1. (-)-Fucose
2. (-)-L-Fucose
3. 6-Deoxy-D-galactopyranose
4. 6-Deoxy-L-beta-galactose
5. 6-Deoxy-L-galactopyranose
6. 6-Deoxy-L-galactose
7. 6-Deoxy-beta-galactose
8. 6-Desoxygalactose
9. 6-methyltetrahydropyran-2,3,4,5-tetraol
10. Fucose
11. L-(-)-Fucose
12. L-Fucose
13. L-Galactomethylose
14. Rhodeose
15. 6-Deoxy-delta-galactopyranose
16. isodulcit
17. L-fucopyranose
18. D-threo-Aldose
19. 6-methyloxane-2,3,4,5-tetrol

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• Cytoplasm
• Extracellular
• lysosome

• Blood
• Breast Milk
• Urine

1. Havenaar EC, Hoff RC, van den Eijnden DH, van Dijk W: Sialyl Lewis(x) epitopes do not occur on acute phase proteins in mice: relationship to the absence of alpha3-fucosyltransferase in the liver. Glycoconj J. 1998 Apr;15(4):389-95. [PubMed ]
2. Roelfzema H, van Erp PE: Studies on the plasma membrane of normal and psoriatic keratinocytes. 6. Cell surface and shed glycoproteins. J Invest Dermatol. 1983 Jan;80(1):24-6. [PubMed ]
3. Nakagawa F, Schulte BA, Spicer SS: Lectin cytochemical evaluation of somatosensory neurons and their peripheral and central processes in rat and man. Cell Tissue Res. 1986;245(3):579-89. [PubMed ]
4. Wiese TJ, Dunlap JA, Yorek MA: Effect of L-fucose and D-glucose concentration on L-fucoprotein metabolism in human Hep G2 cells and changes in fucosyltransferase and alpha-L-fucosidase activity in liver of diabetic rats. Biochim Biophys Acta. 1997 Apr 17;1335(1-2):61-72. [PubMed ]
5. Isnard N, Fodil-Bourahla I, Robert AM, Robert L: Pharmacology of skin aging. Stimulation of glycosaminoglycan biosynthesis by L-fucose and fucose-rich polysaccharides, effect of in vitro aging of fibroblasts. Biomed Pharmacother. 2004 Apr;58(3):202-4. [PubMed ]
6. Rizzi M, Tonetti M, Vigevani P, Sturla L, Bisso A, Flora AD, Bordo D, Bolognesi M: GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from Escherichia coli, a key enzyme in the biosynthesis of GDP-L-fucose, displays the structural characteristics of the RED protein homology superfamily. Structure. 1998 Nov 15;6(11):1453-65. [PubMed ]
7. Gheri G, Sgambati E, Thyrion GD, Vichi D, Orlandini GE: The oligosaccharidic content of the glycoconjugates of the prepubertal descended and undescended testis: lectin histochemical study. Ital J Anat Embryol. 2004 Apr-Jun;109(2):69-84. [PubMed ]
8. Fediv OI, Kolomoiets' MIu: [Role of cytokines in the metabolism of the extracellular matrix carbohydrate-protein components in patients of various ages with gastroduodenal ulcer] Lik Sprava. 2001 Jul-Aug;(4):181-2. [PubMed ]
9. Hutchinson WL, Du MQ, Johnson PJ, Williams R: Fucosyltransferases: differential plasma and tissue alterations in hepatocellular carcinoma and cirrhosis. Hepatology. 1991 Apr;13(4):683-8. [PubMed ]
10. Fleischer M, Przondo-Mordarska A: [Adhesins of Acinetobacter strains] Med Dosw Mikrobiol. 1998;50(3-4):229-37. [PubMed ]
11. Condaminet B, Peguet-Navarro J, Stahl PD, Dalbiez-Gauthier C, Schmitt D, Berthier-Vergnes O: Human epidermal Langerhans cells express the mannose-fucose binding receptor. Eur J Immunol. 1998 Nov;28(11):3541-51. [PubMed ]
12. Gohlke M, Baude G, Nuck R, Grunow D, Kannicht C, Bringmann P, Donner P, Reutter W: O-linked L-fucose is present in Desmodus rotundus salivary plasminogen activator. J Biol Chem. 1996 Mar 29;271(13):7381-6. [PubMed ]
13. Chien CM, Cheng JL, Chang WT, Tien MH, Tsao CM, Chang YH, Chang HY, Hsieh JF, Wong CH, Chen ST: Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. Bioorg Med Chem. 2004 Nov 1;12(21):5603-9. [PubMed ]
14. Hanisch FG, Heimbuchel G, Baldus SE, Uhlenbruck G, Schmits R, Pfreundschuh M, Schwonzen M, Vierbuchen M, Bara J, Peter-Katalinic J: Monoclonal antibody FW6 defines an epitope on alpha 3/4-monofucosylated polylactosaminoglycans expressed by fetal and colon carcinoma-associated mucins. Cancer Res. 1993 Sep 15;53(18):4367-75. [PubMed ]
15. Tonetti M, Sturla L, Bisso A, Zanardi D, Benatti U, De Flora A: The metabolism of 6-deoxyhexoses in bacterial and animal cells. Biochimie. 1998 Nov;80(11):923-31. [PubMed ]
16. Sato T, Sato M, Kiyohara K, Sogabe M, Shikanai T, Kikuchi N, Togayachi A, Ishida H, Ito H, Kameyama A, Gotoh M, Narimatsu H: Molecular cloning and characterization of a novel human {beta}1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain. Glycobiology. 2006 Dec;16(12):1194-1206. Epub 2006 Aug 9. [PubMed ]
17. Coyne MJ, Reinap B, Lee MM, Comstock LE: Human symbionts use a host-like pathway for surface fucosylation. Science. 2005 Mar 18;307(5716):1778-81. [PubMed ]
18. Quirk S, Seley KL: Substrate discrimination by the human GTP fucose pyrophosphorylase. Biochemistry. 2005 Aug 16;44(32):10854-63. [PubMed ]
19. Bathi RJ, Nandimath K, Kannan N, Shetty P: Evaluation of glycoproteins as prognosticators in head and neck malignancy. Indian J Dent Res. 2001 Apr-Jun;12(2):93-9. [PubMed ]
20. Nicholson JK, Foxall PJ, Spraul M, Farrant RD, Lindon JC: 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. Anal Chem. 1995 Mar 1;67(5):793-811. [PubMed ]
21. Wikipedia

1. L-fucose kinase
2. Tissue alpha-L-fucosidase precursor
3. Plasma alpha-L-fucosidase precursor

1. Fucokinase

MEQPKGVDWTVIILTCQYKDSVQVFQRELEVRQKREQIPAGTLLLAVEDPEKRVGSGGAT
LNALLVAAEHLSARAGFTVVTSDVLHSAWILILHMGRDFPFDDCGRAFTCLPVENPEAPV
EALVCNLDCLLDIMTYRLGPGSPPGVWVCSTDMLLSVPANPGISWDSFRGARVIALPGSP
AYAQNHGVYLTDPQGLVLDIYYQGTEAEIQRCVRPDGRVPLVSGVVFFSVETAERLLATH
VSPPLDACTYLGLDSGARPVQLSLFFDILHCMAENVTREDFLVGRPPELGQGDADVAGYL
QSARAQLWRELRDQPLTMAYVSSGSYSYMTSSASEFLLSLTLPGAPGAQIVHSQVEEQQL
LAAGSSVVSCLLEGPVQLGPGSVLQHCHLQGPIHIGAGCLVTGLDTAHSKALHGRELRDL
VLQGHHTRLHGSPGHAFTLVGRLDSWERQGAGTYLNVPWSEFFKRTGVRAWDLWDPETLP
AEYCLPSARLFPVLHPSRELGPQDLLWMLDHQEDGGEALRAWRASWRLSWEQLQPCLDRA
ATLASRRDLFFRQALHKARHVLEARQDLSLRPLIWAAVREGCPGPLLATLDQVAAGAGDP
GVAARALACVADVLGCMAEGRGGLRSGPAANPEWMRPFSYLECGDLAAGVEALAQERDKW
LSRPALLVRAARHYEGAGQILIRQAVMSAQHFVSTEQVELPGPGQWVVAECPARVDFSGG
WSDTPPLAYELGGAVLGLAVRVDGRRPIGARARRIPEPELWLAVGPRQDEMTVKIVCRCL
ADLRDYCQPHAPGALLKAAFICAGIVHVHSELQLSEQLLRTFGGGFELHTWSELPHGSGL
GTSSILAGTALAALQRAAGRVVGTEALIHAVLHLEQVLTTGGGWQDQVGGLMPGIKVGRS
RAQLPLKVEVEEVTVPEGFVQKLNDHLLLVYTGKTRLARNLLQDVLRSWYARLPAVVQNA
HSLVRQTEECAEGFRQGSLPLLGQCLTSYWEQKKLMAPGCEPLTVRRMMDVLAPHVHGQS
LAGAGGGGFLYLLTKEPQQKEALEAVLAKTEGLGNYSIHLVEVDTQGLSLKLLGTEASTC
CPFP

• Fructose and Mannose Metabolism (map00051 )

• ATP + L-fucose = ADP + beta-L-fucose 1-phosphate

• Fucokinase (PF07959 )
• GHMP_kinases_C (PF08544 )
• GHMP_kinases_N (PF00288 )

