0  0
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 18 17  1  0  0  0  0
  4 19  1  1  0  0  0
  3 20  1  6  0  0  0
 21 18  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 25 26  1  0  0  0  0
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 31 32  1  0  0  0  0
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 33 34  1  0  0  0  0
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 35 20  1  0  0  0  0
 35 36  2  0  0  0  0
 37 22  1  0  0  0  0
 38 37  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0011760

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCC

> <INCHI_IDENTIFIER>
InChI=1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1

> <INCHI_KEY>
GCGTXOVNNFGTPQ-JHOUSYSJSA-N

> <FORMULA>
C34H69NO3

> <MOLECULAR_WEIGHT>
539.9166

> <EXACT_MASS>
539.527745079

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_AVERAGE_POLARIZABILITY>
73.80646599139381

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]hexadecanamide

> <ALOGPS_LOGP>
9.44

> <JCHEM_LOGP>
11.071369340333336

> <ALOGPS_LOGS>
-7.11

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.492196702047824

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.831978572939391

> <JCHEM_PKA_STRONGEST_BASIC>
0.03368290724680767

> <JCHEM_POLAR_SURFACE_AREA>
69.56

> <JCHEM_REFRACTIVITY>
164.81310000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
31

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
4.20e-05 g/l

> <JCHEM_TRADITIONAL_IUPAC>
C16DH cer

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0011760
     RDKit          3D
Cer(d18:0/16:0)
107106  0  0  0  0  0  0  0  0999 V2000
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 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  0
 33 34  1  0
 34 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
  1 39  1  0
  1 40  1  0
  1 41  1  0
  2 42  1  0
  2 43  1  0
  3 44  1  0
  3 45  1  0
  4 46  1  0
  4 47  1  0
  5 48  1  0
  5 49  1  0
  6 50  1  0
  6 51  1  0
  7 52  1  0
  7 53  1  0
  8 54  1  0
  8 55  1  0
  9 56  1  0
  9 57  1  0
 10 58  1  0
 10 59  1  0
 11 60  1  0
 11 61  1  0
 12 62  1  0
 12 63  1  0
 13 64  1  0
 13 65  1  0
 14 66  1  0
 14 67  1  0
 15 68  1  0
 15 69  1  0
 18 70  1  0
 19 71  1  1
 20 72  1  0
 20 73  1  0
 21 74  1  0
 22 75  1  1
 23 76  1  0
 24 77  1  0
 24 78  1  0
 25 79  1  0
 25 80  1  0
 26 81  1  0
 26 82  1  0
 27 83  1  0
 27 84  1  0
 28 85  1  0
 28 86  1  0
 29 87  1  0
 29 88  1  0
 30 89  1  0
 30 90  1  0
 31 91  1  0
 31 92  1  0
 32 93  1  0
 32 94  1  0
 33 95  1  0
 33 96  1  0
 34 97  1  0
 34 98  1  0
 35 99  1  0
 35100  1  0
 36101  1  0
 36102  1  0
 37103  1  0
 37104  1  0
 38105  1  0
 38106  1  0
 38107  1  0
M  END

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  O   UNK     0      35.799  -6.219   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      34.456  -5.464   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      33.131  -6.248   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      31.789  -5.493   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      30.464  -6.278   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      29.122  -5.523   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      27.797  -6.308   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      26.454  -5.553   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      25.129  -6.338   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      23.787  -5.583   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      22.462  -6.368   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      21.120  -5.613   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      19.795  -6.398   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      18.453  -5.643   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      17.128  -6.427   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      15.785  -5.672   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      14.460  -6.457   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.118  -5.702   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      31.772  -3.953   0.000  0.00  0.00           O+0
HETATM   20  N   UNK     0      33.148  -7.788   0.000  0.00  0.00           N+0
HETATM   21  C   UNK     0      11.793  -6.487   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      14.477  -7.788   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      15.810  -8.558   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      17.144  -7.788   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      18.478  -8.558   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      19.811  -7.788   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      21.145  -8.558   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      22.479  -7.788   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      23.813  -8.558   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      25.146  -7.788   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      26.480  -8.558   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      27.814  -7.788   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      29.147  -8.558   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      30.481  -7.788   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0      31.815  -8.558   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0      31.815 -10.098   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0      13.143  -8.558   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      11.809  -7.788   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   20                                                  
CONECT    4    3    5   19                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   21                                                       
CONECT   19    4                                                            
CONECT   20    3   35                                                       
CONECT   21   18                                                            
CONECT   22   23   37                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   33                                                       
CONECT   33   32   34                                                       
CONECT   34   33   35                                                       
CONECT   35   34   20   36                                                  
CONECT   36   35                                                            
CONECT   37   22   38                                                       
CONECT   38   37                                                            
MASTER        0    0    0    0    0    0    0    0   38    0   74    0
END

