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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2022-03-07 02:51:48 UTC
HMDB IDHMDB0014946
Secondary Accession Numbers
  • HMDB14946
Metabolite Identification
Common NameIndapamide
DescriptionIndapamide is only found in individuals that have used or taken this drug. It is a benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable. [PubChem]Indapamide blocks the slow component of delayed rectifier potassium current (IKs) without altering the rapid component (IKr) or the inward rectifier current. Specifically it blocks or antagonizes the action the proteins KCNQ1 and KCNE1. Indapamide is also thought to stimulate the synthesis of the vasodilatory hypotensive prostaglandin PGE2.
Structure
Data?1582753239
Synonyms
ValueSource
IndapamidaChEBI
IndapamidumChEBI
LozolKegg
NatrixKegg
MetindamideHMDB
Chemical FormulaC16H16ClN3O3S
Average Molecular Weight365.835
Monoisotopic Molecular Weight365.06008979
IUPAC Name4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
Traditional Nameindapamide
CAS Registry Number26807-65-8
SMILES
CC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O
InChI Identifier
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
InChI KeyNDDAHWYSQHTHNT-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentBenzenesulfonamides
Alternative Parents
Substituents
  • Benzenesulfonamide
  • Halobenzoic acid or derivatives
  • 4-halobenzoic acid or derivatives
  • Benzoic acid or derivatives
  • Benzenesulfonyl group
  • Indole or derivatives
  • Benzoyl
  • Chlorobenzene
  • Halobenzene
  • Aryl chloride
  • Aryl halide
  • Organosulfonic acid amide
  • Aminosulfonyl compound
  • Sulfonyl
  • Organosulfonic acid or derivatives
  • Organic sulfonic acid or derivatives
  • Carboxylic acid hydrazide
  • Organoheterocyclic compound
  • Azacycle
  • Carboxylic acid derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Organosulfur compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point161 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.034 g/LNot Available
LogP2.2Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+CBM185.630932474
[M+H]+Not Available184.63http://allccs.zhulab.cn/database/detail?ID=AllCCS00000804
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.034 g/LALOGPS
logP2.52ALOGPS
logP2.64ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)8.85ChemAxon
pKa (Strongest Basic)0.097ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area92.5 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity103.31 m³·mol⁻¹ChemAxon
Polarizability36.34 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+177.61530932474
DeepCCS[M-H]-175.25730932474
DeepCCS[M-2H]-208.67230932474
DeepCCS[M+Na]+183.89930932474
AllCCS[M+H]+182.632859911
AllCCS[M+H-H2O]+179.632859911
AllCCS[M+NH4]+185.332859911
AllCCS[M+Na]+186.132859911
AllCCS[M-H]-179.032859911
AllCCS[M+Na-2H]-178.732859911
AllCCS[M+HCOO]-178.532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
IndapamideCC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O4491.3Standard polar33892256
IndapamideCC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O3415.0Standard non polar33892256
IndapamideCC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O3350.8Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Indapamide,1TMS,isomer #1CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C)=C13206.4Semi standard non polar33892256
Indapamide,1TMS,isomer #1CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C)=C13172.0Standard non polar33892256
Indapamide,1TMS,isomer #1CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C)=C14145.5Standard polar33892256
Indapamide,1TMS,isomer #2CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1)[Si](C)(C)C3072.8Semi standard non polar33892256
Indapamide,1TMS,isomer #2CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1)[Si](C)(C)C3157.4Standard non polar33892256
Indapamide,1TMS,isomer #2CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1)[Si](C)(C)C4557.2Standard polar33892256
Indapamide,2TMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C)=C1)[Si](C)(C)C3050.4Semi standard non polar33892256
Indapamide,2TMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C)=C1)[Si](C)(C)C3271.8Standard non polar33892256
Indapamide,2TMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C)=C1)[Si](C)(C)C3918.2Standard polar33892256
Indapamide,2TMS,isomer #2CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C)[Si](C)(C)C)=C13174.8Semi standard non polar33892256
Indapamide,2TMS,isomer #2CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C)[Si](C)(C)C)=C13345.7Standard non polar33892256
Indapamide,2TMS,isomer #2CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C)[Si](C)(C)C)=C14085.0Standard polar33892256
Indapamide,3TMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C)[Si](C)(C)C)=C1)[Si](C)(C)C3050.7Semi standard non polar33892256
Indapamide,3TMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C)[Si](C)(C)C)=C1)[Si](C)(C)C3457.1Standard non polar33892256
Indapamide,3TMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C)[Si](C)(C)C)=C1)[Si](C)(C)C3858.3Standard polar33892256
Indapamide,1TBDMS,isomer #1CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C(C)(C)C)=C13440.7Semi standard non polar33892256
Indapamide,1TBDMS,isomer #1CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C(C)(C)C)=C13432.0Standard non polar33892256
Indapamide,1TBDMS,isomer #1CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C(C)(C)C)=C14167.2Standard polar33892256
Indapamide,1TBDMS,isomer #2CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1)[Si](C)(C)C(C)(C)C3307.2Semi standard non polar33892256
Indapamide,1TBDMS,isomer #2CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1)[Si](C)(C)C(C)(C)C3392.6Standard non polar33892256
Indapamide,1TBDMS,isomer #2CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1)[Si](C)(C)C(C)(C)C4581.9Standard polar33892256
