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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:52 UTC
Update Date2023-02-21 17:18:32 UTC
HMDB IDHMDB0015644
Secondary Accession Numbers
  • HMDB15644
Metabolite Identification
Common NameBetahistine
DescriptionBetahistine is only found in individuals that have used or taken this drug. It is an antivertigo drug first used for treating vertigo assosicated with Meniere's disease. It is also commonly used for patients with balance disorders.Betahistine primarily acts as a histamine H1-agonist with 0.07 times the activity of histamine. Stimulating the H1-receptors in the inner ear causes a vasodilatory effect and increased permeability in the blood vessels which results in reduced endolymphatic pressure. Betahistine is believed to act by reducing the asymmetrical functioning of sensory vestibular organs as well as by increasing vestibulocochlear blood flow. Doing so aids in decreasing symptoms of vertigo and balance disorders. Betahistine also acts as a histamine H3-receptor antagonist which causes an increased output of histamine from histaminergic nerve endings which can further increase the direct H1-agonist activity. Furthermore, H3-receptor antagonism increases the levels of neurotransmitters such as serotonin in the brainstem, which inhibits the activity of vestibular nuclei, helping to restore proper balance and decrease in vertigo symptoms.
Structure
Data?1676999912
Synonyms
ValueSource
2-(beta-Methylaminoethyl)pyridineChEBI
2-[2-(Methylamino)ethyl]pyridineChEBI
[2-(2-Pyridyl)ethyl]methylamineChEBI
BetahistinaChEBI
BetahistinumChEBI
N-Methyl-2-(2-pyridinyl)ethanamineChEBI
N-Methyl-2-pyridineethanamineChEBI
VestiboKegg
2-(b-Methylaminoethyl)pyridineGenerator
2-(Β-methylaminoethyl)pyridineGenerator
Betahistin stadaHMDB
Betahistine mesylateHMDB
Betahistine methanesulphonateHMDB
BetavertHMDB
By vertinHMDB
Dihydrobromide, betahistineHMDB
Ergha brand OF betahistine hydrochlorideHMDB
Mesylate, betahistineHMDB
SercHMDB
Solvay brand OF betahistine hydrochlorideHMDB
Stadapharm brand OF betahistine mesylateHMDB
VertigonHMDB
Betahistin alHMDB
Betahistin ratiopharmHMDB
Betahistine methanesulfonateHMDB
By-vertinHMDB
Dexo brand OF betahistine mesylateHMDB
Dihydrochloride, betahistineHMDB
Eurim brand OF betahistine hydrochlorideHMDB
Hennig brand OF betahistine mesylateHMDB
Medopharm brand OF betahistine mesylateHMDB
MelopatHMDB
Unimed brand OF betahistine hydrochlorideHMDB
AequamenHMDB
Altana pharma brand OF betahistine mesylateHMDB
Betahistine dihydrobromideHMDB
BetasercHMDB
Bouchara brand OF betahistine hydrochlorideHMDB
Fides ecopharma brand OF betahistine hydrochlorideHMDB
FidiumHMDB
Methanesulfonate, betahistineHMDB
Methanesulphonate, betahistineHMDB
RibrainHMDB
Ratiopharm brand OF betahistine mesylateHMDB
Aliud brand OF betahistine mesylateHMDB
Betahistin-ratiopharmHMDB
Betahistine bipharHMDB
Betahistine dihydrochlorideHMDB
Betahistine hydrochlorideHMDB
Byk gulden brand OF betahistine hydrochlorideHMDB
ExtovylHMDB
Gerard brand OF betahistine hydrochlorideHMDB
Hydrochloride, betahistineHMDB
LectilHMDB
MersilonHMDB
PT 9HMDB
PT-9HMDB
PT9HMDB
VasomotalHMDB
Chemical FormulaC8H12N2
Average Molecular Weight136.1943
Monoisotopic Molecular Weight136.100048394
IUPAC Namemethyl[2-(pyridin-2-yl)ethyl]amine
Traditional Namebetahistine
CAS Registry Number5638-76-6
SMILES
CNCCC1=CC=CC=N1
InChI Identifier
InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
InChI KeyUUQMNUMQCIQDMZ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct ParentAralkylamines
Alternative Parents
Substituents
  • Aralkylamine
  • Pyridine
  • Heteroaromatic compound
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Secondary aliphatic amine
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available126.022http://allccs.zhulab.cn/database/detail?ID=AllCCS00000705
Predicted Molecular Properties
PropertyValueSource
Water Solubility49.3 g/LALOGPS
logP0.59ALOGPS
logP0.63ChemAxon
logS-0.44ALOGPS
pKa (Strongest Basic)9.77ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area24.92 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity41.33 m³·mol⁻¹ChemAxon
Polarizability15.85 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+128.57831661259
DarkChem[M-H]-125.22931661259
DeepCCS[M+H]+128.09430932474
DeepCCS[M-H]-125.31730932474
DeepCCS[M-2H]-161.72730932474
DeepCCS[M+Na]+136.60130932474
AllCCS[M+H]+128.332859911
AllCCS[M+H-H2O]+123.632859911
AllCCS[M+NH4]+132.732859911
AllCCS[M+Na]+134.032859911
AllCCS[M-H]-132.032859911
AllCCS[M+Na-2H]-133.732859911
AllCCS[M+HCOO]-135.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
BetahistineCNCCC1=CC=CC=N11779.1Standard polar33892256
BetahistineCNCCC1=CC=CC=N11188.4Standard non polar33892256
BetahistineCNCCC1=CC=CC=N11172.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Betahistine,1TMS,isomer #1CN(CCC1=CC=CC=N1)[Si](C)(C)C1391.2Semi standard non polar33892256
Betahistine,1TMS,isomer #1CN(CCC1=CC=CC=N1)[Si](C)(C)C1373.8Standard non polar33892256
Betahistine,1TMS,isomer #1CN(CCC1=CC=CC=N1)[Si](C)(C)C1743.0Standard polar33892256
Betahistine,1TBDMS,isomer #1CN(CCC1=CC=CC=N1)[Si](C)(C)C(C)(C)C1596.9Semi standard non polar33892256
Betahistine,1TBDMS,isomer #1CN(CCC1=CC=CC=N1)[Si](C)(C)C(C)(C)C1631.6Standard non polar33892256
Betahistine,1TBDMS,isomer #1CN(CCC1=CC=CC=N1)[Si](C)(C)C(C)(C)C1891.2Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Betahistine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9200000000-7632c62aa4558c2fb7dd2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Betahistine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine n/a 13V, positive-QTOFsplash10-0006-9100000000-07342e47e4de2ed49a072020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 1V, positive-QTOFsplash10-000i-0900000000-2383d4ee95382a0952b42020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 1V, positive-QTOFsplash10-000i-1900000000-ca585604bb3faa20d6322020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 1V, positive-QTOFsplash10-000i-3900000000-20e6d7b7102f8bdf9f6d2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 2V, positive-QTOFsplash10-000l-6900000000-d6abf363e740f987060b2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 2V, positive-QTOFsplash10-000f-9700000000-6f1719ddcb978f3fb5dd2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 2V, positive-QTOFsplash10-0006-9400000000-0db109b7fd166bbe90d12020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 3V, positive-QTOFsplash10-0006-9300000000-6f9e7848042fb2b00b422020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 3V, positive-QTOFsplash10-0006-9200000000-0fc13e19d4cc0935a41b2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 4V, positive-QTOFsplash10-0006-9100000000-4395f34d6dbb3a0be7582020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 5V, positive-QTOFsplash10-0006-9100000000-f6347495cdf25ea928712020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 6V, positive-QTOFsplash10-0006-9000000000-b8660d839b89a1828fd92020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 8V, positive-QTOFsplash10-0006-9000000000-bb4d952e3112de0fa8552020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 9V, positive-QTOFsplash10-0006-9000000000-5093f4a070434d834dbc2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine Orbitrap 11V, positive-QTOFsplash10-0006-9000000000-41f3edda74912fc48e092020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Betahistine n/a 9V, positive-QTOFsplash10-0006-9100000000-ec255d8163bfe16ea6932020-07-22HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 10V, Positive-QTOFsplash10-052r-0900000000-7f0e238dc7925ca025bc2016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 20V, Positive-QTOFsplash10-0a4r-1900000000-a73b4f9a37585a7631d82016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 40V, Positive-QTOFsplash10-0a6r-9400000000-bdcba572bab1c36614c52016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 10V, Negative-QTOFsplash10-000i-1900000000-5462e3c317b1d05012d92016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 20V, Negative-QTOFsplash10-000i-4900000000-257c19b6692facdce66a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 40V, Negative-QTOFsplash10-0006-9100000000-d813ddb1dd9b7470131f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 10V, Positive-QTOFsplash10-0a4r-1900000000-a399e016fa279418d20c2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 20V, Positive-QTOFsplash10-052f-9400000000-33e9b78ab853fa5c9d3a2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Betahistine 40V, Positive-QTOFsplash10-0006-9100000000-5c82222d49c9fd329ef92021-10-11Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB06698 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB06698 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB06698
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID2276
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkBetahistine
METLIN IDNot Available
PubChem Compound2366
PDB IDNot Available
ChEBI ID35677
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Health Canada [Link]

Enzymes

General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization
Gene Name:
HRH3
Uniprot ID:
Q9Y5N1
Molecular weight:
48670.8
References
  1. Barak N: Betahistine: what's new on the agenda? Expert Opin Investig Drugs. 2008 May;17(5):795-804. doi: 10.1517/13543784.17.5.795 . [PubMed:18447604 ]
  2. Lacour M, Sterkers O: Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs. 2001;15(11):853-70. [PubMed:11700150 ]
  3. Gbahou F, Davenas E, Morisset S, Arrang JM: Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo. J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54. doi: 10.1124/jpet.110.168633. Epub 2010 Jun 8. [PubMed:20530654 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular weight:
55783.6
References
  1. Barak N: Betahistine: what's new on the agenda? Expert Opin Investig Drugs. 2008 May;17(5):795-804. doi: 10.1517/13543784.17.5.795 . [PubMed:18447604 ]
  2. Lacour M, Sterkers O: Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs. 2001;15(11):853-70. [PubMed:11700150 ]