COMPND    HMDB0011760
HETATM    1  C1  UNL     1     -13.638  -1.758   1.519  1.00  0.00           C  
HETATM    2  C2  UNL     1     -13.249  -0.568   2.333  1.00  0.00           C  
HETATM    3  C3  UNL     1     -12.343   0.350   1.547  1.00  0.00           C  
HETATM    4  C4  UNL     1     -12.991   0.877   0.285  1.00  0.00           C  
HETATM    5  C5  UNL     1     -12.033   1.818  -0.458  1.00  0.00           C  
HETATM    6  C6  UNL     1     -10.799   1.073  -0.836  1.00  0.00           C  
HETATM    7  C7  UNL     1      -9.816   1.996  -1.541  1.00  0.00           C  
HETATM    8  C8  UNL     1      -8.568   1.237  -1.971  1.00  0.00           C  
HETATM    9  C9  UNL     1      -7.902   0.569  -0.818  1.00  0.00           C  
HETATM   10  C10 UNL     1      -6.676  -0.182  -1.133  1.00  0.00           C  
HETATM   11  C11 UNL     1      -5.487   0.555  -1.646  1.00  0.00           C  
HETATM   12  C12 UNL     1      -5.040   1.592  -0.609  1.00  0.00           C  
HETATM   13  C13 UNL     1      -4.817   0.954   0.707  1.00  0.00           C  
HETATM   14  C14 UNL     1      -3.828  -0.108   0.870  1.00  0.00           C  
HETATM   15  C15 UNL     1      -2.392   0.235   0.676  1.00  0.00           C  
HETATM   16  C16 UNL     1      -1.576  -1.044   0.973  1.00  0.00           C  
HETATM   17  O1  UNL     1      -2.262  -2.107   0.902  1.00  0.00           O  
HETATM   18  N1  UNL     1      -0.229  -0.996   1.296  1.00  0.00           N  
HETATM   19  C17 UNL     1       1.092  -0.977   1.617  1.00  0.00           C  
HETATM   20  C18 UNL     1       1.742  -2.419   1.695  1.00  0.00           C  
HETATM   21  O2  UNL     1       1.073  -3.113   2.711  1.00  0.00           O  
HETATM   22  C19 UNL     1       2.065  -0.109   0.905  1.00  0.00           C  
HETATM   23  O3  UNL     1       1.772   1.233   0.903  1.00  0.00           O  
HETATM   24  C20 UNL     1       2.344  -0.605  -0.457  1.00  0.00           C  
HETATM   25  C21 UNL     1       3.393   0.188  -1.243  1.00  0.00           C  
HETATM   26  C22 UNL     1       4.670   0.131  -0.505  1.00  0.00           C  
HETATM   27  C23 UNL     1       5.870   0.778  -1.065  1.00  0.00           C  
HETATM   28  C24 UNL     1       6.363   0.277  -2.386  1.00  0.00           C  
HETATM   29  C25 UNL     1       6.687  -1.169  -2.401  1.00  0.00           C  
HETATM   30  C26 UNL     1       7.725  -1.672  -1.480  1.00  0.00           C  
HETATM   31  C27 UNL     1       9.112  -1.142  -1.664  1.00  0.00           C  
HETATM   32  C28 UNL     1      10.026  -1.799  -0.665  1.00  0.00           C  
HETATM   33  C29 UNL     1       9.754  -1.555   0.752  1.00  0.00           C  
HETATM   34  C30 UNL     1       9.767  -0.202   1.327  1.00  0.00           C  
HETATM   35  C31 UNL     1      11.009   0.604   1.282  1.00  0.00           C  
HETATM   36  C32 UNL     1      11.490   1.001  -0.075  1.00  0.00           C  
HETATM   37  C33 UNL     1      12.797   1.803   0.035  1.00  0.00           C  
HETATM   38  C34 UNL     1      13.805   0.890   0.702  1.00  0.00           C  
HETATM   39  H1  UNL     1     -13.958  -2.588   2.193  1.00  0.00           H  
HETATM   40  H2  UNL     1     -14.477  -1.433   0.846  1.00  0.00           H  
