Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2012-09-11 17:33:07 UTC |
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Update Date | 2022-03-07 02:52:19 UTC |
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HMDB ID | HMDB0029864 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline |
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Description | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline, also known as 8-methyl-iqx or 8-meiqx, belongs to the class of organic compounds known as quinoxalines. Quinoxalines are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring. 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline is a primary metabolite. Primary metabolites are metabolically or physiologically essential metabolites. They are directly involved in an organism’s growth, development or reproduction. Based on a literature review a significant number of articles have been published on 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline. |
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Structure | CN1C(N)=NC2=C1C=CC1=C2N=C(C)C=N1 InChI=1S/C11H11N5/c1-6-5-13-7-3-4-8-10(9(7)14-6)15-11(12)16(8)2/h3-5H,1-2H3,(H2,12,15) |
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Synonyms | Value | Source |
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2-Amino-3,8-dimethyl-3H-imidazo(4,5-F)quinoxaline | ChEBI | 2-Amino-3,8-dimethylimidazo[4,5-F]quinoxaline | ChEBI | 8-MeIQX | ChEBI | 8-Methyl-iqx | ChEBI | 2-amino-3,8-dimethylimidazo(4,5-F)Quinoxaline | HMDB, MeSH | 2-amino-3,8-dimethylimidazo[4,5-F ]Quinoxaline | HMDB | 3,8-DiMeIQX | HMDB, MeSH | 3,8-Dimethyl-3H-imidazo(4,5-F)quinoxalin-2-amine | HMDB | 3,8-Dimethyl-3H-imidazo[4,5-F]quinoxalin-2-amine | HMDB | 3,8-Dimethyl-3H-imidazo[4,5-F]quinoxalin-2-amine, 9ci | HMDB | 3,8-dimethylimidazo(4,5-F)Quinoxaline-2-amine | HMDB, MeSH | Me-iqx | HMDB, MeSH | MeIQx | HMDB | Meiqx CPD | HMDB, MeSH |
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Chemical Formula | C11H11N5 |
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Average Molecular Weight | 213.2385 |
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Monoisotopic Molecular Weight | 213.101445377 |
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IUPAC Name | 3,8-dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine |
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Traditional Name | 3,8-dimethylimidazo[4,5-f]quinoxalin-2-amine |
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CAS Registry Number | 77500-04-0 |
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SMILES | CN1C(N)=NC2=C1C=CC1=C2N=C(C)C=N1 |
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InChI Identifier | InChI=1S/C11H11N5/c1-6-5-13-7-3-4-8-10(9(7)14-6)15-11(12)16(8)2/h3-5H,1-2H3,(H2,12,15) |
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InChI Key | DVCCCQNKIYNAKB-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as quinoxalines. Quinoxalines are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Diazanaphthalenes |
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Sub Class | Benzodiazines |
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Direct Parent | Quinoxalines |
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Alternative Parents | |
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Substituents | - Quinoxaline
- Benzimidazole
- Aminoimidazole
- Benzenoid
- Pyrazine
- N-substituted imidazole
- Azole
- Heteroaromatic compound
- Imidazole
- Azacycle
- Primary amine
- Amine
- Hydrocarbon derivative
- Organopnictogen compound
- Organic nitrogen compound
- Organonitrogen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | Not Available |
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Role | Not Available |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 295 - 300 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | 1.01 | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,1TMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N[Si](C)(C)C)N3C)C2=N1 | 2531.8 | Semi standard non polar | 33892256 | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,1TMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N[Si](C)(C)C)N3C)C2=N1 | 2245.7 | Standard non polar | 33892256 | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,2TMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N([Si](C)(C)C)[Si](C)(C)C)N3C)C2=N1 | 2445.6 | Semi standard non polar | 33892256 | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,2TMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N([Si](C)(C)C)[Si](C)(C)C)N3C)C2=N1 | 2386.4 | Standard non polar | 33892256 | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,1TBDMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N[Si](C)(C)C(C)(C)C)N3C)C2=N1 | 2718.2 | Semi standard non polar | 33892256 | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,1TBDMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N[Si](C)(C)C(C)(C)C)N3C)C2=N1 | 2424.0 | Standard non polar | 33892256 | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,2TBDMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N3C)C2=N1 | 2777.6 | Semi standard non polar | 33892256 | 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline,2TBDMS,isomer #1 | CC1=CN=C2C=CC3=C(N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N3C)C2=N1 | 2807.1 | Standard non polar | 33892256 |
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Spectra |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline EI-B (Non-derivatized) | splash10-03di-9630000000-e8a4917bbc669d325e41 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline EI-B (Non-derivatized) | splash10-03di-9630000000-e8a4917bbc669d325e41 | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline GC-MS (Non-derivatized) - 70eV, Positive | splash10-053i-0900000000-0d6af152818e5f530c3d | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline APCI-ITFT , negative-QTOF | splash10-0002-0900000000-03d709fe2574ca7fec31 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline ESI-ITFT , positive-QTOF | splash10-03di-0390000000-8ed87f2afa42aabd3d50 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline APCI-ITFT , positive-QTOF | splash10-006t-0910000000-90504cc9714205cd22e3 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 30V, Positive-QTOF | splash10-03dj-0980000000-50411c62b97c8360d105 