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Human Metabolome Database Version 2.5

 

Showing metabocard for 11-Dehydrocorticosterone (HMDB04029)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2006-08-13 10:21:39
Update Date 2009-05-05 20:59:49
Accession Number HMDB04029
Secondary Accession Numbers Not Available
Common Name 11-Dehydrocorticosterone
Description 11-Dehydrocorticosterone is a mineral corticosteroid. The conversion of inactive 11-ketoglucocorticoids such as 11-dehydrocorticosterone) into active 11b-hydroxyglucocorticoids (such as corticosterone) is catalyzed by 11beta-hydroxysteroid dehydrogenase (11b-HSD1, EC 1.1.1.146), which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver, adipose tissue, skeletal muscles and possibly kidney. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity rather than elevated systemic glucocorticoid levels has been associated with metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that compounds inhibiting 11beta-HSD1 activity ameliorate the adverse effects of excessive glucocorticoid concentrations on metabolic processes, providing promising opportunities for the development of therapeutic interventions. 11-dehydrocorticosterone and corticosterone display antinatriuretic activity, although 11-dehydrocorticosterone is generally a more potent sodium retainer than corticosterone. (PMID: 17584152, Endocr Metab Immune Disord Drug Targets. 2007 Jun;7(2):125-40.)
Synonyms
  1. 11-dehydro-Corticosterone
  2. 11-Dehydrocorticosteron
  3. 11-Dehydrocorticosterone
  4. 11-Oxo-11-deoxycorticosterone
  5. 11-Oxocorticosterone
  6. 17-(1-keto-2-Hydroxyethyl)-D4-androsten-3,11-dione
  7. 17-Deoxycortisone
  8. 21-Hydroxypregn-4-ene-3,11,20-trione
  9. 21-Hydroxypregn-4-ene-3,11-20-trione
  10. 4-Pregnen-21-ol-3,11,20-trione
  11. D4-Pregnen-21-ol-3,11,20-trione
  12. D4-Pregnene-21-ol-3,11,20-trione
  13. Dehydrocorticosterone
  14. Dehydrocortocicosterone
  15. Kendall's compound A
Chemical IUPAC Name 17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11-dione
Chemical Formula C21H28O4
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Cholesterols and derivatives
Class
  • Steroids and Steroid Derivatives
Sub Class
  • Ketosteroids
Family
  • Mammalian Metabolite
Species
  • ketone
  • primary alcohol
  • alkene
Biofunction
  • Hormones, Membrane component
Application
—
Source
  • Endogenous
Average Molecular Weight 344.445
Monoisotopic Molecular Weight 344.198761
Isomeric SMILES C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CCC2C(=O)CO
Canonical SMILES CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO
KEGG Compound ID C05490 Link Image
BioCyc ID Not Available
BiGG ID Not Available
Wikipedia Link Not Available
NuGOwiki Link HMDB04029 Link Image
Metagene Link HMDB04029 Link Image
METLIN ID 7003 Link Image
PubChem Compound 6290 Link Image
PubChem Substance 75081 Link Image
ChEBI ID Not Available
CAS Registry Number 72-23-1
InChI Identifier InChI=1/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16?,19+,20-,21-/m0/s1
Synthesis Reference Nikiforova, O. K.; Suvorov, N. N. Steroids. IV. Synthesis of 11-dehydrocorticosterone from 11-oxopregesterone. Zhurnal Obshchei Khimii (1959), 29 2428-31.