HETATM   41  H3  UNL     1     -12.771  -2.034   0.891  1.00  0.00           H  
HETATM   42  H4  UNL     1     -14.096   0.060   2.676  1.00  0.00           H  
HETATM   43  H5  UNL     1     -12.681  -0.927   3.241  1.00  0.00           H  
HETATM   44  H6  UNL     1     -11.431  -0.271   1.323  1.00  0.00           H  
HETATM   45  H7  UNL     1     -12.069   1.197   2.222  1.00  0.00           H  
HETATM   46  H8  UNL     1     -13.859   1.503   0.596  1.00  0.00           H  
HETATM   47  H9  UNL     1     -13.280   0.068  -0.403  1.00  0.00           H  
HETATM   48  H10 UNL     1     -11.858   2.739   0.124  1.00  0.00           H  
HETATM   49  H11 UNL     1     -12.581   2.163  -1.386  1.00  0.00           H  
HETATM   50  H12 UNL     1     -11.054   0.233  -1.465  1.00  0.00           H  
HETATM   51  H13 UNL     1     -10.277   0.799   0.120  1.00  0.00           H  
HETATM   52  H14 UNL     1     -10.304   2.453  -2.421  1.00  0.00           H  
HETATM   53  H15 UNL     1      -9.581   2.815  -0.838  1.00  0.00           H  
HETATM   54  H16 UNL     1      -7.877   1.980  -2.417  1.00  0.00           H  
HETATM   55  H17 UNL     1      -8.924   0.511  -2.742  1.00  0.00           H  
HETATM   56  H18 UNL     1      -8.589  -0.148  -0.280  1.00  0.00           H  
HETATM   57  H19 UNL     1      -7.689   1.349  -0.027  1.00  0.00           H  
HETATM   58  H20 UNL     1      -6.948  -1.048  -1.834  1.00  0.00           H  
HETATM   59  H21 UNL     1      -6.392  -0.750  -0.194  1.00  0.00           H  
HETATM   60  H22 UNL     1      -5.707   1.088  -2.587  1.00  0.00           H  
HETATM   61  H23 UNL     1      -4.696  -0.186  -1.861  1.00  0.00           H  
HETATM   62  H24 UNL     1      -4.178   2.179  -0.963  1.00  0.00           H  
HETATM   63  H25 UNL     1      -5.889   2.310  -0.520  1.00  0.00           H  
HETATM   64  H26 UNL     1      -5.795   0.625   1.166  1.00  0.00           H  
HETATM   65  H27 UNL     1      -4.506   1.798   1.416  1.00  0.00           H  
HETATM   66  H28 UNL     1      -4.094  -1.055   0.298  1.00  0.00           H  
HETATM   67  H29 UNL     1      -3.911  -0.487   1.942  1.00  0.00           H  
HETATM   68  H30 UNL     1      -2.123   0.960   1.473  1.00  0.00           H  
HETATM   69  H31 UNL     1      -2.077   0.599  -0.283  1.00  0.00           H  
HETATM   70  H32 UNL     1      -0.241  -2.362   1.472  1.00  0.00           H  
HETATM   71  H33 UNL     1       1.209  -0.695   2.763  1.00  0.00           H  
HETATM   72  H34 UNL     1       2.813  -2.310   1.870  1.00  0.00           H  
HETATM   73  H35 UNL     1       1.569  -2.953   0.755  1.00  0.00           H  
HETATM   74  H36 UNL     1       0.513  -2.521   3.251  1.00  0.00           H  
HETATM   75  H37 UNL     1       3.026  -0.182   1.528  1.00  0.00           H  
HETATM   76  H38 UNL     1       2.170   1.715   1.634  1.00  0.00           H  
HETATM   77  H39 UNL     1       2.757  -1.661  -0.467  1.00  0.00           H  
HETATM   78  H40 UNL     1       1.400  -0.669  -1.039  1.00  0.00           H  
HETATM   79  H41 UNL     1       3.428  -0.286  -2.251  1.00  0.00           H  
HETATM   80  H42 UNL     1       2.988   1.243  -1.282  1.00  0.00           H  
HETATM   81  H43 UNL     1       4.467   0.516   0.539  1.00  0.00           H  
HETATM   82  H44 UNL     1       4.927  -0.951  -0.298  1.00  0.00           H  
HETATM   83  H45 UNL     1       5.686   1.886  -1.113  1.00  0.00           H  
HETATM   84  H46 UNL     1       6.724   0.704  -0.320  1.00  0.00           H  
HETATM   85  H47 UNL     1       7.349   0.815  -2.565  1.00  0.00           H  
HETATM   86  H48 UNL     1       5.724   0.511  -3.236  1.00  0.00           H  
HETATM   87  H49 UNL     1       7.084  -1.372  -3.447  1.00  0.00           H  
HETATM   88  H50 UNL     1       5.813  -1.850  -2.338  1.00  0.00           H  
HETATM   89  H51 UNL     1       7.400  -1.592  -0.393  1.00  0.00           H  
HETATM   90  H52 UNL     1       7.808  -2.786  -1.643  1.00  0.00           H  
HETATM   91  H53 UNL     1       9.454  -1.509  -2.676  1.00  0.00           H  
HETATM   92  H54 UNL     1       9.221  -0.060  -1.688  1.00  0.00           H  
HETATM   93  H55 UNL     1       9.746  -2.950  -0.788  1.00  0.00           H  
HETATM   94  H56 UNL     1      11.068  -1.829  -0.955  1.00  0.00           H  
HETATM   95  H57 UNL     1      10.534  -2.156   1.338  1.00  0.00           H  
HETATM   96  H58 UNL     1       8.762  -2.034   1.050  1.00  0.00           H  
HETATM   97  H59 UNL     1       9.512  -0.334   2.433  1.00  0.00           H  
HETATM   98  H60 UNL     1       8.931   0.447   0.960  1.00  0.00           H  
HETATM   99  H61 UNL     1      11.847   0.092   1.853  1.00  0.00           H  
HETATM  100  H62 UNL     1      10.813   1.576   1.836  1.00  0.00           H  
HETATM  101  H63 UNL     1      11.711   0.200  -0.771  1.00  0.00           H  
HETATM  102  H64 UNL     1      10.736   1.679  -0.590  1.00  0.00           H  
HETATM  103  H65 UNL     1      12.604   2.677   0.677  1.00  0.00           H  
HETATM  104  H66 UNL     1      13.108   2.046  -0.993  1.00  0.00           H  
HETATM  105  H67 UNL     1      13.588  -0.136   0.314  1.00  0.00           H  
HETATM  106  H68 UNL     1      14.835   1.212   0.403  1.00  0.00           H  
HETATM  107  H69 UNL     1      13.678   0.941   1.791  1.00  0.00           H  
CONECT    1    2   39   40   41
CONECT    2    3   42   43
CONECT    3    4   44   45
CONECT    4    5   46   47
CONECT    5    6   48   49
CONECT    6    7   50   51
CONECT    7    8   52   53
CONECT    8    9   54   55
CONECT    9   10   56   57
CONECT   10   11   58   59
CONECT   11   12   60   61
CONECT   12   13   62   63
CONECT   13   14   64   65
CONECT   14   15   66   67
CONECT   15   16   68   69
CONECT   16   17   17   18
CONECT   18   19   70
CONECT   19   20   22   71
CONECT   20   21   72   73
CONECT   21   74
CONECT   22   23   24   75
CONECT   23   76
CONECT   24   25   77   78
CONECT   25   26   79   80
CONECT   26   27   81   82
CONECT   27   28   83   84
CONECT   28   29   85   86
CONECT   29   30   87   88
CONECT   30   31   89   90
CONECT   31   32   91   92
CONECT   32   33   93   94
CONECT   33   34   95   96
CONECT   34   35   97   98
CONECT   35   36   99  100
CONECT   36   37  101  102
CONECT   37   38  103  104
CONECT   38  105  106  107
END

HMDB0011760
     RDKit          3D
Cer(d18:0/16:0)
107106  0  0  0  0  0  0  0  0999 V2000
  -13.6377   -1.7585    1.5194 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.2485   -0.5678    2.3329 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.3426    0.3499    1.5470 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.9910    0.8773    0.2855 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.0329    1.8184   -0.4584 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7990    1.0726   -0.8359 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8158    1.9963   -1.5413 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5677    1.2365   -1.9710 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9017    0.5692   -0.8185 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6759   -0.1820   -1.1329 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4870    0.5545   -1.6462 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0400    1.5923   -0.6088 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8172    0.9540    0.7066 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END

View in JSmol View Stereo Labels

Synonyms

Value	Source
C16DH Cer	ChEBI
DHC-a 18:0/16:0	ChEBI
N-(Hexadecanoyl)-dihydroceramide	ChEBI
N-(Hexadecanoyl)-sphinganine	ChEBI
N-(Palmitoyl)-dihydroceramide	ChEBI
N-Hexadecanoyldihydroceramide	ChEBI
N-Hexadecanoyldihydrosphingosine	ChEBI
N-Palmitoyldihydroceramide	ChEBI
N-Palmitoyldihydrosphingosine	ChEBI
N-Palmitoylsphinganine	ChEBI
Ceramide	HMDB
Ceramide(D18:0/16:0)	HMDB
N-(Hexadecanoyl)-dihydrosphingosine	HMDB
N-(Hexadecanoyl)-D-erythro-sphinganine	HMDB
(2S,3R)-2-N-Palmitoyloctadecasphinganine	HMDB
C16-Dihydroceramide	HMDB
N-Hexadecanoylsphinganine	HMDB
N-Palmitoyl sphinganine	HMDB
N-Palmitoyl-D(+)-erythro-sphinganine	HMDB
N-Palmitoyl-sphinganine	HMDB
Cer(d18:0/16:0)	HMDB

Chemical Formula

C₃₄H₆₉NO₃

Average Molecular Weight

539.9166

Monoisotopic Molecular Weight

539.527745079

IUPAC Name

N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]hexadecanamide

Traditional Name

C16DH cer

CAS Registry Number

5966-29-0

SMILES

CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCC

InChI Identifier

InChI=1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1

InChI Key

GCGTXOVNNFGTPQ-JHOUSYSJSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as long-chain ceramides. These are ceramides bearing a long chain fatty acid.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Sphingolipids

Sub Class

Ceramides

Direct Parent

Long-chain ceramides

Alternative Parents

Substituents

Long-chain ceramide
Fatty amide
N-acyl-amine
Fatty acyl
Carboxamide group
Secondary alcohol
Secondary carboxylic acid amide
Carboxylic acid derivative
Primary alcohol
Organooxygen compound
Organonitrogen compound
Organic oxide
Organopnictogen compound
Organic oxygen compound
Alcohol
Organic nitrogen compound
Carbonyl group
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

dihydroceramide (CHEBI:67042 )
N-acylsphinganines (dihydroceramides) (LMSP02020001 )

Ontology

Physiological effect

Health effect

Metabolic syndrome (HMDB: HMDB0011760)
Lipotoxicity (HMDB: HMDB0011760)
Insulin resistance (PMID: 24214972)
Diabetes mellitus (PMID: 17588815)
Neurodegenerative disease (PMID: 17588815)