Indapamide,2TBDMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C3446.7Semi standard non polar33892256
Indapamide,2TBDMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C3778.9Standard non polar33892256
Indapamide,2TBDMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C3975.2Standard polar33892256
Indapamide,2TBDMS,isomer #2CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C13615.9Semi standard non polar33892256
Indapamide,2TBDMS,isomer #2CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C13845.6Standard non polar33892256
Indapamide,2TBDMS,isomer #2CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C14098.8Standard polar33892256
Indapamide,3TBDMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C3650.0Semi standard non polar33892256
Indapamide,3TBDMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C4183.5Standard non polar33892256
Indapamide,3TBDMS,isomer #1CC1CC2=CC=CC=C2N1N(C(=O)C1=CC=C(Cl)C(S(=O)(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C3934.7Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Indapamide GC-MS (Non-derivatized) - 70eV, Positivesplash10-014i-4593000000-5ea2b9ed9ba04df04bf72017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Indapamide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Indapamide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-qTof , Positive-QTOFsplash10-001i-1900000000-861314def0ccc019ac042017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-03di-0009000000-ed04e0a5871badc8b1662017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-03di-1729000000-15aecb441ef4febfe5262017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-000i-2910000000-b72aeba8db62ebdf9c172017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-004r-6900000000-f819fedd1ac654d46dd42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-004i-9300000000-164a2972880c967d21952017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-004i-9100000000-d18afa355f919614b6522017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-01t9-9000000000-9d9e98925e91057389922017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-03fr-9000000000-5e7568f4efd1730f47b92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , negative-QTOFsplash10-03di-9000000000-ecfffadaaa03b447eaf52017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QTOF , positive-QTOFsplash10-001i-0904000000-530b78f6cae834e117682017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QTOF , positive-QTOFsplash10-001i-0900000000-235673a939e2e7d8c5e32017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QTOF , positive-QTOFsplash10-0159-0900000000-a843660d42ffb01666fe2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QTOF , positive-QTOFsplash10-001i-0900000000-cfee205b361c580e36312017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QTOF , positive-QTOFsplash10-00lr-0900000000-a6d8ff4d769ea09e80732017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , positive-QTOFsplash10-001i-0901000000-a76c5fd366807c1805522017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , positive-QTOFsplash10-001i-0900000000-574a71dcc7f0b3f746932017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , positive-QTOFsplash10-001i-1900000000-ab046a8849c404d9b3082017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Indapamide LC-ESI-QFT , positive-QTOFsplash10-00l6-4900000000-93f1cc6465f329fd111e2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Indapamide 10V, Positive-QTOFsplash10-014i-0209000000-9154e3b65e4d452dacb32016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Indapamide 20V, Positive-QTOFsplash10-00ls-0968000000-bfc678a87120a2f04f232016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Indapamide 40V, Positive-QTOFsplash10-014i-0920000000-26f53b22345a5ccf83022016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Indapamide 10V, Negative-QTOFsplash10-03di-1119000000-10d511f58b646ce4b1342016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Indapamide 20V, Negative-QTOFsplash10-01t9-9558000000-8fe9e9ce749aec7877432016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Indapamide 40V, Negative-QTOFsplash10-004i-9210000000-6029683889b96e37eacb2016-08-03Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00808 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00808 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00808
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3574
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkIndapamide
METLIN IDNot Available
PubChem Compound3702
PDB IDNot Available
ChEBI ID5893
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Dong DL, Wang QH, Yue P, Jiao JD, Gu RM, Yang BF: Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. Eur J Pharmacol. 2006 Apr 24;536(1-2):78-84. Epub 2006 Mar 2. [PubMed:16556441 ]

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Sun H, Moore C, Dansette PM, Kumar S, Halpert JR, Yost GS: Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos. 2009 Mar;37(3):672-84. doi: 10.1124/dmd.108.022707. Epub 2008 Dec 12. [PubMed:19074530 ]
General function:
Involved in ion channel activity
Specific function:
Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea
Gene Name:
KCNQ1
Uniprot ID:
P51787
Molecular weight:
74697.9
References
  1. Ohya S, Asakura K, Muraki K, Watanabe M, Imaizumi Y: Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G277-87. [PubMed:11804849 ]
  2. Li RA, Miake J, Hoppe UC, Johns DC, Marban E, Nuss HB: Functional consequences of the arrhythmogenic G306R KvLQT1 K+ channel mutant probed by viral gene transfer in cardiomyocytes. J Physiol. 2001 May 15;533(Pt 1):127-33. [PubMed:11351021 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
General function:
Involved in voltage-gated potassium channel activity
Specific function:
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr)
Gene Name:
KCNE1
Uniprot ID:
P15382
Molecular weight:
14674.7
References
  1. Ohya S, Asakura K, Muraki K, Watanabe M, Imaizumi Y: Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G277-87. [PubMed:11804849 ]