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Showing metabocard for Enprofylline (HMDB0014962)

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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2023-02-21 17:18:20 UTC
HMDB IDHMDB0014962
Secondary Accession Numbers
  • HMDB14962
Metabolite Identification
Common NameEnprofylline
DescriptionEnprofylline, also known as 3-propylxanthine or enprofilina, belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety. Enprofylline is a drug which is used in the management of symptoms of asthma. also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Enprofylline is an extremely weak basic (essentially neutral) compound (based on its pKa). Xanthine bearing a propyl substituent at position 3.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0014962 (Enprofylline)

824
  Mrv0541 02231215022D          

 14 15  0  0  0  0            999 V2000
    1.6500   -0.2063    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    2.2688    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.2063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.2827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741   -0.0451    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0556    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 11  2  0  0  0  0
  2 12  2  0  0  0  0
  3  7  1  0  0  0  0
  3  8  1  0  0  0  0
  3 11  1  0  0  0  0
  4 11  1  0  0  0  0
  4 12  1  0  0  0  0
  5 10  1  0  0  0  0
  5 14  1  0  0  0  0
  6  8  1  0  0  0  0
  6 14  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 13  1  0  0  0  0
 10 12  1  0  0  0  0
M  END
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3D MOL for HMDB0014962 (Enprofylline)

HMDB0014962
     RDKit          3D
Enprofylline
 24 25  0  0  0  0  0  0  0  0999 V2000
    2.8015    0.4510    0.7366 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3151   -0.7370   -0.0569 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3089   -0.3650   -1.0954 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1124    0.2490   -0.5990 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0910    1.5533   -0.4319 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8524    2.3382   -0.7399 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2456    2.0862    0.0465 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2514    1.2560    0.3747 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3456    1.6667    0.8217 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1140   -0.1302    0.2272 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9460   -1.1603    0.4752 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2583   -2.2648    0.1363 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0340   -1.9362   -0.3097 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9124   -0.5902   -0.2642 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2281    1.2403    0.0816 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5646    0.0921    1.4816 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9869    0.9252    1.3197 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9334   -1.4751    0.6804 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1881   -1.1730   -0.5857 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7960    0.3971   -1.7701 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0172   -1.1967   -1.7522 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3448    3.1220    0.1554 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9195   -1.0687    0.8541 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6422   -3.2800    0.2138 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14  4  1  0
 14 10  2  0
  1 15  1  0
  1 16  1  0
  1 17  1  0
  2 18  1  0
  2 19  1  0
  3 20  1  0
  3 21  1  0
  7 22  1  0
 11 23  1  0
 12 24  1  0
M  END
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3D SDF for HMDB0014962 (Enprofylline)

824
  Mrv0541 02231215022D          

 14 15  0  0  0  0            999 V2000
    1.6500   -0.2063    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    2.2688    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.2063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.0313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.2827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741   -0.0451    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7935    1.0313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    1.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0556    0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 11  2  0  0  0  0
  2 12  2  0  0  0  0
  3  7  1  0  0  0  0
  3  8  1  0  0  0  0
  3 11  1  0  0  0  0
  4 11  1  0  0  0  0
  4 12  1  0  0  0  0
  5 10  1  0  0  0  0
  5 14  1  0  0  0  0
  6  8  1  0  0  0  0
  6 14  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 13  1  0  0  0  0
 10 12  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0014962

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCN1C2=C(NC=N2)C(=O)NC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)

> <INCHI_KEY>
SIQPXVQCUCHWDI-UHFFFAOYSA-N

> <FORMULA>
C8H10N4O2

> <MOLECULAR_WEIGHT>
194.1906

> <EXACT_MASS>
194.080375584

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_AVERAGE_POLARIZABILITY>
18.71586644756676

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

> <ALOGPS_LOGP>
0.35

> <JCHEM_LOGP>
-0.11366737333333343

> <ALOGPS_LOGS>
-1.53

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
10.888277633462968

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.83265882650006

> <JCHEM_PKA_STRONGEST_BASIC>
-0.7668985196988481

> <JCHEM_POLAR_SURFACE_AREA>
78.09

> <JCHEM_REFRACTIVITY>
49.310399999999994

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.68e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
enprofylline

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0014962 (Enprofylline)