Melting Point (Experimental) 183.5 oC
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 0.258 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]; 0.0479 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP/Hydrophobicity 1.77 [MEYLAN,WM & HOWARD,PH (1995)]; 2.44 [Predicted by ALOGPS]; 1.3 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS) Not Available
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location Not Available
Biofluid Location
  • Blood
Tissue Location
Tissue References
Adipose Tissue —
Kidney —
Liver —
Placenta —
Concentrations (Normal) Not Available
Concentrations (Abnormal)
Biofluid Blood
Value 0.0278 +/- 0.0060 uM
Age Elderly:>65 yrs old
Sex Male
Condition Kidney cancer
Comments Unilateral nephrectomy with ipsilateral adrenalectomy for kidney cancer - adrenal vein
References
  • Tortorella C, Aragona F, Nussdorfer GG: In vivo evidence that human adrenal glands possess 11 beta-hydroxysteroid dehydrogenase activity. Life Sci. 1999;65(26):2823-7. [PubMed Link Image]
Biofluid Blood
Value 0.0142 +/- 0.0039 uM
Age Elderly:>65 yrs old
Sex Male
Condition Kidney cancer
Comments Unilateral nephrectomy with ipsilateral adrenalectomy for kidney cancer - inferior vena cava
References
  • Tortorella C, Aragona F, Nussdorfer GG: In vivo evidence that human adrenal glands possess 11 beta-hydroxysteroid dehydrogenase activity. Life Sci. 1999;65(26):2823-7. [PubMed Link Image]
Biofluid Blood
Value 0.0204 +/- 0.0034 uM
Age Elderly:>65 yrs old
Sex Female
Condition Kidney cancer
Comments Unilateral nephrectomy with ipsilateral adrenalectomy for kidney cancer - inferior vena cava
References
  • Tortorella C, Aragona F, Nussdorfer GG: In vivo evidence that human adrenal glands possess 11 beta-hydroxysteroid dehydrogenase activity. Life Sci. 1999;65(26):2823-7. [PubMed Link Image]
Biofluid Blood
Value 0.0336 +/- 0.0054 uM
Age Elderly:>65 yrs old
Sex Female
Condition Kidney cancer
Comments Unilateral nephrectomy with ipsilateral adrenalectomy for kidney cancer - adrenal vein
References
  • Tortorella C, Aragona F, Nussdorfer GG: In vivo evidence that human adrenal glands possess 11 beta-hydroxysteroid dehydrogenase activity. Life Sci. 1999;65(26):2823-7. [PubMed Link Image]
Associated Disorders
Condition References
Kidney cancer
  • Tortorella C, Aragona F, Nussdorfer GG: In vivo evidence that human adrenal glands possess 11 beta-hydroxysteroid dehydrogenase activity. Life Sci. 1999;65(26):2823-7. [PubMed Link Image]
OMIM ID Not Available
Pathways
Name SMPDB Link KEGG Link
Steroidogenesis SMP00130 Link Image map00140 Link Image
General References
  1. Ronquist-Nii Y, Edlund PO: Determination of corticosteroids in tissue samples by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2005 Feb 23;37(2):341-50. [PubMed Link Image]
  2. Walker BR, Rodin A, Taylor NF, Clayton RN: Endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2000 Jan;52(1):77-80. [PubMed Link Image]
  3. Edwards CR, Benediktsson R, Lindsay RS, Seckl JR: 11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects. Steroids. 1996 Apr;61(4):263-9. [PubMed Link Image]