• None

• None

ATGGGTCGAGACTTCCCCTTTGATGACTGTGGCAGGGCTTTCACCTGCCTCCCCGTGGAG
AACCCCGAGGCCCCCGTGGAAGCCTTGGTCTGCAACCTGGACTGCCTGCTGGACATCATG
ACCTATCGGCTGGGCCCGGGCTCCCCGCCAGGCGTGTGGGTCTGCAGCACCGACATGCTG
CTGTCTGTTCCTGCAAATCCTGGTATCAGCTGGGACAGCTTCCGGGGAGCCAGAGTGATC
GCCCTCCCAGGGAGCCCGGCCTACGCTCAGAATCATGGCGTCTACCTAACTGACCCCCAG
GGCCTTGTTTTGGACATTTACTACCAGGGCACTGAGGCAGAGATTCAGCGGTGTGTCAGG
CCTGATGGGCGGGTGCCACTGGTCTCTGGGGTTGTCTTCTTCTCTGTGGAGACTGCCGAG
CGCCTCCTAGCCACCCACGTGAGCCCGCCCCTGGATGCCTGCACCTACCTAGGCTTGGAC
TCCGGAGCCCGGCCTGTCCAGCTGTCTCTGTTTTTTGACATTCTCCACTGCATGGCTGAG
AACGTGACCAGGGAGGACTTCCTGGTGGGGAGGCCCCCAGAGTTGGGGCAAGGCGATGCA
GATGTAGCGGGTTATCTGCAGAGCGCCCGGGCCCAGCTGTGGAGGGAGCTTCGCGATCAG
CCCCTTACCATGGCCTATGTCTCCAGCGGCAGCTACAGCTACATGACCTCCTCAGCCAGT
GAGTTCCTGCTCAGCCTCACACTCCCCGGGGCTCCTGGGGCCCAGATTGTGCACTCCCAG
GTGGAGGAGCAGCAGCTTCTGGCGGCCGGGAGCTCTGTGGTCAGCTGCCTGCTGGAGGGC
CCTGTCCAGCTGGGTCCTGGGAGCGTCCTGCAGCACTGCCACCTGCAGGGCCCCATTCAC
ATAGGCGCTGGCTGCTTGGTGACTGGCCTGGATACAGCCCACTCCAAGGCCCTGCATGGC
CGGGAGCTGCGTGACCTTGTCCTGCAGGGACACCACACGCGGCTACACGGCTCCCCGGGC
CACGCCTTCACCCTCGTTGGCCGTCTGGACAGCTGGGAGAGACAGGGGGCAGGCACATAT
CTCAACGTGCCCTGGAGTGAATTCTTCAAGAGGACAGGTGTTCGAGCCTGGGACCTGTGG
GACCCCGAGACGCTGCCCGCAGAGTACTGCCTTCCCAGCGCCCGCCTCTTTCCTGTGCTC
CACCCCTCGAGGGAGCTGGGACCCCAGGACCTGCTGTGGATGCTGGACCACCAGGAGGAT
GGGGGCGAGGCCCTGCGAGCCTGGCGGGCCTCCTGGCGCCTGTCCTGGGAGCAGCTGCAG
CCGTGCCTGGATCGGGCTGCCACGCTGGCCTCTCGCCGGGACCTGTTCTTCCGCCAGGCC
CTGCATAAGGCGCGGCACGTGCTGGAGGCCCGGCAGGACCTCAGCCTGCGCCCGCTGATC
TGGGCTGCTGTCCGCGAGGGCTGCCCCGGGCCCCTGCTGGCCACGCTGGACCAGGTTGCA
