General function:

Involved in peroxidase activity

Specific function:

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Gene Name:

MPO

Uniprot ID:

P05164

Molecular weight:

83867.71

Reactions

General function:

Involved in glutathione transferase activity

Specific function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Gene Name:

GSTM2

Uniprot ID:

P28161

Molecular weight:

25744.395

Reactions

General function:

Involved in glutathione transferase activity

Specific function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Gene Name:

GSTM1

Uniprot ID:

P09488

Molecular weight:

25711.555

Reactions

General function:

Involved in protein disulfide oxidoreductase activity

Specific function:

Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).

Gene Name:

GSTK1

Uniprot ID:

Q9Y2Q3

Molecular weight:

31565.605

Reactions

General function:

Involved in glutathione transferase activity

Specific function:

Also functions as a glutathione peroxidase.

Gene Name:

MGST3

Uniprot ID:

O14880

Molecular weight:

16516.185

Reactions

General function:

Involved in glutathione transferase activity

Specific function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

Gene Name:

GSTM3

Uniprot ID:

P21266

Molecular weight:

26559.32

Reactions

General function:

Involved in glutathione transferase activity

Specific function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Gene Name:

GSTA1

Uniprot ID:

P08263

Molecular weight:

25630.785

Reactions

General function:

Involved in catalytic activity

Specific function:

Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.

Gene Name:

GSTZ1

Uniprot ID:

O43708

Molecular weight:

17895.68

General function:

Involved in glutathione transferase activity

Specific function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Gene Name:

MGST1

Uniprot ID:

P10620

Molecular weight:

17598.45

Reactions

General function:

Involved in glutathione transferase activity

Specific function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene.

Gene Name:

GSTM4

Uniprot ID:

Q03013

Molecular weight:

25561.095

Reactions