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Record Information

Version

5.0

Status

Detected but not Quantified

Creation Date

2019-11-14 17:10:14 UTC

Update Date

2022-10-24 19:44:15 UTC

HMDB ID

HMDB0240588

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Myristoleoylcarnitine

Description

Myristoleoylcarnitine is an acylcarnitine. More specifically, it is an myristoleoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279 ). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review (PMID: 35710135 ), acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. Myristoleoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine myristoleoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748 ). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. In particular myristoleoylcarnitine is elevated in the blood or plasma of individuals with very long-chain acyl-CoA dehydrogenase (VLACD) deficiency (PMID: 25843429 , PMID: 19327992 , PMID: 11433098 , PMID: 18670371 , PMID: 12828998 ), trifunctional protein (mitochondrial long-chain ketoacyl-coa thiolase) deficiency (PMID: 16423905 ), mitochondrial dysfunction in diabetes patients (PMID: 28726959 ), acadvl acyl-coa dehydrogenase very long chain deficiency (PMID: 29491033 ), nonalcoholic fatty liver disease (NAFLD) (PMID: 27211699 ), and insulin resistance type 2 diabetes (PMID: 24358186 ).Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulin's inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774 ). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903 ). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394 ). Myristoleoylcarnitine has also been identified in the human placenta (PMID: 32033212 ). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available (PMID: 35710135 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

  Mrv1652311141918032D          

 26 25  0  0  0  0            999 V2000
 9995.3919 9999.7907    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9996.1059 9999.3774    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9996.8199 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.5339 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.2479 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.9619 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.6759 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.3908 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.1044 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.8180 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.5336 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10003.3586 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.0722 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.7858 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10005.4994 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.2150 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.819910000.6151    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9995.391910000.6151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.677910001.0255    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
 9993.959810000.6130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.677910001.8504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.824910001.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.6862 9999.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.6862 9998.5428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9995.4002 9998.1295    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
 9993.9722 9998.1295    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1 18  1  6  0  0  0
  1 23  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3 17  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  2  19   1  25  -1
M  END

HMDB0242105
     RDKit          3D
O-[(9Z)-Tetradecenoyl]-L-carnitine
 65 64  0  0  0  0  0  0  0  0999 V2000
    8.3225    1.0654    1.9706 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6716    0.7057    0.5539 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7373   -0.3030   -0.0056 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3268    0.0883   -0.1635 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5343    0.4796    0.9942 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4481   -0.2138    1.3900 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9219   -1.4123    0.7496 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4706   -1.1980    0.2395 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5448   -0.0882   -0.7335 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3062    0.3947   -1.3792 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4964   -0.4864   -2.2191 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1270   -1.7047   -1.6948 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0643   -1.5649   -0.5417 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2206   -0.7135   -0.8754 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4510   -0.1751   -1.9745 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1360   -0.4978    0.1445 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3045    0.2919    0.0345 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.3633    1.3541    1.0494 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2081    2.2658    0.9281 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3489    2.0678    0.0432 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0355    3.3602    1.7794 O   0  0  0  0  0  1  0  0  0  0  0  0
   -5.4504   -0.6939    0.1128 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7562   -0.1782    0.0322 N   0  0  0  0  0  4  0  0  0  0  0  0
   -7.5839   -1.2471   -0.5715 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3752    0.0112    1.3583 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9872    0.9881   -0.7438 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6096    0.3155    2.3537 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8605    2.0665    1.9748 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.2563    1.0690    2.6129 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.7088    0.2539    0.5229 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.6824    1.6225   -0.1025 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8640   -1.2436    0.6071 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.0981   -0.6260   -1.0361 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3769    1.0459   -0.8302 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7679   -0.5908   -0.8813 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7230    1.3579    1.6010 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9121    0.1621    2.2783 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5774   -1.8139   -0.0020 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8129   -2.2468    1.5196 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2588   -2.1491   -0.2832 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8078   -1.0170    1.0983 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3025   -0.3707   -1.5129 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9944    0.8158   -0.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914    0.9964   -0.6396 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6559    1.2390   -2.0755 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3079    0.1289   -2.7303 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1392   -0.7973   -3.0973 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4843   -2.6041   -1.5687 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8367   -2.0470   -2.5567 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4835   -2.5963   -0.3480 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5723   -1.2780    0.4057 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2632    0.7336   -0.9834 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2646    2.0022    0.9035 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3569    0.9970    2.1009 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3360   -1.2650    1.0552 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2649   -1.4352   -0.7079 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2401   -1.4452   -1.5897 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6673   -0.9479   -0.5339 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4225   -2.1404    0.0569 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5417   -1.0378    1.7433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7083    0.4868    2.0698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3370    0.5261    1.2042 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1422    1.4345   -1.2556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7784    0.8510   -1.5418 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4292    1.8129   -0.1077 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 17 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
  1 27  1  0
  1 28  1  0
  1 29  1  0
  2 30  1  0
  2 31  1  0
  3 32  1  0
  3 33  1  0
  4 34  1  0
  4 35  1  0
  5 36  1  0
  6 37  1  0
  7 38  1  0
  7 39  1  0
  8 40  1  0
  8 41  1  0
  9 42  1  0
  9 43  1  0
 10 44  1  0
 10 45  1  0
 11 46  1  0
 11 47  1  0
 12 48  1  0
 12 49  1  0
 13 50  1  0
 13 51  1  0
 17 52  1  6
 18 53  1  0
 18 54  1  0
 22 55  1  0
 22 56  1  0
 24 57  1  0
 24 58  1  0
 24 59  1  0
 25 60  1  0
 25 61  1  0
 25 62  1  0
 26 63  1  0
 26 64  1  0
 26 65  1  0
M  CHG  2  21  -1  23   1
M  END

  Mrv1652311141918032D          

 26 25  0  0  0  0            999 V2000
 9995.3919 9999.7907    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9996.1059 9999.3774    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9996.8199 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.5339 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.2479 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.9619 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.6759 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.3908 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.1044 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.8180 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.5336 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10003.3586 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.0722 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.7858 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10005.4994 9999.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10006.2150 9999.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.819910000.6151    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9995.391910000.6151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.677910001.0255    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
 9993.959810000.6130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.677910001.8504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.824910001.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.6862 9999.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.6862 9998.5428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9995.4002 9998.1295    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
 9993.9722 9998.1295    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1 18  1  6  0  0  0
  1 23  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3 17  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  2  19   1  25  -1
M  END
> <DATABASE_ID>
HMDB0240588

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCC\C=C/CCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C21H39NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h8-9,19H,5-7,10-18H2,1-4H3/b9-8-/t19-/m1/s1

> <INCHI_KEY>
ABVVZYXTZLEOHP-OLHLWXQYSA-N

> <FORMULA>
C21H39NO4

> <MOLECULAR_WEIGHT>
369.546

> <EXACT_MASS>
369.28790874

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
44.69168258192142

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3R)-3-[(9Z)-tetradec-9-enoyloxy]-4-(trimethylazaniumyl)butanoate

