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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2022-03-07 02:51:51 UTC
HMDB IDHMDB0015074
Secondary Accession Numbers
  • HMDB15074
Metabolite Identification
Common NameMeclofenamic acid
DescriptionMeclofenamic acid is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease.
Structure
Data?1582753255
Synonyms
ValueSource
Acide meclofenamiqueChEBI
Acido meclofenamicoChEBI
Acidum meclofenamicumChEBI
CI-583ChEBI
INF 4668ChEBI
N-(2,6-Dichloro-3-methylphenyl)anthranilic acidChEBI
N-(2,6-Dichloro-m-tolyl)anthranilic acidChEBI
N-(3-Methyl-2,6-dichlorophenyl)anthranilic acidChEBI
N-(2,6-Dichloro-3-methylphenyl)anthranilateGenerator
N-(2,6-Dichloro-m-tolyl)anthranilateGenerator
N-(3-Methyl-2,6-dichlorophenyl)anthranilateGenerator
MeclofenamateGenerator
Meclomen (free acid)HMDB
Meclophenamic acidHMDB
Meclofenamate sodiumHMDB
MeclomenHMDB
Sodium, meclofenamateHMDB
Meclofenamate, sodiumHMDB
Sodium meclofenamateHMDB
Acid, meclofenamicHMDB
Parke davis brand OF sodium meclofenamateHMDB
Anhydrous, meclofenamate sodiumHMDB
Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrateHMDB
Meclofenamate sodium monohydrateHMDB
Meclofenamate sodium anhydrousHMDB
Chemical FormulaC14H11Cl2NO2
Average Molecular Weight296.149
Monoisotopic Molecular Weight295.016684015
IUPAC Name2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
Traditional Namemeclofenamic acid
CAS Registry Number644-62-2
SMILES
CC1=C(Cl)C(NC2=CC=CC=C2C(O)=O)=C(Cl)C=C1
InChI Identifier
InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
InChI KeySBDNJUWAMKYJOX-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoic acids and derivatives
Direct ParentAminobenzoic acids
Alternative Parents
Substituents
  • Aminobenzoic acid
  • Benzoic acid
  • Benzoyl
  • 1,3-dichlorobenzene
  • Aniline or substituted anilines
  • Aminotoluene
  • Toluene
  • Chlorobenzene
  • Halobenzene
  • Aryl chloride
  • Aryl halide
  • Vinylogous amide
  • Amino acid
  • Amino acid or derivatives
  • Monocarboxylic acid or derivatives
  • Secondary amine
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organohalogen compound
  • Organooxygen compound
  • Organic oxide
  • Amine
  • Organic oxygen compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Organochloride
  • Organonitrogen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Not AvailableNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point257 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.0037 g/LNot Available
LogP5Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.0037 g/LALOGPS
logP5.11ALOGPS
logP6.09ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)3.79ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area49.33 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity76.45 m³·mol⁻¹ChemAxon
Polarizability28.44 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+161.3330932474
DeepCCS[M-H]-158.97230932474
DeepCCS[M-2H]-191.85830932474
DeepCCS[M+Na]+167.42330932474
AllCCS[M+H]+160.432859911
AllCCS[M+H-H2O]+156.932859911
AllCCS[M+NH4]+163.732859911
AllCCS[M+Na]+164.632859911
AllCCS[M-H]-155.032859911
AllCCS[M+Na-2H]-154.332859911
AllCCS[M+HCOO]-153.632859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Meclofenamic acidCC1=C(Cl)C(NC2=CC=CC=C2C(O)=O)=C(Cl)C=C13846.3Standard polar33892256
Meclofenamic acidCC1=C(Cl)C(NC2=CC=CC=C2C(O)=O)=C(Cl)C=C12379.6Standard non polar33892256
Meclofenamic acidCC1=C(Cl)C(NC2=CC=CC=C2C(O)=O)=C(Cl)C=C12393.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Meclofenamic acid,1TMS,isomer #1CC1=CC=C(Cl)C(NC2=CC=CC=C2C(=O)O[Si](C)(C)C)=C1Cl2364.9Semi standard non polar33892256
Meclofenamic acid,1TMS,isomer #2CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O)[Si](C)(C)C)=C1Cl2301.7Semi standard non polar33892256
Meclofenamic acid,2TMS,isomer #1CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O[Si](C)(C)C)[Si](C)(C)C)=C1Cl2301.5Semi standard non polar33892256
Meclofenamic acid,2TMS,isomer #1CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O[Si](C)(C)C)[Si](C)(C)C)=C1Cl2364.0Standard non polar33892256
Meclofenamic acid,2TMS,isomer #1CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O[Si](C)(C)C)[Si](C)(C)C)=C1Cl2713.2Standard polar33892256
Meclofenamic acid,1TBDMS,isomer #1CC1=CC=C(Cl)C(NC2=CC=CC=C2C(=O)O[Si](C)(C)C(C)(C)C)=C1Cl2590.8Semi standard non polar33892256
Meclofenamic acid,1TBDMS,isomer #2CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O)[Si](C)(C)C(C)(C)C)=C1Cl2543.8Semi standard non polar33892256
Meclofenamic acid,2TBDMS,isomer #1CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1Cl2779.7Semi standard non polar33892256
Meclofenamic acid,2TBDMS,isomer #1CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1Cl2744.7Standard non polar33892256
Meclofenamic acid,2TBDMS,isomer #1CC1=CC=C(Cl)C(N(C2=CC=CC=C2C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C1Cl2932.4Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Meclofenamic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-0f92-0190000000-ce5bf5fd48806b5fbdf32017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Meclofenamic acid GC-MS (1 TMS) - 