  4. Livingstone DE, Jones GC, Smith K, Jamieson PM, Andrew R, Kenyon CJ, Walker BR: Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 2000 Feb;141(2):560-3. [PubMed Link Image]
Metabolic Enzymes
  1. 3-oxo-5-beta-steroid 4-dehydrogenase
  2. Corticosteroid 11-beta-dehydrogenase isozyme 1
  3. Hydroxysteroid (11-beta) dehydrogenase 2
  4. cDNA, FLJ94621, Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), mRNA (Hydroxysteroid (11-beta) dehydrogenase 1, isoform CRA_a)
Enzyme 1 [top]
Enzyme 1 ID 5822
Enzyme 1 Name 3-oxo-5-beta-steroid 4-dehydrogenase
Enzyme 1 Synonyms
  1. Delta(4-3- ketosteroid 5-beta-reductase
  2. Aldo-keto reductase family 1 member D1
Enzyme 1 Gene Name AKR1D1
Enzyme 1 Protein Sequence >3-oxo-5-beta-steroid 4-dehydrogenase 
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL
NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK
DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE
ALNKNVRFVELLMWRDHPEYPFHDEY
Enzyme 1 Number of Residues 326
Enzyme 1 Molecular Weight 37377
Enzyme 1 Theoretical pI 7.58
Enzyme 1 GO Classification
Function
  • catalytic activity
  • oxidoreductase activity
Process
—
Component
—
Enzyme 1 General Function Not Available
Enzyme 1 Specific Function Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates
Enzyme 1 Pathways
Enzyme 1 Reactions
  • 4,5beta-dihydrocortisone + NADP+ = cortisone + NADPH + H+
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 431857 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID P51857 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name AK1D1_HUMAN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >981 bp 
ATGGATCTCAGTGCTGCAAGTCACCGCATACCTCTAAGTGATGGAAACAGCATTCCCATC
ATCGGACTTGGTACCTACTCAGAACCTAAATCGACCCCTAAGGGAGCCTGTGCAACATCG
GTGAAGGTTGCTATTGACACAGGGTACCGACATATTGATGGGGCCTACATCTACCAAAAT
GAACACGAAGTTGGGGAGGCCATCAGGGAGAAGATAGCAGAAGGAAAGGTGCGGAGGGAA
GATATCTTCTACTGTGGAAAGCTATGGGCTACAAATCATGTCCCAGAGATGGTCCGCCCA
ACCCTGGAGAGGACACTCAGGGTCCTCCAGCTAGATTATGTGGATCTTTACATCATTGAA
GTACCCATGGCCTTTAAGCCAGGAGATGAAATATACCCTAGAGATGAGAATGGCAAATGG
TTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGGCGATGGAAGCTTGCAAAGACGCT
GGCTTGGTGAAATCCCTGGGAGTGTCCAATTTTAACCGCAGGCAGCTGGAGCTCATCCTG
AACAAGCCAGGACTCAAACACAAGCCAGTCAGCAACCAGGTTGAGTGCCATCCGTATTTC
ACCCAGCCAAAACTCTTGAAATTTTGCCAACAACATGACATTGTCATTACTGCATATAGC
CCTTTGGGGACCAGTAGGAATCCAATCTGGGTGAATGTTTCTTCTCCACCTTTGTTAAAG
GATGCACTTCTAAACTCATTGGGGAAAAGGTACAATAAGACAGCAGCTCAAATTGTTTTG
CGTTTCAACATCCAGCGAGGGGTGGTTGTCATTCCTAAAAGCTTTAATCTTGAAAGGATC
AAAGAAAATTTTCAGATCTTTGACTTTTCTCTCACTGAAGAAGAAATGAAGGACATTGAA
GCCTTGAATAAAAATGTCCGCTTTGTAGAATTGCTCATGTGGCGCGATCATCCTGAATAC
CCATTTCATGATGAATACTGA
Enzyme 1 GenBank Gene ID Z28339 Link Image
Enzyme 1 GeneCard ID AKR1D1 Link Image
Enzyme 1 GenAtlas ID AKR1D1 Link Image
Enzyme 1 HGNC ID HGNC:388 Link Image
Enzyme 1 Chromosome Location 7
Enzyme 1 Locus 7q32-q33
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. Kondo KH, Kai MH, Setoguchi Y, Eggertsen G, Sjoblom P, Setoguchi T, Okuda KI, Bjorkhem I: Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme. Eur J Biochem. 1994 Jan 15;219(1-2):357-63. [PubMed Link Image]
  2. Charbonneau A, The VL: Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme. Biochim Biophys Acta. 2001 Jan 26;1517(2):228-35. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 5992