> <ALOGPS_LOGP>
0.37

> <JCHEM_LOGP>
0.7824888675282539

> <ALOGPS_LOGS>
-7.36

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.216763902737658

> <JCHEM_PKA_STRONGEST_BASIC>
-7.0571868920224

> <JCHEM_POLAR_SURFACE_AREA>
66.43

> <JCHEM_REFRACTIVITY>
128.9913

> <JCHEM_ROTATABLE_BOND_COUNT>
17

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.84e-05 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3R)-3-[(9Z)-tetradec-9-enoyloxy]-4-(trimethylammonio)butanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0242105
     RDKit          3D
O-[(9Z)-Tetradecenoyl]-L-carnitine
 65 64  0  0  0  0  0  0  0  0999 V2000
    8.3225    1.0654    1.9706 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6716    0.7057    0.5539 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7373   -0.3030   -0.0056 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3268    0.0883   -0.1635 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5343    0.4796    0.9942 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4481   -0.2138    1.3900 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9219   -1.4123    0.7496 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4706   -1.1980    0.2395 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5448   -0.0882   -0.7335 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3062    0.3947   -1.3792 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4964   -0.4864   -2.2191 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1270   -1.7047   -1.6948 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0643   -1.5649   -0.5417 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2206   -0.7135   -0.8754 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4510   -0.1751   -1.9745 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1360   -0.4978    0.1445 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3045    0.2919    0.0345 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.3633    1.3541    1.0494 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2081    2.2658    0.9281 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3489    2.0678    0.0432 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0355    3.3602    1.7794 O   0  0  0  0  0  1  0  0  0  0  0  0
   -5.4504   -0.6939    0.1128 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7562   -0.1782    0.0322 N   0  0  0  0  0  4  0  0  0  0  0  0
   -7.5839   -1.2471   -0.5715 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3752    0.0112    1.3583 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9872    0.9881   -0.7438 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6096    0.3155    2.3537 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8605    2.0665    1.9748 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.2563    1.0690    2.6129 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.7088    0.2539    0.5229 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.6824    1.6225   -0.1025 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8640   -1.2436    0.6071 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.0981   -0.6260   -1.0361 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3769    1.0459   -0.8302 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7679   -0.5908   -0.8813 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7230    1.3579    1.6010 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9121    0.1621    2.2783 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5774   -1.8139   -0.0020 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8129   -2.2468    1.5196 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2588   -2.1491   -0.2832 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8078   -1.0170    1.0983 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3025   -0.3707   -1.5129 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9944    0.8158   -0.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914    0.9964   -0.6396 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6559    1.2390   -2.0755 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3079    0.1289   -2.7303 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1392   -0.7973   -3.0973 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4843   -2.6041   -1.5687 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8367   -2.0470   -2.5567 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4835   -2.5963   -0.3480 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5723   -1.2780    0.4057 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2632    0.7336   -0.9834 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2646    2.0022    0.9035 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3569    0.9970    2.1009 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3360   -1.2650    1.0552 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2649   -1.4352   -0.7079 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2401   -1.4452   -1.5897 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6673   -0.9479   -0.5339 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4225   -2.1404    0.0569 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5417   -1.0378    1.7433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7083    0.4868    2.0698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3370    0.5261    1.2042 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1422    1.4345   -1.2556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7784    0.8510   -1.5418 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4292    1.8129   -0.1077 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 17 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
  1 27  1  0
  1 28  1  0
  1 29  1  0
  2 30  1  0
  2 31  1  0
  3 32  1  0
  3 33  1  0
  4 34  1  0
  4 35  1  0
  5 36  1  0
  6 37  1  0
  7 38  1  0
  7 39  1  0
  8 40  1  0
  8 41  1  0
  9 42  1  0
  9 43  1  0
 10 44  1  0
 10 45  1  0
 11 46  1  0
 11 47  1  0
 12 48  1  0
 12 49  1  0
 13 50  1  0
 13 51  1  0
 17 52  1  6
 18 53  1  0
 18 54  1  0
 22 55  1  0
 22 56  1  0
 24 57  1  0
 24 58  1  0
 24 59  1  0
 25 60  1  0
 25 61  1  0
 25 62  1  0
 26 63  1  0
 26 64  1  0
 26 65  1  0
M  CHG  2  21  -1  23   1
M  END

HEADER    PROTEIN                                 14-NOV-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   14-NOV-19         0                                  
HETATM    1  C   UNK     0    8658.0658666.276   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0    8659.3988665.504   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0    8660.7308666.276   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8662.0638665.504   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0    8663.3968666.276   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0    8664.7298665.504   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0    8666.0628666.276   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8667.3968665.504   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8668.7288666.276   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8670.0608665.504   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0    8671.3968666.276   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8672.9368666.276   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0    8674.2688665.504   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0    8675.6008666.276   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0    8676.9328665.504   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0    8678.2688666.276   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0    8660.7308667.815   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0    8658.0658667.815   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0    8656.7328668.581   0.000  0.00  0.00           N+1
HETATM   20  C   UNK     0    8655.3928667.811   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0    8656.7328670.121   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0    8655.1408669.501   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0    8656.7488665.485   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0    8656.7488663.947   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0    8658.0808663.175   0.000  0.00  0.00           O-1
HETATM   26  O   UNK     0    8655.4158663.175   0.000  0.00  0.00           O+0
CONECT    1    2   18   23                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4   17                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15                                                            
CONECT   17    3                                                            
CONECT   18    1   19                                                       
CONECT   19   18   20   21   22                                             
CONECT   20   19                                                            
CONECT   21   19                                                            
CONECT   22   19                                                            
CONECT   23    1   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24                                                            
MASTER        0    0    0    0    0    0    0    0   26    0   50    0
END

