Human Metabolome Database Version 2.5

Showing metabocard for Malic acid (HMDB00744)

Legend: metabolite field enzyme field

Version

2.5

Creation Date

2005-11-16 15:48:42

Update Date

2009-05-05 20:58:15

Accession Number

HMDB00744

Secondary Accession Numbers

Not Available

Common Name

Malic acid

Description

Malic acid is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. In its ionised form it is malate, an intermediate of the TCA cycle along with fumarate. It can also be formed from pyruvate as one of the anaplerotic reactions.

Synonyms

2-Hydroxybutanedioic acid
2-Hydroxyethane-1,2-dicarboxylate
2-Hydroxyethane-1,2-dicarboxylic acid
2-Hydroxysuccinate
2-Hydroxysuccinic acid
DL-Malate
DL-Malic acid
Deoxytetrarate
Deoxytetraric acid
Hydroxybutanedioic acid
Hydroxysuccinate
Hydroxysuccinic acid
Musashi-no-Ringosan
Pomalus acid
R,S-Malate
R,S-Malic acid
R,SMalate
R,SMalic acid
a-Hydroxysuccinate
a-Hydroxysuccinic acid
alpha-Hydroxysuccinate
alpha-Hydroxysuccinic acid
2-Hydroxybutanedioate
Hydroxybutanedioate

Chemical IUPAC Name

2-hydroxybutanedioic acid

Chemical Formula

C₄H₆O₅

Chemical Structure

Chemical Taxonomy

Kingdom
Organic
Super Class
Organic acids
Class
Dicarboxylic Acids
Sub Class
Short chain dicarboxylic acids
Family
Mammalian Metabolite
Species
secondary alcohol carboxylic acid alpha-hydroxyacid
Biofunction
Component of Glyoxylate and dicarboxylate metabolism Component of Pyruvate metabolism
Application
—
Source
Endogenous

Average Molecular Weight

134.087

Monoisotopic Molecular Weight

134.021530

Isomeric SMILES

OC(CC(O)=O)C(O)=O

Canonical SMILES

OC(CC(O)=O)C(O)=O

KEGG Compound ID

C00149

BioCyc ID

MAL

BiGG ID

Not Available

Wikipedia Link

Malic acid Link Image

NuGOwiki Link

Metagene Link

METLIN ID

PubChem Compound

PubChem Substance

ChEBI ID

CAS Registry Number

6915-15-7

InChI Identifier

InChI=1/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)

Synthesis Reference

Weiss, J. M.; Downs, C. R. Preliminary study on the formation of malic acid. Journal of the American Chemical Society (1922), 44 1118-25.

Melting Point (Experimental)

131-133 oC

Experimental Water Solubility

1000.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp

Predicted Water Solubility

218.0 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS

Physiological Charge

-2

State

Solid

Experimental LogP/Hydrophobicity

-1.26 [HANSCH,C ET AL. (1995)] Source: PhysProp

Predicted LogP/Hydrophobicity

-0.87 [Predicted by ALOGPS]; -1.5 [Predicted by PubChem via XLOGP] Calculated using ALOGPS

Material Safety Data Sheet (MSDS)

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MOL File

Show

SDF File

Show

PDB File

Show

2D Structure

3D Structure

Experimental PDB ID

Not Available

Experimental ¹H NMR Spectrum

Download Spectrum
Download FID (Varian)
Show Experimental Conditions Link Image

Experimental ¹³C NMR Spectrum

Download Spectrum
Download FID (Bruker)
Show Experimental Conditions Link Image

Experimental ¹³C HSQC Spectrum

Download Spectrum
Download FID (Bruker)
Show Experimental Conditions Link Image

Predicted ¹H NMR Spectrum

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Show Peaklist

Predicted ¹³C NMR Spectrum

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Show Peaklist

Mass Spectrum

Low Energy
Download File Show Experimental Conditions
Medium Energy
Download File Show Experimental Conditions
High Energy
Download File Show Experimental Conditions

Simplified TOCSY Spectrum

Show Image
Show Peaklist

BMRB Spectrum

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Show Peaklist

Cellular Location

Cytoplasm (Predicted from LogP)

Biofluid Location

Not Available

Tissue Location

Not Available

Concentrations (Normal)

Not Available

Concentrations (Abnormal)

Not Available

Associated Disorders

Not Available

OMIM ID

Not Available

Pathways

Name	SMPDB Link	KEGG Link
Gluconeogenesis	SMP00128	map00010
Malate-Aspartate Shuttle	SMP00129

