Hmdb loader

Showing metabocard for Nicardipine (HMDB0014760)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (23)transporters (1) Show 24 proteinsXML
enzymes (23)transporters (1) Show 24 proteins
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2022-03-07 02:51:44 UTC
HMDB IDHMDB0014760
Secondary Accession Numbers
  • HMDB14760
Metabolite Identification
Common NameNicardipine
DescriptionNicardipine, also known as cardene or flusemide, belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. Dihydropyridinecarboxylic acids and derivatives are compounds containing a dihydropyridine moiety bearing a carboxylic acid group. Nicardipine is a drug which is used for the management of patients with chronic stable angina and for the treatment of hypertension. The patent for both Cardene and Cardene SR expired in October 1995. Nicardipine is a very strong basic compound (based on its pKa). It belongs to the dihydropyridine class of calcium channel blockers. It was patented in 1973 and approved for medical use in 1981. It has been used in percutaneous coronary intervention. Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. Nicardipine (Cardene) is a medication used to treat high blood pressure and angina. Nicardipine was approved by the FDA in December 1988.
Structure
Data?1582753218
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0014760 (Nicardipine)

622
  Mrv0541 02231214492D          

 35 37  0  0  1  0            999 V2000
    6.6515   -0.9818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9383   -0.9818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3659    0.2558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239    0.2558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239    2.7308    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   10.9383    1.4933    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7949   -2.2193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5080   -0.5693    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239    1.9058    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
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    8.0804   -1.8068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3659   -0.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5094    0.6683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0804    0.6683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3659   -2.2193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239   -0.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239   -2.2193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224   -0.9818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6500    0.2558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  CHG  2   5  -1   9   1
M  END
Download

3D MOL for HMDB0014760 (Nicardipine)

HMDB0014760
     RDKit          3D
Nicardipine
 64 66  0  0  0  0  0  0  0  0999 V2000
   -7.9398   -1.0425    0.7397 C   0  0  0  0  0  0  0  0  0  0  0  0
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 30 63  1  0
 35 64  1  0
M  CHG  2  32   1  34  -1
M  END
Download

3D SDF for HMDB0014760 (Nicardipine)

622
  Mrv0541 02231214492D          

 35 37  0  0  1  0            999 V2000
    6.6515   -0.9818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9383   -0.9818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3659    0.2558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239    0.2558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239    2.7308    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   10.9383    1.4933    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7949   -2.2193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5080   -0.5693    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2239    1.9058    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.7949   -0.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 20  1  0  0  0  0
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 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 21  1  0  0  0  0
 17 24  1  0  0  0  0
 18 25  2  0  0  0  0
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 26 28  1  0  0  0  0
 28 30  2  0  0  0  0
 28 31  1  0  0  0  0
 30 33  1  0  0  0  0
 31 34  2  0  0  0  0
 33 35  2  0  0  0  0
 34 35  1  0  0  0  0
M  CHG  2   5  -1   9   1
M  END
> <DATABASE_ID>
HMDB0014760

> <DATABASE_NAME>
hmdb

> <SMILES>
COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3

> <INCHI_KEY>
ZBBHBTPTTSWHBA-UHFFFAOYSA-N

> <FORMULA>
C26H29N3O6

> <MOLECULAR_WEIGHT>
479.525

> <EXACT_MASS>
479.205635675

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_AVERAGE_POLARIZABILITY>
49.95135467285003

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

> <ALOGPS_LOGP>
4.34

> <JCHEM_LOGP>
3.558611921333333

> <ALOGPS_LOGS>
-5.29

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
8.180525795176274

> <JCHEM_POLAR_SURFACE_AREA>
113.69

> <JCHEM_REFRACTIVITY>
134.7964

> <JCHEM_ROTATABLE_BOND_COUNT>
11

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.47e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
nicardipine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0014760 (Nicardipine)

