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Record Information

Version

5.0

Status

Detected but not Quantified

Creation Date

2012-09-06 21:03:17 UTC

Update Date

2022-09-22 18:34:22 UTC

HMDB ID

HMDB0028995

Secondary Accession Numbers

HMDB28995

Metabolite Identification

Common Name

Phenylalanylglycine

Description

Phenylalanylglycine is a dipeptide composed of phenylalanine and glycine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0028995
     RDKit          3D
Phenylalanylglycine
 30 30  0  0  0  0  0  0  0  0999 V2000
   -0.2753   -2.4242   -0.2802 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2080   -1.1285   -0.5242 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3541   -0.0228    0.2777 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8015    0.2340    0.1361 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5982   -0.2295   -0.8492 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9446    0.1246   -0.9888 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4627    1.0041   -0.0410 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6547    1.4934    0.9737 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3527    1.0997    1.0378 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6771   -1.0395   -0.4236 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3672   -1.5855   -1.3444 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3415   -0.3519    0.6692 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7650   -0.3370    0.6283 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3090    0.9863    0.2449 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4492    1.2732    0.6597 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5926    1.8914   -0.5191 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2827   -2.6940    0.7064 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0338   -3.1693   -0.9574 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0539   -0.9205   -1.6455 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2304    0.9088    0.0928 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2030   -0.3099    1.3666 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1177   -0.9019   -1.5717 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5885   -0.2654   -1.7272 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4737    1.3417   -0.0793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0736    2.1742    1.7147 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7416    1.5106    1.8699 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7808    0.1113    1.3729 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2204   -0.5586    1.6629 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1957   -1.1037   -0.0287 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8751    2.8893   -0.4147 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  2 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
  9  4  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  6
  3 20  1  0
  3 21  1  0
  5 22  1  0
  6 23  1  0
  7 24  1  0
  8 25  1  0
  9 26  1  0
 12 27  1  0
 13 28  1  0
 13 29  1  0
 16 30  1  0
M  END

  Mrv1652304062014052D          

 16 16  0  0  0  0            999 V2000
 9998.937910000.3927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.6525 9999.9804    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10000.366410000.3927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.0818 9999.9804    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10001.797210000.3927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.5105 9999.9804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10003.225910000.3927    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10002.5105 9999.1561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.366410001.2174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.6525 9999.1561    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9998.2230 9999.9806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.508610000.3930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.7941 9999.9805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.7940 9999.1555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.5085 9998.7430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.2231 9999.1556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2 10  1  1  0  0  0
  3  4  1  0  0  0  0
  3  9  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 11  1  0  0  0  0
  1 11  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0028995

> <DATABASE_NAME>
hmdb

> <SMILES>
N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C11H14N2O3/c12-9(11(16)13-7-10(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15)/t9-/m0/s1

> <INCHI_KEY>
GLUBLISJVJFHQS-VIFPVBQESA-N

> <FORMULA>
C11H14N2O3

> <MOLECULAR_WEIGHT>
222.244

> <EXACT_MASS>
222.100442319

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
30

> <JCHEM_AVERAGE_POLARIZABILITY>
22.764249288715025

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-[(2S)-2-amino-3-phenylpropanamido]acetic acid