COMPND    HMDB0242105
HETATM    1  C1  UNL     1       8.323   1.065   1.971  1.00  0.00           C  
HETATM    2  C2  UNL     1       8.672   0.706   0.554  1.00  0.00           C  
HETATM    3  C3  UNL     1       7.737  -0.303  -0.006  1.00  0.00           C  
HETATM    4  C4  UNL     1       6.327   0.088  -0.164  1.00  0.00           C  
HETATM    5  C5  UNL     1       5.534   0.480   0.994  1.00  0.00           C  
HETATM    6  C6  UNL     1       4.448  -0.214   1.390  1.00  0.00           C  
HETATM    7  C7  UNL     1       3.922  -1.412   0.750  1.00  0.00           C  
HETATM    8  C8  UNL     1       2.471  -1.198   0.239  1.00  0.00           C  
HETATM    9  C9  UNL     1       2.545  -0.088  -0.733  1.00  0.00           C  
HETATM   10  C10 UNL     1       1.306   0.395  -1.379  1.00  0.00           C  
HETATM   11  C11 UNL     1       0.496  -0.486  -2.219  1.00  0.00           C  
HETATM   12  C12 UNL     1      -0.127  -1.705  -1.695  1.00  0.00           C  
HETATM   13  C13 UNL     1      -1.064  -1.565  -0.542  1.00  0.00           C  
HETATM   14  C14 UNL     1      -2.221  -0.713  -0.875  1.00  0.00           C  
HETATM   15  O1  UNL     1      -2.451  -0.175  -1.974  1.00  0.00           O  
HETATM   16  O2  UNL     1      -3.136  -0.498   0.145  1.00  0.00           O  
HETATM   17  C15 UNL     1      -4.304   0.292   0.035  1.00  0.00           C  
HETATM   18  C16 UNL     1      -4.363   1.354   1.049  1.00  0.00           C  
HETATM   19  C17 UNL     1      -3.208   2.266   0.928  1.00  0.00           C  
HETATM   20  O3  UNL     1      -2.349   2.068   0.043  1.00  0.00           O  
HETATM   21  O4  UNL     1      -3.035   3.360   1.779  1.00  0.00           O1-
HETATM   22  C18 UNL     1      -5.450  -0.694   0.113  1.00  0.00           C  
HETATM   23  N1  UNL     1      -6.756  -0.178   0.032  1.00  0.00           N1+
HETATM   24  C19 UNL     1      -7.584  -1.247  -0.572  1.00  0.00           C  
HETATM   25  C20 UNL     1      -7.375   0.011   1.358  1.00  0.00           C  
HETATM   26  C21 UNL     1      -6.987   0.988  -0.744  1.00  0.00           C  
HETATM   27  H1  UNL     1       7.610   0.315   2.354  1.00  0.00           H  
HETATM   28  H2  UNL     1       7.860   2.067   1.975  1.00  0.00           H  
HETATM   29  H3  UNL     1       9.256   1.069   2.613  1.00  0.00           H  
HETATM   30  H4  UNL     1       9.709   0.254   0.523  1.00  0.00           H  
HETATM   31  H5  UNL     1       8.682   1.622  -0.102  1.00  0.00           H  
HETATM   32  H6  UNL     1       7.864  -1.244   0.607  1.00  0.00           H  
HETATM   33  H7  UNL     1       8.098  -0.626  -1.036  1.00  0.00           H  
HETATM   34  H8  UNL     1       6.377   1.046  -0.830  1.00  0.00           H  
HETATM   35  H9  UNL     1       5.768  -0.591  -0.881  1.00  0.00           H  
HETATM   36  H10 UNL     1       5.723   1.358   1.601  1.00  0.00           H  
HETATM   37  H11 UNL     1       3.912   0.162   2.278  1.00  0.00           H  
HETATM   38  H12 UNL     1       4.577  -1.814  -0.002  1.00  0.00           H  
HETATM   39  H13 UNL     1       3.813  -2.247   1.520  1.00  0.00           H  
HETATM   40  H14 UNL     1       2.259  -2.149  -0.283  1.00  0.00           H  
HETATM   41  H15 UNL     1       1.808  -1.017   1.098  1.00  0.00           H  
HETATM   42  H16 UNL     1       3.303  -0.371  -1.513  1.00  0.00           H  
HETATM   43  H17 UNL     1       2.994   0.816  -0.201  1.00  0.00           H  
HETATM   44  H18 UNL     1       0.691   0.996  -0.640  1.00  0.00           H  
HETATM   45  H19 UNL     1       1.656   1.239  -2.076  1.00  0.00           H  
HETATM   46  H20 UNL     1      -0.308   0.129  -2.730  1.00  0.00           H  
HETATM   47  H21 UNL     1       1.139  -0.797  -3.097  1.00  0.00           H  
HETATM   48  H22 UNL     1       0.484  -2.604  -1.569  1.00  0.00           H  
HETATM   49  H23 UNL     1      -0.837  -2.047  -2.557  1.00  0.00           H  
HETATM   50  H24 UNL     1      -1.484  -2.596  -0.348  1.00  0.00           H  
HETATM   51  H25 UNL     1      -0.572  -1.278   0.406  1.00  0.00           H  
HETATM   52  H26 UNL     1      -4.263   0.734  -0.983  1.00  0.00           H  
HETATM   53  H27 UNL     1      -5.265   2.002   0.904  1.00  0.00           H  
HETATM   54  H28 UNL     1      -4.357   0.997   2.101  1.00  0.00           H  
HETATM   55  H29 UNL     1      -5.336  -1.265   1.055  1.00  0.00           H  
HETATM   56  H30 UNL     1      -5.265  -1.435  -0.708  1.00  0.00           H  
HETATM   57  H31 UNL     1      -7.240  -1.445  -1.590  1.00  0.00           H  
HETATM   58  H32 UNL     1      -8.667  -0.948  -0.534  1.00  0.00           H  
HETATM   59  H33 UNL     1      -7.422  -2.140   0.057  1.00  0.00           H  
HETATM   60  H34 UNL     1      -7.542  -1.038   1.743  1.00  0.00           H  
HETATM   61  H35 UNL     1      -6.708   0.487   2.070  1.00  0.00           H  
HETATM   62  H36 UNL     1      -8.337   0.526   1.204  1.00  0.00           H  
HETATM   63  H37 UNL     1      -6.142   1.434  -1.256  1.00  0.00           H  
HETATM   64  H38 UNL     1      -7.778   0.851  -1.542  1.00  0.00           H  
HETATM   65  H39 UNL     1      -7.429   1.813  -0.108  1.00  0.00           H  
CONECT    1    2   27   28   29
CONECT    2    3   30   31
CONECT    3    4   32   33
CONECT    4    5   34   35
CONECT    5    6    6   36
CONECT    6    7   37
CONECT    7    8   38   39
CONECT    8    9   40   41
CONECT    9   10   42   43
CONECT   10   11   44   45
CONECT   11   12   46   47
CONECT   12   13   48   49
CONECT   13   14   50   51
CONECT   14   15   15   16
CONECT   16   17
CONECT   17   18   22   52
CONECT   18   19   53   54
CONECT   19   20   20   21
CONECT   22   23   55   56
CONECT   23   24   25   26
CONECT   24   57   58   59
CONECT   25   60   61   62
CONECT   26   63   64   65
END

