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Showing metabocard for Glucaric acid (HMDB0000663)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:02 UTC
HMDB IDHMDB0000663
Secondary Accession Numbers
  • HMDB0029881
  • HMDB00663
  • HMDB29881
Metabolite Identification
Common NameGlucaric acid
DescriptionGlucaric acid, also known as glucarate or D-saccharic acid, belongs to the class of organic compounds known as glucuronic acid derivatives. Glucuronic acid derivatives are compounds containing a glucuronic acid moiety (or a derivative), which consists of a glucose moiety with the C6 carbon oxidized to a carboxylic acid. Glucaric acid is a sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups. D-glucaric acid is found in fruits, vegetables, and mammals. The highest concentrations of glucaric acid are found in grapefruits, apples, oranges, and cruciferous vegetables (PMID: 18772850 ). Glucaric acid is produced through the oxidation of glucose. Cytochrome P450 is thought to be responsible for the production of D-glucaric acid in vivo (PMID: 3779687 ). In mammals, D-glucaric acid and D-glucaro-l,4-lactone are also known end-products of the D-glucuronic acid pathway (PMID: 18772850 ). Glucaric is available as a dietary supplement in the form of calcium D-glucarate and has been studied for therapeutic purposes including cholesterol reduction and cancer chemotherapy (PMID: 9101079 ). D-Glucaric acid has a potential use as a building block for a number of polymers, including new nylons and hyperbranched polyesters. D-glucaric acid produced from D-glucose has been successfully utilized to produce a hydroxylated nylon.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000663 (Glucaric acid)

  Mrv1652309042000052D          

 14 13  0  0  0  0            999 V2000
 9992.3250 9992.8934    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9993.0390 9992.4815    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9993.7546 9992.8934    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9994.4701 9992.4815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9995.1836 9992.8934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9994.4701 9991.6561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9993.7546 9993.7182    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9993.0390 9991.6561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.6103 9992.4815    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9990.8955 9992.8934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9990.1808 9992.4815    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9990.8955 9993.7182    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.6103 9991.6561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.3250 9993.7182    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  9  1  0  0  0  0
  1 14  1  1  0  0  0
  2  3  1  0  0  0  0
  2  8  1  1  0  0  0
  3  4  1  0  0  0  0
  3  7  1  6  0  0  0
  4  5  1  0  0  0  0
  4  6  2  0  0  0  0
  9 10  1  0  0  0  0
  9 13  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
M  END
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3D MOL for HMDB0000663 (Glucaric acid)

HMDB0000663
     RDKit          3D
Glucaric acid
 24 23  0  0  0  0  0  0  0  0999 V2000
   -3.5026    1.1306    1.4568 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9640    0.3148    0.6543 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5554   -0.9112    0.5094 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7305    0.7217   -0.0832 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3754    2.0089    0.2697 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6485   -0.2506    0.3020 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0096   -1.5472   -0.0550 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6887    0.1334   -0.3229 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6494    0.0802   -1.6933 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7958   -0.6786    0.2833 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6990   -2.0292   -0.0362 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0986   -0.1152   -0.1822 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9020   -0.8802   -0.7704 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3837    1.2048    0.0400 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4541   -1.4004   -0.3712 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9389    0.7176   -1.1667 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2085    2.5023    0.5309 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5492   -0.2278    1.4076 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0569   -1.6325   -1.0277 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8666    1.1951   -0.0288 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7653    0.9508   -2.1374 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7219   -0.5996    1.3807 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3914   -2.2043   -0.9450 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0311    1.5166    0.7431 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 12 14  1  0
  3 15  1  0
  4 16  1  6
  5 17  1  0
  6 18  1  1
  7 19  1  0
  8 20  1  6
  9 21  1  0
 10 22  1  1
 11 23  1  0
 14 24  1  0
M  END
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3D SDF for HMDB0000663 (Glucaric acid)