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 40V, Positive-QTOF | splash10-0002-0900000000-11e6669d06720d9153bd | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 20V, Positive-QTOF | splash10-03di-0090000000-f43e697cafe001331dbe | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 10V, Positive-QTOF | splash10-03di-0090000000-159c1d3a85e946b03eca | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 50V, Positive-QTOF | splash10-008a-0900000000-36b0714ea24bc0b0f53c | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 30V, Positive-QTOF | splash10-03dj-0980000000-52e3471483370bb41dd4 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 35V, Positive-QTOF | splash10-03di-0390000000-07cadffeea6f6a02ab84 | 2021-09-20 | HMDB team, MONA | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 10V, Positive-QTOF | splash10-03di-0090000000-3d4e5561b68230947db9 | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 20V, Positive-QTOF | splash10-03di-0590000000-9909fec9d9bf2ce2c608 | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 40V, Positive-QTOF | splash10-053r-1900000000-fa1c95b62ff0a0d20450 | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 10V, Negative-QTOF | splash10-03di-0090000000-75942ba4bbc76a904bf8 | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 20V, Negative-QTOF | splash10-03di-0390000000-123f616c3a9c164347fc | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 40V, Negative-QTOF | splash10-002b-3900000000-2678374bc011990ab3ac | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 10V, Negative-QTOF | splash10-03di-0090000000-30d0b34fa4acc6bca290 | 2021-09-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 20V, Negative-QTOF | splash10-03di-0390000000-4fe19f6505755b2da029 | 2021-09-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 40V, Negative-QTOF | splash10-001i-0920000000-a36acb9976b8ad2b2f1a | 2021-09-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 10V, Positive-QTOF | splash10-03di-0090000000-36fa26cf92b7f44a3ce6 | 2021-09-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 20V, Positive-QTOF | splash10-03di-0090000000-e822b8dab153205d5822 | 2021-09-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline 40V, Positive-QTOF | splash10-052f-0900000000-86a61ce4e597d5f3de49 | 2021-09-24 | Wishart Lab | View Spectrum |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | |
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Normal Concentrations |
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Abnormal Concentrations |
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| Not Available |
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Associated Disorders and Diseases |
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Disease References | None |
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Associated OMIM IDs | None |
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External Links |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | FDB001093 |
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KNApSAcK ID | Not Available |
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Chemspider ID | 56076 |
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KEGG Compound ID | C19255 |
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BioCyc ID | Not Available |
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BiGG ID | Not Available |
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Wikipedia Link | Not Available |
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METLIN ID | Not Available |
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PubChem Compound | 62275 |
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PDB ID | Not Available |
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ChEBI ID | 76604 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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MarkerDB ID | Not Available |
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Good Scents ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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Material Safety Data Sheet (MSDS) | Not Available |
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General References | - Zaidi R, Kumar S, Rawat PR: Rapid detection and quantification of dietary mutagens in food using mass spectrometry and ultra performance liquid chromatography. Food Chem. 2012 Dec 15;135(4):2897-903. doi: 10.1016/j.foodchem.2012.07.065. Epub 2012 Jul 20. [PubMed:22980887 ]
- Aschebrook-Kilfoy B, Ollberding NJ, Kolar C, Lawson TA, Smith SM, Weisenburger DD, Chiu BC: Meat intake and risk of non-Hodgkin lymphoma. Cancer Causes Control. 2012 Oct;23(10):1681-92. doi: 10.1007/s10552-012-0047-2. Epub 2012 Aug 14. [PubMed:22890783 ]
- Gibis M, Weiss J: Antioxidant capacity and inhibitory effect of grape seed and rosemary extract in marinades on the formation of heterocyclic amines in fried beef patties. Food Chem. 2012 Sep 15;134(2):766-74. doi: 10.1016/j.foodchem.2012.02.179. Epub 2012 Mar 10. [PubMed:23107689 ]
- Guo H, Pan H, Wang Z, Chen L, Zhang D: [Simultaneous determination of nine heterocyclic aromatic amines in mutton products by solid phase extraction-high performance liquid chromatography]. Se Pu. 2012 Oct;30(10):1074-80. [PubMed:23383498 ]
- Liao GZ, Wang GY, Zhang YJ, Xu XL, Zhou GH: Formation of heterocyclic amines during cooking of duck meat. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(11):1668-78. doi: 10.1080/19440049.2012.702928. Epub 2012 Jul 30. [PubMed:22838849 ]
- Hayashi H, Taniai E, Morita R, Hayashi M, Nakamura D, Wakita A, Suzuki K, Shibutani M, Mitsumori K: Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and beta-naphthoflavone. J Toxicol Sci. 2012;37(5):969-85. [PubMed:23038005 ]
- Wei M, Kakehashi A, Yamano S, Tamano S, Shirai T, Wanibuchi H, Fukushima S: Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens. J Toxicol Pathol. 2012 Sep;25(3):209-14. doi: 10.1293/tox.25.209. Epub 2012 Oct 1. [PubMed:22988339 ]
- Miller PE, Lazarus P, Lesko SM, Cross AJ, Sinha R, Laio J, Zhu J, Harper G, Muscat JE, Hartman TJ: Meat-related compounds and colorectal cancer risk by anatomical subsite. Nutr Cancer. 2013;65(2):202-26. doi: 10.1080/01635581.2013.756534. [PubMed:23441608 ]
- (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .
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