Enzyme 2 Name Corticosteroid 11-beta-dehydrogenase isozyme 1
Enzyme 2 Synonyms
  1. 11-DH
  2. 11-beta-hydroxysteroid dehydrogenase 1
  3. 11-beta-HSD1
Enzyme 2 Gene Name HSD11B1
Enzyme 2 Protein Sequence >Corticosteroid 11-beta-dehydrogenase isozyme 1 
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Enzyme 2 Number of Residues 292
Enzyme 2 Molecular Weight 32401
Enzyme 2 Theoretical pI 8.77
Enzyme 2 GO Classification
Function
  • catalytic activity
  • oxidoreductase activity
Process
  • metabolism
  • physiological process
Component
—
Enzyme 2 General Function Lipid transport and metabolism
Enzyme 2 Specific Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol
Enzyme 2 Pathways
Enzyme 2 Reactions
  • an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • 1-23
Enzyme 2 Transmembrane Regions Not Available
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 179475 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID P28845 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name DHI1_HUMAN Link Image
Enzyme 2 PDB ID 1XU9 Link Image
Enzyme 2 PDB File Show
Enzyme 2 3D Structure
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >879 bp 
ATGGCTTTTATGAAAAAATATCTCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTAC
TATTCTGCAAACGAGGAATTCAGACCAGAGATGCTCCAAGGAAAGAAAGTGATTGTCACA
GGGGCCAGCAAAGGGATCGGAAGAGAGATGGCTTATCATCTGGCGAAGATGGGAGCCCAT
GTGGTGGTGACAGCGAGGTCAAAAGAAACTCTACAGAAGGTGGTATCCCACTGCCTGGAG
CTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCATGGAAGACATGACCTTCGCAGAG
CAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACATGCTCATTCTCAACCAC
ATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATGTGCGCAAAAGCATG
GAAGTCAACTTCCTCAGTTACGTGGTCCTGACTGTAGCTGCCTTGCCCATGCTGAAGCAG
AGCAATGGAAGCATTGTTGTCGTCTCCTCTCTGGCTGGGAAAGTGGCTTATCCAATGGTT
GCTGCCTATTCTGCAAGCAAGTTTGCTTTGGATGGGTTCTTCTCCTCCATCAGAAAGGAA
TATTCAGTGTCCAGGGTCAATGTATCAATCACTCTCTGTGTTCTTGGCCTCATAGACACA
GAAACAGCCATGAAGGCAGTTTCTGGGATAGTCCATATGCAAGCAGCTCCAAAGGAGGAA
TGTGCCCTGGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTGTATTATGACAGC
TCACTCTGGACCACTCTTCTGATCAGAAATCCATGCAGGAAGATCCTGGAATTTCTCTAC
TCAACGAGCTATAATATGGACAGATTCATAAACAAGTAG
Enzyme 2 GenBank Gene ID M76665 Link Image
Enzyme 2 GeneCard ID HSD11B1 Link Image
Enzyme 2 GenAtlas ID HSD11B1 Link Image
Enzyme 2 HGNC ID HGNC:5208 Link Image
Enzyme 2 Chromosome Location 1
Enzyme 2 Locus 1q32-q41
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. Tannin GM, Agarwal AK, Monder C, New MI, White PC: The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem. 1991 Sep 5;266(25):16653-8. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 15188
Enzyme 3 Name Hydroxysteroid (11-beta) dehydrogenase 2
Enzyme 3 Synonyms Not Available
Enzyme 3 Gene Name HSD11B2
Enzyme 3 Protein Sequence >Hydroxysteroid (11-beta) dehydrogenase 2 
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
Enzyme 3 Number of Residues 405
Enzyme 3 Molecular Weight 44127
Enzyme 3 Theoretical pI 9.58
Enzyme 3 GO Classification
Function
  • catalytic activity
  • oxidoreductase activity
Process
  • metabolism
  • physiological process
Component
—
Enzyme 3 General Function Lipid transport and metabolism
