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Showing metabocard for Isoflurophate (HMDB0014815)

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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2023-02-21 17:18:17 UTC
HMDB IDHMDB0014815
Secondary Accession Numbers
  • HMDB14815
Metabolite Identification
Common NameIsoflurophate
DescriptionIsoflurophate, also known as DFP or fluostigmine, belongs to the class of organic compounds known as phosphate esters. These are organic compounds containing phosphoric acid ester functional group, with the general structure R1P(=O)(R2)OR3. R1,R2 = O,N, or halogen atom; R3 = organyl group. Isoflurophate is a drug which is used for use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. Based on a literature review very few articles have been published on Isoflurophate.
Structure
Data?1676999897
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0014815 (Isoflurophate)

677
  Mrv0541 02231214552D          

 11 10  0  0  0  0            999 V2000
    3.7935    0.0000    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    3.3810    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5080    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2060   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9370    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  1  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
M  END
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3D MOL for HMDB0014815 (Isoflurophate)

HMDB0014815
     RDKit          3D
Isoflurophate
 25 24  0  0  0  0  0  0  0  0999 V2000
   -3.5654    0.3169   -0.9270 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4371   -0.1289   -0.0197 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9463    0.0281    1.4084 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3488    0.6795   -0.2707 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0163   -0.2278   -0.7619 P   0  0  0  0  0  5  0  0  0  0  0  0
   -0.3285   -1.7067   -0.6573 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3770    0.1406   -2.3613 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2636    0.1638    0.2742 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5166   -0.1082   -0.2020 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2897    1.2175   -0.2137 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1924   -1.0599    0.7798 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1449    1.1343   -0.4076 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2921   -0.4903   -1.1304 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1757    0.7984   -1.8523 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1280   -1.1785   -0.2087 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1261   -0.0921    2.1434 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7120   -0.7350    1.5726 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4388    1.0215    1.4839 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5543   -0.5505   -1.2047 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2389    1.6390   -1.2428 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3051    1.0170    0.1305 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8038    1.9449    0.4927 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8000   -0.4357    1.4932 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8299   -1.8006    0.2733 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4561   -1.5873    1.4079 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
  1 12  1  0
  1 13  1  0
  1 14  1  0
  2 15  1  0
  3 16  1  0
  3 17  1  0
  3 18  1  0
  9 19  1  0
 10 20  1  0
 10 21  1  0
 10 22  1  0
 11 23  1  0
 11 24  1  0
 11 25  1  0
M  END
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3D SDF for HMDB0014815 (Isoflurophate)

677
  Mrv0541 02231214552D          

 11 10  0  0  0  0            999 V2000
    3.7935    0.0000    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    3.3810    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5080    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2060   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9370    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  1  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0014815

> <DATABASE_NAME>
hmdb

> <SMILES>
CC(C)OP(F)(=O)OC(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3

> <INCHI_KEY>
MUCZHBLJLSDCSD-UHFFFAOYSA-N

> <FORMULA>
C6H14FO3P

> <MOLECULAR_WEIGHT>
184.1457

> <EXACT_MASS>
184.066459031

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_AVERAGE_POLARIZABILITY>
16.75087214906687

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
bis(propan-2-yl) fluorophosphonate

> <ALOGPS_LOGP>
1.10

> <JCHEM_LOGP>
1.7603906453333336

> <ALOGPS_LOGS>
-1.43

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-9.64521439025244

> <JCHEM_POLAR_SURFACE_AREA>
35.53

> <JCHEM_REFRACTIVITY>
40.888000000000005

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.78e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
isoflurophate

> <JCHEM_VEBER_RULE>
1

$$$$
Download

3D-SDF for HMDB0014815 (Isoflurophate)