  Mrv1652309042000052D          

 14 13  0  0  0  0            999 V2000
 9992.3250 9992.8934    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9993.0390 9992.4815    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9993.7546 9992.8934    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9994.4701 9992.4815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9995.1836 9992.8934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9994.4701 9991.6561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9993.7546 9993.7182    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9993.0390 9991.6561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.6103 9992.4815    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 9990.8955 9992.8934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9990.1808 9992.4815    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9990.8955 9993.7182    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9991.6103 9991.6561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.3250 9993.7182    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  9  1  0  0  0  0
  1 14  1  1  0  0  0
  2  3  1  0  0  0  0
  2  8  1  1  0  0  0
  3  4  1  0  0  0  0
  3  7  1  6  0  0  0
  4  5  1  0  0  0  0
  4  6  2  0  0  0  0
  9 10  1  0  0  0  0
  9 13  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000663

> <DATABASE_NAME>
hmdb

> <SMILES>
O[C@@H]([C@H](O)[C@@H](O)C(O)=O)[C@H](O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2-,3-,4+/m0/s1

> <INCHI_KEY>
DSLZVSRJTYRBFB-LLEIAEIESA-N

> <FORMULA>
C6H10O8

> <MOLECULAR_WEIGHT>
210.1388

> <EXACT_MASS>
210.037567296

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
24

> <JCHEM_AVERAGE_POLARIZABILITY>
16.8047219717019

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3S,4S,5S)-2,3,4,5-tetrahydroxyhexanedioic acid

> <ALOGPS_LOGP>
-1.77

> <JCHEM_LOGP>
-3.089469772666667

> <ALOGPS_LOGS>
-0.52

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.5410690508784013

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.828604159491

> <JCHEM_PKA_STRONGEST_BASIC>
-3.7307040369214137

> <JCHEM_POLAR_SURFACE_AREA>
155.52

> <JCHEM_REFRACTIVITY>
38.13840000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
6.31e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
saccharic acid

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0000663 (Glucaric acid)

HMDB0000663
     RDKit          3D
Glucaric acid
 24 23  0  0  0  0  0  0  0  0999 V2000
   -3.5026    1.1306    1.4568 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9640    0.3148    0.6543 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5554   -0.9112    0.5094 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7305    0.7217   -0.0832 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3754    2.0089    0.2697 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6485   -0.2506    0.3020 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0096   -1.5472   -0.0550 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6887    0.1334   -0.3229 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6494    0.0802   -1.6933 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7958   -0.6786    0.2833 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6990   -2.0292   -0.0362 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0986   -0.1152   -0.1822 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9020   -0.8802   -0.7704 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3837    1.2048    0.0400 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4541   -1.4004   -0.3712 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9389    0.7176   -1.1667 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2085    2.5023    0.5309 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5492   -0.2278    1.4076 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0569   -1.6325   -1.0277 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8666    1.1951   -0.0288 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7653    0.9508   -2.1374 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7219   -0.5996    1.3807 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3914   -2.2043   -0.9450 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0311    1.5166    0.7431 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  2  0
 12 14  1  0
  3 15  1  0
  4 16  1  6
  5 17  1  0
  6 18  1  1
  7 19  1  0
  8 20  1  6
  9 21  1  0
 10 22  1  1
 11 23  1  0
 14 24  1  0
M  END
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PDB for HMDB0000663 (Glucaric acid)

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0    8652.3408653.401   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8653.6738652.632   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8655.0098653.401   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8656.3448652.632   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0    8657.6768653.401   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8656.3448651.091   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0    8655.0098654.941   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0    8653.6738651.091   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0    8651.0068652.632   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8649.6728653.401   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0    8648.3378652.632   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0    8649.6728654.941   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0    8651.0068651.091   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0    8652.3408654.941   0.000  0.00  0.00           O+0
CONECT    1    2    9   14                                                  
CONECT    2    1    3    8                                                  
CONECT    3    2    4    7                                                  
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4                                                            
CONECT    7    3                                                            
CONECT    8    2                                                            
CONECT    9    1   10   13                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10                                                            
CONECT   13    9                                                            
CONECT   14    1                                                            
MASTER        0    0    0    0    0    0    0    0   14    0   26    0
END
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3D PDB for HMDB0000663 (Glucaric acid)

COMPND    HMDB0000663
HETATM    1  O1  UNL     1      -3.503   1.131   1.457  1.00  0.00           O  
HETATM    2  C1  UNL     1      -2.964   0.315   0.654  1.00  0.00           C  
HETATM    3  O2  UNL     1      -3.555  -0.911   0.509  1.00  0.00           O  
HETATM    4  C2  UNL     1      -1.730   0.722  -0.083  1.00  0.00           C  
HETATM    5  O3  UNL     1      -1.375   2.009   0.270  1.00  0.00           O  
HETATM    6  C3  UNL     1      -0.648  -0.251   0.302  1.00  0.00           C  
HETATM    7  O4  UNL     1      -1.010  -1.547  -0.055  1.00  0.00           O  
HETATM    8  C4  UNL     1       0.689   0.133  -0.323  1.00  0.00           C  
HETATM    9  O5  UNL     1       0.649   0.080  -1.693  1.00  0.00           O  
HETATM   10  C5  UNL     1       1.796  -0.679   0.283  1.00  0.00           C  
HETATM   11  O6  UNL     1       1.699  -2.029  -0.036  1.00  0.00           O  
HETATM   12  C6  UNL     1       3.099  -0.115  -0.182  1.00  0.00           C  
HETATM   13  O7  UNL     1       3.902  -0.880  -0.770  1.00  0.00           O  
HETATM   14  O8  UNL     1       3.384   1.205   0.040  1.00  0.00           O  
HETATM   15  H1  UNL     1      -3.454  -1.400  -0.371  1.00  0.00           H  
HETATM   16  H2  UNL     1      -1.939   0.718  -1.167  1.00  0.00           H  
HETATM   17  H3  UNL     1      -2.208   2.502   0.531  1.00  0.00           H  
HETATM   18  H4  UNL     1      -0.549  -0.228   1.408  1.00  0.00           H  
HETATM   19  H5  UNL     1      -1.057  -1.632  -1.028  1.00  0.00           H  
HETATM   20  H6  UNL     1       0.867   1.195  -0.029  1.00  0.00           H  
HETATM   21  H7  UNL     1       0.765   0.951  -2.137  1.00  0.00           H  
HETATM   22  H8  UNL     1       1.722  -0.600   1.381  1.00  0.00           H  
HETATM   23  H9  UNL     1       1.391  -2.204  -0.945  1.00  0.00           H  
HETATM   24  H10 UNL     1       4.031   1.517   0.743  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   15
CONECT    4    5    6   16
CONECT    5   17
CONECT    6    7    8   18
CONECT    7   19
CONECT    8    9   10   20
CONECT    9   21
CONECT   10   11   12   22
CONECT   11   23
CONECT   12   13   13   14
CONECT   14   24
END
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SMILES for HMDB0000663 (Glucaric acid)

O[C@@H]([C@H](O)[C@@H](O)C(O)=O)[C@H](O)C(O)=O
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INCHI for HMDB0000663 (Glucaric acid)

InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2-,3-,4+/m0/s1
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC6H10O8
Average Molecular Weight210.1388
Monoisotopic Molecular Weight210.037567296
IUPAC Name(2R,3S,4S,5S)-2,3,4,5-tetrahydroxyhexanedioic acid
Traditional Namesaccharic acid
CAS Registry Number87-73-0
SMILES
O[C@@H]([C@H](O)[C@@H](O)C(O)=O)[C@H](O)C(O)=O
InChI Identifier
InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2-,3-,4+/m0/s1
InChI KeyDSLZVSRJTYRBFB-LLEIAEIESA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as glucuronic acid derivatives. Glucuronic acid derivatives are compounds containing a glucuronic acid moiety (or a derivative), which consists of a glucose moiety with the C6 carbon oxidized to a carboxylic acid.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentGlucuronic acid derivatives
Alternative Parents
Substituents
  • Glucuronic acid or derivatives
  • Medium-chain hydroxy acid
  • Medium-chain fatty acid
  • Beta-hydroxy acid
  • Hydroxy fatty acid
  • Monosaccharide
  • Hydroxy acid
  • Dicarboxylic acid or derivatives
  • Alpha-hydroxy acid
  • Fatty acyl
  • Fatty acid
  • Secondary alcohol
  • Polyol
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationRoute of exposureSource
ProcessNot Available
Role
Industrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility912 mg/mLNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available133.3http://allccs.zhulab.cn/database/detail?ID=AllCCS00000379
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Mitochondria
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue Locations
  • Liver
  • Prostate
Pathways
Normal Concentrations
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
UrineDetected and Quantified44.819 +/- 50.56 umol/mmol creatinineChildren (1 - 13 years old)Not Specified
Eosinophilic esophagitis
    • Analysis of 30 no...
 details
Associated Disorders and Diseases
Disease References
Eosinophilic esophagitis
  1. Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
Associated OMIM IDs
DrugBank IDDB03603
Phenol Explorer Compound IDNot Available
FooDB IDFDB022169
KNApSAcK IDC00052287
Chemspider ID30577
KEGG Compound IDC00818
BioCyc IDD-GLUCARATE
BiGG ID35926
Wikipedia LinkSaccharic_acid
METLIN ID5633
PubChem Compound33037
PDB IDNot Available
ChEBI ID16002
Food Biomarker OntologyNot Available
VMH IDGLCR
MarkerDB IDNot Available
Good Scents IDrw1736771
References
Synthesis ReferenceBamba, K.; Kokoh, K. B.; Servat, K.; Leger, J.-M. Electrocatalytic oxidation of monosaccharides on platinum electrodes modified by thallium adatoms in carbonate buffered medium. Journal of Applied Electrochemistry (2006), 36(2), 233-238.
Material Safety Data Sheet (MSDS)Not Available
General References

Only showing the first 10 proteins. There are 11 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. 4-trimethylaminobutyraldehyde dehydrogenase
General function:
Involved in oxidoreductase activity
Specific function:
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
Gene Name:
ALDH9A1
Uniprot ID:
P49189
Molecular weight:
56291.485
Reactions
D-Glucurono-6,3-lactone + NAD + Water → Glucaric acid + NADH + Hydrogen Iondetails
Enzyme Details
2. Alpha-aminoadipic semialdehyde dehydrogenase
General function:
Involved in oxidoreductase activity
Specific function:
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Gene Name:
ALDH7A1
Uniprot ID:
P49419
Molecular weight:
58486.74
Reactions
D-Glucurono-6,3-lactone + NAD + Water → Glucaric acid + NADH + Hydrogen Iondetails
Enzyme Details
3. Aldehyde dehydrogenase, mitochondrial
General function:
Involved in oxidoreductase activity
Specific function:
Not Available
Gene Name:
ALDH2
Uniprot ID:
P05091
Molecular weight:
56380.93
Reactions
D-Glucurono-6,3-lactone + NAD + Water → Glucaric acid + NADH + Hydrogen Iondetails
Enzyme Details
4. Fatty aldehyde dehydrogenase
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Gene Name:
ALDH3A2
Uniprot ID:
P51648
Molecular weight:
54847.36
Reactions
D-Glucurono-6,3-lactone + NAD + Water → Glucaric acid + NADH + Hydrogen Iondetails
Enzyme Details
5. Aldehyde dehydrogenase X, mitochondrial
General function:
Involved in oxidoreductase activity
Specific function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Gene Name:
ALDH1B1
Uniprot ID:
P30837
Molecular weight:
57248.96
Reactions
D-Glucurono-6,3-lactone + NAD + Water → Glucaric acid + NADH + Hydrogen Iondetails
Enzyme Details
6. UDP-glucuronosyltransferase 2B4
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
Gene Name:
UGT2B4
Uniprot ID:
P06133
Molecular weight:
60512.035
Enzyme Details
7. UDP-glucuronosyltransferase 1-4
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.
Gene Name:
UGT1A4
Uniprot ID:
P22310
Molecular weight:
60024.535
Enzyme Details
8. UDP-glucuronosyltransferase 2B7
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular weight:
60720.15
Enzyme Details
9. UDP-glucuronosyltransferase 1-1
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular weight:
59590.91
Enzyme Details
10. UDP-glucuronosyltransferase 1-9
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
Gene Name:
UGT1A9
Uniprot ID:
O60656
Molecular weight:
59940.495

Only showing the first 10 proteins. There are 11 proteins in total.

Show all enzymes and transporters