General References

Hem SL: Elimination of aluminum adjuvants. Vaccine. 2002 May 31;20 Suppl 3:S40-3. [PubMed ]
Spiteller M, Spiteller G: [Occurrence of alpha-alkyl-substituted malic acids, and beta-hydroxy-beta-alkyl-substituted dicarboxylic and tricarboxylic acid derivatives in normal urine (author's transl)] J Chromatogr. 1979 Nov 11;164(3):319-29. [PubMed ]
Anneroth G, Nordenram G, Bengtsson S: Effect of saliva stimulants (Hybrin and malic acid) on cervical root surfaces in vitro. Scand J Dent Res. 1980 Jun;88(3):214-8. [PubMed ]
Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38. [PubMed ]
Wikipedia

Metabolic Enzymes

Enzyme 1 [top]

Enzyme 1 ID

6138

Enzyme 1 Name

NADP-dependent malic enzyme

Enzyme 1 Synonyms

NADP-ME
Malic enzyme 1

Enzyme 1 Gene Name

ME1

Enzyme 1 Protein Sequence

>NADP-dependent malic enzyme

MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVK
NFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKP
RGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC
GGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNC
LIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQ
GAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEE
MKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC
YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLT
TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV
RSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ

Enzyme 1 Number of Residues

572

Enzyme 1 Molecular Weight

64150

Enzyme 1 Theoretical pI

6.01

Enzyme 1 GO Classification

Function
NAD binding binding catalytic activity coenzyme binding cofactor binding malate dehydrogenase activity malic enzyme activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
cellular metabolism energy derivation by oxidation of organic compounds generation of precursor metabolites and energy main pathways of carbohydrate metabolism malate metabolism metabolism physiological process tricarboxylic acid cycle intermediate metabolism
Component
—

Enzyme 1 General Function

Energy production and conversion

Enzyme 1 Specific Function

(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

Enzyme 1 Pathways

Carbon fixation (map00710 )
Pyruvate Metabolism (map00620 )

Enzyme 1 Reactions

(S)-malate + NADP+ = pyruvate + CO2 + NADPH

Enzyme 1 Pfam Domain Function

malic (PF00390 )
Malic_M (PF03949 )

Enzyme 1 Signals

None

Enzyme 1 Transmembrane Regions

None

Enzyme 1 Essentiality

Not Available

Enzyme 1 GenBank ID Protein

495123

Enzyme 1 UniProtKB/Swiss-Prot ID

P48163

Enzyme 1 UniProtKB/Swiss-Prot Entry Name

MAOX_HUMAN Link Image

Enzyme 1 PDB ID

Not Available

Enzyme 1 Cellular Location

Not Available

Enzyme 1 Gene Sequence

>1719 bp

ATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGACACGG
AACCCTCACCTCAACAAGGACTTGGCCTTTACCCTGGAAGAGAGACAGCAATTGAACATT
CATGGATTGTTGCCACCTTCCTTCAACAGTCAGGAGATCCAGGTTCTTAGAGTAGTAAAA
AATTTCGAGCATCTGAACTCTGACTTTGACAGGTATCTTCTCTTAATGGATCTCCAAGAT
AGAAATGAAAAACTCTTTTATAGAGTGCTGACATCTGACATTGAGAAATTCATGCCTATT
GTTTATACTCCCACTGTGGGTCTGGCTTGCCAACAATATAGTTTGGTGTTTCGGAAGCCA
AGAGGTCTCTTTATTACTATCCACGATCGAGGGCATATTGCTTCAGTTCTCAATGCATGG
CCAGAAGATGTCATCAAGGCCATTGTGGTGACTGATGGAGAGCGTATTCTTGGCTTGGGA
GACCTTGGCTGTAATGGAATGGGCATCCCTGTGGGTAAATTGGCTCTATATACAGCTTGC
GGAGGGATGAATCCTCAAGAATGTCTGCCTGTCATTCTGGATGTGGGAACCGAAAATGAG
GAGTTACTTAAAGATCCACTCTACATTGGACTACGGCAGAGAAGAGTAAGAGGTTCTGAA
TATGATGATTTTTTGGACGAATTCATGGAGGCAGTTTCTTCCAAGTATGGCATGAATTGC
CTTATTCAGTTTGAAGATTTTGCCAATGTGAATGCATTTCGTCTCCTGAACAAGTATCGA
AACCAGTATTGCACATTCAATGATGATATTCAAGGAACAGCATCTGTTGCAGTTGCAGGT
CTCCTTGCAGCTCTTCGAATAACCAAGAACAAACTGTCTGATCAAACAATACTATTCCAA
GGAGCTGGAGAGGCTGCCCTAGGGATTGCACACCTGATTGTGATGGCCTTGGAAAAAGAA
GGTTTACCAAAAGAGAAAGCCATCAAAAAGATATGGCTGGTTGATTCAAAAGGATTAATA
GTTAAGGGACGTGCTTCCTTAACACAAGAGAAAGAGAAGTTTGCCCATGAACATGAAGAA
ATGAAGAACCTAGAAGCCATTGTTCAAGAAATAAAACCAACTGCCCTCATAGGAGTTGCT
GCAATTGGTGGTGCATTCTCAGAACAAATTCTCAAAGATATGGCTGCCTTCAATGAACGG
CCTATTATTTTTGCTTTGAGTAATCCAACTAGCAAAGCAGAATGTTCTGCAGAGCAGTGC
TACAAAATAACCAAGGGACGTGCAATTTTTGCCAGTGGCAGTCCTTTTGATCCAGTCACT
CTTCCAAATGGACAGACCCTATATCCTGGCCAAGGCAACAATTCCTACGTGTTCCCTGGA
GTTGCTCTTGGTGTTGTGGCGTGTGGATTGAGGCAGATCACAGATAATATTTTCCTCACT
ACTGCTGAGGTTATAGCTCAGCAAGTGTCAGATAAACACTTGGAAGAGGGTCGGCTTTAT
CCTCCTTTGAATACCATTAGAGATGTTTCTCTGAAAATTGCAGAAAAGATTGTGAAAGAT
GCATACCAAGAAAAGACAGCCACAGTTTATCCTGAACCGCAAAACAAAGAAGCATTTGTC
CGCTCCCAGATGTATAGTACTGATTATGACCAGATTCTACCTGATTGTTATTCTTGGCCT
GAAGAGGTGCAGAAAATACAGACCAAAGTTGACCAGTAG