Enzyme 3 Specific Function Not Available
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 152112970 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID A7LB28 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name A7LB28_HUMAN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1218 bp 
ATGGAGCGCTGGCCTTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGGCTGCCCGCGCGCTG
CTGCAGCTGCTGCGCTCAGACCTGCGTCTGGGCCGCCCGCTGCTGGCGGCGCTGGCGCTG
CTGGCCGCGCTCGACTGGCTGTGCCAGCGCCTGCTGCCCCCGCCGGCCGCACTCGCCGTG
CTGGCCGCCGCCGGCTGGATCGCGTTGTCCCGCCTGGCGCGCCCGCAGCGCCTGCCGGTG
GCCACTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTTTTGGCAAGGAGACGGCCAAG
AAACTGGACTCCATGGGCTTCACGGTGCTGGCCACCGTATTGGAGTTGAACAGCCCCGGT
GCCATCGAGCTGCGTACCTGCTGCTCCCCTCGCCTAAGGCTGCTGCAGATGGACCTGACC
AAACCAGGAGACATTAGCCGCGTGCTAGAGTTCACCAAGGCCCACACCACCAGCACCGGC
CTGTGGGGCCTCGTCAACAACGCAGGCCACAATGAAGTAGTTGCTGATGCGGAGCTGTCT
CCAGTGGCCACTTTCCGTAGCTGCATGGAGGTGAATTTCTTTGGCGCGCTCGAGCTGACC
AAGGGCCTCCTGCCCCTGCTGCGCAGCTCAAGGGGCCGCATCGTGACTGTGGGGAGCCCA
GCGGGGGACATGCCATATCCGTGCTTGGGGGCCTATGGAACCTCCAAAGCGGCCGTGGCG
CTACTCATGGACACATTCAGCTGTGAACTCCTTCCCTGGGGGGTCAAGGTCAGCATCATC
CAGCCTGGCTGCTTCAAGACAGAGTCAGTGAGAAACGTGGGTCAGTGGGAAAAGCGCAAG
CAATTGCTGCTGGCCAACCTGCCTCAAGAGCTGCTGCAGGCCTACGGCAAGGACTACATC
GAGCACTTGCATGGGCAGTTCCTGCACTCGCTACGCCTGGCCATGTCCGACCTCACCCCA
GTTGTAGATGCCATCACAGATGCGCTGCTGGCAGCTCGGCCCCGCCGCCGCTATTACCCC
GGCCAGGGCCTGGGGCTCATGTACTTCATCCACTACTACCTGCCTGAAGGCCTGCGGCGC
CGCTTCCTGCAGGCCTTCTTCATCAGTCACTGTCTGCCTCGAGCACTGCAGCCTGGCCAG
CCTGGCACTACCCCACCACAGGACGCAGCCCAGGACCCAAACCTGAGCCCCGGCCCTTCC
CCAGCAGTGGCTCGGTGA
Enzyme 3 GenBank Gene ID EF694683 Link Image
Enzyme 3 GeneCard ID A7LB28 Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location 16
Enzyme 3 Locus 16q22
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References Not Available
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 16473
Enzyme 4 Name cDNA, FLJ94621, Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), mRNA (Hydroxysteroid (11-beta) dehydrogenase 1, isoform CRA_a)
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name HSD11B1
Enzyme 4 Protein Sequence >cDNA, FLJ94621, Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), mRNA (Hydroxysteroid (11-beta) dehydrogenase 1, isoform CRA_a) 
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Enzyme 4 Number of Residues 292
Enzyme 4 Molecular Weight 32401
Enzyme 4 Theoretical pI 8.77
Enzyme 4 GO Classification
Function
  • catalytic activity
  • oxidoreductase activity
Process
  • metabolism
  • physiological process
Component
—
Enzyme 4 General Function Lipid transport and metabolism
Enzyme 4 Specific Function Not Available
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein Not Available
Enzyme 4 UniProtKB/Swiss-Prot ID B2R9Z1 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name B2R9Z1_HUMAN Link Image
Enzyme 4 PDB ID 1XU9 Link Image
Enzyme 4 PDB File Show
Enzyme 4 3D Structure
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence Not Available
Enzyme 4 GenBank Gene ID AK313973 Link Image
Enzyme 4 GeneCard ID B2R9Z1 Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus Not Available
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available