> <ALOGPS_LOGP>
-0.90

> <JCHEM_LOGP>
-2.292126300574983

> <ALOGPS_LOGS>
-2.45

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.399565245921018

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.709022259922749

> <JCHEM_PKA_STRONGEST_BASIC>
8.010007600994834

> <JCHEM_POLAR_SURFACE_AREA>
92.42

> <JCHEM_REFRACTIVITY>
57.91980000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
7.82e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
[(2S)-2-amino-3-phenylpropanamido]acetic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0028995
     RDKit          3D
Phenylalanylglycine
 30 30  0  0  0  0  0  0  0  0999 V2000
   -0.2753   -2.4242   -0.2802 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2080   -1.1285   -0.5242 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3541   -0.0228    0.2777 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8015    0.2340    0.1361 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5982   -0.2295   -0.8492 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9446    0.1246   -0.9888 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4627    1.0041   -0.0410 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6547    1.4934    0.9737 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3527    1.0997    1.0378 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6771   -1.0395   -0.4236 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3672   -1.5855   -1.3444 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3415   -0.3519    0.6692 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7650   -0.3370    0.6283 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3090    0.9863    0.2449 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4492    1.2732    0.6597 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5926    1.8914   -0.5191 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2827   -2.6940    0.7064 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0338   -3.1693   -0.9574 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0539   -0.9205   -1.6455 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2304    0.9088    0.0928 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2030   -0.3099    1.3666 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1177   -0.9019   -1.5717 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5885   -0.2654   -1.7272 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4737    1.3417   -0.0793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0736    2.1742    1.7147 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7416    1.5106    1.8699 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7808    0.1113    1.3729 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2204   -0.5586    1.6629 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1957   -1.1037   -0.0287 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8751    2.8893   -0.4147 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  2 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
  9  4  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  6
  3 20  1  0
  3 21  1  0
  5 22  1  0
  6 23  1  0
  7 24  1  0
  8 25  1  0
  9 26  1  0
 12 27  1  0
 13 28  1  0
 13 29  1  0
 16 30  1  0
M  END

HEADER    PROTEIN                                 06-APR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-APR-20         0                                  
HETATM    1  C   UNK     0    8664.6848667.400   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8666.0188666.630   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8667.3518667.400   0.000  0.00  0.00           C+0
HETATM    4  N   UNK     0    8668.6868666.630   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0    8670.0218667.400   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0    8671.3538666.630   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0    8672.6888667.400   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0    8671.3538665.091   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0    8667.3518668.939   0.000  0.00  0.00           O+0
HETATM   10  N   UNK     0    8666.0188665.091   0.000  0.00  0.00           N+0
HETATM   11  C   UNK     0    8663.3508666.630   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8662.0168667.400   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0    8660.6828666.630   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0    8660.6828665.090   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0    8662.0168664.320   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0    8663.3508665.090   0.000  0.00  0.00           C+0
CONECT    1    2   11                                                       
CONECT    2    1    3   10                                                  
CONECT    3    2    4    9                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6                                                            
CONECT    9    3                                                            
CONECT   10    2                                                            
CONECT   11   12   16    1                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   11                                                       
MASTER        0    0    0    0    0    0    0    0   16    0   32    0
END

COMPND    HMDB0028995
HETATM    1  N1  UNL     1      -0.275  -2.424  -0.280  1.00  0.00           N  
HETATM    2  C1  UNL     1       0.208  -1.128  -0.524  1.00  0.00           C  
HETATM    3  C2  UNL     1      -0.354  -0.023   0.278  1.00  0.00           C  
HETATM    4  C3  UNL     1      -1.802   0.234   0.136  1.00  0.00           C  
HETATM    5  C4  UNL     1      -2.598  -0.229  -0.849  1.00  0.00           C  
HETATM    6  C5  UNL     1      -3.945   0.125  -0.989  1.00  0.00           C  
HETATM    7  C6  UNL     1      -4.463   1.004  -0.041  1.00  0.00           C  
HETATM    8  C7  UNL     1      -3.655   1.493   0.974  1.00  0.00           C  
HETATM    9  C8  UNL     1      -2.353   1.100   1.038  1.00  0.00           C  
HETATM   10  C9  UNL     1       1.677  -1.039  -0.424  1.00  0.00           C  
HETATM   11  O1  UNL     1       2.367  -1.586  -1.344  1.00  0.00           O  
HETATM   12  N2  UNL     1       2.342  -0.352   0.669  1.00  0.00           N  
HETATM   13  C10 UNL     1       3.765  -0.337   0.628  1.00  0.00           C  
HETATM   14  C11 UNL     1       4.309   0.986   0.245  1.00  0.00           C  
HETATM   15  O2  UNL     1       5.449   1.273   0.660  1.00  0.00           O  
HETATM   16  O3  UNL     1       3.593   1.891  -0.519  1.00  0.00           O  
HETATM   17  H1  UNL     1      -0.283  -2.694   0.706  1.00  0.00           H  
HETATM   18  H2  UNL     1      -0.034  -3.169  -0.957  1.00  0.00           H  
HETATM   19  H3  UNL     1      -0.054  -0.920  -1.646  1.00  0.00           H  
HETATM   20  H4  UNL     1       0.230   0.909   0.093  1.00  0.00           H  
HETATM   21  H5  UNL     1      -0.203  -0.310   1.367  1.00  0.00           H  
HETATM   22  H6  UNL     1      -2.118  -0.902  -1.572  1.00  0.00           H  
HETATM   23  H7  UNL     1      -4.588  -0.265  -1.727  1.00  0.00           H  
HETATM   24  H8  UNL     1      -5.474   1.342  -0.079  1.00  0.00           H  
HETATM   25  H9  UNL     1      -4.074   2.174   1.715  1.00  0.00           H  
HETATM   26  H10 UNL     1      -1.742   1.511   1.870  1.00  0.00           H  
HETATM   27  H11 UNL     1       1.781   0.111   1.373  1.00  0.00           H  
HETATM   28  H12 UNL     1       4.220  -0.559   1.663  1.00  0.00           H  
HETATM   29  H13 UNL     1       4.196  -1.104  -0.029  1.00  0.00           H  
HETATM   30  H14 UNL     1       3.875   2.889  -0.415  1.00  0.00           H  
CONECT    1    2   17   18
CONECT    2    3   10   19
CONECT    3    4   20   21
CONECT    4    5    5    9
CONECT    5    6   22
CONECT    6    7    7   23
CONECT    7    8   24
CONECT    8    9    9   25
CONECT    9   26
CONECT   10   11   11   12
CONECT   12   13   27
CONECT   13   14   28   29
CONECT   14   15   15   16
CONECT   16   30
END