HMDB0242105
     RDKit          3D
O-[(9Z)-Tetradecenoyl]-L-carnitine
 65 64  0  0  0  0  0  0  0  0999 V2000
    8.3225    1.0654    1.9706 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6716    0.7057    0.5539 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7373   -0.3030   -0.0056 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3268    0.0883   -0.1635 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5343    0.4796    0.9942 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4481   -0.2138    1.3900 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9219   -1.4123    0.7496 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4706   -1.1980    0.2395 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5448   -0.0882   -0.7335 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3062    0.3947   -1.3792 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4964   -0.4864   -2.2191 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1270   -1.7047   -1.6948 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0643   -1.5649   -0.5417 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2206   -0.7135   -0.8754 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4510   -0.1751   -1.9745 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1360   -0.4978    0.1445 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3045    0.2919    0.0345 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.3633    1.3541    1.0494 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2081    2.2658    0.9281 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3489    2.0678    0.0432 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0355    3.3602    1.7794 O   0  0  0  0  0  1  0  0  0  0  0  0
   -5.4504   -0.6939    0.1128 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7562   -0.1782    0.0322 N   0  0  0  0  0  4  0  0  0  0  0  0
   -7.5839   -1.2471   -0.5715 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3752    0.0112    1.3583 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9872    0.9881   -0.7438 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6096    0.3155    2.3537 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8605    2.0665    1.9748 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.2563    1.0690    2.6129 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.7088    0.2539    0.5229 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.6824    1.6225   -0.1025 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.8640   -1.2436    0.6071 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.0981   -0.6260   -1.0361 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3769    1.0459   -0.8302 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7679   -0.5908   -0.8813 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7230    1.3579    1.6010 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9121    0.1621    2.2783 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5774   -1.8139   -0.0020 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8129   -2.2468    1.5196 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2588   -2.1491   -0.2832 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8078   -1.0170    1.0983 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3025   -0.3707   -1.5129 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9944    0.8158   -0.2014 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914    0.9964   -0.6396 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6559    1.2390   -2.0755 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3079    0.1289   -2.7303 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1392   -0.7973   -3.0973 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4843   -2.6041   -1.5687 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8367   -2.0470   -2.5567 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4835   -2.5963   -0.3480 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5723   -1.2780    0.4057 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2632    0.7336   -0.9834 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2646    2.0022    0.9035 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3569    0.9970    2.1009 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3360   -1.2650    1.0552 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2649   -1.4352   -0.7079 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2401   -1.4452   -1.5897 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6673   -0.9479   -0.5339 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4225   -2.1404    0.0569 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5417   -1.0378    1.7433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7083    0.4868    2.0698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3370    0.5261    1.2042 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1422    1.4345   -1.2556 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7784    0.8510   -1.5418 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4292    1.8129   -0.1077 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  2  0
 19 21  1  0
 17 22  1  0
 22 23  1  0
 23 24  1  0
 23 25  1  0
 23 26  1  0
  1 27  1  0
  1 28  1  0
  1 29  1  0
  2 30  1  0
  2 31  1  0
  3 32  1  0
  3 33  1  0
  4 34  1  0
  4 35  1  0
  5 36  1  0
  6 37  1  0
  7 38  1  0
  7 39  1  0
  8 40  1  0
  8 41  1  0
  9 42  1  0
  9 43  1  0
 10 44  1  0
 10 45  1  0
 11 46  1  0
 11 47  1  0
 12 48  1  0
 12 49  1  0
 13 50  1  0
 13 51  1  0
 17 52  1  6
 18 53  1  0
 18 54  1  0
 22 55  1  0
 22 56  1  0
 24 57  1  0
 24 58  1  0
 24 59  1  0
 25 60  1  0
 25 61  1  0
 25 62  1  0
 26 63  1  0
 26 64  1  0
 26 65  1  0
M  CHG  2  21  -1  23   1
M  END

