Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2009-07-25 00:03:04 UTC |
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Update Date | 2022-03-07 02:51:26 UTC |
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HMDB ID | HMDB0012567 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | 13-HETE |
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Description | 13-Hydroxyeicosatetraenoic acid is one of the main metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands of PPARr. It can inhibit cell proliferation and induce apoptosis in several types of human cancer. 13-HETE is an arachidonic acid metabolite in rat liver microsomes, and is a metabolite of red algae.Hydroxyeicosatetraenoic acids (HETEs) are formed in numerous cell types by enzymatically-mediated hydroxylation of arachidonic acid. There are three distinct enzymes involved in HETE biosynthesis:lipoxygenase (LOX), prostaglandin H (PGH) synthase, and cytochrome P-450. LOX- and PGH-synthase-mediated arachidonic acid metabolism is normally highly stereoselective. |
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Structure | CCCCC\C=C/C(O)\C=C/C\C=C/C\C=C/CCCC(O)=O InChI=1S/C20H32O3/c1-2-3-4-10-13-16-19(21)17-14-11-8-6-5-7-9-12-15-18-20(22)23/h6-9,13-14,16-17,19,21H,2-5,10-12,15,18H2,1H3,(H,22,23)/b8-6-,9-7-,16-13-,17-14- |
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Synonyms | Value | Source |
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(5Z,8Z,11Z,14Z)-13-Hydroxyicosatetraenoic acid | ChEBI | 13-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid | ChEBI | 13-Hydroxy-(5Z,8Z,11Z,14Z)-icosatetraenoic acid | ChEBI | 13-Hydroxyeicosatetraenoic acid | ChEBI | (5Z,8Z,11Z,14Z)-13-Hydroxyicosatetraenoate | Generator | 13-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate | Generator | 13-Hydroxy-(5Z,8Z,11Z,14Z)-icosatetraenoate | Generator | 13-Hydroxyeicosatetraenoate | Generator | 13-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate | HMDB | 13-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid | HMDB | 13-Hydroxyeicosatetraenoic acid, (S)-(all-Z)-isomer | MeSH, HMDB |
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Chemical Formula | C20H32O3 |
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Average Molecular Weight | 320.4663 |
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Monoisotopic Molecular Weight | 320.23514489 |
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IUPAC Name | (5Z,8Z,11Z,14Z)-13-hydroxyicosa-5,8,11,14-tetraenoic acid |
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Traditional Name | (5Z,8Z,11Z,14Z)-13-hydroxyicosa-5,8,11,14-tetraenoic acid |
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CAS Registry Number | 151910-72-4 |
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SMILES | CCCCC\C=C/C(O)\C=C/C\C=C/C\C=C/CCCC(O)=O |
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InChI Identifier | InChI=1S/C20H32O3/c1-2-3-4-10-13-16-19(21)17-14-11-8-6-5-7-9-12-15-18-20(22)23/h6-9,13-14,16-17,19,21H,2-5,10-12,15,18H2,1H3,(H,22,23)/b8-6-,9-7-,16-13-,17-14- |
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InChI Key | SAKQICHVWOJSNI-BWWNDVLWSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as hydroxyeicosatetraenoic acids. These are eicosanoic acids with an attached hydroxyl group and four CC double bonds. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Fatty Acyls |
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Sub Class | Eicosanoids |
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Direct Parent | Hydroxyeicosatetraenoic acids |
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Alternative Parents | |
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Substituents | - Hydroxyeicosatetraenoic acid
- Long-chain fatty acid
- Hydroxy fatty acid
- Fatty acid
- Unsaturated fatty acid
- Secondary alcohol
- Carboxylic acid derivative
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Organic oxide
- Organic oxygen compound
- Alcohol
- Hydrocarbon derivative
- Carbonyl group
- Organooxygen compound
- Aliphatic acyclic compound
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | Not Available |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | | Show more...