70eV, Positivesplash10-0kmj-5139000000-a73b6d1b9aebb773ea602017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Meclofenamic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , negative-QTOFsplash10-0006-0090000000-dc6d0aaa7ee1998998302017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , negative-QTOFsplash10-052f-0090000000-4f2a28033e59bab0257a2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , negative-QTOFsplash10-03di-0190000000-b6abcaff657bfa67b5992017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , negative-QTOFsplash10-03fr-0690000000-eccbe792d08156c89c392017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , negative-QTOFsplash10-004i-0920000000-fdcf8eff9ac77cf86d5b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , negative-QTOFsplash10-004i-0900000000-77140947d50a131a9be62017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , negative-QTOFsplash10-004i-0900000000-5d2a4942eea2a2d2f2522017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-004i-0090000000-85032b374ac40bac481a2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-004l-0090000000-a2cbafbde1150bf5812e2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-0006-0090000000-47d80abc4f95a2c5ef4c2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-0006-0090000000-cfa40a800c6a52f6a2642017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-0006-0290000000-2e34cb2892f6263b39fa2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-0563-0980000000-54fb4017b6a67acb639b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-004i-0910000000-26fefd3e49fc0ba3e36e2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-0fb9-1900000000-448908b1e79c92a656d72017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid LC-ESI-QFT , positive-QTOFsplash10-0fb9-2900000000-71b13766bf05541800b42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid 60V, Negative-QTOFsplash10-03fr-0690000000-00efb213d800845550a82021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid 75V, Negative-QTOFsplash10-004i-0920000000-fdcf8eff9ac77cf86d5b2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meclofenamic acid 15V, Positive-QTOFsplash10-004i-0090000000-85032b374ac40bac481a2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meclofenamic acid 10V, Positive-QTOFsplash10-0002-0090000000-499829b8629f7135db602016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meclofenamic acid 20V, Positive-QTOFsplash10-0ufr-0090000000-bce444b767c6cc91af252016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meclofenamic acid 40V, Positive-QTOFsplash10-0udi-3090000000-9eedeb81aec059f12e402016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meclofenamic acid 10V, Negative-QTOFsplash10-0udl-0090000000-de90eca3751b173b8e3a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meclofenamic acid 20V, Negative-QTOFsplash10-0udi-0090000000-d3726ae14682e4737b662016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meclofenamic acid 40V, Negative-QTOFsplash10-0w2c-1190000000-9bc69c7e4771495d751a2016-08-03Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00939 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00939 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00939
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3897
KEGG Compound IDC07117
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMeclofenamic_acid
METLIN IDNot Available
PubChem Compound4037
PDB IDNot Available
ChEBI ID6710
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in metal ion binding
Specific function:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Gene Name:
ALOX5
Uniprot ID:
P09917
Molecular weight:
77982.595
References
  1. Yu XY, Hubbard W, Spannhake EW: Inhibition of canine tracheal smooth muscle by mediators from cultured bronchial epithelial cells. Am J Physiol. 1992 Feb;262(2 Pt 1):L229-34. [PubMed:1539679 ]
  2. Boctor AM, Eickholt M, Pugsley TA: Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro. Prostaglandins Leukot Med. 1986 Aug;23(2-3):229-38. [PubMed:3020588 ]
General function:
Involved in peroxidase activity
Specific function:
Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular weight:
68995.625
References
  1. Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, Marnett LJ: Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):925-30. [PubMed:10639181 ]
  2. Traupe T, Lang M, Goettsch W, Munter K, Morawietz H, Vetter W, Barton M: Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression. J Hypertens. 2002 Nov;20(11):2239-45. [PubMed:12409963 ]
  3. Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res. 2004 Jun;65(6):810-8. [PubMed:15198222 ]
  4. Narsinghani T, Chaturvedi SC: QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):461-8. Epub 2005 Nov 14. [PubMed:16290292 ]
  5. Smith WL, Meade EA, DeWitt DL: Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann N Y Acad Sci. 1994 Nov 15;744:50-7. [PubMed:7825862 ]
General function:
Involved in peroxidase activity
Specific function:
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular weight:
68685.82
References
  1. Perez-Vizcaino F, Lopez-Lopez JG, Santiago R, Cogolludo A, Zaragoza-Arnaez F, Moreno L, Alonso MJ, Salaices M, Tamargo J: Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity. Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L839-48. [PubMed:12225961 ]
  2. Shiels IA, Whitehouse MW: Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea. Allerg Immunol (Paris). 2000 Sep;32(7):279-83. [PubMed:11094641 ]
  3. Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res. 2004 Jun;65(6):810-8. [PubMed:15198222 ]
  4. Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, Marnett LJ: Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):925-30. [PubMed:10639181 ]
  5. Meade EA, Smith WL, DeWitt DL: Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1993 Mar 25;268(9):6610-4. [PubMed:8454631 ]

Transporters

General function:
Involved in transporter activity
Specific function:
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency
Gene Name:
SLCO1C1
Uniprot ID:
Q9NYB5
Molecular weight:
78695.6
References
  1. Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. doi: 10.1210/en.2008-0188. Epub 2008 Oct 9. [PubMed:18845642 ]
  2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
General function:
Involved in ion transmembrane transporter activity
Specific function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular weight:
61815.8
References
  1. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. [PubMed:10220563 ]