HMDB0014962
     RDKit          3D
Enprofylline
 24 25  0  0  0  0  0  0  0  0999 V2000
    2.8015    0.4510    0.7366 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3151   -0.7370   -0.0569 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3089   -0.3650   -1.0954 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1124    0.2490   -0.5990 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0910    1.5533   -0.4319 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8524    2.3382   -0.7399 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2456    2.0862    0.0465 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2514    1.2560    0.3747 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3456    1.6667    0.8217 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1140   -0.1302    0.2272 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9460   -1.1603    0.4752 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2583   -2.2648    0.1363 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0340   -1.9362   -0.3097 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9124   -0.5902   -0.2642 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2281    1.2403    0.0816 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5646    0.0921    1.4816 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9869    0.9252    1.3197 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9334   -1.4751    0.6804 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1881   -1.1730   -0.5857 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7960    0.3971   -1.7701 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0172   -1.1967   -1.7522 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3448    3.1220    0.1554 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9195   -1.0687    0.8541 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6422   -3.2800    0.2138 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14  4  1  0
 14 10  2  0
  1 15  1  0
  1 16  1  0
  1 17  1  0
  2 18  1  0
  2 19  1  0
  3 20  1  0
  3 21  1  0
  7 22  1  0
 11 23  1  0
 12 24  1  0
M  END
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PDB for HMDB0014962 (Enprofylline)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 824                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  O   UNK     0       3.080  -0.385   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0       5.748   4.235   0.000  0.00  0.00           O+0
HETATM    3  N   UNK     0       5.748  -0.385   0.000  0.00  0.00           N+0
HETATM    4  N   UNK     0       4.414   1.925   0.000  0.00  0.00           N+0
HETATM    5  N   UNK     0       8.538   2.394   0.000  0.00  0.00           N+0
HETATM    6  N   UNK     0       8.538  -0.084   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0       5.748  -1.925   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.081   0.385   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.414  -2.695   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.081   1.925   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.414   0.385   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.748   2.695   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.414  -4.235   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.437   1.155   0.000  0.00  0.00           C+0
CONECT    1   11                                                            
CONECT    2   12                                                            
CONECT    3    7    8   11                                                  
CONECT    4   11   12                                                       
CONECT    5   10   14                                                       
CONECT    6    8   14                                                       
CONECT    7    3    9                                                       
CONECT    8    3    6   10                                                  
CONECT    9    7   13                                                       
CONECT   10    5    8   12                                                  
CONECT   11    1    3    4                                                  
CONECT   12    2    4   10                                                  
CONECT   13    9                                                            
CONECT   14    5    6                                                       
MASTER        0    0    0    0    0    0    0    0   14    0   30    0
END
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3D PDB for HMDB0014962 (Enprofylline)

COMPND    HMDB0014962
HETATM    1  C1  UNL     1       2.801   0.451   0.737  1.00  0.00           C  
HETATM    2  C2  UNL     1       2.315  -0.737  -0.057  1.00  0.00           C  
HETATM    3  C3  UNL     1       1.309  -0.365  -1.095  1.00  0.00           C  
HETATM    4  N1  UNL     1       0.112   0.249  -0.599  1.00  0.00           N  
HETATM    5  C4  UNL     1      -0.091   1.553  -0.432  1.00  0.00           C  
HETATM    6  O1  UNL     1       0.852   2.338  -0.740  1.00  0.00           O  
HETATM    7  N2  UNL     1      -1.246   2.086   0.047  1.00  0.00           N  
HETATM    8  C5  UNL     1      -2.251   1.256   0.375  1.00  0.00           C  
HETATM    9  O2  UNL     1      -3.346   1.667   0.822  1.00  0.00           O  
HETATM   10  C6  UNL     1      -2.114  -0.130   0.227  1.00  0.00           C  
HETATM   11  N3  UNL     1      -2.946  -1.160   0.475  1.00  0.00           N  
HETATM   12  C7  UNL     1      -2.258  -2.265   0.136  1.00  0.00           C  
HETATM   13  N4  UNL     1      -1.034  -1.936  -0.310  1.00  0.00           N  
HETATM   14  C8  UNL     1      -0.912  -0.590  -0.264  1.00  0.00           C  
HETATM   15  H1  UNL     1       3.228   1.240   0.082  1.00  0.00           H  
HETATM   16  H2  UNL     1       3.565   0.092   1.482  1.00  0.00           H  
HETATM   17  H3  UNL     1       1.987   0.925   1.320  1.00  0.00           H  
HETATM   18  H4  UNL     1       1.933  -1.475   0.680  1.00  0.00           H  
HETATM   19  H5  UNL     1       3.188  -1.173  -0.586  1.00  0.00           H  
HETATM   20  H6  UNL     1       1.796   0.397  -1.770  1.00  0.00           H  
HETATM   21  H7  UNL     1       1.017  -1.197  -1.752  1.00  0.00           H  
HETATM   22  H8  UNL     1      -1.345   3.122   0.155  1.00  0.00           H  
HETATM   23  H9  UNL     1      -3.920  -1.069   0.854  1.00  0.00           H  
HETATM   24  H10 UNL     1      -2.642  -3.280   0.214  1.00  0.00           H  
CONECT    1    2   15   16   17
CONECT    2    3   18   19
CONECT    3    4   20   21
CONECT    4    5   14
CONECT    5    6    6    7
CONECT    7    8   22
CONECT    8    9    9   10
CONECT   10   11   14   14
CONECT   11   12   23
CONECT   12   13   13   24
CONECT   13   14
END
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SMILES for HMDB0014962 (Enprofylline)

