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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2022-03-07 02:51:43 UTC
HMDB IDHMDB0014742
Secondary Accession Numbers
  • HMDB14742
Metabolite Identification
Common NameCisapride
DescriptionCisapride, also known as (+-)-cisapride or cisapridum, belongs to the class of organic compounds known as aminobenzamides. These are organic compounds containing a benzamide moiety with an amine group attached to the benzene ring. Cisapride is a drug which is used for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. Cisapride is a very strong basic compound (based on its pKa). Cisapride is a potentially toxic compound.
Structure
Data?1582753216
Synonyms
ValueSource
(+-)-CisaprideChEBI
4-Amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamideChEBI
4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamideChEBI
cis-4-Amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidyl)-O-anisamideChEBI
cis-4-Amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-2-methoxybenzamideChEBI
cis-4-Amino-5-chloro-N-{1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-O-anisamideChEBI
CisapridaChEBI
CisapridumChEBI
PropulsidHMDB
Chemical FormulaC23H29ClFN3O4
Average Molecular Weight465.945
Monoisotopic Molecular Weight465.183062343
IUPAC Name4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
Traditional Name(+-)-cisapride
CAS Registry Number81098-60-4
SMILES
CO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=CC(Cl)=C(N)C=C1OC
InChI Identifier
InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/m1/s1
InChI KeyDCSUBABJRXZOMT-IRLDBZIGSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aminobenzamides. These are organic compounds containing a benzamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoic acids and derivatives
Direct ParentAminobenzamides
Alternative Parents
Substituents
  • Aminobenzamide
  • Halobenzoic acid or derivatives
  • 3-halobenzoic acid or derivatives
  • Aminophenyl ether
  • Methoxyaniline
  • Benzamide
  • Phenoxy compound
  • Anisole
  • Methoxybenzene
  • Aniline or substituted anilines
  • Benzoyl
  • Phenol ether
  • Alkyl aryl ether
  • Halobenzene
  • Fluorobenzene
  • Chlorobenzene
  • Aryl chloride
  • Aryl fluoride
  • Aryl halide
  • Piperidine
  • Amino acid or derivatives
  • Tertiary aliphatic amine
  • Carboxamide group
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Dialkyl ether
  • Ether
  • Organic oxygen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Amine
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organofluoride
  • Organopnictogen compound
  • Organic oxide
  • Organochloride
  • Organohalogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point110 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.012 g/LNot Available
LogP3.3Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.012 g/LALOGPS
logP2.95ALOGPS
logP2.49ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)14.58ChemAxon
pKa (Strongest Basic)8.24ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area86.05 ŲChemAxon
Rotatable Bond Count9ChemAxon
Refractivity122.93 m³·mol⁻¹ChemAxon
Polarizability49.11 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+204.5530932474
DeepCCS[M-H]-202.19230932474
DeepCCS[M-2H]-235.08830932474
DeepCCS[M+Na]+210.64430932474
AllCCS[M+H]+208.932859911
AllCCS[M+H-H2O]+206.932859911
AllCCS[M+NH4]+210.732859911
AllCCS[M+Na]+211.232859911
AllCCS[M-H]-203.332859911
AllCCS[M+Na-2H]-204.332859911
AllCCS[M+HCOO]-205.532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
CisaprideCO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=CC(Cl)=C(N)C=C1OC4809.0Standard polar33892256
CisaprideCO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=CC(Cl)=C(N)C=C1OC3864.1Standard non polar33892256
CisaprideCO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=CC(Cl)=C(N)C=C1OC3835.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Cisapride,1TMS,isomer #1COC1=CC(N[Si](C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC3830.1Semi standard non polar33892256
Cisapride,1TMS,isomer #1COC1=CC(N[Si](C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC3389.2Standard non polar33892256
Cisapride,1TMS,isomer #1COC1=CC(N[Si](C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC4660.8Standard polar33892256
Cisapride,1TMS,isomer #2COC1=CC(N)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C3612.0Semi standard non polar33892256
Cisapride,1TMS,isomer #2COC1=CC(N)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C3312.2Standard non polar33892256
Cisapride,1TMS,isomer #2COC1=CC(N)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C4933.3Standard polar33892256
Cisapride,2TMS,isomer #1COC1=CC(N([Si](C)(C)C)[Si](C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC3670.1Semi standard non polar33892256
Cisapride,2TMS,isomer #1COC1=CC(N([Si](C)(C)C)[Si](C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC3358.0Standard non polar33892256
Cisapride,2TMS,isomer #1COC1=CC(N([Si](C)(C)C)[Si](C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC4417.8Standard polar33892256
Cisapride,2TMS,isomer #2COC1=CC(N[Si](C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C3696.5Semi standard non polar33892256
Cisapride,2TMS,isomer #2COC1=CC(N[Si](C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C3334.5Standard non polar33892256
Cisapride,2TMS,isomer #2COC1=CC(N[Si](C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C4380.2Standard polar33892256
Cisapride,3TMS,isomer #1COC1=CC(N([Si](C)(C)C)[Si](C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C3576.3Semi standard non polar33892256
Cisapride,3TMS,isomer #1COC1=CC(N([Si](C)(C)C)[Si](C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C3250.5Standard non polar33892256