HMDB0028995
     RDKit          3D
Phenylalanylglycine
 30 30  0  0  0  0  0  0  0  0999 V2000
   -0.2753   -2.4242   -0.2802 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2080   -1.1285   -0.5242 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3541   -0.0228    0.2777 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8015    0.2340    0.1361 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5982   -0.2295   -0.8492 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9446    0.1246   -0.9888 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4627    1.0041   -0.0410 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6547    1.4934    0.9737 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3527    1.0997    1.0378 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6771   -1.0395   -0.4236 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3672   -1.5855   -1.3444 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3415   -0.3519    0.6692 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7650   -0.3370    0.6283 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3090    0.9863    0.2449 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4492    1.2732    0.6597 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5926    1.8914   -0.5191 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2827   -2.6940    0.7064 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0338   -3.1693   -0.9574 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0539   -0.9205   -1.6455 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2304    0.9088    0.0928 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2030   -0.3099    1.3666 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1177   -0.9019   -1.5717 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5885   -0.2654   -1.7272 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4737    1.3417   -0.0793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0736    2.1742    1.7147 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7416    1.5106    1.8699 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7808    0.1113    1.3729 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2204   -0.5586    1.6629 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1957   -1.1037   -0.0287 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8751    2.8893   -0.4147 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  2 10  1  0
 10 11  2  0
 10 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
  9  4  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  6
  3 20  1  0
  3 21  1  0
  5 22  1  0
  6 23  1  0
  7 24  1  0
  8 25  1  0
  9 26  1  0
 12 27  1  0
 13 28  1  0
 13 29  1  0
 16 30  1  0
M  END

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
F-G	ChEBI
FG	ChEBI
L-Phe-gly	ChEBI
F-g Dipeptide	HMDB
FG Dipeptide	HMDB
L-Phenylalanylglycine	HMDB
N-L-Phenylalanylglycine	HMDB
N-Phenylalanylglycine	HMDB
Phe-gly	HMDB
Phenylalanine glycine dipeptide	HMDB
Phenylalanine-glycine dipeptide	HMDB
Phenylalanyl-glycine	HMDB
Phenylalanylglycine	ChEBI

Chemical Formula

C₁₁H₁₄N₂O₃

Average Molecular Weight

222.244

Monoisotopic Molecular Weight

222.100442319

IUPAC Name

2-[(2S)-2-amino-3-phenylpropanamido]acetic acid

Traditional Name

[(2S)-2-amino-3-phenylpropanamido]acetic acid

CAS Registry Number

721-90-4

SMILES

N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O

InChI Identifier

InChI=1S/C11H14N2O3/c12-9(11(16)13-7-10(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15)/t9-/m0/s1

InChI Key

GLUBLISJVJFHQS-VIFPVBQESA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Dipeptides