Organoleptic effect

Touch

Smooth (HMDB: HMDB0011760)

Disposition

Biological location

Cell membrane (HMDB: HMDB0011760)
Intracellular membrane (HMDB: HMDB0011760)

Biofluid or Excreta

Non-excretory biofluid

Blood (PMID: 20671299)

Excreta

Feces (PMID: 23210743)
Urine (PMID: 32966057)

Cellular substructure

Organelle

Endosome

Endosome (HMDB: HMDB0011760)

endoplasmic reticulum (PMID: 12408751)

Membrane (HMDB: HMDB0011760)
Extracellular (HMDB: HMDB0011760)
golgi apparatus membrane (PMID: 12408751)
cell membrane (PMID: 12408751)

Organ

Placenta (HMDB: HMDB0011760)

Cell

All cells and tissues (HMDB: HMDB0011760)

Route of exposure

Enteral

Ingestion (HMDB: HMDB0011760)

Source

Endogenous

Endogenous (HMDB: HMDB0011760)

Animal

Animal (HMDB: HMDB0011760)

Exogenous

Food

Food (HMDB: HMDB0011760)

Milk and milk product

Unfermented milk

Milk (Cow) (FooDB: FOOD00618)

Animal origin

Poultry

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Process

Naturally occurring process

Apoptosis (PMID: 18216770)

Apoptosis (HMDB: HMDB0011760)

Chemical reaction

Lipid peroxidation (HMDB: HMDB0011760)

Biochemical process

Fatty acid metabolism (HMDB: HMDB0011760)