Enzyme 1 GenBank Gene ID

Enzyme 1 GeneCard ID

Enzyme 1 GenAtlas ID

Enzyme 1 HGNC ID

Enzyme 1 Chromosome Location

Enzyme 1 Locus

6q12

Enzyme 1 SNPs

SNPJam Report Link Image

Enzyme 1 General References

Loeber G, Dworkin MB, Infante A, Ahorn H: Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 1994 May 16;344(2-3):181-6. [PubMed ]
Gonzalez-Manchon C, Ferrer M, Ayuso MS, Parrilla R: Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. Gene. 1995 Jul 4;159(2):255-60. [PubMed ]
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [PubMed ]
Chou WY, Huang SM, Chang GG: Nonidentity of the cDNA sequence of human breast cancer cell malic enzyme to that from the normal human cell. J Protein Chem. 1996 Apr;15(3):273-9. [PubMed ]

Enzyme 1 Metabolite References

Not Available

Enzyme 2 [top]

Enzyme 2 ID

6139

Enzyme 2 Name

Malate dehydrogenase, mitochondrial precursor

Enzyme 2 Synonyms

Not Available

Enzyme 2 Gene Name

MDH2

Enzyme 2 Protein Sequence

>Malate dehydrogenase, mitochondrial precursor

MLSALARPVSAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK

Enzyme 2 Number of Residues

338

Enzyme 2 Molecular Weight

35532

Enzyme 2 Theoretical pI

8.90

Enzyme 2 GO Classification

Function
L-lactate dehydrogenase activity L-malate dehydrogenase activity catalytic activity lactate dehydrogenase activity malate dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors
Process
alcohol metabolism cellular metabolism energy derivation by oxidation of organic compounds generation of precursor metabolites and energy glucose catabolism glucose metabolism glycolysis hexose metabolism main pathways of carbohydrate metabolism malate metabolism metabolism monosaccharide metabolism physiological process tricarboxylic acid cycle intermediate metabolism
Component
—

Enzyme 2 General Function

Energy production and conversion

Enzyme 2 Specific Function

(S)-malate + NAD(+) = oxaloacetate + NADH

Enzyme 2 Pathways

Carbon fixation (map00710 )
Citrate Cycle (map00020 )
Glyoxylate and Dicarboxylate Metabolism (map00630 )
Pyruvate Metabolism (map00620 )

Enzyme 2 Reactions

(S)-malate + NAD+ = oxaloacetate + NADH + H+

Enzyme 2 Pfam Domain Function

Ldh_1_C (PF02866 )
Ldh_1_N (PF00056 )

Enzyme 2 Signals

1-11

Enzyme 2 Transmembrane Regions

Not Available

Enzyme 2 Essentiality

Not Available

Enzyme 2 GenBank ID Protein

2906146

Enzyme 2 UniProtKB/Swiss-Prot ID

P40926

Enzyme 2 UniProtKB/Swiss-Prot Entry Name

MDHM_HUMAN Link Image

Enzyme 2 PDB ID

1MLD

Enzyme 2 PDB File

Show

Enzyme 2 3D Structure

Enzyme 2 Cellular Location

Not Available

Enzyme 2 Gene Sequence

>1017 bp

ATGCTCTCCGCCCTCGCCCGGCCTGTCAGCGCTGCTCTCCGCCGCAGCTTCAGCACCTCA
GCCCAGAACAATGCTAAAGTAGCTGTGCTAGGGGCCTCTGGAGGCATCGGGCAGCCACTT
TCACTTCTCCTGAAGAACAGCCCCTTGGTGAGCCGCCTGACCCTCTATGATATCGCGCAC
ACACCCGGAGTGGCCGCAGATCTGAGCCACATCGAGACCAAAGCCGCTGTGAAAGGCTAC
CTCGGACCTGAACAGCTGCCTGACTGCCTGAAAGGTTGTGATGTGGTAGTTATTCCGGCT
GGAGTCCCCAGAAAGCCAGGCATGACCCGGGACGACCTGTTCAACACCAATGCCACGATT
GTGGCCACCCTGACCGCTGCCTGTGCCCAGCACTGCCCGGAAGCCATGATCTGCGTCATT
GCCAATCCGGTTAATTCCACCATCCCCATCACAGCAGAAGTTTTCAAGAAGCATGGAGTG
TACAACCCCAACAAAATCTTCGGCGTGACGACCCTGGACATCGTCAGAGCCAACACCTTT
GTTGCAGAGCTGAAGGGTTTGGATCCAGCTCGAGTCAACGTCCCTGTCATTGGTGGCCAT
GCTGGGAAGACCATCATCCCCCTGATCTCTCAGTGCACCCCCAAGGTGGACTTTCCCCAG
GACCAGCTGACAGCACTCACTGGGCGGATCCAGGAGGCCGGCACGGAGGTGGTCAAGGCT
AAAGCCGGAGCAGGCTCTGCCACCCTCTCCATGGCGTATGCCGGCGCCCGCTTTGTCTTC
TCCCTTGTGGATGCAATGAATGGAAAGGAAGGTGTTGTGGAATGTTCCTTCGTTAAGTCA
CAGGAAACGGAATGTACCTACTTCTCCACACCGCTGCTGCTTGGGAAAAAGGGCATCGAG
AAGAACCTGGGCATCGGCAAAGTCTCCTCTTTTGAGGAGAAGATGATCTCGGATGCCATC
CCCGAGCTGAAGGCCTCCATCAAGAAGGGGGAAGATTTCGTGAAGACCCTGAAGTGA

Enzyme 2 GenBank Gene ID

Enzyme 2 GeneCard ID

Enzyme 2 GenAtlas ID

Enzyme 2 HGNC ID

Enzyme 2 Chromosome Location

Enzyme 2 Locus

7p12.3-q11.2

Enzyme 2 SNPs

SNPJam Report Link Image

Enzyme 2 General References

Not Available

Enzyme 2 Metabolite References

Not Available

Enzyme 3 [top]

Enzyme 3 ID

6140

Enzyme 3 Name

NADP-dependent malic enzyme, mitochondrial precursor

Enzyme 3 Synonyms

NADP-ME
Malic enzyme 3

Enzyme 3 Gene Name

ME3

Enzyme 3 Protein Sequence

>NADP-dependent malic enzyme, mitochondrial precursor

MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
VQTV

Enzyme 3 Number of Residues

604

Enzyme 3 Molecular Weight

67055

Enzyme 3 Theoretical pI

7.92

Enzyme 3 GO Classification

Function
NAD binding binding catalytic activity coenzyme binding cofactor binding malate dehydrogenase activity malic enzyme activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
cellular metabolism energy derivation by oxidation of organic compounds generation of precursor metabolites and energy main pathways of carbohydrate metabolism malate metabolism metabolism physiological process tricarboxylic acid cycle intermediate metabolism
Component
—

Enzyme 3 General Function

Energy production and conversion

Enzyme 3 Specific Function

(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

Enzyme 3 Pathways

Carbon fixation (map00710 )
Pyruvate Metabolism (map00620 )

Enzyme 3 Reactions

(S)-malate + NADP+ = pyruvate + CO2 + NADPH

Enzyme 3 Pfam Domain Function

malic (PF00390 )
Malic_M (PF03949 )

Enzyme 3 Signals

None

Enzyme 3 Transmembrane Regions

None

Enzyme 3 Essentiality

Not Available

Enzyme 3 GenBank ID Protein

535012

Enzyme 3 UniProtKB/Swiss-Prot ID

Q16798

Enzyme 3 UniProtKB/Swiss-Prot Entry Name

MAON_HUMAN Link Image

Enzyme 3 PDB ID

Not Available

Enzyme 3 Cellular Location

Not Available

Enzyme 3 Gene Sequence

>1815 bp

ATGGGTGCCGCGCTGGGGACAGGCACGCGGCTGGCTCCCTGGCCGGGCCGGGCCTGCGGC
GCCCTCCCGCGCTGGACACCCACCGCGCCCGCCCAAGGCTGCCACTCCAAGCCTGGCCCG
GCGCGCCCTGTGCCCCTGAAGAAGCGCGGATACGATGTCACCAGGAACCCTCATCTCAAC
AAGGGGATGGCCTTTACCCTTGAAGAAAGGCTGCAGCTTGGAATCCACGGCCTAATCCCG
CCCTGCTTTCTGAGCCAGGACGTCCAGCTCCTCCGAATCATGAGATATTACGAGCGGCAG
CAGAGTGACCTGGACAAGTACATCATTCTCATGACACTCCAAGACCGGAACGAGAAGCTC
TTCTACCGAGTGCTGACTTCGGATGTGGAGAAGTTCATGCCAATCGTGTACACGCCTACC
GTGGGGCTGGCCTGTCAGCACTATGGCCTGACTTTCCGCAGGCCCCGTGGACTGTTCATC
ACCATTCATGACAAAGGTCATCTTGCAACAATGCTGAATTCTTGGCCAGAAGACAATATT
AAGGCCGTGGTGGTGACTGATGGGGAGCGCATCCTGGGCCTGGGAGACCTGGGCTGCTAC
GGCATGGGCATCCCTGTGGGCAAGCTGGCCCTGTACACGGCATGCGGAGGGGTGAACCCG
CAGCAGTGCCTCCCTGTGCTGCTGGACGTCGGCACCAACAATGAGGAGCTGCTCAGAGAC
CCTCTGTACATCGGCCTGAAACACCAGCGCGTGCACGGGAAGGCATACGATGACTTGCTG
GATGAGTTCATGCAGGCTGTGACAGACAAGTTTGGAATAAATTGCCTCATCCAATTTGAA
GACTTCGCCAATGCCAATGCCTTCCGCCTGCTCAACAAATACCGTAACAAGTACTGCATG
TTCAATGATGACATCCAAGGCACAGCCTCCGTTGCTGTGGCAGGGATCTTGGCTGCTCTG
CGAATCACCAACAACAAGCTTTCCAATCACGTGTTTGTTTTCCAAGGTGCAGGCGAGGCA
GCTATGGGCATTGCCCACCTCCTTGTCATGGCCCTAGAGAAAGAAGGTGTACCGAAGGCA
GAGGCCACAAGAAAGATCTGGATGGTGGACTCTAAAGGGCTCATTGTCAAGGGGAGGAGC
CACCTGAACCATGAAAAGGAGATGTTTGCCCAAGACCATCCTGAAGTCAACTCCCTGGAG
GAGGTGGTGAGGCTGGTGAAGCCCACAGCCATCATAGGTGTTGCTGCCATCGCAGGAGCC
TTCACGGAGCAGATTCTGAGGGACATGGCCTCCTTCCACGAGCGCCCTATCATCTTTGCC
CTGAGCAACCCCACCAGCAAGGCCGAGTGCACGGCTGAGAAGTGCTACCGGGTCACCGAG
GGCCGAGGGATTTTTGCCAGTGGAAGTCCTTTTAAGAGTGTGACTCTGGAAGATGGCAAG
ACCTTCATTCCTGGGCAGGGAAACAATGCTTACGTGTTCCCCGGGGTGGCACTGGGAGTC
ATCGCCGGCGGGATCCGGCACATCCCAGATGAGATCTTCCTCCTGACAGCAGAGCAAATT
GCCCAGGAAGTCTCTGAGCAGCATCTGTCCCAGGGGAGACTCTATCCACCACTCAGCACC
ATCCGAGACGTGTCTTTGAGAATTGCCATCAAAGTTCTCGACTACGCGTACAAACACAAC
CTGGCTTCCTACTACCCAGAGCCTAAGGACAAGGAGGCTTTTGTAAGATCCCTGGTCTAC
ACTCCAGACTATGACTCCTTTACACTGGACAGCTACACTTGGCCCAAGGAAGCCATGAAT
GTTCAGACGGTCTGA

Enzyme 3 GenBank Gene ID

Enzyme 3 GeneCard ID

Enzyme 3 GenAtlas ID

Enzyme 3 HGNC ID

Enzyme 3 Chromosome Location

Enzyme 3 Locus

11cen-q22.3

Enzyme 3 SNPs

SNPJam Report Link Image

Enzyme 3 General References

Loeber G, Maurer-Fogy I, Schwendenwein R: Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. Biochem J. 1994 Dec 15;304 ( Pt 3):687-92. [PubMed ]

Enzyme 3 Metabolite References

Not Available

Enzyme 4 [top]

Enzyme 4 ID

6141

Enzyme 4 Name

Malate dehydrogenase, cytoplasmic

Enzyme 4 Synonyms

Cytosolic malate dehydrogenase

Enzyme 4 Gene Name

MDH1

Enzyme 4 Protein Sequence

>Malate dehydrogenase, cytoplasmic

MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA

Enzyme 4 Number of Residues

334

Enzyme 4 Molecular Weight

36426

Enzyme 4 Theoretical pI

7.45

Enzyme 4 GO Classification

Function
L-lactate dehydrogenase activity L-malate dehydrogenase activity catalytic activity lactate dehydrogenase activity malate dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors
Process
alcohol metabolism cellular metabolism energy derivation by oxidation of organic compounds generation of precursor metabolites and energy glucose catabolism glucose metabolism glycolysis hexose metabolism main pathways of carbohydrate metabolism malate metabolism metabolism monosaccharide metabolism physiological process tricarboxylic acid cycle intermediate metabolism
Component
—

Enzyme 4 General Function

Energy production and conversion

Enzyme 4 Specific Function

(S)-malate + NAD(+) = oxaloacetate + NADH

Enzyme 4 Pathways

Carbon fixation (map00710 )
Citrate Cycle (map00020 )
Glyoxylate and Dicarboxylate Metabolism (map00630 )
Pyruvate Metabolism (map00620 )

Enzyme 4 Reactions

(S)-malate + NAD+ = oxaloacetate + NADH + H+

Enzyme 4 Pfam Domain Function

Ldh_1_C (PF02866 )
Ldh_1_N (PF00056 )

Enzyme 4 Signals

None

Enzyme 4 Transmembrane Regions

None

Enzyme 4 Essentiality

Not Available

Enzyme 4 GenBank ID Protein

1255604

Enzyme 4 UniProtKB/Swiss-Prot ID

P40925

Enzyme 4 UniProtKB/Swiss-Prot Entry Name

MDHC_HUMAN Link Image

Enzyme 4 PDB ID

5MDH

Enzyme 4 PDB File

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Enzyme 4 3D Structure

Enzyme 4 Cellular Location

Not Available

Enzyme 4 Gene Sequence

>1005 bp

ATGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTG
CTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTG
TTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGT
GCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGAC
CTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGAT
TTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCC
AAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCT
TCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCAC
AACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAAT
GTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTG
AAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAG
GGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTA
TCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGA
ACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTT
CCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTT
GAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTG
ACAGAAGAAAAAGAAAGTGCTTTTGAATTTCTTTCCTCTGCCTGA

Enzyme 4 GenBank Gene ID

Enzyme 4 GeneCard ID

Enzyme 4 GenAtlas ID

Enzyme 4 HGNC ID

Enzyme 4 Chromosome Location

Enzyme 4 Locus

2p13.3

Enzyme 4 SNPs

SNPJam Report Link Image

Enzyme 4 General References

Tanaka T, Inazawa J, Nakamura Y: Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase (MDH1). Genomics. 1996 Feb 15;32(1):128-30. [PubMed ]
Corbett JM, Wheeler CH, Baker CS, Yacoub MH, Dunn MJ: The human myocardial two-dimensional gel protein database: update 1994. Electrophoresis. 1994 Nov;15(11):1459-65. [PubMed ]

Enzyme 4 Metabolite References

Not Available

Enzyme 5 [top]

Enzyme 5 ID

6143

Enzyme 5 Name

NAD-dependent malic enzyme, mitochondrial precursor

Enzyme 5 Synonyms

NAD-ME
Malic enzyme 2

Enzyme 5 Gene Name

ME2

Enzyme 5 Protein Sequence

>NAD-dependent malic enzyme, mitochondrial precursor

MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIET
QDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLAC
SQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP
VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMK
AITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISK
PISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS
YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALS
NPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVIL
CNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMA
FRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE

Enzyme 5 Number of Residues

584

Enzyme 5 Molecular Weight

65444

Enzyme 5 Theoretical pI

7.67

Enzyme 5 GO Classification

Function
NAD binding binding catalytic activity coenzyme binding cofactor binding malate dehydrogenase activity malic enzyme activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
cellular metabolism energy derivation by oxidation of organic compounds generation of precursor metabolites and energy main pathways of carbohydrate metabolism malate metabolism metabolism physiological process tricarboxylic acid cycle intermediate metabolism
Component
—

Enzyme 5 General Function

Energy production and conversion

Enzyme 5 Specific Function

(S)-malate + NAD(+) = pyruvate + CO(2) + NADH

Enzyme 5 Pathways

Pyruvate Metabolism (map00620 )

Enzyme 5 Reactions

(S)-malate + NAD+ = pyruvate + CO2 + NADH

Enzyme 5 Pfam Domain Function

malic (PF00390 )
Malic_M (PF03949 )

Enzyme 5 Signals

1-15

Enzyme 5 Transmembrane Regions

Not Available

Enzyme 5 Essentiality

Not Available

Enzyme 5 GenBank ID Protein

187300

Enzyme 5 UniProtKB/Swiss-Prot ID

P23368

Enzyme 5 UniProtKB/Swiss-Prot Entry Name

MAOM_HUMAN Link Image

Enzyme 5 PDB ID

1QR6

Enzyme 5 PDB File

Show

Enzyme 5 3D Structure

Enzyme 5 Cellular Location

Not Available

Enzyme 5 Gene Sequence

>1755 bp

ATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCAC
ATAAAAGAAAAAGGCAAGCCACTTATGCTGAACCCAAGAACAAACAAGGGAATGGCATTT
ACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGACA
CAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAA
AAATATATCTACATAATGGGAATACAAGAAAGAAATGAGAAATTGTTTTATAGAATACTG
CAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCTGC
TCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGA
GGTCATGTTAGATCAATTGTGGATAACTGGCCAGAAAATCATGTTAAGGCTGTTGTAGTG
ACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTCCA
GTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCA
GTGTGTATTGATGTGGGAACTGATAATATCGCACTCTTAAAAGACCCATTTTACATGGGC
TTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGAAA
GCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCAT
AATGCATTCAGGTTCTTGAGAAAGTACCGAGAAAAATATTGTACTTTCAATGATGATATT
CAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTAAA
CCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCA
AATCTTATAGTTATGTCTATGGTAGAAAATGGCCTGTCAGAACAAGAGGCACAAAAGAAA
ATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATAGT
TATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCA
GTGAATATACTGAAGCCTTCAACTATTATTGGAGTTGCAGGTGCTGGCCGTCTTTTCACT
CCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAAGT
AATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGG
TGTTTGTTTGCCAGTGGCAGTCCATTTGGGCCAGTGAAACTTACAGATGGGCGAGTCTTT
ACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTCTC
TGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGC
CAATTGACAGATGAAGAGCTAGCCCAAGGGAGACTTTACCCACCGCTTGCTAATATTCAG
GAAGTTTCTATTAACATTGCTATTAAAGTTACAGAATACCTATATGCTAATAAAATGGCT
TTCCGATACCCAGAACCTGAAGACAAGGCCAAATATGTTAAAGAAAGAACATGGCGGAGT
GAATATGATTCCCTGCTGCCAGATGTGTATGAATGGCCAGAATCTGCATCAAGCCCTCCT
GTGATAACAGAATAG

Enzyme 5 GenBank Gene ID

Enzyme 5 GeneCard ID

Enzyme 5 GenAtlas ID

Enzyme 5 HGNC ID

Enzyme 5 Chromosome Location

Enzyme 5 Locus

6p25-p24|18q21

Enzyme 5 SNPs

SNPJam Report Link Image

Enzyme 5 General References

Loeber G, Infante AA, Maurer-Fogy I, Krystek E, Dworkin MB: Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli. J Biol Chem. 1991 Feb 15;266(5):3016-21. [PubMed ]
Yanaihara N, Kohno T, Takakura S, Takei K, Otsuka A, Sunaga N, Takahashi M, Yamazaki M, Tashiro H, Fukuzumi Y, Fujimori Y, Hagiwara K, Tanaka T, Yokota J: Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. Genomics. 2001 Mar 1;72(2):169-79. [PubMed ]
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed ]
Yang Z, Lanks CW, Tong L: Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate. Structure. 2002 Jul;10(7):951-60. [PubMed ]
Tao X, Yang Z, Tong L: Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism. Structure. 2003 Sep;11(9):1141-50. [PubMed ]

Enzyme 5 Metabolite References

Not Available

Enzyme 6 [top]

Enzyme 6 ID

13015

Enzyme 6 Name

Fumarate hydratase (Fumarate hydratase, isoform CRA_c) (cDNA, FLJ92753, Homo sapiens fumarate hydratase (FH), nuclear gene encodingmitochondrial protein, mRNA)

Enzyme 6 Synonyms

Not Available

Enzyme 6 Gene Name

Enzyme 6 Protein Sequence

>Fumarate hydratase (Fumarate hydratase, isoform CRA_c)

MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL
KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI
MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH
VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV
PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL
TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE
NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA
RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS
TLKETAIELGYLTAEQFDEWVKPKDMLGPK

Enzyme 6 Number of Residues

510

Enzyme 6 Molecular Weight

54637

Enzyme 6 Theoretical pI

Not Available

Enzyme 6 GO Classification

Not Available

Enzyme 6 General Function

Not Available

Enzyme 6 Specific Function

Not Available

Enzyme 6 Pathways

Not Available

Enzyme 6 Reactions

Not Available

Enzyme 6 Pfam Domain Function

Lyase_1 (PF00206 )

Enzyme 6 Signals

None

Enzyme 6 Transmembrane Regions

None

Enzyme 6 Essentiality

Not Available

Enzyme 6 GenBank ID Protein

Not Available

Enzyme 6 UniProtKB/Swiss-Prot ID

B1ANK7

Enzyme 6 UniProtKB/Swiss-Prot Entry Name

B1ANK7_HUMAN Link Image

Enzyme 6 PDB ID

Not Available

Enzyme 6 Cellular Location

Not Available

Enzyme 6 Gene Sequence

Not Available

Enzyme 6 GenBank Gene ID

Not Available

Enzyme 6 GeneCard ID

B1ANK7

Enzyme 6 GenAtlas ID

Not Available

Enzyme 6 HGNC ID

Not Available

Enzyme 6 Chromosome Location

Not Available

Enzyme 6 Locus

Not Available

Enzyme 6 SNPs

SNPJam Report Link Image

Enzyme 6 General References

Not Available

Enzyme 6 Metabolite References

Not Available

Enzyme 7 [top]

Enzyme 7 ID

16504

Enzyme 7 Name

cDNA, FLJ92645, Homo sapiens malate dehydrogenase 1, NAD (soluble) (MDH1), mRNA (Malate dehydrogenase 1, NAD (Soluble), isoform CRA_a)

Enzyme 7 Synonyms

Not Available

Enzyme 7 Gene Name

MDH1

Enzyme 7 Protein Sequence

>cDNA, FLJ92645, Homo sapiens malate dehydrogenase 1, NAD (soluble) (MDH1), mRNA (Malate dehydrogenase 1, NAD (Soluble), isoform CRA_a)

MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA

Enzyme 7 Number of Residues

334

Enzyme 7 Molecular Weight

36426

Enzyme 7 Theoretical pI

7.45

Enzyme 7 GO Classification

Function
L-lactate dehydrogenase activity L-malate dehydrogenase activity catalytic activity lactate dehydrogenase activity malate dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on CH-OH group of donors
Process
alcohol metabolism cellular metabolism energy derivation by oxidation of organic compounds generation of precursor metabolites and energy glucose catabolism glucose metabolism glycolysis hexose metabolism main pathways of carbohydrate metabolism malate metabolism metabolism monosaccharide metabolism physiological process tricarboxylic acid cycle intermediate metabolism
Component
—

Enzyme 7 General Function

Energy production and conversion

Enzyme 7 Specific Function

Not Available

Enzyme 7 Pathways

Not Available

Enzyme 7 Reactions

Not Available

Enzyme 7 Pfam Domain Function

Ldh_1_C (PF02866 )
Ldh_1_N (PF00056 )

Enzyme 7 Signals

None

Enzyme 7 Transmembrane Regions

None

Enzyme 7 Essentiality

Not Available

Enzyme 7 GenBank ID Protein

Not Available

Enzyme 7 UniProtKB/Swiss-Prot ID

B2R5V5

Enzyme 7 UniProtKB/Swiss-Prot Entry Name

B2R5V5_HUMAN Link Image

Enzyme 7 PDB ID

5MDH

Enzyme 7 PDB File

Show

Enzyme 7 3D Structure

Enzyme 7 Cellular Location

Not Available

Enzyme 7 Gene Sequence

Not Available

Enzyme 7 GenBank Gene ID

AK312331

Enzyme 7 GeneCard ID

B2R5V5

Enzyme 7 GenAtlas ID

Not Available

Enzyme 7 HGNC ID

Not Available

Enzyme 7 Chromosome Location

Not Available

Enzyme 7 Locus

Not Available

Enzyme 7 SNPs

SNPJam Report Link Image

Enzyme 7 General References

Not Available

Enzyme 7 Metabolite References

Not Available

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Human Metabolome Database Version 2.5

Showing metabocard for Malic acid (HMDB00744)