Alternative Parents

Substituents

Alpha-dipeptide
Phenylalanine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
Alpha-amino acid or derivatives
Amphetamine or derivatives
Aralkylamine
Monocyclic benzene moiety
Fatty amide
Fatty acyl
Benzenoid
Amino acid or derivatives
Carboxamide group
Carboxylic acid salt
Amino acid
Secondary carboxylic acid amide
Monocarboxylic acid or derivatives
Carboxylic acid
Organic salt
Hydrocarbon derivative
Primary aliphatic amine
Organic nitrogen compound
Amine
Organic oxygen compound
Carbonyl group
Organic oxide
Organonitrogen compound
Organooxygen compound
Primary amine
Organopnictogen compound
Organic zwitterion
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

dipeptide (CHEBI:73635 )

Ontology

Not Available

Placenta (HMDB: HMDB0028995)

Excreta

Biofluid or Excreta

Feces (PMID: 27543620)

Source

Endogenous

Endogenous (HMDB: HMDB0028995)

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Process

Not Available

Role

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	-2.29	Extrapolated

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	0.78 g/L	ALOGPS
logP	-0.9	ALOGPS
logP	-2.3	ChemAxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	3.71	ChemAxon
pKa (Strongest Basic)	8.01	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	92.42 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	57.92 m³·mol⁻¹	ChemAxon
Polarizability	22.76 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DeepCCS	[M+H]+	150.043	30932474
DeepCCS	[M-H]-	147.648	30932474
DeepCCS	[M-2H]-	180.763	30932474
DeepCCS	[M+Na]+	155.956	30932474

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Phenylalanylglycine	N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O	3388.8	Standard polar	33892256
Phenylalanylglycine	N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O	1674.2	Standard non polar	33892256
Phenylalanylglycine	N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O	2241.2	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
Phenylalanylglycine,1TMS,isomer #1	C[Si](C)(C)OC(=O)CNC(=O)[C@@H](N)CC1=CC=CC=C1	2135.5	Semi standard non polar	33892256
Phenylalanylglycine,1TMS,isomer #2	C[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O	2164.8	Semi standard non polar	33892256
Phenylalanylglycine,1TMS,isomer #3	C[Si](C)(C)N(CC(=O)O)C(=O)[C@@H](N)CC1=CC=CC=C1	2105.3	Semi standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #1	C[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O[Si](C)(C)C	2151.3	Semi standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #1	C[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O[Si](C)(C)C	2131.0	Standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #2	C[Si](C)(C)OC(=O)CN(C(=O)[C@@H](N)CC1=CC=CC=C1)[Si](C)(C)C	2074.4	Semi standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #2	C[Si](C)(C)OC(=O)CN(C(=O)[C@@H](N)CC1=CC=CC=C1)[Si](C)(C)C	2148.1	Standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #3	C[Si](C)(C)N([C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O)[Si](C)(C)C	2310.7	Semi standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #3	C[Si](C)(C)N([C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O)[Si](C)(C)C	2158.4	Standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #4	C[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O)[Si](C)(C)C	2161.3	Semi standard non polar	33892256
Phenylalanylglycine,2TMS,isomer #4	C[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O)[Si](C)(C)C	2166.8	Standard non polar	33892256
Phenylalanylglycine,3TMS,isomer #1	C[Si](C)(C)OC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C	2269.2	Semi standard non polar	33892256
Phenylalanylglycine,3TMS,isomer #1	C[Si](C)(C)OC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C	2241.6	Standard non polar	33892256
Phenylalanylglycine,3TMS,isomer #2	C[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O[Si](C)(C)C)[Si](C)(C)C	2111.1	Semi standard non polar	33892256