Cisapride,3TMS,isomer #1COC1=CC(N([Si](C)(C)C)[Si](C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C4109.0Standard polar33892256
Cisapride,1TBDMS,isomer #1COC1=CC(N[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC4014.2Semi standard non polar33892256
Cisapride,1TBDMS,isomer #1COC1=CC(N[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC3592.3Standard non polar33892256
Cisapride,1TBDMS,isomer #1COC1=CC(N[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC4698.1Standard polar33892256
Cisapride,1TBDMS,isomer #2COC1=CC(N)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C3805.0Semi standard non polar33892256
Cisapride,1TBDMS,isomer #2COC1=CC(N)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C3517.0Standard non polar33892256
Cisapride,1TBDMS,isomer #2COC1=CC(N)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C4905.2Standard polar33892256
Cisapride,2TBDMS,isomer #1COC1=CC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC4101.4Semi standard non polar33892256
Cisapride,2TBDMS,isomer #1COC1=CC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC3768.1Standard non polar33892256
Cisapride,2TBDMS,isomer #1COC1=CC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N[C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC4464.3Standard polar33892256
Cisapride,2TBDMS,isomer #2COC1=CC(N[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C4039.9Semi standard non polar33892256
Cisapride,2TBDMS,isomer #2COC1=CC(N[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C3696.4Standard non polar33892256
Cisapride,2TBDMS,isomer #2COC1=CC(N[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C4463.5Standard polar33892256
Cisapride,3TBDMS,isomer #1COC1=CC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C4155.2Semi standard non polar33892256
Cisapride,3TBDMS,isomer #1COC1=CC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C3833.8Standard non polar33892256
Cisapride,3TBDMS,isomer #1COC1=CC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C(Cl)C=C1C(=O)N([C@@H]1CCN(CCCOC2=CC=C(F)C=C2)C[C@@H]1OC)[Si](C)(C)C(C)(C)C4220.3Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Cisapride GC-MS (Non-derivatized) - 70eV, Positivesplash10-001i-2922000000-0772f474daac82b426ee2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Cisapride GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Cisapride GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Cisapride LC-ESI-qTof , Positive-QTOFsplash10-001i-0980000000-a0df861122e90da3494b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cisapride , positive-QTOFsplash10-001i-0980000000-a0df861122e90da3494b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cisapride , positive-QTOFsplash10-0159-0710900000-262b97df953edaab4cfa2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 10V, Positive-QTOFsplash10-0159-0111900000-61265dea2a01bd8e83782016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 20V, Positive-QTOFsplash10-001i-0943300000-cdcfabdf19797140d7952016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 40V, Positive-QTOFsplash10-0006-9861100000-46b94051a1f1227c93632016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 10V, Negative-QTOFsplash10-03di-0400900000-c6cda5b55f88160e99de2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 20V, Negative-QTOFsplash10-03di-0921500000-6011948830548e90b8dc2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 40V, Negative-QTOFsplash10-03di-2910000000-5144f15cb7a70d64b8a32016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 10V, Positive-QTOFsplash10-014i-0001900000-8df7d19bd80f8e92fe732021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 20V, Positive-QTOFsplash10-0gb9-0439600000-d40cbd486ff327890e072021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 40V, Positive-QTOFsplash10-03ea-4902100000-c20a14020bf3f34d23dd2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 10V, Negative-QTOFsplash10-03di-0100900000-10eb08fa13f12fb9bc9d2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 20V, Negative-QTOFsplash10-03di-5915600000-de23551ac41099e763f92021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cisapride 40V, Negative-QTOFsplash10-0il0-9411000000-a20e7213ffcaf2d0f91f2021-10-11Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00604 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00604 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00604
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID5292927
KEGG Compound IDC06910
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkCisapride
METLIN IDNot Available
PubChem Compound6917698
PDB IDNot Available
ChEBI ID3720
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Pearce RE, Gotschall RR, Kearns GL, Leeder JS: Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms. Drug Metab Dispos. 2001 Dec;29(12):1548-54. [PubMed:11717173 ]

Only showing the first 10 proteins. There are 14 proteins in total.

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Pearce RE, Gotschall RR, Kearns GL, Leeder JS: Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms. Drug Metab Dispos. 2001 Dec;29(12):1548-54. [PubMed:11717173 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55768.94
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular weight:
57108.065
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular weight:
57525.03
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular weight:
58406.915
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular weight:
55824.275
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular weight:
56517.005
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Only showing the first 10 proteins. There are 14 proteins in total.