Hmdb loader

Showing metabocard for Homo-L-arginine (HMDB0000670)

Jump To Section:
IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (1) Show 1 proteinXML
enzymes (1) Show 1 protein
Show more...Show more...Show more...Show more...Show more...
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:03 UTC
HMDB IDHMDB0000670
Secondary Accession Numbers
  • HMDB00670
Metabolite Identification
Common NameHomo-L-arginine
DescriptionL-homoarginine, also known as N6-(aminoiminomethyl)-L-lysine or N6-amidino-L-lysine, is a member of the class of compounds known as L-alpha-amino acids. L-alpha-amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. More specifically, L-homoarginine is a naturally occurring, non-proteinogenic, cationic amino acid. It is formed in the liver in a reaction catalyzed by L-arginine:glycine amidinotransferase (AGAT) when transferring the amidino group from arginine to lysine. It is an alternative substrate for nitric oxide (NO) synthase. L-homoarginine increases the availability of NO and thereby affects endothelial function. High homoarginine levels may exert positive actions that are relevant to cardiovascular health, including enhanced endothelial function, inhibition of platelet aggregation and stimulation of insulin secretion (PMID: 30866658 ). Recent studies have demonstrated that low serum homoarginine levels are a strong predictor of cardiovascular mortality (PMID: 24583919 ). L-homoarginine is a substrate of the human cationic amino acid CAT1 [solute carrier family 7 (SLC7A1)], CAT2A (SLC7A2A) or CAT2B (SLC7A2B) (PMID: 28684763 ). According to published human metabolomic data, L-homoarginine can be found primarily in blood, cerebrospinal fluid (CSF), and urine, as well as in human intestinal and testes tissues. Moreover, L-homoarginine has been found to be associated with liver cirrhosis and the genetic disorder, hyperargininemia. Homoarginine is an organ-specific uncompetitive inhibitor of human liver and bone alkaline phosphohydrolase (PMID: 5063678 ).
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000670 (Homo-L-arginine)

  Mrv1652304202019212D          

 13 12  0  0  0  0            999 V2000
10009.830310008.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10010.546010008.9496    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10011.259510008.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10011.975010008.9496    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10011.259510007.7121    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10010.546010009.7744    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10009.114810008.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10008.400710008.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10007.686010008.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.970910008.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10006.256210008.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.256210009.7744    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10005.541510008.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  7  1  0  0  0  0
  2  3  1  0  0  0  0
  2  6  1  6  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
M  END
Download

3D MOL for HMDB0000670 (Homo-L-arginine)

HMDB0000670
     RDKit          3D
Homo-L-arginine
 29 28  0  0  0  0  0  0  0  0999 V2000
   -4.3069    1.4322   -1.1089 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1408    0.4090   -0.3398 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1548   -0.5864   -0.3265 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9711    0.3000    0.4622 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6998    0.2068   -0.2285 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5421    0.0960    0.7389 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7234    0.0054   -0.0485 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9500   -0.1096    0.8284 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1465   -0.1922   -0.1274 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9647   -1.3503   -0.9505 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4135   -0.2064    0.6229 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2465   -1.1449    0.5432 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6785    0.8827    1.4534 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5759    2.1913   -1.1455 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0358   -0.3789    0.1990 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0561   -1.4969   -0.8106 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0816    0.2926    1.4843 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6063    1.1150   -0.8587 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7544   -0.6599   -0.9032 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5551    0.8593    1.5132 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6808   -0.8919    1.2666 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6545   -0.8168   -0.7678 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8317    0.9481   -0.6372 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9385   -0.9799    1.4849 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1146    0.8146    1.4180 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1390    0.7370   -0.7591 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3793   -1.1760   -1.7965 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5452   -2.1340   -0.4148 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4355    1.8342    1.1899 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  2  0
 11 13  1  0
  1 14  1  0
  3 15  1  0
  3 16  1  0
  4 17  1  0
  5 18  1  0
  5 19  1  0
  6 20  1  0
  6 21  1  0
  7 22  1  0
  7 23  1  0
  8 24  1  0
  8 25  1  0
  9 26  1  6
 10 27  1  0
 10 28  1  0
 13 29  1  0
M  END
Download

3D SDF for HMDB0000670 (Homo-L-arginine)

  Mrv1652304202019212D          

 13 12  0  0  0  0            999 V2000
10009.830310008.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10010.546010008.9496    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10011.259510008.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10011.975010008.9496    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10011.259510007.7121    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10010.546010009.7744    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10009.114810008.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10008.400710008.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10007.686010008.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.970910008.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10006.256210008.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.256210009.7744    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10005.541510008.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  7  1  0  0  0  0
  2  3  1  0  0  0  0
  2  6  1  6  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000670

> <DATABASE_NAME>
hmdb

> <SMILES>
N[C@@H](CCCCNC(N)=N)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)/t5-/m0/s1

> <INCHI_KEY>
QUOGESRFPZDMMT-YFKPBYRVSA-N

> <FORMULA>
C7H16N4O2

> <MOLECULAR_WEIGHT>
188.2275

> <EXACT_MASS>
188.127325776

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
29

> <JCHEM_AVERAGE_POLARIZABILITY>
20.03779635520079

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-amino-6-carbamimidamidohexanoic acid

> <ALOGPS_LOGP>
-3.73

> <JCHEM_LOGP>
-2.722308785706772

> <ALOGPS_LOGS>
-2.07

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.4910361487073844

> <JCHEM_PKA_STRONGEST_BASIC>
12.302434226350789

> <JCHEM_POLAR_SURFACE_AREA>
125.22

> <JCHEM_REFRACTIVITY>
58.5241

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.58e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
L-homoarginine

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0000670 (Homo-L-arginine)

HMDB0000670
     RDKit          3D
Homo-L-arginine
 29 28  0  0  0  0  0  0  0  0999 V2000
   -4.3069    1.4322   -1.1089 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1408    0.4090   -0.3398 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1548   -0.5864   -0.3265 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9711    0.3000    0.4622 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6998    0.2068   -0.2285 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5421    0.0960    0.7389 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7234    0.0054   -0.0485 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9500   -0.1096    0.8284 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1465   -0.1922   -0.1274 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9647   -1.3503   -0.9505 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4135   -0.2064    0.6229 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2465   -1.1449    0.5432 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6785    0.8827    1.4534 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5759    2.1913   -1.1455 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0358   -0.3789    0.1990 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0561   -1.4969   -0.8106 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0816    0.2926    1.4843 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6063    1.1150   -0.8587 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7544   -0.6599   -0.9032 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5551    0.8593    1.5132 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6808   -0.8919    1.2666 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6545   -0.8168   -0.7678 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8317    0.9481   -0.6372 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9385   -0.9799    1.4849 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1146    0.8146    1.4180 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1390    0.7370   -0.7591 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3793   -1.1760   -1.7965 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5452   -2.1340   -0.4148 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4355    1.8342    1.1899 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  3
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  2  0
 11 13  1  0
  1 14  1  0
  3 15  1  0
  3 16  1  0
  4 17  1  0
  5 18  1  0
  5 19  1  0
  6 20  1  0
  6 21  1  0
  7 22  1  0
  7 23  1  0
  8 24  1  0
  8 25  1  0
  9 26  1  6
 10 27  1  0
 10 28  1  0
 13 29  1  0
M  END
Download

PDB for HMDB0000670 (Homo-L-arginine)

HEADER    PROTEIN                                 20-APR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   20-APR-20         0                                  
HETATM    1  C   UNK     0    8685.0178682.603   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8686.3538683.373   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8687.6848682.603   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0    8689.0208683.373   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0    8687.6848681.063   0.000  0.00  0.00           O+0
HETATM    6  N   UNK     0    8686.3538684.912   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0    8683.6818683.373   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8682.3488682.603   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8681.0148683.373   0.000  0.00  0.00           C+0
HETATM   10  N   UNK     0    8679.6798682.603   0.000  0.00  0.00           N+0
HETATM   11  C   UNK     0    8678.3458683.373   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0    8678.3458684.912   0.000  0.00  0.00           N+0
HETATM   13  N   UNK     0    8677.0118682.603   0.000  0.00  0.00           N+0
CONECT    1    2    7                                                       
CONECT    2    1    3    6                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    2                                                            
CONECT    7    1    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11                                                            
MASTER        0    0    0    0    0    0    0    0   13    0   24    0
END
Download

3D PDB for HMDB0000670 (Homo-L-arginine)

COMPND    HMDB0000670
HETATM    1  N1  UNL     1      -4.307   1.432  -1.109  1.00  0.00           N  
HETATM    2  C1  UNL     1      -4.141   0.409  -0.340  1.00  0.00           C  
HETATM    3  N2  UNL     1      -5.155  -0.586  -0.326  1.00  0.00           N  
HETATM    4  N3  UNL     1      -2.971   0.300   0.462  1.00  0.00           N  
HETATM    5  C2  UNL     1      -1.700   0.207  -0.229  1.00  0.00           C  
HETATM    6  C3  UNL     1      -0.542   0.096   0.739  1.00  0.00           C  
HETATM    7  C4  UNL     1       0.723   0.005  -0.048  1.00  0.00           C  
HETATM    8  C5  UNL     1       1.950  -0.110   0.828  1.00  0.00           C  
HETATM    9  C6  UNL     1       3.147  -0.192  -0.127  1.00  0.00           C  
HETATM   10  N4  UNL     1       2.965  -1.350  -0.951  1.00  0.00           N  
HETATM   11  C7  UNL     1       4.414  -0.206   0.623  1.00  0.00           C  
HETATM   12  O1  UNL     1       5.247  -1.145   0.543  1.00  0.00           O  
HETATM   13  O2  UNL     1       4.679   0.883   1.453  1.00  0.00           O  
HETATM   14  H1  UNL     1      -3.576   2.191  -1.146  1.00  0.00           H  
HETATM   15  H2  UNL     1      -6.036  -0.379   0.199  1.00  0.00           H  
HETATM   16  H3  UNL     1      -5.056  -1.497  -0.811  1.00  0.00           H  
HETATM   17  H4  UNL     1      -3.082   0.293   1.484  1.00  0.00           H  
HETATM   18  H5  UNL     1      -1.606   1.115  -0.859  1.00  0.00           H  
HETATM   19  H6  UNL     1      -1.754  -0.660  -0.903  1.00  0.00           H  
HETATM   20  H7  UNL     1      -0.555   0.859   1.513  1.00  0.00           H  
HETATM   21  H8  UNL     1      -0.681  -0.892   1.267  1.00  0.00           H  
HETATM   22  H9  UNL     1       0.655  -0.817  -0.768  1.00  0.00           H  
HETATM   23  H10 UNL     1       0.832   0.948  -0.637  1.00  0.00           H  
HETATM   24  H11 UNL     1       1.939  -0.980   1.485  1.00  0.00           H  
HETATM   25  H12 UNL     1       2.115   0.815   1.418  1.00  0.00           H  
HETATM   26  H13 UNL     1       3.139   0.737  -0.759  1.00  0.00           H  
HETATM   27  H14 UNL     1       2.379  -1.176  -1.797  1.00  0.00           H  
HETATM   28  H15 UNL     1       2.545  -2.134  -0.415  1.00  0.00           H  
HETATM   29  H16 UNL     1       4.435   1.834   1.190  1.00  0.00           H  
CONECT    1    2    2   14
CONECT    2    3    4
CONECT    3   15   16
CONECT    4    5   17
CONECT    5    6   18   19
CONECT    6    7   20   21
CONECT    7    8   22   23
CONECT    8    9   24   25
CONECT    9   10   11   26
CONECT   10   27   28
CONECT   11   12   12   13
CONECT   13   29
END
Download

SMILES for HMDB0000670 (Homo-L-arginine)

N[C@@H](CCCCNC(N)=N)C(O)=O
Download

INCHI for HMDB0000670 (Homo-L-arginine)

InChI=1S/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)/t5-/m0/s1
Download
View in JSmolView Stereo Labels
Synonyms
ValueSource
HomoarginineChEBI
L-N(6)-AmidinolysineChEBI
N6-(Aminoiminomethyl)-L-lysineChEBI
N6-Amidino-L-lysineChEBI
N6-Amidino-lysineChEBI
L-HomoarginineKegg
Homo-L-arginineChEBI
Chemical FormulaC7H16N4O2
Average Molecular Weight188.2275
Monoisotopic Molecular Weight188.127325776
IUPAC Name(2S)-2-amino-6-carbamimidamidohexanoic acid
Traditional NameL-homoarginine
CAS Registry Number156-86-5
SMILES
N[C@@H](CCCCNC(N)=N)C(O)=O
InChI Identifier
InChI=1S/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)/t5-/m0/s1
InChI KeyQUOGESRFPZDMMT-YFKPBYRVSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentL-alpha-amino acids
Alternative Parents
Substituents
  • L-alpha-amino acid
  • Medium-chain fatty acid
  • Amino fatty acid
  • Fatty acid
  • Fatty acyl
  • Guanidine
  • Amino acid
  • Carboximidamide
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Imine
  • Carbonyl group
  • Organic nitrogen compound
  • Amine
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process
Role
Biological roleIndustrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point213 - 215 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility363900 mg/L @ 25 °C (est)The Good Scents Company Information System
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Urine
Tissue Locations
  • Intestine
  • Placenta
  • Testis
Pathways
Normal Concentrations
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified1.65 +/- 0.70 uMAdult (>18 years old)BothCirrhosis details
Cerebrospinal Fluid (CSF)Detected and Quantified1.16 uMAdult (>18 years old)BothHyperargininemia details
Associated Disorders and Diseases
Disease References
Cirrhosis
  1. Marescau B, De Deyn PP, Holvoet J, Possemiers I, Nagels G, Saxena V, Mahler C: Guanidino compounds in serum and urine of cirrhotic patients. Metabolism. 1995 May;44(5):584-8. [PubMed:7752905 ]
Hyperargininemia
  1. Mizutani N, Hayakawa C, Ohya Y, Watanabe K, Watanabe Y, Mori A: Guanidino compounds in hyperargininemia. Tohoku J Exp Med. 1987 Nov;153(3):197-205. [PubMed:3433275 ]
Associated OMIM IDs
DrugBank IDDB03974
Phenol Explorer Compound IDNot Available
FooDB IDFDB112164
KNApSAcK IDC00001364
Chemspider ID8732
KEGG Compound IDC01924
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID5640
PubChem Compound9085
PDB IDNot Available
ChEBI ID27747
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDMDB00000212
Good Scents IDrw1346121
References
Synthesis ReferenceIzumiya, Nobuo. Synthesis of DL-homoarginine and Na-methyl-DL-homoarginine. Nippon Kagaku Zasshi (1951), 72 521-3. CODEN: NPKZAZ ISSN:0369-5387. CAN 46:42183 AN 1952:42183
Material Safety Data Sheet (MSDS)Not Available
General References

Enzymes

Enzyme Details
1. Nitric oxide synthase, endothelial
General function:
Involved in oxidoreductase activity
Specific function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Gene Name:
NOS3
Uniprot ID:
P29474
Molecular weight:
133273.59
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]