HMDB0014760
     RDKit          3D
Nicardipine
 64 66  0  0  0  0  0  0  0  0999 V2000
   -7.9398   -1.0425    0.7397 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6064   -1.3793    1.0903 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5126   -0.8100    0.5223 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6872    0.0613   -0.3597 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1286   -1.1551    0.8808 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9562   -2.0658    1.8035 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1442   -2.7338    2.4724 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6612   -2.4811    2.2254 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5426   -1.8644    1.6011 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1465   -2.2703    2.0130 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6810   -0.9507    0.6752 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4713   -0.3457    0.0623 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6308    0.5207   -0.8205 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7794   -0.7049    0.4323 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9491   -0.1441   -0.1358 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2008   -0.7270    0.4798 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3980   -0.2038   -0.0480 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7189    1.1465    0.2067 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0046   -0.8533   -1.1432 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2572   -0.1917   -1.6035 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4602   -0.4368   -0.9727 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6193    0.1719   -1.4002 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6068    1.0413   -2.4690 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4138    1.2878   -3.0986 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2538    0.6787   -2.6708 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0054   -0.5073    0.2375 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1100    0.9603    0.1248 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0439    1.8049    1.2089 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1443    3.1665    1.0708 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3194    3.7389   -0.1964 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3866    2.9092   -1.2801 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5639    3.4652   -2.5793 N   0  0  0  0  0  4  0  0  0  0  0  0
   -3.6312    2.7443   -3.5986 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6669    4.8096   -2.7577 O   0  0  0  0  0  1  0  0  0  0  0  0
   -3.2824    1.5393   -1.1130 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2544   -1.6345   -0.1511 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5762   -1.2869    1.6335 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0653    0.0368    0.5641 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7235   -3.4574    3.2249 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7054   -3.3171    1.7478 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7464   -2.0219    3.0537 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5237   -3.2082    2.9631 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4023   -1.4842    2.5192 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3054   -3.0853    2.7919 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3294   -2.7918    1.1848 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9363    0.9425   -0.0035 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9647   -0.3804   -1.2111 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2058   -0.5680    1.5979 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2187   -1.8358    0.3625 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0376    1.5332    0.9863 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6468    1.7910   -0.6915 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7465    1.1924    0.6603 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3292   -1.8785   -0.7943 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2901   -1.0167   -1.9674 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4728   -1.1311   -0.1183 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.5295   -0.0542   -0.8736 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.5223    1.5330   -2.8207 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3717    1.9712   -3.9482 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3228    0.8908   -3.1873 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0735   -0.8874   -0.8458 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9099    1.3661    2.1754 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0968    3.8460    1.8946 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4005    4.8072   -0.3306 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3448    0.9507   -2.0160 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  2  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  2  0
 11 26  1  0
 26 27  1  0
 27 28  2  0
 28 29  1  0
 29 30  2  0
 30 31  1  0
 31 32  1  0
 32 33  2  0
 32 34  1  0
 31 35  2  0
 26  5  1  0
 35 27  1  0
 25 20  1  0
  1 36  1  0
  1 37  1  0
  1 38  1  0
  7 39  1  0
  7 40  1  0
  7 41  1  0
  8 42  1  0
 10 43  1  0
 10 44  1  0
 10 45  1  0
 15 46  1  0
 15 47  1  0
 16 48  1  0
 16 49  1  0
 18 50  1  0
 18 51  1  0
 18 52  1  0
 19 53  1  0
 19 54  1  0
 21 55  1  0
 22 56  1  0
 23 57  1  0
 24 58  1  0
 25 59  1  0
 26 60  1  0
 28 61  1  0
 29 62  1  0
 30 63  1  0
 35 64  1  0
M  CHG  2  32   1  34  -1
M  END
Download

