Hmdb loader
Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2008-10-29 08:56:52 UTC
Update Date2022-03-07 02:51:03 UTC
HMDB IDHMDB0011131
Secondary Accession Numbers
  • HMDB0031075
  • HMDB11131
  • HMDB31075
Metabolite Identification
Common NameMG(18:0/0:0/0:0)
DescriptionMG(18:0/0:0/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups: 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1/3-isomers are not distinguished from each other and are termed 'alpha-monoacylglycerols', while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well. MG(18:0/0:0/0:0), in particular, consists of one chain of stearic acid at the C-1 position. MG(18:0/0:0/0:0 is used as a food additive (EAFUS: Everything Added to Food in the United States).
Structure
Data?1582752871
Synonyms
ValueSource
(2S)-2,3-Dihydroxypropyl octadecanoateChEBI
(S)-(+)-1-O-StearoylglycerolChEBI
(S)-1-MonostearinChEBI
1-Octadecanoyl-sn-glycerolChEBI
MG (18:0/0:0/0:0)ChEBI
sn-1-Octadecanoyl-monoglycerideChEBI
(2S)-2,3-Dihydroxypropyl octadecanoic acidGenerator
1-MonoacylglycerideHMDB
1-MonoacylglycerolHMDB
1-Octadecanoyl-rac-glycerolHMDB
1-Stearoyl-glycerolHMDB
a-MonoacylglycerolHMDB
alpha-MonoacylglycerolHMDB
MAG(18:0)HMDB
MAG(18:0/0:0)HMDB
MG(18:0)HMDB
MG(18:0/0:0)HMDB
Glycerol 1-octadecanoateHMDB
1-OctadecanoylglycerolChEBI, HMDB
Glyceryl monostearateChEBI, HMDB
Glycerol 1-octadecanoic acidGenerator, HMDB
Glyceryl monostearic acidGenerator, HMDB
(1)-2,3-Dihydroxypropyl stearateHMDB
1,2,3-Propanetriol 1-octadecanoyl esterHMDB
1,2,3-Propanetriol monooctadecanoateHMDB
1,2,3-Propanetriol, homopolymer, isooctadecanoateHMDB
1-Glyceryl stearateHMDB
1-mono-StearinHMDB
1-Monooctadecanoyl-rac-glycerolHMDB
1-MonostearinHMDB
1-MonostearoylglycerolHMDB
1-O-OctadecanoylglycerolHMDB
1-O-StearoylglycerolHMDB
1-Stearoyl-rac-glycerolHMDB
2,3-Dihydroxypropyl stearateHMDB
3-Stearoyloxy-1,2-propanediolHMDB
a-MonostearinHMDB
alpha-MonostearinHMDB
CefatinHMDB
DermagineHMDB
FEMA 2527HMDB
Glycerin 1-monostearateHMDB
Glycerin 1-stearateHMDB
Glycerol 1-monostearateHMDB
Glycerol 1-stearateHMDB
Glycerol alpha -monostearateHMDB
Glycerol alpha -sterateHMDB
Glycerol alpha-monostearateHMDB
Glyceryl 1-monostearateHMDB
Glyceryl-1-monostearateHMDB
Octadecanoic acid 2,3-dihydroxypropyl esterHMDB
Octadecanoic acid, 2,3-dihydroxypropyl esterHMDB
Octadecanoic acid, ester with 1,2,3-propanetriolHMDB
Stearic acid 1-monoglycerideHMDB
Stearic acid alpha -monoglycerideHMDB
Stearic acid alpha-monoglycerideHMDB
1-StearoylglycerolHMDB
(±)-2,3-Dihydroxypropyl octadecanoateHMDB
1-MonooctadecanoylglycerolHMDB
1-O-Octadecanoyl-sn-glycerolHMDB
1-monostearoyl-rac-glycerolHMDB
2,3-Dihydroxypropyl octadecanoateHMDB
Glycerol α-monostearateHMDB
Glyceryl 1-octadecanoateHMDB
Stearic acid α-monoglycerideHMDB
α-MonostearinHMDB
1-GMSPhytoBank
Octadecanoic acid-2,3-dihydroxypropyl esterPhytoBank
Glycerol monostearatePhytoBank
GMSPhytoBank
Chemical FormulaC21H42O4
Average Molecular Weight358.5558
Monoisotopic Molecular Weight358.308309832
IUPAC Name(2S)-2,3-dihydroxypropyl octadecanoate
Traditional Name(2S)-2,3-dihydroxypropyl octadecanoate
CAS Registry Number22610-61-3
SMILES
[H][C@](O)(CO)COC(=O)CCCCCCCCCCCCCCCCC
InChI Identifier
InChI=1S/C21H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h20,22-23H,2-19H2,1H3/t20-/m0/s1
InChI KeyVBICKXHEKHSIBG-FQEVSTJZSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 1-monoacylglycerols. These are monoacylglycerols containing a glycerol acylated at the 1-position.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerolipids
Sub ClassMonoradylglycerols
Direct Parent1-monoacylglycerols
Alternative Parents
Substituents
  • 1-acyl-sn-glycerol
  • Fatty acid ester
  • Fatty acyl
  • 1,2-diol
  • Carboxylic acid ester
  • Secondary alcohol
  • Carboxylic acid derivative
  • Monocarboxylic acid or derivatives
  • Primary alcohol
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Carbonyl group
  • Alcohol
  • Organic oxide
  • Organooxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.0011 g/LALOGPS
logP6.73ALOGPS
logP5.97ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)13.62ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area66.76 ŲChemAxon
Rotatable Bond Count20ChemAxon
Refractivity103.31 m³·mol⁻¹ChemAxon
Polarizability46.48 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+194.12531661259
DarkChem[M-H]-194.34831661259
DeepCCS[M+H]+183.75430932474
DeepCCS[M-H]-181.39630932474
DeepCCS[M-2H]-214.92830932474
DeepCCS[M+Na]+190.15430932474
AllCCS[M+H]+200.932859911
AllCCS[M+H-H2O]+198.532859911
AllCCS[M+NH4]+203.032859911
AllCCS[M+Na]+203.632859911
AllCCS[M-H]-195.532859911
AllCCS[M+Na-2H]-197.132859911
AllCCS[M+HCOO]-199.132859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
MG(18:0/0:0/0:0)[H][C@](O)(CO)COC(=O)CCCCCCCCCCCCCCCCC3623.3Standard polar33892256
MG(18:0/0:0/0:0)[H][C@](O)(CO)COC(=O)CCCCCCCCCCCCCCCCC2614.3Standard non polar33892256
MG(18:0/0:0/0:0)[H][C@](O)(CO)COC(=O)CCCCCCCCCCCCCCCCC2750.7Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
MG(18:0/0:0/0:0),1TMS,isomer #1CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO)O[Si](C)(C)C2743.0Semi standard non polar33892256
MG(18:0/0:0/0:0),1TMS,isomer #2CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)CO[Si](C)(C)C2750.4Semi standard non polar33892256
MG(18:0/0:0/0:0),2TMS,isomer #1CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[Si](C)(C)C)O[Si](C)(C)C2807.5Semi standard non polar33892256
MG(18:0/0:0/0:0),1TBDMS,isomer #1CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO)O[Si](C)(C)C(C)(C)C3006.9Semi standard non polar33892256
MG(18:0/0:0/0:0),1TBDMS,isomer #2CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)CO[Si](C)(C)C(C)(C)C3004.9Semi standard non polar33892256
MG(18:0/0:0/0:0),2TBDMS,isomer #1CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3311.5Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - MG(18:0/0:0/0:0) GC-MS (2 TMS) - 70eV, Positivesplash10-000i-9670300000-c997fc24da788ae94c352017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - MG(18:0/0:0/0:0) GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 10V, Positive-QTOFsplash10-004i-0009000000-2580e940ca1f2f1cbca32017-10-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 20V, Positive-QTOFsplash10-004i-0009000000-2580e940ca1f2f1cbca32017-10-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 40V, Positive-QTOFsplash10-0be6-0069000000-6f7c44088fdbecb9e3842017-10-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 10V, Negative-QTOFNot Available2020-06-30Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 20V, Negative-QTOFNot Available2020-06-30Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 40V, Negative-QTOFNot Available2020-06-30Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 10V, Positive-QTOFsplash10-014i-0009000000-026fbec0f6407de8e2ce2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 20V, Positive-QTOFsplash10-014i-0009000000-026fbec0f6407de8e2ce2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 40V, Positive-QTOFsplash10-00kb-9005000000-e028cc5d6c2346a05df22021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 10V, Positive-QTOFsplash10-066u-2179000000-d89ad1f7041af7ca70b32021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 20V, Positive-QTOFsplash10-06fr-9374000000-6e9b2f1885f95c9755662021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 40V, Positive-QTOFsplash10-0a4i-9000000000-c9fb1ba8b26bbe6a7cc72021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 10V, Negative-QTOFsplash10-0aor-9066000000-290de81cb17b28ab282f2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 20V, Negative-QTOFsplash10-014l-8090000000-24c902aeb2bf2c0a39882021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 40V, Negative-QTOFsplash10-067i-5490000000-693b21cabc4379777e212021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 10V, Positive-QTOFsplash10-004i-0009000000-5210059a7b8013bca3ec2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 20V, Positive-QTOFsplash10-004i-0009000000-5210059a7b8013bca3ec2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - MG(18:0/0:0/0:0) 40V, Positive-QTOFsplash10-0676-0089000000-9f2768696bd76725446e2021-09-25Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, H2O, predicted)2022-08-18Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Feces
  • Sweat
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
SweatDetected but not QuantifiedNot QuantifiedAdult BothNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
Associated Disorders and Diseases
Disease References
Colorectal cancer
  1. Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
  2. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
  3. Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20. [PubMed:28587349 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB027910
KNApSAcK IDNot Available
Chemspider ID10381543
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound15560610
PDB IDNot Available
ChEBI ID75550
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  2. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  3. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  4. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  5. Ghosh S, Strum JC, Bell RM: Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling. FASEB J. 1997 Jan;11(1):45-50. [PubMed:9034165 ]
  6. (). EAFUS: Everything Added to Food in the United States.. .
  7. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Enzymes

General function:
Lipid transport and metabolism
Specific function:
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Gene Name:
MGLL
Uniprot ID:
Q99685
Molecular weight:
Not Available
General function:
Involved in hydrolase activity
Specific function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Gene Name:
LIPE
Uniprot ID:
Q05469
Molecular weight:
116596.715
General function:
Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.
Gene Name:
MOGAT2
Uniprot ID:
Q3SYC2
Molecular weight:
38195.285
General function:
Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).
Gene Name:
MOGAT1
Uniprot ID:
Q96PD6
Molecular weight:
38812.19
General function:
Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.
Gene Name:
MOGAT3
Uniprot ID:
Q86VF5
Molecular weight:
38729.84
General function:
Involved in acid phosphatase activity
Specific function:
Hydrolyzes lysophosphatidic acid to monoacylglycerol.
Gene Name:
ACP6
Uniprot ID:
Q9NPH0
Molecular weight:
48853.955
General function:
Involved in NAD+ kinase activity
Specific function:
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth
Gene Name:
AGK
Uniprot ID:
Q53H12
Molecular weight:
47136.8
General function:
Involved in catalytic activity
Specific function:
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
Gene Name:
ENPP6
Uniprot ID:
Q6UWR7
Molecular weight:
50240.625