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Human Metabolome Database Version 2.5

 

Showing metabocard for 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol (HMDB01286)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2005-11-16 15:48:42
Update Date 2009-05-05 20:58:41
Accession Number HMDB01286
Secondary Accession Numbers Not Available
Common Name 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol
Description 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol (14-demethyllanosterol) is an intermediate in sterol biosynthesis. In particular, it is an intermediate in the conversion of lanosterol to zymosterol. 4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol is a substrate for C-4 methyl sterol oxidase, NAD(P)-dependent steroid dehydrogenase, Cytochrome P450 51A1 and Delta(14)-sterol reductase.
Synonyms
  1. 14-demethyllanosterol
  2. 4,4-Dimethyl-5alpha-cholest-7-en-3beta-ol
  3. 4,4-dimethyl-5 alpha -cholesta-8,24-dien-3 beta -ol
  4. 4,4-dimethyl-5alpha -cholesta-8,24-dien-3-beta -ol
  5. 4,4-dimethyl-8,24-cholestadienol
  6. 4,4-dimethylzymosterol
  7. 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol
  8. 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol
  9. (3beta,5alpha)-4,4-dimethylcholesta-8,24-dien-3-ol
  10. 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol
  11. 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol
Chemical IUPAC Name 4,4,10,13-tetramethyl-17-(6-methylheptan-2-yl)-1,2,3,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ol
Chemical Formula C29H48O
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Cholesterols and derivatives
Class
  • Steroids and Steroid Derivatives
Sub Class
  • Miscellaneous steroids
Family
  • Mammalian Metabolite
Species
  • secondary alcohol
  • alkene
Biofunction
  • Hormones, Membrane component
Application
—
Source
  • Endogenous
Average Molecular Weight 412.691
Monoisotopic Molecular Weight 412.370514
Isomeric SMILES C[C@H](CCC=C(/C)C)C1CC[C@H]2C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@@H]1CC3
Canonical SMILES CC(CCC=C(C)C)C1CCC2C3=C(CCC12C)C1(C)CCC(O)C(C)(C)C1CC3
KEGG Compound ID C05108 Link Image
BioCyc ID 44-DIMETHYL-5ALPHA-CHOLEST-7-EN-3BET Link Image
BiGG ID 45128 Link Image
Wikipedia Link Not Available
NuGOwiki Link HMDB01286 Link Image
Metagene Link HMDB01286 Link Image
METLIN ID 6135 Link Image
PubChem Compound 165609 Link Image
PubChem Substance 8144525 Link Image
ChEBI ID 18364 Link Image
CAS Registry Number 7448-02-4
InChI Identifier InChI=1/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22?,23+,25+,26+,28-,29-/m1/s1
Synthesis Reference Not Available
Melting Point (Experimental) Not Available
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 5.44e-04 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP/Hydrophobicity 7.14 [Predicted by ALOGPS]; 9.1 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS) Not Available
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Membrane
  • endoplasmic reticulum
Biofluid Location Not Available
Tissue Location Not Available
Concentrations (Normal) Not Available
Concentrations (Abnormal) Not Available
Associated Disorders Not Available
OMIM ID Not Available
Pathways
Name SMPDB Link KEGG Link
Steroid Biosynthesis SMP00023 Link Image map00100 Link Image
General References Not Available
Metabolic Enzymes
  1. Delta(14)-sterol reductase
  2. C-4 methylsterol oxidase
  3. 24-dehydrocholesterol reductase precursor
  4. Uncharacterized protein SC4MOL
Enzyme 1 [top]
Enzyme 1 ID 5494
Enzyme 1 Name Delta(14)-sterol reductase
Enzyme 1 Synonyms
  1. C-14 sterol reductase
  2. Sterol C14-reductase
  3. Delta-14-SR
  4. Transmembrane 7 superfamily member 2
  5. Another new gene 1 protein
  6. Putative sterol reductase SR- 1
Enzyme 1 Gene Name TM7SF2
Enzyme 1 Protein Sequence >Delta(14)-sterol reductase 
MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP
RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG
LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN
PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH
EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATG
YYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA
WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
Enzyme 1 Number of Residues 418
Enzyme 1 Molecular Weight 46407
Enzyme 1 Theoretical pI 9.04
Enzyme 1 GO Classification
Function
—
Process
—
Component
  • cell
  • membrane
Enzyme 1 General Function Not Available
Enzyme 1 Specific Function Involved in the conversion of lanosterol to cholesterol
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions
  • 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • 1-36
Enzyme 1 Transmembrane Regions Not Available
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 3211744 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID O76062 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name ERG24_HUMAN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1770 bp 
ATGGAAGGCTTTGGGGGTGTCGGAGGCAGAGGGACCCGGGGGTTTGCAGCGAAGGGTGTC
TGGAGAGGGAGAGCTGAGGAGGGGCCGGTTCTGGGGGCTGCAGAACGGGGATTTATGGTG
TCGACTGGGAGCAGGAGGAGGGTCTTCGAGGGGCCTGGGGGCGGGGGACTAAGATGGACG
CCTGGGAAGGGAACTGGGAGGCAGCGGGGTGCCTGGGGGCCGAGGGCTGAGGACGGGGTG
CGGAGGCGCACTCTGGGAATGCCGAGAGGGTCCCGCAGAGACGTCAGGGCGCCGTGCGGG
CCGGCGGGGAGCTGGGGGGCTAGGGGCGGACGCCGACGTGATGGCCCTTCCCGCAGGCGC
CGCGGCTCTGCTACTGCTGCTGCCCGCCACCATGTTCCACCTGCTCCTGGCGGCCCGTTC
GGGCCCCGCGCGCCTGCTGGGTCCACCCGCGTCCCTGCCCGGGCTGGAGGTGCTGTGGAG
CCCACGGGCGCTGCTGCTGTGGCTCGCCTGGCTCGGCCTGCAGGCGGCGCTCTACCTACT
GCCGGCGCGCAAGGTGCGGGCCCCGCTCGCGGACGCTCGGGGGAGGGAAGCGAATGGGCT
CGGCGAGGGAAAGGACGCCCCGGGCCTTATCAGAGCCCCCTTGGACCCGCAGTGGCCGAG
GGGCAGGAATTGAAGGACAAGAGTCGCCTGCGCTATCCTATTAACGGCTTCCAGGCCCTG
GTGCTGACAGCCCTGTTGGTGGGGCTGGGGATGTCAGCGGGGCTGCCTCTGGGGGCGCTC
CCGGAAATGCTCCTGCCCTTGGCGTTTGTCGCCACCCTCACCGCTTTCATCTTCAGCCTC
TTTCTCTACATGAAGGCGCAGGTAGCCCCAGTTTCGGCCCTGGCACCTGGGGGGAACTCA
GGCAATCCGATTTACGACTTTTTTCTGGGACGAGAGCTCAACCCTCGTATCTGTTTCTTC
GACTTCAAATATTTCTGTGAACTGCGACCCGGCCTCATCGGCTGGGTCCTCATCAACCTG
GCCCTGTTGATGAAGGAGGCAGAGCTTCGAGGCAGTCCCTCACTGGCCATGTGGCTGGTC
AATGGCTTCCAGTTGCTCTACGTGGGTGATGCCCTCTGGCACGAGGAGGCCGTCCTCACC
ACCATGGATATCACACATGACGGGTTTGGCTTCATGCTGGCGTTTGGGGACATGGCCTGG
GTGCCCTTCACCTACAGCCTGCAGGCCCAGTTCCTGCTGCACCACCCGCAGCCCCTGGGG
TTGCCCATGGCCTCTGTCATCTGCCTCATCAATGCTACTGGTTACTACATCTTCCGTGGG
GCGAATTCCCAGAAAAACACTTTCCGAAAGAATCCTTCTGACCCCAGAGTGGCTGGGCTT
GAGACCATCTCTACAGCCACAGGGCGGAAACTGCTGGTGTCTGGGTGGTGGGGTATGGTC
CGCCATCCCAACTATCTTGGAGACCTCATCATGGCTCTGGCTTGGTCCTTGCCCTGCGGG
GTGTCACACCTGCTGCCCTACTTCTACCTCCTCTACTTCACCGCGCTGCTGGTGCACCGT
GAGGCCCGGGATGAGCGGAGTGCCTGCAGAAGTACGGCCTGGCCTGGCAGGAGTACTGCC
GGCGTGTGCCTTACCGCATCATGCCCTACATCTACTGAAGCGGCTCCACCACCCCAGGTG
GGGCATGTGCCCACTCATCCACCAGCACACCCAGGACCAGGAGCCTCGACACACTTGGGA
CTCAAGGGCTTGCACCCCACCCAGCCCTGA
Enzyme 1 GenBank Gene ID AF048704 Link Image
Enzyme 1 GeneCard ID TM7SF2 Link Image
Enzyme 1 GenAtlas ID TM7SF2 Link Image
Enzyme 1 HGNC ID HGNC:11863 Link Image
Enzyme 1 Chromosome Location Not Available
Enzyme 1 Locus Not Available
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. Lemmens IH, Kas K, Merregaert J, Van de Ven WJ: Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13. Genomics. 1998 May 1;49(3):437-42. [PubMed Link Image]
  2. Holmer L, Pezhman A, Worman HJ: The human lamin B receptor/sterol reductase multigene family. Genomics. 1998 Dec 15;54(3):469-76. [PubMed Link Image]
  3. Roberti R, Bennati AM, Galli G, Caruso D, Maras B, Aisa C, Beccari T, Della Fazia MA, Servillo G: Cloning and expression of sterol Delta 14-reductase from bovine liver. Eur J Biochem. 2002 Jan;269(1):283-90. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 5495
Enzyme 2 Name C-4 methylsterol oxidase
Enzyme 2 Synonyms
  1. Methylsterol monooxygenase
Enzyme 2 Gene Name SC4MOL
Enzyme 2 Protein Sequence >C-4 methylsterol oxidase 
MATNESVSIFSSASLAVEYVDSLLPENPLQEPFKNAWNYMLNNYTKFQIATWGSLIVHEA
LYFLFCLPGFLFQFIPYMKKYKIQKDKPETWENQWKCFKVLLFNHFCIQLPLICGTYYFT
EYFNIPYDWERMPRWYFLLARCFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPF
GMEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVTIRLLETIDVHSGYDIPLNPLNL
IPFYAGSRHHDFHHMNFIGNYASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE
Enzyme 2 Number of Residues 293
Enzyme 2 Molecular Weight 35216
Enzyme 2 Theoretical pI 7.25
Enzyme 2 GO Classification
Function
  • catalytic activity
Process
  • metabolism
  • physiological process
Component
—
Enzyme 2 General Function Lipid transport and metabolism
Enzyme 2 Specific Function 4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha- cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O
Enzyme 2 Pathways Not Available
Enzyme 2 Reactions
  • (1) 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)+ + H2O
  • (2) 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)+ + 2 H2O
  • (3) 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ + H2O
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • 55-75 100-120 199-219
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 1408206 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q15800 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name ERG25_HUMAN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >882 bp 
ATGGCAACAAATGAAAGTGTCAGCATCTTTAGTTCAGCATCCTTGGCTGTGGAATATGTA
GATTCACTTTTACCTGAGAATCCTCTGCAAGAACCATTTAAAAATGCTTGGAACTATATG
TTGAATAATTATACAAAGTTCCAGATTGCAACATGGGGATCCCTTATAGTTCATGAAGCC
CTTTATTTCTTATTCTGTTTACCTGGATTTTTATTTCAATTTATACCTTATATGAAAAAA
TACAAAATTCAAAAGGATAAGCCAGAGACATGGGAAAACCAATGGAAGTGTTTCAAAGTT
CTTCTCTTTAATCACTTCTGTATCCAGCTGCCTTTGATTTGTGGAACCTATTATTTTACA
GAGTATTTCAATATTCCTTATGATTGGGAAAGAATGCCAAGATGGTATTTTCTTTTGGCA
AGATGCTTTGGTTGTGCAGTCATTGAAGATACTTGGCACTATTTTCTGCATAGACTCTTA
CACCACAAAAGAATATACAAGTATATTCATAAAGTTCATCATGAGTTTCAGGCTCCATTT
GGAATGGAAGCTGAATATGCACATCCTTTGGAGACTCTAATTCTTGGAACTGGATTTTTC
ATTGGAATCGTGCTTTTGTGTGATCATGTAATTCTTCTTTGGGCATGGGTGACCATTCGT
TTATTAGAAACTATTGATGTCCATAGTGGTTATGATATTCCTCTCAACCCTTTAAATCTG
ATCCCTTTCTATGCTGGTTCTCGGCATCATGATTTCCACCACATGAACTTCATTGGAAAC
TATGCTTCAACATTTACATGGTGGGATCGAATTTTTGGAACAGACTCTCAGTATAATGCC
TATAATGAAAAGAGGAAGAAGTTTGAGAAAAAGACTGAATAA
Enzyme 2 GenBank Gene ID U60205 Link Image
Enzyme 2 GeneCard ID SC4MOL Link Image
Enzyme 2 GenAtlas ID SC4MOL Link Image
Enzyme 2 HGNC ID HGNC:10545 Link Image
Enzyme 2 Chromosome Location Not Available
Enzyme 2 Locus Not Available
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. Li L, Kaplan J: Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem. 1996 Jul 12;271(28):16927-33. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 7345
Enzyme 3 Name 24-dehydrocholesterol reductase precursor
Enzyme 3 Synonyms
  1. 3-beta- hydroxysterol delta-24-reductase
  2. Seladin-1
  3. Diminuto/dwarf1 homolog
Enzyme 3 Gene Name DHCR24
Enzyme 3 Protein Sequence >24-dehydrocholesterol reductase precursor 
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKL
SSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMD
ILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKY
GLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKL
RFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYY
KPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVP
PKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQ
PGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREE
FWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
Enzyme 3 Number of Residues 516
Enzyme 3 Molecular Weight 60102
Enzyme 3 Theoretical pI 8.24
Enzyme 3 GO Classification
Function
—
Process
  • cellular metabolism
  • electron transport
  • generation of precursor metabolites and energy
  • metabolism
  • physiological process
Component
—
Enzyme 3 General Function Energy production and conversion
Enzyme 3 Specific Function Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • 1-22