PDB for HMDB0014760 (Nicardipine)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 622                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  O   UNK     0      12.416  -1.833   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      20.418  -1.833   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      13.750   0.477   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      19.085   0.477   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      19.085   5.097   0.000  0.00  0.00           O-1
HETATM    6  O   UNK     0      20.418   2.787   0.000  0.00  0.00           O+0
HETATM    7  N   UNK     0      16.417  -4.143   0.000  0.00  0.00           N+0
HETATM    8  N   UNK     0       8.415  -1.063   0.000  0.00  0.00           N+0
HETATM    9  N   UNK     0      19.085   3.557   0.000  0.00  0.00           N+1
HETATM   10  C   UNK     0      16.417  -1.063   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      15.083  -1.833   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      17.751  -1.833   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      16.417   0.477   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      15.083  -3.373   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      17.751  -3.373   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      13.750  -1.063   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      17.751   1.247   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      15.083   1.247   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      13.750  -4.143   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      19.085  -1.063   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      19.085  -4.143   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       9.748  -1.833   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      11.082  -1.063   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      17.751   2.787   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      15.083   2.787   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       7.081  -1.833   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      16.417   3.557   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       5.748  -1.063   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       8.415   0.477   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       4.414  -1.833   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       5.748   0.477   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      21.752  -1.063   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       3.080  -1.063   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       4.414   1.247   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       3.080   0.477   0.000  0.00  0.00           C+0
CONECT    1   16   23                                                       
CONECT    2   20   32                                                       
CONECT    3   16                                                            
CONECT    4   20                                                            
CONECT    5    9                                                            
CONECT    6    9                                                            
CONECT    7   14   15                                                       
CONECT    8   22   26   29                                                  
CONECT    9    5    6   24                                                  
CONECT   10   11   12   13                                                  
CONECT   11   10   14   16                                                  
CONECT   12   10   15   20                                                  
CONECT   13   10   17   18                                                  
CONECT   14    7   11   19                                                  
CONECT   15    7   12   21                                                  
CONECT   16    1    3   11                                                  
CONECT   17   13   24                                                       
CONECT   18   13   25                                                       
CONECT   19   14                                                            
CONECT   20    2    4   12                                                  
CONECT   21   15                                                            
CONECT   22    8   23                                                       
CONECT   23    1   22                                                       
CONECT   24    9   17   27                                                  
CONECT   25   18   27                                                       
CONECT   26    8   28                                                       
CONECT   27   24   25                                                       
CONECT   28   26   30   31                                                  
CONECT   29    8                                                            
CONECT   30   28   33                                                       
CONECT   31   28   34                                                       
CONECT   32    2                                                            
CONECT   33   30   35                                                       
CONECT   34   31   35                                                       
CONECT   35   33   34                                                       
MASTER        0    0    0    0    0    0    0    0   35    0   74    0
END
Download

3D PDB for HMDB0014760 (Nicardipine)

COMPND    HMDB0014760
HETATM    1  C1  UNL     1      -7.940  -1.043   0.740  1.00  0.00           C  
HETATM    2  O1  UNL     1      -6.606  -1.379   1.090  1.00  0.00           O  
HETATM    3  C2  UNL     1      -5.513  -0.810   0.522  1.00  0.00           C  
HETATM    4  O2  UNL     1      -5.687   0.061  -0.360  1.00  0.00           O  
HETATM    5  C3  UNL     1      -4.129  -1.155   0.881  1.00  0.00           C  
HETATM    6  C4  UNL     1      -3.956  -2.066   1.803  1.00  0.00           C  
HETATM    7  C5  UNL     1      -5.144  -2.734   2.472  1.00  0.00           C  
HETATM    8  N1  UNL     1      -2.661  -2.481   2.225  1.00  0.00           N  
HETATM    9  C6  UNL     1      -1.543  -1.864   1.601  1.00  0.00           C  
HETATM   10  C7  UNL     1      -0.147  -2.270   2.013  1.00  0.00           C  
HETATM   11  C8  UNL     1      -1.681  -0.951   0.675  1.00  0.00           C  
HETATM   12  C9  UNL     1      -0.471  -0.346   0.062  1.00  0.00           C  
HETATM   13  O3  UNL     1      -0.631   0.521  -0.820  1.00  0.00           O  
HETATM   14  O4  UNL     1       0.779  -0.705   0.432  1.00  0.00           O  
HETATM   15  C10 UNL     1       1.949  -0.144  -0.136  1.00  0.00           C  
HETATM   16  C11 UNL     1       3.201  -0.727   0.480  1.00  0.00           C  
HETATM   17  N2  UNL     1       4.398  -0.204  -0.048  1.00  0.00           N  
HETATM   18  C12 UNL     1       4.719   1.146   0.207  1.00  0.00           C  
HETATM   19  C13 UNL     1       5.005  -0.853  -1.143  1.00  0.00           C  
HETATM   20  C14 UNL     1       6.257  -0.192  -1.604  1.00  0.00           C  
HETATM   21  C15 UNL     1       7.460  -0.437  -0.973  1.00  0.00           C  
HETATM   22  C16 UNL     1       8.619   0.172  -1.400  1.00  0.00           C  
HETATM   23  C17 UNL     1       8.607   1.041  -2.469  1.00  0.00           C  
HETATM   24  C18 UNL     1       7.414   1.288  -3.099  1.00  0.00           C  
HETATM   25  C19 UNL     1       6.254   0.679  -2.671  1.00  0.00           C  
HETATM   26  C20 UNL     1      -3.005  -0.507   0.238  1.00  0.00           C  
HETATM   27  C21 UNL     1      -3.110   0.960   0.125  1.00  0.00           C  
HETATM   28  C22 UNL     1      -3.044   1.805   1.209  1.00  0.00           C  
HETATM   29  C23 UNL     1      -3.144   3.166   1.071  1.00  0.00           C  
HETATM   30  C24 UNL     1      -3.319   3.739  -0.196  1.00  0.00           C  
HETATM   31  C25 UNL     1      -3.387   2.909  -1.280  1.00  0.00           C  
HETATM   32  N3  UNL     1      -3.564   3.465  -2.579  1.00  0.00           N1+
HETATM   33  O5  UNL     1      -3.631   2.744  -3.599  1.00  0.00           O  
HETATM   34  O6  UNL     1      -3.667   4.810  -2.758  1.00  0.00           O1-
HETATM   35  C26 UNL     1      -3.282   1.539  -1.113  1.00  0.00           C  
HETATM   36  H1  UNL     1      -8.254  -1.634  -0.151  1.00  0.00           H  
HETATM   37  H2  UNL     1      -8.576  -1.287   1.634  1.00  0.00           H  
HETATM   38  H3  UNL     1      -8.065   0.037   0.564  1.00  0.00           H  
HETATM   39  H4  UNL     1      -4.724  -3.457   3.225  1.00  0.00           H  
HETATM   40  H5  UNL     1      -5.705  -3.317   1.748  1.00  0.00           H  
HETATM   41  H6  UNL     1      -5.746  -2.022   3.054  1.00  0.00           H  
HETATM   42  H7  UNL     1      -2.524  -3.208   2.963  1.00  0.00           H  
HETATM   43  H8  UNL     1       0.402  -1.484   2.519  1.00  0.00           H  
HETATM   44  H9  UNL     1      -0.305  -3.085   2.792  1.00  0.00           H  
HETATM   45  H10 UNL     1       0.329  -2.792   1.185  1.00  0.00           H  
HETATM   46  H11 UNL     1       1.936   0.943  -0.003  1.00  0.00           H  
HETATM   47  H12 UNL     1       1.965  -0.380  -1.211  1.00  0.00           H  
HETATM   48  H13 UNL     1       3.206  -0.568   1.598  1.00  0.00           H  
HETATM   49  H14 UNL     1       3.219  -1.836   0.363  1.00  0.00           H  
HETATM   50  H15 UNL     1       4.038   1.533   0.986  1.00  0.00           H  
HETATM   51  H16 UNL     1       4.647   1.791  -0.692  1.00  0.00           H  
HETATM   52  H17 UNL     1       5.747   1.192   0.660  1.00  0.00           H  
HETATM   53  H18 UNL     1       5.329  -1.879  -0.794  1.00  0.00           H  
HETATM   54  H19 UNL     1       4.290  -1.017  -1.967  1.00  0.00           H  
HETATM   55  H20 UNL     1       7.473  -1.131  -0.118  1.00  0.00           H  
HETATM   56  H21 UNL     1       9.529  -0.054  -0.874  1.00  0.00           H  
HETATM   57  H22 UNL     1       9.522   1.533  -2.821  1.00  0.00           H  
HETATM   58  H23 UNL     1       7.372   1.971  -3.948  1.00  0.00           H  
HETATM   59  H24 UNL     1       5.323   0.891  -3.187  1.00  0.00           H  
HETATM   60  H25 UNL     1      -3.074  -0.887  -0.846  1.00  0.00           H  
HETATM   61  H26 UNL     1      -2.910   1.366   2.175  1.00  0.00           H  
HETATM   62  H27 UNL     1      -3.097   3.846   1.895  1.00  0.00           H  
HETATM   63  H28 UNL     1      -3.401   4.807  -0.331  1.00  0.00           H  
HETATM   64  H29 UNL     1      -3.345   0.951  -2.016  1.00  0.00           H  
CONECT    1    2   36   37   38
CONECT    2    3
CONECT    3    4    4    5
CONECT    5    6    6   26
CONECT    6    7    8
CONECT    7   39   40   41
CONECT    8    9   42
CONECT    9   10   11   11
CONECT   10   43   44   45
CONECT   11   12   26
CONECT   12   13   13   14
CONECT   14   15
CONECT   15   16   46   47
CONECT   16   17   48   49
CONECT   17   18   19
CONECT   18   50   51   52
CONECT   19   20   53   54
CONECT   20   21   21   25
CONECT   21   22   55
CONECT   22   23   23   56
CONECT   23   24   57
CONECT   24   25   25   58
CONECT   25   59
CONECT   26   27   60
CONECT   27   28   28   35
CONECT   28   29   61
CONECT   29   30   30   62
CONECT   30   31   63
CONECT   31   32   35   35
CONECT   32   33   33   34
CONECT   35   64
END
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SMILES for HMDB0014760 (Nicardipine)

COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C1
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INCHI for HMDB0014760 (Nicardipine)

InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
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View in JSmolView Stereo Labels
Synonyms
ValueSource
CardeneKegg
FlusemideHMDB
LA, nicardipineHMDB
LincilHMDB
LucenfalHMDB
Nicardipine hydrochlorideHMDB
Nicardipino ratiopharmHMDB
Novartis brand OF nicardipine hydrochlorideHMDB
Roche brand OF nicardipine hydrochlorideHMDB
Tedec meiji brand OF nicardipine hydrochlorideHMDB
Yamanouchi brand 3 OF nicardipine hydrochlorideHMDB
Farma lepori brand OF nicardipine hydrochlorideHMDB
LoxenHMDB
Ratiopharm brand OF nicardipine hydrochlorideHMDB
RideneHMDB
Seid brand OF nicardipineHMDB
Solvay brand OF nicardipine hydrochlorideHMDB
Syntex brand OF nicardipine hydrochlorideHMDB
UCB brand OF nicardipine hydrochlorideHMDB
VasonaseHMDB
Cardene i.v.HMDB
Cardene SRHMDB
DaganHMDB
Nicardipine seid brandHMDB
Nicardipino seidHMDB
PerdipineHMDB
Yamanouchi brand 2 OF nicardipine hydrochlorideHMDB
Almirall brand OF nicardipine hydrochlorideHMDB
AntagonilHMDB
ESP pharma brand OF nicardipine hydrochlorideHMDB
Hydrochloride, nicardipineHMDB
LecibralHMDB
Nicardipine laHMDB
Yamanouchi brand 1 OF nicardipine hydrochlorideHMDB
Chemical FormulaC26H29N3O6
Average Molecular Weight479.525
Monoisotopic Molecular Weight479.205635675
IUPAC Name3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Traditional Namenicardipine
CAS Registry Number55985-32-5
SMILES
COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C1
InChI Identifier
InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
InChI KeyZBBHBTPTTSWHBA-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. Dihydropyridinecarboxylic acids and derivatives are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassHydropyridines
Direct ParentDihydropyridinecarboxylic acids and derivatives
Alternative Parents
Substituents
  • Dihydropyridinecarboxylic acid derivative
  • Nitrobenzene
  • Nitroaromatic compound
  • Benzylamine
  • Phenylmethylamine
  • Aralkylamine
  • Monocyclic benzene moiety
  • Dicarboxylic acid or derivatives
  • Benzenoid
  • Methyl ester
  • Vinylogous amide
  • Enoate ester
  • Alpha,beta-unsaturated carboxylic ester
  • Amino acid or derivatives
  • Carboxylic acid ester
  • C-nitro compound
  • Tertiary amine
  • Tertiary aliphatic amine
  • Organic nitro compound
  • Allyl-type 1,3-dipolar organic compound
  • Secondary amine
  • Azacycle
  • Propargyl-type 1,3-dipolar organic compound
  • Organic 1,3-dipolar compound
  • Organic oxoazanium
  • Carboxylic acid derivative
  • Secondary aliphatic amine
  • Enamine
  • Organic nitrogen compound
  • Organic oxide
  • Organopnictogen compound
  • Amine
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Carbonyl group
  • Organic zwitterion
  • Organonitrogen compound
  • Organooxygen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological location
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point136 - 138 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.0025 g/LNot Available
LogP3.6Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+CBM212.130932474
[M+H]+Not Available211.875http://allccs.zhulab.cn/database/detail?ID=AllCCS00000967
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.0025 g/LALOGPS
logP4.34ALOGPS
logP3.56ChemAxon
logS-5.3ALOGPS
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area113.69 ŲChemAxon
Rotatable Bond Count11ChemAxon
Refractivity134.8 m³·mol⁻¹ChemAxon
Polarizability49.95 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+211.08831661259
DarkChem[M-H]-206.46231661259
DeepCCS[M+H]+212.05230932474
DeepCCS[M-H]-209.65730932474
DeepCCS[M-2H]-242.66330932474
DeepCCS[M+Na]+218.85830932474
AllCCS[M+H]+215.032859911
AllCCS[M+H-H2O]+212.932859911
AllCCS[M+NH4]+217.032859911
AllCCS[M+Na]+217.632859911
AllCCS[M-H]-214.132859911
AllCCS[M+Na-2H]-215.132859911
AllCCS[M+HCOO]-216.332859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
NicardipineCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C14742.9Standard polar33892256
NicardipineCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C13429.4Standard non polar33892256
NicardipineCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C13691.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Nicardipine,1TMS,isomer #1COC(=O)C1=C(C)N([Si](C)(C)C)C(C)=C(C(=O)OCCN(C)CC2=CC=CC=C2)C1C1=CC=CC([N+](=O)[O-])=C13515.1Semi standard non polar33892256
Nicardipine,1TMS,isomer #1COC(=O)C1=C(C)N([Si](C)(C)C)C(C)=C(C(=O)OCCN(C)CC2=CC=CC=C2)C1C1=CC=CC([N+](=O)[O-])=C12750.5Standard non polar33892256
Nicardipine,1TMS,isomer #1COC(=O)C1=C(C)N([Si](C)(C)C)C(C)=C(C(=O)OCCN(C)CC2=CC=CC=C2)C1C1=CC=CC([N+](=O)[O-])=C14661.3Standard polar33892256
Nicardipine,1TBDMS,isomer #1COC(=O)C1=C(C)N([Si](C)(C)C(C)(C)C)C(C)=C(C(=O)OCCN(C)CC2=CC=CC=C2)C1C1=CC=CC([N+](=O)[O-])=C13761.1Semi standard non polar33892256
Nicardipine,1TBDMS,isomer #1COC(=O)C1=C(C)N([Si](C)(C)C(C)(C)C)C(C)=C(C(=O)OCCN(C)CC2=CC=CC=C2)C1C1=CC=CC([N+](=O)[O-])=C13005.6Standard non polar33892256
Nicardipine,1TBDMS,isomer #1COC(=O)C1=C(C)N([Si](C)(C)C(C)(C)C)C(C)=C(C(=O)OCCN(C)CC2=CC=CC=C2)C1C1=CC=CC([N+](=O)[O-])=C14623.9Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Nicardipine GC-MS (Non-derivatized) - 70eV, Positivesplash10-00kg-6945600000-88fa08ae55dce8fa50bb2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Nicardipine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 90V, Negative-QTOFsplash10-0a4i-2930000000-9730aac08522ec25e87b2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 45V, Negative-QTOFsplash10-00di-1930000000-281a892aa3ef3862da092021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 30V, Negative-QTOFsplash10-00di-0921000000-cb717805fcb949f5cd9a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 60V, Negative-QTOFsplash10-05fr-2940000000-aa69d5c0a6969ff1eda82021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 75V, Negative-QTOFsplash10-0a4i-2940000000-12b6cb09ae1c275c76732021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 40V, Positive-QTOFsplash10-014l-7396000000-c37106851497811f15622021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 10V, Positive-QTOFsplash10-001i-0101900000-a42f7527bca4c53562502021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 90V, Positive-QTOFsplash10-0006-9410000000-9b61ce9910712434cbf12021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 75V, Positive-QTOFsplash10-0006-9230000000-0639e2b5cef885fc94e32021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 15V, Positive-QTOFsplash10-00lr-0503900000-381c26b1efa1dc70b3092021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 30V, Positive-QTOFsplash10-014i-1609000000-ec654bea9500a31f81d32021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 60V, Positive-QTOFsplash10-0006-9160000000-abe9ea0826770248f05a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 45V, Positive-QTOFsplash10-00kf-9476000000-c1b72913df485a05a9f52021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 15V, Negative-QTOFsplash10-004i-0101900000-7acc467f68a49da381e92021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 20V, Positive-QTOFsplash10-014i-0609100000-d1f0dc228a16564ab5692021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 30V, Positive-QTOFsplash10-014i-1609000000-500b44165886e391edd42021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nicardipine 60V, Positive-QTOFsplash10-05fr-2940000000-e613896be89cd6b8fc752021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nicardipine 10V, Positive-QTOFsplash10-001i-0000900000-fa29fcb6e7ce3db6662f2016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nicardipine 20V, Positive-QTOFsplash10-001i-0000900000-8be9abda1139b11b5a6f2016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nicardipine 40V, Positive-QTOFsplash10-05fr-5973800000-d273cf4770983e873fea2016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nicardipine 10V, Negative-QTOFsplash10-004i-0000900000-b1a63db11b02197bfca22016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nicardipine 20V, Negative-QTOFsplash10-004i-0000900000-336ef9a38bbb2a65be232016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nicardipine 40V, Negative-QTOFsplash10-0016-5294800000-0cd026f9bd2da079e0492016-08-03Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00622 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00622 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00622
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID4319
KEGG Compound IDC07264
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNicardipine
METLIN IDNot Available
PubChem Compound4474
PDB IDNot Available
ChEBI ID507549
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Only showing the first 10 proteins. There are 24 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Gene Name:
PDE1A
Uniprot ID:
P54750
Molecular weight:
61251.38
References
  1. Sharma RK, Wang JH, Wu Z: Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists. J Neurochem. 1997 Aug;69(2):845-50. [PubMed:9231746 ]
Enzyme Details
2. Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
General function:
Involved in catalytic activity
Specific function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Gene Name:
PDE1B
Uniprot ID:
Q01064
Molecular weight:
61379.235
References
  1. Sharma RK, Wang JH, Wu Z: Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists. J Neurochem. 1997 Aug;69(2):845-50. [PubMed:9231746 ]
Enzyme Details
3. Cytochrome P450 3A4
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
4. Cytochrome P450 2C9
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
5. Cytochrome P450 2C19
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
6. Cytochrome P450 2E1
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
7. Cytochrome P450 2D6
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55768.94
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
8. Cytochrome P450 2B6
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
9. Cytochrome P450 3A5
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular weight:
57108.065
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
10. Cytochrome P450 2C8
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular weight:
55824.275
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Enzyme Details
1. Multidrug resistance protein 1
General function:
Involved in ATP binding
Specific function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular weight:
141477.3
References
  1. Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. Pharm Res. 2000 Oct;17(10):1189-97. [PubMed:11145223 ]
  2. Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE: Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm Res. 2000 Dec;17(12):1456-60. [PubMed:11303953 ]
  3. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  4. Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. [PubMed:12128170 ]
  5. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  6. Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. [PubMed:11082465 ]
  7. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]

Only showing the first 10 proteins. There are 24 proteins in total.

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