Phenylalanylglycine,3TMS,isomer #2	C[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O[Si](C)(C)C)[Si](C)(C)C	2212.2	Standard non polar	33892256
Phenylalanylglycine,3TMS,isomer #3	C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C	2267.2	Semi standard non polar	33892256
Phenylalanylglycine,3TMS,isomer #3	C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C	2293.2	Standard non polar	33892256
Phenylalanylglycine,4TMS,isomer #1	C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2295.4	Semi standard non polar	33892256
Phenylalanylglycine,4TMS,isomer #1	C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2334.5	Standard non polar	33892256
Phenylalanylglycine,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@@H](N)CC1=CC=CC=C1	2389.7	Semi standard non polar	33892256
Phenylalanylglycine,1TBDMS,isomer #2	CC(C)(C)[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O	2385.9	Semi standard non polar	33892256
Phenylalanylglycine,1TBDMS,isomer #3	CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)[C@@H](N)CC1=CC=CC=C1	2348.2	Semi standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O[Si](C)(C)C(C)(C)C	2609.8	Semi standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O[Si](C)(C)C(C)(C)C	2527.8	Standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)[C@@H](N)CC1=CC=CC=C1)[Si](C)(C)C(C)(C)C	2587.6	Semi standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)[C@@H](N)CC1=CC=CC=C1)[Si](C)(C)C(C)(C)C	2554.3	Standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)N([C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O)[Si](C)(C)C(C)(C)C	2754.3	Semi standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)N([C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O)[Si](C)(C)C(C)(C)C	2546.8	Standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C	2621.4	Semi standard non polar	33892256
Phenylalanylglycine,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C	2558.9	Standard non polar	33892256
Phenylalanylglycine,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2967.0	Semi standard non polar	33892256
Phenylalanylglycine,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2798.3	Standard non polar	33892256
Phenylalanylglycine,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2815.5	Semi standard non polar	33892256
Phenylalanylglycine,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)N[C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2780.8	Standard non polar	33892256
Phenylalanylglycine,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2957.8	Semi standard non polar	33892256
Phenylalanylglycine,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2835.2	Standard non polar	33892256
Phenylalanylglycine,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3153.8	Semi standard non polar	33892256
Phenylalanylglycine,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)[C@H](CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3049.0	Standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - Phenylalanylglycine GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Phenylalanylglycine GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phenylalanylglycine 10V, Positive-QTOF	splash10-00di-1910000000-69f6b703e4914169a960	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phenylalanylglycine 20V, Positive-QTOF	splash10-006x-9400000000-d2f0749424189385b61c	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phenylalanylglycine 40V, Positive-QTOF	splash10-0006-9500000000-990725f616a852839088	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phenylalanylglycine 10V, Negative-QTOF	splash10-00di-1190000000-d9cf02536a5a863769b3	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phenylalanylglycine 20V, Negative-QTOF	splash10-0006-9810000000-3c953bf79faee88c837e	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Phenylalanylglycine 40V, Negative-QTOF	splash10-05bf-9200000000-a42bc5f9b3b0a4113bf4	2021-09-25	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Blood
Feces
Urine