Role

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	4.2e-05 g/L	ALOGPS
logP	9.44	ALOGPS
logP	11.07	ChemAxon
logS	-7.1	ALOGPS
pKa (Strongest Acidic)	13.83	ChemAxon
pKa (Strongest Basic)	0.034	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	69.56 Å²	ChemAxon
Rotatable Bond Count	31	ChemAxon
Refractivity	164.81 m³·mol⁻¹	ChemAxon
Polarizability	73.81 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	242.117	31661259
DarkChem	[M-H]-	234.645	31661259
DeepCCS	[M+H]+	241.368	30932474
DeepCCS	[M-H]-	239.01	30932474
DeepCCS	[M-2H]-	273.196	30932474
DeepCCS	[M+Na]+	248.426	30932474
AllCCS	[M+H]+	260.2	32859911
AllCCS	[M+H-H2O]+	259.4	32859911
AllCCS	[M+NH4]+	260.9	32859911
AllCCS	[M+Na]+	261.0	32859911
AllCCS	[M-H]-	244.0	32859911
AllCCS	[M+Na-2H]-	246.7	32859911
AllCCS	[M+HCOO]-	249.9	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Cer(d18:0/16:0)	CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCC	3643.0	Standard polar	33892256
Cer(d18:0/16:0)	CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCC	3818.0	Standard non polar	33892256
Cer(d18:0/16:0)	CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCC	4254.0	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
Cer(d18:0/16:0),1TMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C	4119.8	Semi standard non polar	33892256
Cer(d18:0/16:0),1TMS,isomer #2	CCCCCCCCCCCCCCCC(=O)N[C@@H](CO[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCCC	4043.5	Semi standard non polar	33892256
Cer(d18:0/16:0),1TMS,isomer #3	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC)[Si](C)(C)C	4009.7	Semi standard non polar	33892256
Cer(d18:0/16:0),2TMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N[C@@H](CO[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C	4087.7	Semi standard non polar	33892256
Cer(d18:0/16:0),2TMS,isomer #2	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C)[Si](C)(C)C	4082.3	Semi standard non polar	33892256
Cer(d18:0/16:0),2TMS,isomer #3	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCCC)[Si](C)(C)C	4054.2	Semi standard non polar	33892256
Cer(d18:0/16:0),3TMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C)[Si](C)(C)C	4121.4	Semi standard non polar	33892256
Cer(d18:0/16:0),3TMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C)[Si](C)(C)C	3923.4	Standard non polar	33892256
Cer(d18:0/16:0),3TMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C)[Si](C)(C)C	3983.3	Standard polar	33892256
Cer(d18:0/16:0),1TBDMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C(C)(C)C	4359.3	Semi standard non polar	33892256
Cer(d18:0/16:0),1TBDMS,isomer #2	CCCCCCCCCCCCCCCC(=O)N[C@@H](CO[Si](C)(C)C(C)(C)C)[C@H](O)CCCCCCCCCCCCCCC	4320.3	Semi standard non polar	33892256
Cer(d18:0/16:0),1TBDMS,isomer #3	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C	4272.4	Semi standard non polar	33892256
Cer(d18:0/16:0),2TBDMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N[C@@H](CO[Si](C)(C)C(C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C(C)(C)C	4601.2	Semi standard non polar	33892256
Cer(d18:0/16:0),2TBDMS,isomer #2	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	4583.6	Semi standard non polar	33892256
Cer(d18:0/16:0),2TBDMS,isomer #3	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C(C)(C)C)[C@H](O)CCCCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C	4535.2	Semi standard non polar	33892256
Cer(d18:0/16:0),3TBDMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C(C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	4838.2	Semi standard non polar	33892256
Cer(d18:0/16:0),3TBDMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C(C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	4325.0	Standard non polar	33892256
Cer(d18:0/16:0),3TBDMS,isomer #1	CCCCCCCCCCCCCCCC(=O)N([C@@H](CO[Si](C)(C)C(C)(C)C)[C@@H](CCCCCCCCCCCCCCC)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	4200.6	Standard polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (2 TMS) - 70eV, Positive	splash10-00di-4341976000-d1998545e42653fb2fc3	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TMS_1_2) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TMS_1_3) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TMS_2_2) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TMS_2_3) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TBDMS_1_3) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TBDMS_2_1) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TBDMS_2_2) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS (TBDMS_2_3) - 70eV, Positive	Not Available	2021-10-13	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Cer(d18:0/16:0) GC-MS ("Cer(d18:0/16:0),1TMS,#1" TMS) - 70eV, Positive	Not Available	2021-10-14	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 10V, Positive-QTOF	splash10-0006-0000090000-0422f982c25b3654f076	2017-10-04	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 20V, Positive-QTOF	splash10-00kf-0050090000-f49cbabeec31a5dcde0d	2017-10-04	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 40V, Positive-QTOF	splash10-01c0-0090050000-368a3b39652565b388dd	2017-10-04	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 10V, Positive-QTOF	splash10-0006-0000090000-21ff866e5e4a07849e7c	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 20V, Positive-QTOF	splash10-00kf-0050090000-60ae35e227382fa1241c	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 40V, Positive-QTOF	splash10-01c0-0090050000-b4c163fbd83370809aee	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 10V, Negative-QTOF	splash10-000i-0000090000-c13a080bf1fdfb8329cf	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 20V, Negative-QTOF	splash10-000i-0010090000-395fb31e5fdba9428fb4	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 40V, Negative-QTOF	splash10-052r-0040090000-daca485f6a3e80f4073d	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 10V, Positive-QTOF	splash10-0002-0000090000-7ced1facabcfbd3e5559	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 20V, Positive-QTOF	splash10-0002-0000090000-7ced1facabcfbd3e5559	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Cer(d18:0/16:0) 40V, Positive-QTOF	splash10-004i-0000190000-2d15d5fbdc988e27f710	2021-09-25	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted 1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-18	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Blood
Feces
Urine

Tissue Locations

Placenta

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	32966057	details
Blood	Detected and Quantified	0.261 +/- 0.0004 uM	Adult (>18 years old)	Both	Normal	20671299	details
Urine	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	32966057	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Feces	Detected but not Quantified	Not Quantified	Newborn (0-30 days old)	Not Specified	Premature neonates	23210743	details