View in JSmol View Stereo Labels

Synonyms

Value	Source
(9Z)-Tetradecenoyl-L-carnitine	ChEBI
(9Z)-Tetradecenoylcarnitine	ChEBI
(R)-[(9Z)-Tetradecenoyl]-L-carnitine	ChEBI
(R)-[(Z)-Myristoleoyl]-L-carnitine	ChEBI
(Z)-Myristoleoyl-L-carnitine	ChEBI
(Z)-Myristoleoylcarnitine	ChEBI
O-(9Z)-Tetradecenoyl-(R)-carnitine	ChEBI
O-[(Z)-Myristoleoyl]-L-carnitine	ChEBI
Myristoleyl carnitine	HMDB
Myristoleoylcarnitine	HMDB

Chemical Formula

C₂₁H₄₀NO₄

Average Molecular Weight

370.553

Monoisotopic Molecular Weight

370.295185192

IUPAC Name

(3R)-3-[(9Z)-tetradec-9-enoyloxy]-4-(trimethylazaniumyl)butanoate

Traditional Name

(3R)-3-[(9Z)-tetradec-9-enoyloxy]-4-(trimethylammonio)butanoate

CAS Registry Number

889848-55-9

SMILES

CCCC\C=C/CCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C

InChI Identifier

InChI=1S/C21H39NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h8-9,19H,5-7,10-18H2,1-4H3/p+1/b9-8-/t19-/m1/s1

InChI Key

ABVVZYXTZLEOHP-OLHLWXQYSA-O

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as acyl carnitines. These are organic compounds containing a fatty acid with the carboxylic acid attached to carnitine through an ester bond.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acid esters

Direct Parent

Acyl carnitines

Alternative Parents

Substituents

Acyl-carnitine
Dicarboxylic acid or derivatives
Tetraalkylammonium salt
Quaternary ammonium salt
Carboxylic acid ester
Carboxylic acid salt
Carboxylic acid derivative
Carboxylic acid
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Organic salt
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic oxygen compound
Carbonyl group
Amine
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

O-tetradecenoyl-L-carnitine (CHEBI:84647 )

Ontology

Placenta (HMDB: HMDB0240588)

Non-excretory biofluid

Biofluid or Excreta

Blood (PMID: 35710135)

Cell

All cells and tissues (PMID: 35710135)

Excreta

Biofluid or Excreta

Urine (PMID: 35710135)

Cellular substructure

Cytoplasm (PMID: 35710135)
Mitochondrion matrix (PMID: 35710135)

Organelle

Peroxisome (PMID: 35710135)

Source

Exogenous

Exogenous (HMDB: HMDB0240588)

Process

Not Available

Role

Biological role

Energy source (PMID: 35710135)

Industrial application

Pharmaceutical industry

Biomarker

Physical Properties

State

Not Available

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
logP	0.37	ALOGPS
logP	0.78	ChemAxon
logS	-7.4	ALOGPS
pKa (Strongest Acidic)	4.22	ChemAxon
pKa (Strongest Basic)	-7.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	66.43 Å²	ChemAxon
Rotatable Bond Count	17	ChemAxon
Refractivity	128.99 m³·mol⁻¹	ChemAxon
Polarizability	44.69 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DeepCCS	[M+H]+	204.136	30932474
DeepCCS	[M-H]-	200.116	30932474
DeepCCS	[M-2H]-	236.659	30932474
DeepCCS	[M+Na]+	212.951	30932474