GCTGGGGCAGGAGACCCTGGTGTGGCGGCACGGGCACTGGCCTGTGTGGCGGACGTCCTG
GGCTGCATGGCAGAGGGCCGTGGGGGCTTGCGGAGCGGGCCAGCTGCCAACCCTGAGTGG
ATGCGGCCCTTCTCATACCTGGAGTGTGGAGACCTGGCAGCGGGCGTGGAGGCGCTTGCC
CAGGAGAGGGACAAGTGGCTAAGCAGGCCAGCCTTGCTGGTGCGAGCGGCCCGCCACTAT
GAGGGGGCTGGTCAGATCCTGATCCGCCAGGCTGTGATGTCAGCCCAGCACTTTGTCTCC
ACAGAGCAGGTGGAACTGCCGGGACCTGGGCAGTGGGTGGTGGCTGAGTGCCCGGCCCGT
GTGGATTTCTCTGGGGGCTGGAGTGACACGCCACCCCTTGCCTATGAGCTTGGCGGGGCT
GTGCTGGGCCTGGCTGTGCGAGTGGACGGCCGCCGGCCCATCGGAGCCAGGGCACGCCGC
ATCCCGGAGCCTGAGCTGTGGCTGGCGGTGGGGCCTCGGCAGGATGAGATGACTGTGAAG
ATAGTGTGCCGGTGCCTGGCTGACCTGCGGGACTACTGCCAGCCTCATGCCCCAGGGGCC
CTGCTGAAGGCGGCCTTCATCTGTGCAGGGATCGTGCATGTCCACTCGGAACTCCAGCTG
AGTGAGCAGCTGCTCCGCACCTTCGGGGGCGGCTTTGAGCTGCACACCTGGTCTGAGCTG
CCCCACGGCTCTGGCCTGGGCACCAGCAGCATCCTGGCAGGCACTGCCCTGGCTGCCTTG
CAGCGAGCCGCAGGCCGGGTGGTGGGCACGGAAGCCCTGATCCACGCAGTGCTGCACCTG
GAGCAGGTGCTCACCACTGGAGGTGGCTGGCAGGACCAAGTAGGTGGCCTAATGCCTGGC
ATCAAGGTGGGGCGCTCCCGGGCTCAGCTGCCACTGAAGGTGGAGGTAGAAGAGGTCACG
GTGCCTGAGGGCTTTGTCCAGAAGCTCAATGACCACCTGCTCTTGGTGTACACTGGCAAG
ACCCGCCTGGCTCGGAACCTGCTGCAGGATGTGCTGAGGAGCTGGTATGCCCGACTTCCT
GCTGTGGTGCAGAATGCCCACAGCCTGGTACGGCAAACTGAGGAGTGTGCTGAAGGCTTC
CGCCAAGGAAGCCTGCCTCTGCTGGGCCAGTGCCTGACCTCGTACTGGGAGCAGAAGAAG
CTCATGGCTCCAGGCTGTGAGCCCCTGACTGTGCGGCGTATGATGGATGTCCTGGCCCCC
CACGTGCATGGCCAGAGCCTGGCTGGGGCAGGCGGTGGAGGCTTTCTCTATCTGTTGACC
AAGGAGCCACAGCAAAAGGAGGCCTTGGAGGCGGTGCTGGCCAAGACCGAGGGCCTTGGG
AATTACAGCATCCACCTGGTTGAAGTGGACACTCAGGGCCTGAGCCTGAAGCTGCTGGGG
ACCGAGGCCTCAACCTGTTGCCCTTTCCCATGA

1. Hinderlich S, Berger M, Blume A, Chen H, Ghaderi D, Bauer C: Identification of human L-fucose kinase amino acid sequence. Biochem Biophys Res Commun. 2002 Jun 14;294(3):650-4. [PubMed ]

1. Alpha-L-fucosidase I
2. Alpha-L-fucoside fucohydrolase

MRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWG
VFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQ
AAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSL
LEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNF
LSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWG
YRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSIN
GEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLG
IQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK

• N-Glycan degradation (map00511 )

• an alpha-L-fucoside + H2O = L-fucose + an alcohol

• Alpha_L_fucos (PF01120 )

• 1-26

ATGAGGTCGCGGCCGGCGGGTCCCGCGCTGTTGCTGCTGCTGCTCTTCCTCGGAGCGGCC
GAGTCGGTGCGTCGGGCCCAGCCTCCGCGCCGCTACACCCCAGACTGGCCGAGCCTGGAT
TCTCGGCCGCTGCCGGCCTGGTTCGACGAAGCCAAGTTCGGGGTGTTCATCCACTGGGGC
GTGTTCTCGGTGCCCGCCTGGGGCAGCGAGTGGTTCTGGTGGCACTGGCAGGGCGAGGGG
CGGCCGCAGTACCAGCGCTTCATGCGCGACAACTACCCGCCCGGCTTCAGCTACGCCGAC
TTCGGACCGCAGTTCACTGCGCGCTTCTTCCACCCGGAGGAGTGGGCCGACCTCTTCCAG
GCCGCGGGCGCCAAGTATGTAGTTTTGACGACAAAGCATCACGAAGGCTTCACAAACTGG
CCGAGTCCTGTGTCTTGGAACTGGAACTCCAAAGACGTGGGGCCTCATCGGGATTTGGTT
GGTGAATTGGGAACAGCTCTCCGGAAGAGGAACATCCGCTATGGACTATACCACTCACTC
TTAGAGTGGTTCCATCCACTCTATCTACTTGATAAGAAAAATGGCTTCAAAACACAGCAT
TTTGTCAGTGCAAAAACAATGCCAGAGCTGTACGACCTTGTTAACAGCTATAAACCTGAT
CTGATCTGGTCTGATGGGGAGTGGGAATGTCCTGATACTTACTGGAACTCCACAAATTTT
CTTTCATGGCTCTACAATGACAGCCCTGTCAAGGATGAGGTGGTAGTAAATGACCGATGG
GGTCAGAACTCTTCCTGTCACCATGGAGGATACTATAACTGTGAAGATAAATTCAAGCCA
CAGAGCTTGCCAGATCACAAGTGGGAGATGTGCACCAGCATTGACAAGTTTTCCTGGGGC
TATCGTCGTGACATGGCATTGTCTGATGTTACAGAAGAATCTGAAATCATTTCGGAACTG
GTTCAGACAGTAAGTTTGGGAGGCAACTATCTTCTGAACATTGGACCAACTAAAGATGGA
CTGATTGTTCCCATCTTCCAAGAAAGGCTTCTTGCTGTTGGGAAATGGCTGAGCATCAAT
GGGGAGGCTATCTATGCCTCCAAACCATGGCGGGTGCAATGGGAAAAGAACACAACATCT
GTATGGTATACCTCAAAGGGATCGGCTGTTTATGCCATTTTTCTGCACTGGCCAGAAAAT
GGAGTCTTAAACCTTGAATCCCCCATAACTACCTCAACTACAAAGATAACAATGCTGGGA
ATTCAAGGAGATCTGAAGTGGTCCACAGATCCAGATAAAGGTCTCTTCATCTCTCTACCC
CAGTTGCCACCCTCTGCTGTCCCCGCAGAGTTTGCTTGGACTATAAAGCTGACAGGAGTG
AAGTAA

1. Occhiodoro T, Beckmann KR, Morris CP, Hopwood JJ: Human alpha-L-fucosidase: complete coding sequence from cDNA clones. Biochem Biophys Res Commun. 1989 Oct 16;164(1):439-45. [PubMed ]
2. Seo HC, Willems PJ, Kretz KA, Martin BM, O'Brien JS: Fucosidosis: four new mutations and a new polymorphism. Hum Mol Genet. 1993 Apr;2(4):423-9. [PubMed ]
3. Fukushima H, Nishimoto J, Okada S: Sequencing and expression of a full-length cDNA for human alpha-L-fucosidase. J Inherit Metab Dis. 1990;13(5):761-5. [PubMed ]
4. de Wet JR, Fukushima H, Dewji NN, Wilcox E, O'Brien JS, Helinski DR: Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA. 1984 Dec;3(6):437-47. [PubMed ]
5. Fukushima H, de Wet JR, O'Brien JS: Molecular cloning of a cDNA for human alpha-L-fucosidase. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1262-5. [PubMed ]
6. O'Brien JS, Willems PJ, Fukushima H, de Wet JR, Darby JK, Di Cioccio R, Fowler ML, Shows TB: Molecular biology of the alpha-L-fucosidase gene and fucosidosis. Enzyme. 1987;38(1-4):45-53. [PubMed ]
7. Willems PJ, Seo HC, Coucke P, Tonlorenzi R, O'Brien JS: Spectrum of mutations in fucosidosis. Eur J Hum Genet. 1999 Jan;7(1):60-7. [PubMed ]
8. Yang M, Allen H, DiCioccio RA: Pedigree analysis of alpha-L-fucosidase gene mutations in a fucosidosis family. Biochim Biophys Acta. 1993 Oct 20;1182(3):245-9. [PubMed ]
9. Seo HC, Yang M, Tonlorenzi R, Willems PJ, Kim AH, Filocamo M, Gatti R, DiCioccio RA, O'Brien JS: A missense mutation (S63L) in alpha-L-fucosidase is responsible for fucosidosis in an Italian patient. Hum Mol Genet. 1994 Nov;3(11):2065-6. [PubMed ]
10. Cragg H, Winchester B, Seo HC, O'Brien J, Swallow D: Molecular basis of the common electrophoretic polymorphism (Fu1/Fu2) in human alpha-L-fucosidase. J Med Genet. 1994 Aug;31(8):659-60. [PubMed ]
11. Fleming CJ, Sinclair DU, White EJ, Winchester B, Whiteford ML, Connor JM: A fucosidosis patient with relative longevity and a missense mutation in exon 7 of the alpha-fucosidase gene. J Inherit Metab Dis. 1998 Aug;21(6):688-9. [PubMed ]
12. Ip P, Goh W, Chan KW, Cheung PT: A novel FUCA1 mutation causing fucosidosis in a Chinese boy. J Inherit Metab Dis. 2002 Sep;25(5):415-6. [PubMed ]

1. Alpha-L-fucosidase 2
2. Alpha-L-fucoside fucohydrolase 2

MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIH
WGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADI
FQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLY
YSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNS
TGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKL
SWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQVGSWL
KVNGEAIYETYTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGAT
EVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI

• N-Glycan degradation (map00511 )

• an alpha-L-fucoside + H2O = L-fucose + an alcohol

• Alpha_L_fucos (PF01120 )

• 1-28

ATGCGGCCCCAGGAGCTCCCCAGGCTCGCGTTCCCGTTGCTGCTGTTGCTGTTGCTGCTG
CTGCCGCCGCCGCCGTGCCCTGCCCACAGCGCCACGCGCTTCGACCCCACCTGGGAGTCC
CTGGACGCCCGCCAGCTGCCCGCGTGGTTTGACCAGGCCAAGTTCGGCATCTTCATCCAC
TGGGGAGTGTTTTCCGTGCCCAGCTTCGGTAGCGAGTGGTTCTGGTGGTATTGGCAAAAG
GAAAAGATACCGAAGTATGTGGAATTTATGAAAGATAATTACCCTCCTAGTTTCAAATAT
GAAGATTTTGGACCACTATTTACAGCAAAATTTTTTAATGCCAACCAGTGGGCAGATATT
TTTCAGGCCTCTGGTGCCAAATACATTGTCTTAACTTCCAAACATCATGAAGGCTTTACC
TTGTGGGGGTCAGAATATTCGTGGAACTGGAATGCCATAGATGAGGGGCCCAAGAGGGAC
ATTGTCAAGGAACTTGAGGTAGCCATTAGGAACAGAACTGACCTGCGTTTTGGACTGTAC
TATTCCCTTTTTGAATGGTTTCATCCGCTCTTCCTTGAGGATGAATCCAGTTCATTCCAT
AAGCGGCAATTTCCAGTTTCTAAGACATTGCCAGAGCTCTATGAGTTAGTGAACAACTAT
CAGCCTGAGGTTCTGTGGTCGGATGGTGACGGAGGAGCACCGGATCAATACTGGAACAGC
ACAGGCTTCTTGGCCTGGTTATATAATGAAAGCCCAGTTCGGGGCACAGTAGTCACCAAT
GATCGTTGGGGAGCTGGTAGCATCTGTAAGCATGGTGGCTTCTATACCTGCAGTGATCGT
TATAACCCAGGACATCTTTTGCCACATAAATGGGAAAACTGCATGACAATAGACAAACTG
TCCTGGGGCTATAGGAGGGAAGCTGGAATCTCTGACTATCTTACAATTGAAGAATTGGTG
AAGCAACTTGTAGAGACAGTTTCATGTGGAGGAAATCTTTTGATGAATATTGGGCCCACA
CTAGATGGCACCATTTCTGTAGTTTTTGAGGAGCGACTGAGGCAAGTGGGGTCCTGGCTA
AAAGTCAATGGAGAAGCTATTTATGAAACCTATACCTGGCGATCCCAGAACGACACTGTC
ACCCCAGATGTGTGGTACACATCCAAGCCTAAAGAAAAATTAGTCTATGCCATTTTTCCT
AAATGGCCCACATCAGGACAGCTGTTCCTTGGCCATCCCAAAGCTATTCTGGGGGCAACA
GAGGTGAAACTACTGGGCCATGGACAGCCACTTAACTGGATTTCTTTGGAGCAAAATGGC
ATTATGGTAGAACTGCCACAGCTAACCATTCATCAGATGCCGTGTAAATGGGGCTGGGCT
CTAGCCCTAACTAATGTGATCTAA

1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed ]
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