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB028430

KNApSAcK ID

Not Available

Chemspider ID

4446685

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5283572

PDB ID

Not Available

ChEBI ID

67042

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Bowser PA, Gray GM: Sphingomyelinase in pig and human epidermis. J Invest Dermatol. 1978 Jun;70(6):331-5. [PubMed:25935 ]
Tserng KY, Griffin RL: Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. Biochem J. 2004 Jun 15;380(Pt 3):715-22. [PubMed:14998372 ]
Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
Divecha N, Irvine RF: Phospholipid signaling. Cell. 1995 Jan 27;80(2):269-78. [PubMed:7834746 ]
Ghosh S, Strum JC, Bell RM: Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling. FASEB J. 1997 Jan;11(1):45-50. [PubMed:9034165 ]
Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH Jr: Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res. 2008 Aug;49(8):1621-39. doi: 10.1194/jlr.R800012-JLR200. Epub 2008 May 21. [PubMed:18499644 ]
Hannun YA, Obeid LM: Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995 Feb;20(2):73-7. [PubMed:7701566 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
Cevc, Gregor (1993). Phospholipids Handbook. Marcel Dekker.
Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Only showing the first 10 proteins. There are 66 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. Galactocerebrosidase

General function:: Involved in galactosylceramidase activity
Specific function:: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Gene Name:: GALC
Uniprot ID:: P54803
Molecular weight:: 77062.86

Enzyme Details

2. Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens
Gene Name:: GBGT1
Uniprot ID:: Q8N5D6
Molecular weight:: 40126.9

Enzyme Details

3. N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

General function:: Involved in N-acetylglucosaminylphosphatidylinositol de
Specific function:: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Gene Name:: PIGL
Uniprot ID:: Q9Y2B2
Molecular weight:: 28530.965

Enzyme Details

4. Phosphatidylcholine:ceramide cholinephosphotransferase 2

General function:: Involved in catalytic activity
Specific function:: Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Required for cell growth
Gene Name:: SGMS2
Uniprot ID:: Q8NHU3
Molecular weight:: 42279.8

Enzyme Details

5. Phosphatidylcholine:ceramide cholinephosphotransferase 1

General function:: Involved in catalytic activity
Specific function:: Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth
Gene Name:: SGMS1
Uniprot ID:: Q86VZ5
Molecular weight:: 49207.3

Enzyme Details

6. Sphingomyelin phosphodiesterase

General function:: Involved in hydrolase activity
Specific function:: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
Gene Name:: SMPD1
Uniprot ID:: P17405
Molecular weight:: 69935.53

Enzyme Details

7. Ceramide glucosyltransferase

General function:: Cell wall/membrane/envelope biogenesis
Specific function:: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".
Gene Name:: UGCG
Uniprot ID:: Q16739
Molecular weight:: 44853.255

Enzyme Details

8. Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

General function:: Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity
Specific function:: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:: PIGQ
Uniprot ID:: Q9BRB3
Molecular weight:: 65343.25

Enzyme Details

9. Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

General function:: Involved in biosynthetic process
Specific function:: Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Gene Name:: PIGA
Uniprot ID:: P37287
Molecular weight:: 54126.065

Enzyme Details

10. Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

General function:: Involved in phosphatidylinositol N-acetylglucosaminyltr
Specific function:: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:: PIGH
Uniprot ID:: Q14442
Molecular weight:: 21080.415

Only showing the first 10 proteins. There are 66 proteins in total.

Show all enzymes and transporters

Showing metabocard for Cer(d18:0/16:0) (HMDB0011760)

MOL for HMDB0011760 (Cer(d18:0/16:0))

3D MOL for HMDB0011760 (Cer(d18:0/16:0))

3D SDF for HMDB0011760 (Cer(d18:0/16:0))

3D-SDF for HMDB0011760 (Cer(d18:0/16:0))

PDB for HMDB0011760 (Cer(d18:0/16:0))

3D PDB for HMDB0011760 (Cer(d18:0/16:0))

SMILES for HMDB0011760 (Cer(d18:0/16:0))

INCHI for HMDB0011760 (Cer(d18:0/16:0))

Structure for HMDB0011760 (Cer(d18:0/16:0))

3D Structure for HMDB0011760 (Cer(d18:0/16:0))

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra

Enzymes