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Myristoleoylcarnitine	CCCC\C=C/CCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C	3422.6	Standard polar	33892256
Myristoleoylcarnitine	CCCC\C=C/CCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C	2255.3	Standard non polar	33892256
Myristoleoylcarnitine	CCCC\C=C/CCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C	2552.7	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
Myristoleoylcarnitine,1TMS,isomer #1	CCCC/C=C\CCCCCCCC(=O)O[C@H](CC(=O)O[Si](C)(C)C)C[N+](C)(C)C	2572.0	Semi standard non polar	33892256
Myristoleoylcarnitine,1TBDMS,isomer #1	CCCC/C=C\CCCCCCCC(=O)O[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)C[N+](C)(C)C	2795.8	Semi standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - O-[(9Z)-Tetradecenoyl]-L-carnitine GC-MS (Non-derivatized) - 70eV, Positive	splash10-0596-8931000000-7c8bbadb74835652ea06	2021-09-24	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - O-[(9Z)-Tetradecenoyl]-L-carnitine GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - O-[(9Z)-Tetradecenoyl]-L-carnitine GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Myristoleoylcarnitine 10V, Positive-QTOF	splash10-00di-0009000000-1a5965dc435463ee085f	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Myristoleoylcarnitine 20V, Positive-QTOF	splash10-0079-9005000000-84dcf946c3b41ee8ec83	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Myristoleoylcarnitine 40V, Positive-QTOF	splash10-000i-9000000000-e9262cbaff8cb4ad0ba6	2021-09-22	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Blood
Urine

Tissue Locations

Placenta

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Not Available

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Expected but not Quantified	Not Quantified	Not Specified	Not Specified	Cancer patients undergoing total body irradiation	31424920	details
Urine	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Cancer patients undergoing total body irradiation	31424920	details