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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13-HETE,1TMS,isomer #1 | CCCCC/C=C\C(/C=C\C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C | 2697.0 | Semi standard non polar | 33892256 | 13-HETE,1TMS,isomer #2 | CCCCC/C=C\C(O)/C=C\C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C | 2556.6 | Semi standard non polar | 33892256 | 13-HETE,2TMS,isomer #1 | CCCCC/C=C\C(/C=C\C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C | 2616.9 | Semi standard non polar | 33892256 | 13-HETE,1TBDMS,isomer #1 | CCCCC/C=C\C(/C=C\C/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C | 2928.3 | Semi standard non polar | 33892256 | 13-HETE,1TBDMS,isomer #2 | CCCCC/C=C\C(O)/C=C\C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C | 2809.1 | Semi standard non polar | 33892256 | 13-HETE,2TBDMS,isomer #1 | CCCCC/C=C\C(/C=C\C/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C | 3104.4 | Semi standard non polar | 33892256 |
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Spectra |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - 13-HETE GC-MS (Non-derivatized) - 70eV, Positive | splash10-0udm-9573000000-fd1ef654a114fbdce8f9 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 13-HETE GC-MS (2 TMS) - 70eV, Positive | splash10-004j-9225300000-d57a6b96d837ca425c07 | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 13-HETE GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 10V, Positive-QTOF | splash10-0udi-0049000000-33aab7be1c53ffedfa68 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 20V, Positive-QTOF | splash10-0zj0-7694000000-b0537b8d894c47d11ded | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 40V, Positive-QTOF | splash10-000f-9730000000-89f61926136ab6394c48 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 10V, Negative-QTOF | splash10-014i-0019000000-907ce78259323183429e | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 20V, Negative-QTOF | splash10-0uxr-2149000000-b29439c6107511b4f9e1 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 40V, Negative-QTOF | splash10-0a4l-9430000000-f999fd58d02e9da56145 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 10V, Positive-QTOF | splash10-0udi-1349000000-82fcf33dd08cfc69ca34 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 20V, Positive-QTOF | splash10-0udv-9864000000-93e04762b76a59d719c3 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 40V, Positive-QTOF | splash10-00kf-9610000000-18b551ab2467c2b0b627 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 10V, Negative-QTOF | splash10-014i-0009000000-db4700af17a6033433d3 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 20V, Negative-QTOF | splash10-0gb9-1239000000-5462bef50ee96ca03f6c | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 13-HETE 40V, Negative-QTOF | splash10-0kfx-9241000000-28671b487cbe8094a2e3 | 2021-09-25 | Wishart Lab | View Spectrum |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | |
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Normal Concentrations |
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Abnormal Concentrations |
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Associated Disorders and Diseases |
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Disease References | None |
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Associated OMIM IDs | None |
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External Links |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | FDB029131 |
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KNApSAcK ID | Not Available |
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Chemspider ID | 35032542 |
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KEGG Compound ID | Not Available |
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BioCyc ID | Not Available |
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BiGG ID | Not Available |
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Wikipedia Link | Not Available |
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METLIN ID | Not Available |
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PubChem Compound | 53481471 |
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PDB ID | Not Available |
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ChEBI ID | 137345 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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MarkerDB ID | Not Available |
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Good Scents ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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Material Safety Data Sheet (MSDS) | Not Available |
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General References | - Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
- Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
- Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
- Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
- Oliw EH: bis-Allylic hydroxylation of linoleic acid and arachidonic acid by human hepatic monooxygenases. Biochim Biophys Acta. 1993 Feb 24;1166(2-3):258-63. [PubMed:8443245 ]
- Hornsten L, Bylund J, Oliw EH: Dexamethasone induces bisallylic hydroxylation of polyunsaturated fatty acids by rat liver microsomes. Arch Biochem Biophys. 1996 Aug 15;332(2):261-8. [PubMed:8806734 ]
- Bylund J, Kunz T, Valmsen K, Oliw EH: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. J Pharmacol Exp Ther. 1998 Jan;284(1):51-60. [PubMed:9435160 ]
- Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.
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