CCCN1C2=C(NC=N2)C(=O)NC1=O
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INCHI for HMDB0014962 (Enprofylline)

InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
3,7-Dihydro-3-propyl-1H-purine-2,6-dioneChEBI
3-N-PropylxanthineChEBI
3-Propyl-3,7-dihydro-purine-2,6-dioneChEBI
3-PropylxanthineChEBI
EnprofilinaChEBI
EnprofyllinumChEBI
Chemical FormulaC8H10N4O2
Average Molecular Weight194.1906
Monoisotopic Molecular Weight194.080375584
IUPAC Name3-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Traditional Nameenprofylline
CAS Registry Number41078-02-8
SMILES
CCCN1C2=C(NC=N2)C(=O)NC1=O
InChI Identifier
InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)
InChI KeySIQPXVQCUCHWDI-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassImidazopyrimidines
Sub ClassPurines and purine derivatives
Direct ParentXanthines
Alternative Parents
Substituents
  • Xanthine
  • 6-oxopurine
  • Purinone
  • Alkaloid or derivatives
  • Pyrimidone
  • Pyrimidine
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Vinylogous amide
  • Lactam
  • Urea
  • Azacycle
  • Hydrocarbon derivative
  • Organic oxide
  • Organooxygen compound
  • Organonitrogen compound
  • Organic nitrogen compound
  • Organopnictogen compound
  • Organic oxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point287 - 289 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility5.68 g/LNot Available
LogP-0.2Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00824 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00824 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00824
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID1613
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkEnprofylline
METLIN IDNot Available
PubChem Compound1676
PDB IDNot Available
ChEBI ID126237
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. cAMP-specific 3',5'-cyclic phosphodiesterase 4B
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Gene Name:
PDE4B
Uniprot ID:
Q07343
Molecular weight:
64351.765
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Enzyme Details
2. cAMP-specific 3',5'-cyclic phosphodiesterase 4A
General function:
Involved in 3',5'-cyclic-nucleotide phosphodiesterase activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Name:
PDE4A
Uniprot ID:
P27815
Molecular weight:
98142.155
References
  1. Featherstone RL, Chambers DJ: Long-term hypothermic lung preservation: does adenosine A1 receptor antagonism have a role in ischemic preconditioning protection? Interact Cardiovasc Thorac Surg. 2004 Mar;3(1):182-7. [PubMed:17670210 ]
  2. Dulloo AG, Seydoux J, Girardier L: Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. Int J Obes. 1991 May;15(5):317-26. [PubMed:1885257 ]
  3. Dar MS: Central adenosinergic system involvement in ethanol-induced motor incoordination in mice. J Pharmacol Exp Ther. 1990 Dec;255(3):1202-9. [PubMed:2262902 ]
  4. Ukena D, Schirren CG, Schwabe U: Effects of enprofylline on A1 and A2 adenosine receptors. Eur J Pharmacol. 1985 Oct 29;117(1):25-33. [PubMed:3002801 ]
  5. Berg G, Andersson RG, Ryden G: Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study. Arch Int Pharmacodyn Ther. 1987 Dec;290(2):288-92. [PubMed:3446047 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Enzyme Details
3. Adenosine receptor A2b
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Gene Name:
ADORA2B
Uniprot ID:
P29275
Molecular weight:
36332.7
References
  1. Holgate ST: The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. Br J Pharmacol. 2005 Aug;145(8):1009-15. [PubMed:15980878 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]