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

34999520

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

90659872

PDB ID

Not Available

ChEBI ID

84647

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Okun JG, Kolker S, Schulze A, Kohlmuller D, Olgemoller K, Lindner M, Hoffmann GF, Wanders RJ, Mayatepek E: A method for quantitative acylcarnitine profiling in human skin fibroblasts using unlabelled palmitic acid: diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of MCAD deficiency. Biochim Biophys Acta. 2002 Oct 10;1584(2-3):91-8. [PubMed:12385891 ]
Shigematsu Y, Hirano S, Hata I, Tanaka Y, Sudo M, Tajima T, Sakura N, Yamaguchi S, Takayanagi M: Selective screening for fatty acid oxidation disorders by tandem mass spectrometry: difficulties in practical discrimination. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):63-72. [PubMed:12828998 ]
Wood JC, Magera MJ, Rinaldo P, Seashore MR, Strauss AW, Friedman A: Diagnosis of very long chain acyl-dehydrogenase deficiency from an infant's newborn screening card. Pediatrics. 2001 Jul;108(1):E19. [PubMed:11433098 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
FRITZ IB: Action of carnitine on long chain fatty acid oxidation by liver. Am J Physiol. 1959 Aug;197:297-304. doi: 10.1152/ajplegacy.1959.197.2.297. [PubMed:13825279 ]
Reuter SE, Evans AM: Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects. Clin Pharmacokinet. 2012 Sep 1;51(9):553-72. doi: 10.1007/BF03261931. [PubMed:22804748 ]
Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, Cooney GJ, Febbraio MA, Kraegen EW: Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes. 2009 Mar;58(3):550-8. doi: 10.2337/db08-1078. Epub 2008 Dec 10. [PubMed:19073774 ]
Schooneman MG, Vaz FM, Houten SM, Soeters MR: Acylcarnitines: reflecting or inflicting insulin resistance? Diabetes. 2013 Jan;62(1):1-8. doi: 10.2337/db12-0466. [PubMed:23258903 ]
Ahmad T, Kelly JP, McGarrah RW, Hellkamp AS, Fiuzat M, Testani JM, Wang TS, Verma A, Samsky MD, Donahue MP, Ilkayeva OR, Bowles DE, Patel CB, Milano CA, Rogers JG, Felker GM, O'Connor CM, Shah SH, Kraus WE: Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support. J Am Coll Cardiol. 2016 Jan 26;67(3):291-9. doi: 10.1016/j.jacc.2015.10.079. [PubMed:26796394 ]
Abu Bakar MH, Sarmidi MR: Association of cultured myotubes and fasting plasma metabolite profiles with mitochondrial dysfunction in type 2 diabetes subjects. Mol Biosyst. 2017 Aug 22;13(9):1838-1853. doi: 10.1039/c7mb00333a. [PubMed:28726959 ]
Hisahara S, Matsushita T, Furuyama H, Tajima G, Shigematsu Y, Imai T, Shimohama S: A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis. Tohoku J Exp Med. 2015 Apr;235(4):305-10. doi: 10.1620/tjem.235.305. [PubMed:25843429 ]
Laforet P, Acquaviva-Bourdain C, Rigal O, Brivet M, Penisson-Besnier I, Chabrol B, Chaigne D, Boespflug-Tanguy O, Laroche C, Bedat-Millet AL, Behin A, Delevaux I, Lombes A, Andresen BS, Eymard B, Vianey-Saban C: Diagnostic assessment and long-term follow-up of 13 patients with Very Long-Chain Acyl-Coenzyme A dehydrogenase (VLCAD) deficiency. Neuromuscul Disord. 2009 May;19(5):324-9. doi: 10.1016/j.nmd.2009.02.007. Epub 2009 Mar 26. [PubMed:19327992 ]
Tajima G, Sakura N, Shirao K, Okada S, Tsumura M, Nishimura Y, Ono H, Hasegawa Y, Hata I, Naito E, Yamaguchi S, Shigematsu Y, Kobayashi M: Development of a new enzymatic diagnosis method for very-long-chain Acyl-CoA dehydrogenase deficiency by detecting 2-hexadecenoyl-CoA production and its application in tandem mass spectrometry-based selective screening and newborn screening in Japan. Pediatr Res. 2008 Dec;64(6):667-72. doi: 10.1203/PDR.0b013e318187cc44. [PubMed:18670371 ]
Das AM, Illsinger S, Lucke T, Hartmann H, Ruiter JP, Steuerwald U, Waterham HR, Duran M, Wanders RJ: Isolated mitochondrial long-chain ketoacyl-CoA thiolase deficiency resulting from mutations in the HADHB gene. Clin Chem. 2006 Mar;52(3):530-4. doi: 10.1373/clinchem.2005.062000. Epub 2006 Jan 19. [PubMed:16423905 ]
Lepori V, Muhlhause F, Sewell AC, Jagannathan V, Janzen N, Rosati M, Alves de Sousa FMM, Tschopp A, Schupbach G, Matiasek K, Tipold A, Leeb T, Kornberg M: A Nonsense Variant in the ACADVL Gene in German Hunting Terriers with Exercise Induced Metabolic Myopathy. G3 (Bethesda). 2018 May 4;8(5):1545-1554. doi: 10.1534/g3.118.200084. [PubMed:29491033 ]
Chen Y, Li C, Liu L, Guo F, Li S, Huang L, Sun C, Feng R: Serum metabonomics of NAFLD plus T2DM based on liquid chromatography-mass spectrometry. Clin Biochem. 2016 Sep;49(13-14):962-6. doi: 10.1016/j.clinbiochem.2016.05.016. Epub 2016 May 20. [PubMed:27211699 ]
Mai M, Tonjes A, Kovacs P, Stumvoll M, Fiedler GM, Leichtle AB: Serum levels of acylcarnitines are altered in prediabetic conditions. PLoS One. 2013 Dec 16;8(12):e82459. doi: 10.1371/journal.pone.0082459. eCollection 2013. [PubMed:24358186 ]
Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood MM, Smesny S, Sen ZD, Guo AC, Oler E, Tian S, Zheng J, Wishart DS, Liepinsh E, Schioth HB: Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials. Pharmacol Rev. 2022 Jul;74(3):506-551. doi: 10.1124/pharmrev.121.000408. [PubMed:35710135 ]

Showing metabocard for Myristoleoylcarnitine (HMDB0240588)

MOL for HMDB0240588 (Myristoleoylcarnitine)

3D MOL for HMDB0240588 (Myristoleoylcarnitine)

3D SDF for HMDB0240588 (Myristoleoylcarnitine)

3D-SDF for HMDB0240588 (Myristoleoylcarnitine)

PDB for HMDB0240588 (Myristoleoylcarnitine)

3D PDB for HMDB0240588 (Myristoleoylcarnitine)

SMILES for HMDB0240588 (Myristoleoylcarnitine)

INCHI for HMDB0240588 (Myristoleoylcarnitine)

Structure for HMDB0240588 (Myristoleoylcarnitine)

3D Structure for HMDB0240588 (Myristoleoylcarnitine)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra