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Showing metabocard for 2-Phospho-D-glyceric acid (HMDB0003391)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-12 20:03:00 UTC
Update Date2022-01-20 23:10:40 UTC
HMDB IDHMDB0003391
Secondary Accession Numbers
  • HMDB03391
Metabolite Identification
Common Name2-Phospho-D-glyceric acid
Description2-Phospho-D-glyceric acid, also known as 2-phospho-D-glycerate or D-glycerate 2-phosphate, belongs to the class of organic compounds known as sugar acids and derivatives. Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group. 2-Phospho-D-glyceric acid is an extremely weak basic (essentially neutral) compound (based on its pKa). 2-Phospho-D-glyceric acid exists in all living species, ranging from bacteria to humans. Within humans, 2-phospho-D-glyceric acid participates in a number of enzymatic reactions. In particular, 2-phospho-D-glyceric acid can be biosynthesized from 3-phosphoglyceric acid; which is mediated by the enzyme phosphoglycerate mutase 2. In addition, 2-phospho-D-glyceric acid can be converted into phosphoenolpyruvic acid through the action of the enzyme Alpha-enolase. In humans, 2-phospho-D-glyceric acid is involved in the metabolic disorder called the glycogen storage disease type 1A (gsd1a) or von gierke disease pathway. Outside of the human body, 2-Phospho-D-glyceric acid has been detected, but not quantified in, rices. This could make 2-phospho-D-glyceric acid a potential biomarker for the consumption of these foods. A 2-Phospho-D-glyceric acid in which the glyceric acid moiety has D (R) configuration.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0003391 (2-Phospho-D-glyceric acid)

  Mrv1652309042000292D          

 11 10  0  0  0  0            999 V2000
10018.431310018.7965    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10018.431310017.9700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.146710017.5560    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10018.733810016.8407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.863210017.9700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.559610016.8407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10017.716110019.2074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10017.000810018.7965    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10017.716110020.0333    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.146710019.2074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10019.863210018.7965    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  1  0  0  0
  1  7  1  0  0  0  0
  1 10  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
 10 11  1  0  0  0  0
M  END
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3D MOL for HMDB0003391 (2-Phospho-D-glyceric acid)

HMDB0003391
     RDKit          3D
2-Phospho-D-glyceric acid
 18 17  0  0  0  0  0  0  0  0999 V2000
   -0.8824    1.0154   -2.1208 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1305    1.2014   -0.9046 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9862    2.2347   -0.5561 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5152    0.3284    0.1214 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.6153   -0.4124    0.8874 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3321   -1.1436   -0.0753 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2766   -0.5969   -0.5020 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8829   -0.5694   -0.0039 P   0  0  0  0  0  5  0  0  0  0  0  0
    2.3953    0.8460    0.1271 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8007   -1.3298   -1.2078 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1304   -1.3960    1.4407 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6227    3.1772   -0.3656 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0224    0.9547    0.8592 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2780    0.2719    1.4222 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0775   -1.1157    1.5710 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7059   -1.7377   -0.5437 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7071   -0.7506   -2.0210 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9308   -0.9774    1.8718 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  8 11  1  0
  3 12  1  0
  4 13  1  1
  5 14  1  0
  5 15  1  0
  6 16  1  0
 10 17  1  0
 11 18  1  0
M  END
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3D SDF for HMDB0003391 (2-Phospho-D-glyceric acid)

  Mrv1652309042000292D          

 11 10  0  0  0  0            999 V2000
10018.431310018.7965    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10018.431310017.9700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.146710017.5560    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
10018.733810016.8407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.863210017.9700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.559610016.8407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10017.716110019.2074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10017.000810018.7965    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10017.716110020.0333    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10019.146710019.2074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10019.863210018.7965    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  1  0  0  0
  1  7  1  0  0  0  0
  1 10  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
 10 11  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0003391

> <DATABASE_NAME>
hmdb

> <SMILES>
OC[C@@H](OP(O)(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1

> <INCHI_KEY>
GXIURPTVHJPJLF-UWTATZPHSA-N

> <FORMULA>
C3H7O7P

> <MOLECULAR_WEIGHT>
186.0572

> <EXACT_MASS>
185.99293909

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
18

> <JCHEM_AVERAGE_POLARIZABILITY>
13.363889103214117

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R)-3-hydroxy-2-(phosphonooxy)propanoic acid

> <ALOGPS_LOGP>
-2.24

> <JCHEM_LOGP>
-1.642305516

> <ALOGPS_LOGS>
-0.96

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-3

> <JCHEM_PKA>
3.483549412336347

> <JCHEM_PKA_STRONGEST_ACIDIC>
0.8080623457428864

> <JCHEM_PKA_STRONGEST_BASIC>
-3.0640832510433764

> <JCHEM_POLAR_SURFACE_AREA>
124.29000000000002

> <JCHEM_REFRACTIVITY>
31.2564

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.03e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(+-)-2-phosphoglycerate

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0003391 (2-Phospho-D-glyceric acid)

HMDB0003391
     RDKit          3D
2-Phospho-D-glyceric acid
 18 17  0  0  0  0  0  0  0  0999 V2000
   -0.8824    1.0154   -2.1208 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1305    1.2014   -0.9046 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9862    2.2347   -0.5561 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5152    0.3284    0.1214 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.6153   -0.4124    0.8874 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3321   -1.1436   -0.0753 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2766   -0.5969   -0.5020 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8829   -0.5694   -0.0039 P   0  0  0  0  0  5  0  0  0  0  0  0
    2.3953    0.8460    0.1271 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8007   -1.3298   -1.2078 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1304   -1.3960    1.4407 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6227    3.1772   -0.3656 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0224    0.9547    0.8592 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2780    0.2719    1.4222 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0775   -1.1157    1.5710 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7059   -1.7377   -0.5437 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7071   -0.7506   -2.0210 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9308   -0.9774    1.8718 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  4  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  8 11  1  0
  3 12  1  0
  4 13  1  1
  5 14  1  0
  5 15  1  0
  6 16  1  0
 10 17  1  0
 11 18  1  0
M  END
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PDB for HMDB0003391 (2-Phospho-D-glyceric acid)

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0    8701.0728701.753   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0    8701.0728700.211   0.000  0.00  0.00           O+0
HETATM    3  P   UNK     0    8702.4078699.438   0.000  0.00  0.00           P+0
HETATM    4  O   UNK     0    8701.6368698.103   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0    8703.7458700.211   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8703.1788698.103   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0    8699.7378702.520   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0    8698.4018701.753   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0    8699.7378704.062   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0    8702.4078702.520   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0    8703.7458701.753   0.000  0.00  0.00           O+0
CONECT    1    2    7   10                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4    5    6                                             
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    3                                                            
CONECT    7    1    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7                                                            
CONECT   10    1   11                                                       
CONECT   11   10                                                            
MASTER        0    0    0    0    0    0    0    0   11    0   20    0
END
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3D PDB for HMDB0003391 (2-Phospho-D-glyceric acid)

COMPND    HMDB0003391
HETATM    1  O1  UNL     1      -0.882   1.015  -2.121  1.00  0.00           O  
HETATM    2  C1  UNL     1      -1.131   1.201  -0.905  1.00  0.00           C  
HETATM    3  O2  UNL     1      -1.986   2.235  -0.556  1.00  0.00           O  
HETATM    4  C2  UNL     1      -0.515   0.328   0.121  1.00  0.00           C  
HETATM    5  C3  UNL     1      -1.615  -0.412   0.887  1.00  0.00           C  
HETATM    6  O3  UNL     1      -2.332  -1.144  -0.075  1.00  0.00           O  
HETATM    7  O4  UNL     1       0.277  -0.597  -0.502  1.00  0.00           O  
HETATM    8  P1  UNL     1       1.883  -0.569  -0.004  1.00  0.00           P  
HETATM    9  O5  UNL     1       2.395   0.846   0.127  1.00  0.00           O  
HETATM   10  O6  UNL     1       2.801  -1.330  -1.208  1.00  0.00           O  
HETATM   11  O7  UNL     1       2.130  -1.396   1.441  1.00  0.00           O  
HETATM   12  H1  UNL     1      -1.623   3.177  -0.366  1.00  0.00           H  
HETATM   13  H2  UNL     1       0.022   0.955   0.859  1.00  0.00           H  
HETATM   14  H3  UNL     1      -2.278   0.272   1.422  1.00  0.00           H  
HETATM   15  H4  UNL     1      -1.077  -1.116   1.571  1.00  0.00           H  
HETATM   16  H5  UNL     1      -1.706  -1.738  -0.544  1.00  0.00           H  
HETATM   17  H6  UNL     1       2.707  -0.751  -2.021  1.00  0.00           H  
HETATM   18  H7  UNL     1       2.931  -0.977   1.872  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   12
CONECT    4    5    7   13
CONECT    5    6   14   15
CONECT    6   16
CONECT    7    8
CONECT    8    9    9   10   11
CONECT   10   17
CONECT   11   18
END
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SMILES for HMDB0003391 (2-Phospho-D-glyceric acid)

OC[C@@H](OP(O)(O)=O)C(O)=O
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INCHI for HMDB0003391 (2-Phospho-D-glyceric acid)

InChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
2-Phospho-D-glycerateChEBI
2-PHOSPHOGLYCERIC ACIDChEBI
D-Glycerate 2-phosphateChEBI
2-Phospho-(R)-glycerateKegg
2-PHOSPHOGLYCERateGenerator
D-Glyceric acid 2-phosphoric acidGenerator
2-Phospho-(R)-glyceric acidGenerator
(2R)-3-Hydroxy-2-(phosphonooxy)propanoateHMDB
(2R)-3-Hydroxy-2-(phosphonooxy)propanoic acidHMDB
3-D-Hydroxy-2-phosphonooxy-propanoateHMDB
3-D-Hydroxy-2-phosphonooxy-propanoic acidHMDB
D-(+)-2-Phosphoglyceric acidHMDB
D-2-Phosphoglyceric acidHMDB
D-Glyceric acid 2-phosphateHMDB
2-Phospho-D-glyceric acidHMDB
Chemical FormulaC3H7O7P
Average Molecular Weight186.0572
Monoisotopic Molecular Weight185.99293909
IUPAC Name(2R)-3-hydroxy-2-(phosphonooxy)propanoic acid
Traditional Name(+-)-2-phosphoglycerate
CAS Registry Number3443-57-0
SMILES
OC[C@@H](OP(O)(O)=O)C(O)=O
InChI Identifier
InChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1
InChI KeyGXIURPTVHJPJLF-UWTATZPHSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as sugar acids and derivatives. Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentSugar acids and derivatives
Alternative Parents
Substituents
  • Beta-hydroxy acid
  • Glyceric_acid
  • Monoalkyl phosphate
  • Hydroxy acid
  • Monosaccharide
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Alcohol
  • Organic oxide
  • Carbonyl group
  • Primary alcohol
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Industrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen Locations
  • Urine
Tissue Locations
  • Placenta
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified57.274 +/- 80.719 umol/mmol creatinineChildren (1 - 13 years old)Not Specified
Eosinophilic esophagitis
    • Analysis of 30 no...
 details
Associated Disorders and Diseases
Disease References
Eosinophilic esophagitis
  1. Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
Associated OMIM IDs
DrugBank IDDB01709
Phenol Explorer Compound IDNot Available
FooDB IDFDB001407
KNApSAcK IDC00000123
Chemspider ID388411
KEGG Compound IDC00631
BioCyc ID2-PG
BiGG ID35542
Wikipedia LinkNot Available
METLIN ID6915
PubChem Compound439278
PDB IDNot Available
ChEBI ID17835
Food Biomarker OntologyNot Available
VMH ID2PG
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Enzymes

Enzyme Details
1. Bisphosphoglycerate mutase
General function:
Involved in catalytic activity
Specific function:
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
Gene Name:
BPGM
Uniprot ID:
P07738
Molecular weight:
30004.98
Reactions
2-Phospho-D-glyceric acid → 3-Phosphoglyceric aciddetails
Enzyme Details
2. Phosphoglycerate mutase 2
General function:
Involved in catalytic activity
Specific function:
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Gene Name:
PGAM2
Uniprot ID:
P15259
Molecular weight:
28765.96
Reactions
2-Phospho-D-glyceric acid → 3-Phosphoglyceric aciddetails
Enzyme Details
3. Probable phosphoglycerate mutase 4
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
PGAM4
Uniprot ID:
Q8N0Y7
Molecular weight:
28776.605
Reactions
2-Phospho-D-glyceric acid → 3-Phosphoglyceric aciddetails
3-Phosphoglyceric acid → 2-Phospho-D-glyceric aciddetails
Enzyme Details
4. Phosphoglycerate mutase 1
General function:
Involved in catalytic activity
Specific function:
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
Gene Name:
PGAM1
Uniprot ID:
P18669
Molecular weight:
28803.675
Reactions
2-Phospho-D-glyceric acid → 3-Phosphoglyceric aciddetails
Enzyme Details
5. Beta-enolase
General function:
Involved in magnesium ion binding
Specific function:
Appears to have a function in striated muscle development and regeneration.
Gene Name:
ENO3
Uniprot ID:
P13929
Molecular weight:
42248.03
Reactions
2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Waterdetails
Enzyme Details
6. Gamma-enolase
General function:
Involved in magnesium ion binding
Specific function:
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
Gene Name:
ENO2
Uniprot ID:
P09104
Molecular weight:
47268.125
Reactions
2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Waterdetails
Enzyme Details
7. Alpha-enolase
General function:
Involved in magnesium ion binding
Specific function:
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Gene Name:
ENO1
Uniprot ID:
P06733
Molecular weight:
36927.84
Reactions
2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Waterdetails
Enzyme Details
8. Multiple inositol polyphosphate phosphatase 1
General function:
Involved in acid phosphatase activity
Specific function:
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification).
Gene Name:
MINPP1
Uniprot ID:
Q9UNW1
Molecular weight:
34660.555
Reactions
2,3-Diphosphoglyceric acid + Water → 2-Phospho-D-glyceric acid + Phosphatedetails