Enzyme 3 Transmembrane Regions
  • 32-52
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 10442025 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q15392 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name DHC24_HUMAN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1551 bp 
ATGGAGCCCGCCGTGTCGCTGGCCGTGTGCGCGCTGCTCTTCCTGCTGTGGGTGCGCCTG
AAGGGGCTGGAGTTCGTGCTCATCCACCAGCGCTGGGTGTTCGTGTGCCTCTTCCTCCTG
CCGCTCTCGCTTATCTTCGATATCTACTACTACGTGCGCGCCTGGGTGGTGTTCAAGCTC
AGCAGCGCTCCGCGCCTGCACGAGCAGCGCGTGCGGGACATCCAGAAGCAGGTGCGGGAA
TGGAAGGAGCAGGGTAGCAAGACCTTCATGTGCACGGGGCGCCCTGGCTGGCTCACTGTC
TCACTACGTGTCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAACCTGATGGAC
ATTCTGGAAGTGGACACCAAGAAACAGATTGTCCGTGTGGAGCCCTTGGTGACCATGGGC
CAGGTGACTGCCCTGCTGACCTCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGAT
GACCTCACAGTGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCCCACAAGTAC
GGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCCTGGCTGATGGCAGCTTTGTG
CGATGCACTCCGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACG
CTGGGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTG
CGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCCCAG
CGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATG
ACAGGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTAC
AAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGACAAACCGAGAGGGCCTGGAG
TACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAG
GACATCATCCCCTTTGGCAACAACCCCATCTTCCGCTACCTCTTTGGCTGGATGGTGCCT
CCCAAGATCTCCCTCCTGAAGCTGACCCAGGGTGAGACCCTGCGCAAGCTGTACGAGCAG
CACCACGTGGTGCAGGACATGCTGGTGCCCATGAAGTGCCTGCAGCAGGCCCTGCACACC
TTCCAAAACGACATCCACGTCTACCCCATCTGGCTGTGTCCGTTCATCCTGCCCAGCCAG
CCAGGCCTAGTGCACCCCAAAGGAAATGAGGCAGAGCTCTACATCGACATTGGAGCATAT
GGGGAGCCGCGTGTGAAACACTTTGAAGCCAGGTCCTGCATGAGGCAGCTGGAGAAGTTT
GTCCGCAGCGTGCATGGCTTCCAGATGCTGTATGCCGACTGCTACATGAACCGGGAGGAG
TTCTGGGAGATGTTTGATGGCTCCTTGTACCACAAGCTGCGAGAGAAGCTGGGTTGCCAG
GACGCCTTCCCCGAGGTGTACGACAAGATCTGCAAGGCCGCCAGGCACTGA
Enzyme 3 GenBank Gene ID AF261758 Link Image
Enzyme 3 GeneCard ID DHCR24 Link Image
Enzyme 3 GenAtlas ID DHCR24 Link Image
Enzyme 3 HGNC ID HGNC:2859 Link Image
Enzyme 3 Chromosome Location 1
Enzyme 3 Locus 1p33-p31.1
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, Levkau B, Nitsch RM: The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J Neurosci. 2000 Oct 1;20(19):7345-52. [PubMed Link Image]
  2. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ: Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am J Hum Genet. 2001 Oct;69(4):685-94. Epub 2001 Aug 22. [PubMed Link Image]
  3. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1994;1(1):27-35. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 15243
Enzyme 4 Name Uncharacterized protein SC4MOL
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name SC4MOL
Enzyme 4 Protein Sequence >Uncharacterized protein SC4MOL 
MPRWYFLLARCFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGMEAEYAHPLE
TLILGTGFFIGIVLLCDHVILLWAWVTIRLLETIDVHSGYDIPLNPLNLIPFYAGSRHHD
FHHMNFIGNYASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE
Enzyme 4 Number of Residues 162
Enzyme 4 Molecular Weight 19471
Enzyme 4 Theoretical pI 7.79
Enzyme 4 GO Classification Not Available
Enzyme 4 General Function Lipid transport and metabolism
Enzyme 4 Specific Function Not Available
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function Not Available
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein Not Available
Enzyme 4 UniProtKB/Swiss-Prot ID A8MYF6 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name A8MYF6_HUMAN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence Not Available
Enzyme 4 GenBank Gene ID AC012504 Link Image
Enzyme 4 GeneCard ID A8MYF6 Link Image
Enzyme 4 GenAtlas ID SC4MOL Link Image
Enzyme 4 HGNC ID HGNC:10545 Link Image
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus Not Available
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available