HMDB0014815
     RDKit          3D
Isoflurophate
 25 24  0  0  0  0  0  0  0  0999 V2000
   -3.5654    0.3169   -0.9270 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4371   -0.1289   -0.0197 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9463    0.0281    1.4084 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3488    0.6795   -0.2707 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0163   -0.2278   -0.7619 P   0  0  0  0  0  5  0  0  0  0  0  0
   -0.3285   -1.7067   -0.6573 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3770    0.1406   -2.3613 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2636    0.1638    0.2742 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5166   -0.1082   -0.2020 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2897    1.2175   -0.2137 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1924   -1.0599    0.7798 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1449    1.1343   -0.4076 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2921   -0.4903   -1.1304 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1757    0.7984   -1.8523 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1280   -1.1785   -0.2087 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1261   -0.0921    2.1434 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7120   -0.7350    1.5726 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4388    1.0215    1.4839 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5543   -0.5505   -1.2047 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2389    1.6390   -1.2428 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3051    1.0170    0.1305 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8038    1.9449    0.4927 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8000   -0.4357    1.4932 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8299   -1.8006    0.2733 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4561   -1.5873    1.4079 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  5  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
  1 12  1  0
  1 13  1  0
  1 14  1  0
  2 15  1  0
  3 16  1  0
  3 17  1  0
  3 18  1  0
  9 19  1  0
 10 20  1  0
 10 21  1  0
 10 22  1  0
 11 23  1  0
 11 24  1  0
 11 25  1  0
M  END
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PDB for HMDB0014815 (Isoflurophate)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 677                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  P   UNK     0       7.081   0.000   0.000  0.00  0.00           P+0
HETATM    2  F   UNK     0       6.311   1.334   0.000  0.00  0.00           F+0
HETATM    3  O   UNK     0       8.415   0.770   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0       5.748  -0.770   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0       7.851  -1.334   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       9.748   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.414   0.000   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      11.082   0.770   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.748  -1.540   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.080  -0.770   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.414   1.540   0.000  0.00  0.00           C+0
CONECT    1    2    3    4    5                                             
CONECT    2    1                                                            
CONECT    3    1    6                                                       
CONECT    4    1    7                                                       
CONECT    5    1                                                            
CONECT    6    3    8    9                                                  
CONECT    7    4   10   11                                                  
CONECT    8    6                                                            
CONECT    9    6                                                            
CONECT   10    7                                                            
CONECT   11    7                                                            
MASTER        0    0    0    0    0    0    0    0   11    0   20    0
END
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3D PDB for HMDB0014815 (Isoflurophate)

COMPND    HMDB0014815
HETATM    1  C1  UNL     1      -3.565   0.317  -0.927  1.00  0.00           C  
HETATM    2  C2  UNL     1      -2.437  -0.129  -0.020  1.00  0.00           C  
HETATM    3  C3  UNL     1      -2.946   0.028   1.408  1.00  0.00           C  
HETATM    4  O1  UNL     1      -1.349   0.680  -0.271  1.00  0.00           O  
HETATM    5  P1  UNL     1       0.016  -0.228  -0.762  1.00  0.00           P  
HETATM    6  O2  UNL     1      -0.328  -1.707  -0.657  1.00  0.00           O  
HETATM    7  F1  UNL     1       0.377   0.141  -2.361  1.00  0.00           F  
HETATM    8  O3  UNL     1       1.264   0.164   0.274  1.00  0.00           O  
HETATM    9  C4  UNL     1       2.517  -0.108  -0.202  1.00  0.00           C  
HETATM   10  C5  UNL     1       3.290   1.217  -0.214  1.00  0.00           C  
HETATM   11  C6  UNL     1       3.192  -1.060   0.780  1.00  0.00           C  
HETATM   12  H1  UNL     1      -4.145   1.134  -0.408  1.00  0.00           H  
HETATM   13  H2  UNL     1      -4.292  -0.490  -1.130  1.00  0.00           H  
HETATM   14  H3  UNL     1      -3.176   0.798  -1.852  1.00  0.00           H  
HETATM   15  H4  UNL     1      -2.128  -1.178  -0.209  1.00  0.00           H  
HETATM   16  H5  UNL     1      -2.126  -0.092   2.143  1.00  0.00           H  
HETATM   17  H6  UNL     1      -3.712  -0.735   1.573  1.00  0.00           H  
HETATM   18  H7  UNL     1      -3.439   1.022   1.484  1.00  0.00           H  
HETATM   19  H8  UNL     1       2.554  -0.551  -1.205  1.00  0.00           H  
HETATM   20  H9  UNL     1       3.239   1.639  -1.243  1.00  0.00           H  
HETATM   21  H10 UNL     1       4.305   1.017   0.130  1.00  0.00           H  
HETATM   22  H11 UNL     1       2.804   1.945   0.493  1.00  0.00           H  
HETATM   23  H12 UNL     1       3.800  -0.436   1.493  1.00  0.00           H  
HETATM   24  H13 UNL     1       3.830  -1.801   0.273  1.00  0.00           H  
HETATM   25  H14 UNL     1       2.456  -1.587   1.408  1.00  0.00           H  
CONECT    1    2   12   13   14
CONECT    2    3    4   15
CONECT    3   16   17   18
CONECT    4    5
CONECT    5    6    6    7    8
CONECT    8    9
CONECT    9   10   11   19
CONECT   10   20   21   22
CONECT   11   23   24   25
END
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SMILES for HMDB0014815 (Isoflurophate)

CC(C)OP(F)(=O)OC(C)C
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INCHI for HMDB0014815 (Isoflurophate)

InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC6H14FO3P
Average Molecular Weight184.1457
Monoisotopic Molecular Weight184.066459031
IUPAC Namebis(propan-2-yl) fluorophosphonate
Traditional Nameisoflurophate
CAS Registry Number55-91-4
SMILES
CC(C)OP(F)(=O)OC(C)C
InChI Identifier
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
InChI KeyMUCZHBLJLSDCSD-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phosphate esters. These are organic compounds containing phosphoric acid ester functional group, with the general structure R1P(=O)(R2)OR3. R1,R2 = O,N, or halogen atom; R3 = organyl group.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassOrganic phosphoric acids and derivatives
Sub ClassPhosphate esters
Direct ParentPhosphate esters
Alternative Parents
Substituents
  • Phosphoric acid ester
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
ProcessNot Available
RoleNot Available
Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting Point-82 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility6.78 g/LNot Available
LogP1.4Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00677 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00677 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00677
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID5723
KEGG Compound IDC00202
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkIsoflurophate
METLIN IDNot Available
PubChem Compound5936
PDB IDNot Available
ChEBI ID17941
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Acetylcholinesterase
General function:
Involved in carboxylesterase activity
Specific function:
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Gene Name:
ACHE
Uniprot ID:
P22303
Molecular weight:
67795.525
References
  1. Malatova Z, Gottlieb M, Marsala J: Depression of acetylcholinesterase synthesis following transient cerebral ischemia in rat: pharmacohistochemical and biochemical investigation. Gen Physiol Biophys. 1999 Mar;18(1):57-71. [PubMed:10378121 ]
  2. Quistad GB, Zhang N, Sparks SE, Casida JE: Phosphoacetylcholinesterase: toxicity of phosphorus oxychloride to mammals and insects that can be attributed to selective phosphorylation of acetylcholinesterase by phosphorodichloridic acid. Chem Res Toxicol. 2000 Jul;13(7):652-7. [PubMed:10898598 ]
  3. da Costa VL Jr, Lapa AJ, Godinho RO: Short- and long-term influences of calcitonin gene-related peptide on the synthesis of acetylcholinesterase in mammalian myotubes. Br J Pharmacol. 2001 May;133(2):229-36. [PubMed:11350858 ]
  4. Pang YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S: Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun;10(6):491-502. [PubMed:12837382 ]
  5. Ashani Y, Gentry MK, Doctor BP: Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody. Biochemistry. 1990 Mar 13;29(10):2456-63. [PubMed:1692236 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Enzyme Details
2. Cholinesterase
General function:
Involved in carboxylesterase activity
Specific function:
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Gene Name:
BCHE
Uniprot ID:
P06276
Molecular weight:
68417.575
References
  1. Kamata R, Saito S, Suzuki T, Takewaki T, Kobayashi H: Correlation of binding sites for diisopropyl phosphorofluoridate with cholinesterase and neuropathy target esterase in membrane and cytosol preparations from hen. Neurotoxicology. 2001 Apr;22(2):203-14. [PubMed:11405252 ]
  2. Acey RA, Bailey S, Healy P, Jo C, Unger TF, Hudson RA: A butyrylcholinesterase in the early development of the brine shrimp (Artemia salina) larvae: a target for phthalate ester embryotoxicity? Biochem Biophys Res Commun. 2002 Dec 13;299(4):659-62. [PubMed:12459190 ]
  3. Pittel Z, Cohen S, Fisher A, Heldman E: Differential long-term effect of AF64A on [3H]ACh synthesis and release in rat hippocampal synaptosomes. Brain Res. 1992 Jul 17;586(1):148-51. [PubMed:1511344 ]
  4. Miller RB, Blank CL: Determination of serum cholinesterase activity by liquid chromatography with electrochemical detection. Anal Biochem. 1991 Aug 1;196(2):377-84. [PubMed:1776688 ]
  5. Kelly SS, Ferry CB, Bamforth JP: The effects of anticholinesterases on the latencies of action potentials in mouse skeletal muscles. Br J Pharmacol. 1990 Apr;99(4):721-6. [PubMed:2361169 ]
  6. Masson P, Fortier PL, Albaret C, Froment MT, Bartels CF, Lockridge O: Aging of di-isopropyl-phosphorylated human butyrylcholinesterase. Biochem J. 1997 Oct 15;327 ( Pt 2):601-7. [PubMed:9359435 ]