Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2012-09-11 17:51:21 UTC |
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Update Date | 2022-03-07 02:53:26 UTC |
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HMDB ID | HMDB0032714 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | cis-Uvariamicin IB |
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Description | cis-Uvariamicin IB belongs to the class of organic compounds known as annonaceous acetogenins. These are waxy derivatives of fatty acids (usually C32 or C34), containing a terminal carboxylic acid combined with a 2-propanol unit at the C-2 position to form a methyl- substituted alpha,beta-unsaturated-gamma-lactone. One of their interesting structural features is a single, adjacent, or nonadjacent tetrahydrofuran (THF) or tetrahydropyran (THP) system with one or two flanking hydroxyl group(s) at the center of a long hydrocarbon chain. Based on a literature review a small amount of articles have been published on cis-Uvariamicin IB. |
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Structure | CCCCCCCCCCCCCCC(O)C1CCC(O1)C(O)CCCCCCCCCCCCC1=CC(C)OC1=O InChI=1S/C37H68O5/c1-3-4-5-6-7-8-9-10-14-17-20-23-26-33(38)35-28-29-36(42-35)34(39)27-24-21-18-15-12-11-13-16-19-22-25-32-30-31(2)41-37(32)40/h30-31,33-36,38-39H,3-29H2,1-2H3 |
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Synonyms | Value | Source |
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cis-Uvariamicin I | HMDB |
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Chemical Formula | C37H68O5 |
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Average Molecular Weight | 592.9328 |
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Monoisotopic Molecular Weight | 592.506675286 |
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IUPAC Name | 3-{13-hydroxy-13-[5-(1-hydroxypentadecyl)oxolan-2-yl]tridecyl}-5-methyl-2,5-dihydrofuran-2-one |
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Traditional Name | 3-{13-hydroxy-13-[5-(1-hydroxypentadecyl)oxolan-2-yl]tridecyl}-5-methyl-5H-furan-2-one |
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CAS Registry Number | Not Available |
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SMILES | CCCCCCCCCCCCCCC(O)C1CCC(O1)C(O)CCCCCCCCCCCCC1=CC(C)OC1=O |
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InChI Identifier | InChI=1S/C37H68O5/c1-3-4-5-6-7-8-9-10-14-17-20-23-26-33(38)35-28-29-36(42-35)34(39)27-24-21-18-15-12-11-13-16-19-22-25-32-30-31(2)41-37(32)40/h30-31,33-36,38-39H,3-29H2,1-2H3 |
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InChI Key | UXILAQXAZFVOFT-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as annonaceous acetogenins. These are waxy derivatives of fatty acids (usually C32 or C34), containing a terminal carboxylic acid combined with a 2-propanol unit at the C-2 position to form a methyl- substituted alpha,beta-unsaturated-gamma-lactone. One of their interesting structural features is a single, adjacent, or nonadjacent tetrahydrofuran (THF) or tetrahydropyran (THP) system with one or two flanking hydroxyl group(s) at the center of a long hydrocarbon chain. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Fatty Acyls |
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Sub Class | Fatty alcohols |
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Direct Parent | Annonaceous acetogenins |
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Alternative Parents | |
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Substituents | - Annonaceae acetogenin skeleton
- Long chain fatty alcohol
- 2-furanone
- Dihydrofuran
- Tetrahydrofuran
- Enoate ester
- Alpha,beta-unsaturated carboxylic ester
- Secondary alcohol
- Lactone
- Carboxylic acid ester
- Monocarboxylic acid or derivatives
- Ether
- Dialkyl ether
- Carboxylic acid derivative
- Organoheterocyclic compound
- Oxacycle
- Organooxygen compound
- Hydrocarbon derivative
- Alcohol
- Carbonyl group
- Organic oxygen compound
- Organic oxide
- Aliphatic heteromonocyclic compound
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Molecular Framework | Aliphatic heteromonocyclic compounds |
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External Descriptors | Not Available |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | |
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Role | |
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Physical Properties |
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State | Not Available |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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cis-Uvariamicin IB,1TMS,isomer #1 | CCCCCCCCCCCCCCC(O[Si](C)(C)C)C1CCC(C(O)CCCCCCCCCCCCC2=CC(C)OC2=O)O1 | 4472.4 | Semi standard non polar | 33892256 | cis-Uvariamicin IB,1TMS,isomer #2 | CCCCCCCCCCCCCCC(O)C1CCC(C(CCCCCCCCCCCCC2=CC(C)OC2=O)O[Si](C)(C)C)O1 | 4472.4 | Semi standard non polar | 33892256 | cis-Uvariamicin IB,2TMS,isomer #1 | CCCCCCCCCCCCCCC(O[Si](C)(C)C)C1CCC(C(CCCCCCCCCCCCC2=CC(C)OC2=O)O[Si](C)(C)C)O1 | 4422.2 | Semi standard non polar | 33892256 | cis-Uvariamicin IB,1TBDMS,isomer #1 | CCCCCCCCCCCCCCC(O[Si](C)(C)C(C)(C)C)C1CCC(C(O)CCCCCCCCCCCCC2=CC(C)OC2=O)O1 | 4717.5 | Semi standard non polar | 33892256 | cis-Uvariamicin IB,1TBDMS,isomer #2 | CCCCCCCCCCCCCCC(O)C1CCC(C(CCCCCCCCCCCCC2=CC(C)OC2=O)O[Si](C)(C)C(C)(C)C)O1 | 4717.5 | Semi standard non polar | 33892256 | cis-Uvariamicin IB,2TBDMS,isomer #1 | CCCCCCCCCCCCCCC(O[Si](C)(C)C(C)(C)C)C1CCC(C(CCCCCCCCCCCCC2=CC(C)OC2=O)O[Si](C)(C)C(C)(C)C)O1 | 4886.5 | Semi standard non polar | 33892256 |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS (Non-derivatized) - 70eV, Positive | splash10-0002-3196120000-417666b3cb4934e8682e | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS (1 TMS) - 70eV, Positive | splash10-014j-5129011000-a7ba802c1c5f4326e2cb | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS ("cis-Uvariamicin IB,1TMS,#1" TMS) - 70eV, Positive | Not Available | 2021-10-14 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS (TMS_1_2) - 70eV, Positive | Not Available | 2021-10-15 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS (TMS_2_1) - 70eV, Positive | Not Available | 2021-10-15 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS (TBDMS_1_1) - 70eV, Positive | Not Available | 2021-10-15 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS (TBDMS_1_2) - 70eV, Positive | Not Available | 2021-10-15 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - cis-Uvariamicin IB GC-MS (TBDMS_2_1) - 70eV, Positive | Not Available | 2021-10-15 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 10V, Positive-QTOF | splash10-0006-0020090000-c6bf292994424022d39c | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 20V, Positive-QTOF | splash10-00mk-1930130000-bbe5e908ee28c14f0e66 | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 40V, Positive-QTOF | splash10-002e-3930010000-bcfa7e280f8df41d2ebf | 2015-04-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 10V, Negative-QTOF | splash10-0006-0000090000-ad677937afa32f6b5eee | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 20V, Negative-QTOF | splash10-0002-1264090000-3d878d9cd8be8e7a4cca | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 40V, Negative-QTOF | splash10-016u-2195010000-1d3a350ea884c5acbeff | 2015-04-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 10V, Positive-QTOF | splash10-056u-1010190000-e2efab2a9f939e43f441 | 2021-09-21 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 20V, Positive-QTOF | splash10-004j-3000090000-f034bd9e7ea650c59d02 | 2021-09-21 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 40V, Positive-QTOF | splash10-0006-9001000000-052ebc70f9ac15b626d2 | 2021-09-21 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 10V, Negative-QTOF | splash10-0006-0000090000-4495ea4244b0ed4455f3 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 20V, Negative-QTOF | splash10-0006-2052090000-131d227388befa2336a7 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - cis-Uvariamicin IB 40V, Negative-QTOF | splash10-014j-9157010000-7e7bfcfb0d1949ab4d29 | 2021-09-25 | Wishart Lab | View Spectrum |
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General References | - Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
- Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
- Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
- Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
- (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .
- Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.
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