Tissue Locations

Placenta

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	27543620	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	25037050	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	29808030	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Expected but not Quantified	Not Quantified	Not Specified	Not Specified	Cancer patients undergoing total body irradiation	31424920	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal cancer	25037050	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal cancer	27015276	details
Urine	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Cancer patients undergoing total body irradiation	31424920	details

Associated Disorders and Diseases

Disease References

Colorectal cancer

Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]

Associated OMIM IDs

114500 (Colorectal cancer)

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB112015

KNApSAcK ID

Not Available

Chemspider ID

5360444

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

6992303

PDB ID

Not Available

ChEBI ID

73635

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Pingitore F, Wesdemiotis C: Characterization of dipeptide isomers by tandem mass spectrometry of their mono- versus dilithiated complexes. Anal Chem. 2005 Mar 15;77(6):1796-806. [PubMed:15762588 ]
Thirumoorthy K, Soni K, Nandi N: The molecular recognition of dipeptide by oligoglycyl head group of amphiphile: a quantum chemical study. J Nanosci Nanotechnol. 2009 Jan;9(1):77-89. [PubMed:19441281 ]
Epand RM: Virus replication inhibitory peptide inhibits the conversion of phospholipid bilayers to the hexagonal phase. Biosci Rep. 1986 Jul;6(7):647-53. [PubMed:3779040 ]
Storer AC, Angus RH, Carey PR: Comparison of the kinetics of the papain-catalyzed hydrolysis of glycine- and alanine-based esters and thiono esters. Biochemistry. 1988 Jan 12;27(1):264-8. [PubMed:3349032 ]
Li L, Zheng LX, Yang FY: Effect of propensity of hexagonal II phase formation on the activity of mitochondrial ubiquinol-cytochrome c reductase and H(+)-ATPase. Chem Phys Lipids. 1995 Jun 19;76(2):135-44. [PubMed:7634362 ]
Ningsih F, Kitani S, Fukushima E, Nihira T: VisG is essential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine. Microbiology. 2011 Nov;157(Pt 11):3213-20. doi: 10.1099/mic.0.050203-0. Epub 2011 Aug 4. [PubMed:21816878 ]
Kruger RG, Lu W, Oberthur M, Tao J, Kahne D, Walsh CT: Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons. Chem Biol. 2005 Jan;12(1):131-40. [PubMed:15664522 ]
Makowski M, Lisowski M, Maciag A, Wiktor M, Szlachcic A, Lis T: Two pentadehydropeptides with different configurations of the DeltaPhe residues. Acta Crystallogr C. 2010 Mar;66(Pt 3):o119-23. doi: 10.1107/S0108270110003094. Epub 2010 Feb 3. [PubMed:20203407 ]
Fujita T, Morishita Y, Ito H, Kuribayashi D, Yamamoto A, Muranishi S: Enhancement of the small intestinal uptake of phenylalanylglycine via a H+/oligopeptide transport system by chemical modification with fatty acids. Life Sci. 1997;61(25):2455-65. [PubMed:9416764 ]
Yeagle PL, Young J, Hui SW, Epand RM: On the mechanism of inhibition of viral and vesicle membrane fusion by carbobenzoxy-D-phenylalanyl-L-phenylalanylglycine. Biochemistry. 1992 Mar 31;31(12):3177-83. [PubMed:1554703 ]
Varela AS, Bosco Lopez Saez JJ: Utility of serum activity of angiotensin-converting enzyme as a tumor marker. Oncology. 1993 Nov-Dec;50(6):430-5. [PubMed:8233282 ]
Wang P, Polce MJ, Ohanessian G, Wesdemiotis C: The sodium ion affinities of cytosine and its methylated derivatives. J Mass Spectrom. 2008 Apr;43(4):485-94. [PubMed:17994645 ]
Andersson LI, Muller R, Vlatakis G, Mosbach K: Mimics of the binding sites of opioid receptors obtained by molecular imprinting of enkephalin and morphine. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4788-92. [PubMed:7761401 ]
Mizuma T, Masubuchi S, Awazu S: Intestinal absorption of stable cyclic glycylphenylalanine: comparison with the linear form. J Pharm Pharmacol. 1997 Nov;49(11):1067-71. [PubMed:9401939 ]
Ram S, Buchsbaum DJ: Synthesis of a new class of isothiocyanatopeptide bifunctional chelating agents for coupling to monoclonal antibodies. Int J Pept Protein Res. 1996 Jul;48(1):79-86. [PubMed:8844266 ]
Yeagle PL, Dentino AR, Smith FT, Spooner P, Watts A: The antiviral peptide carbobenzoxy-D-phenylalanyl-L-phenylalanylglycine changes the average conformation of phospholipids in membranes. Biochemistry. 1993 Nov 16;32(45):12197-202. [PubMed:8218297 ]
Kelsey DR, Flanagan TD, Young JE, Yeagle PL: Inhibition of Sendai virus fusion with phospholipid vesicles and human erythrocyte membranes by hydrophobic peptides. Virology. 1991 Jun;182(2):690-702. [PubMed:1850923 ]
Kelsey DR, Flanagan TD, Young J, Yeagle PL: Peptide inhibitors of enveloped virus infection inhibit phospholipid vesicle fusion and Sendai virus fusion with phospholipid vesicles. J Biol Chem. 1990 Jul 25;265(21):12178-83. [PubMed:2165053 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for Phenylalanylglycine (HMDB0028995)

MOL for HMDB0028995 (Phenylalanylglycine)

3D MOL for HMDB0028995 (Phenylalanylglycine)

3D SDF for HMDB0028995 (Phenylalanylglycine)

3D-SDF for HMDB0028995 (Phenylalanylglycine)

PDB for HMDB0028995 (Phenylalanylglycine)

3D PDB for HMDB0028995 (Phenylalanylglycine)

SMILES for HMDB0028995 (Phenylalanylglycine)

INCHI for HMDB0028995 (Phenylalanylglycine)

Structure for HMDB0028995 (Phenylalanylglycine)

3D Structure for HMDB0028995 (Phenylalanylglycine)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra