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Showing metabocard for Phosphatidylinositol-3,4,5-trisphosphate (HMDB0004249)

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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2006-08-13 15:16:34 UTC
Update Date2021-09-16 15:27:29 UTC
HMDB IDHMDB0004249
Secondary Accession Numbers
  • HMDB04249
Metabolite Identification
Common NamePhosphatidylinositol-3,4,5-trisphosphate
Description

Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol (4,5)-bisphosphate. PtdIns(3,4,5)P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring.

.

The PH domain in a number of proteins binds to PtdIns(3,4,5)P3. Such proteins include Akt/PKB, PDK1, Btk1 and ARNO. The generation of PtdIns(3,4,5)P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity. The PH domain allows binding between PtdIns(3,4,5)P3 and G-protein coupled receptor kinases (GRKs). This enhances the binding of the GRK to the plasma membrane. (Wikipedia)

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Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

  Mrv0541 02231219552D          

 38 38  0  0  1  0            999 V2000
   11.7242   -5.8018    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   12.5492  -10.0887    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867   -9.3742    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -8.6597    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   11.3117   -6.5163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9617   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3117   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.7867   -7.9452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867   -7.9452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9617   -6.5163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1367   -5.0873    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0097   -5.3893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8347   -9.6762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.2637  -10.5012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867   -8.5492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867  -10.1992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4847   -9.0722    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.9137   -8.2472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.4387   -6.2143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1367  -10.8031    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6617   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6117   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9617   -2.2294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -2.9438    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.5492   -8.6597    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.7242   -8.6597    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9617   -7.9452    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   11.7242   -7.2307    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.3117   -7.9452    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.5492   -7.2307    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9617   -5.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3742   -4.3728    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9617   -3.6584    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3742   -2.9438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -4.3728    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.4368   -5.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -5.8018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6117   -5.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 35 38  1  0  0  0  0
M  END
Download

3D MOL for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

HMDB0004249
     RDKit          3D
Phosphatidylinositol-3,4,5-trisphosphate
 62 62  0  0  0  0  0  0  0  0999 V2000
    6.7918    1.3938   -2.9077 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9325    0.3116   -2.3522 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6679   -0.6580   -3.1040 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4277    0.3371   -1.0668 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6220   -0.7263   -0.6164 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2418   -0.2062   -0.2069 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3646    0.7294    0.8208 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8930    1.3394    1.3177 P   0  0  0  0  0  5  0  0  0  0  0  0
    2.0560    2.7432    1.9063 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3475    0.3652    2.6141 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7532    1.4466    0.1000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4829    0.9090    0.4580 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8883   -0.2027   -0.4331 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.3460    0.0629   -1.7136 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3119   -0.5201   -0.5444 C   0  0  2  0  0  0  0  0  0  0  0  0
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    5.5503   -3.3329   -0.4282 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2985    1.8731   -2.0677 H   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5219   -1.4615   -1.4355 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7384    0.1986   -1.0919 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7101   -1.0811    0.2215 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0956    0.1261    3.1867 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3521    0.5374    1.5176 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3322   -1.1258   -0.0905 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5599   -1.4642    0.0250 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4359   -2.6910   -2.2833 H   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.1356   -0.3629    3.1972 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7444    2.3963   -0.4709 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2489    3.8724    1.0713 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4993   -3.0706    1.6890 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0664   -4.0911    2.0725 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1591   -2.3890    2.6474 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
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 33 12  1  0
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  5 42  1  0
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 10 45  1  0
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 21 52  1  6
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 33 58  1  6
 34 59  1  0
 37 60  1  0
 37 61  1  0
 37 62  1  0
M  END
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3D SDF for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

  Mrv0541 02231219552D          

 38 38  0  0  1  0            999 V2000
   11.7242   -5.8018    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   12.5492  -10.0887    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867   -9.3742    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -8.6597    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   11.3117   -6.5163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9617   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3117   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.7867   -7.9452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867   -7.9452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9617   -6.5163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1367   -5.0873    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0097   -5.3893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8347   -9.6762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.2637  -10.5012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867   -8.5492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4867  -10.1992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4847   -9.0722    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.9137   -8.2472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.4387   -6.2143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1367  -10.8031    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6617   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6117   -9.3742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9617   -2.2294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -2.9438    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.5492   -8.6597    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.7242   -8.6597    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9617   -7.9452    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   11.7242   -7.2307    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.3117   -7.9452    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.5492   -7.2307    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9617   -5.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3742   -4.3728    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.9617   -3.6584    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3742   -2.9438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -4.3728    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.4368   -5.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1992   -5.8018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.6117   -5.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  5  1  0  0  0  0
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  3  7  1  0  0  0  0
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  4 17  1  0  0  0  0
  4 18  1  0  0  0  0
  4 22  2  0  0  0  0
 28  5  1  1  0  0  0
 25  6  1  6  0  0  0
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 27  8  1  1  0  0  0
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 30 10  1  6  0  0  0
 11 31  1  0  0  0  0
 23 34  1  0  0  0  0
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 32 33  1  6  0  0  0
 33 34  1  0  0  0  0
 35 32  1  0  0  0  0
 36 38  1  0  0  0  0
 37 38  2  0  0  0  0
 35 38  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0004249

> <DATABASE_NAME>
hmdb

> <SMILES>
CC(=O)OC(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(C)=O

> <INCHI_IDENTIFIER>
InChI=1S/C12H24O22P4/c1-4(13)29-6(30-5(2)14)3-28-38(26,27)34-9-7(15)10(31-35(17,18)19)12(33-37(23,24)25)11(8(9)16)32-36(20,21)22/h6-12,15-16H,3H2,1-2H3,(H,26,27)(H2,17,18,19)(H2,20,21,22)(H2,23,24,25)/t7-,8-,9-,10+,11-,12-/m0/s1

> <INCHI_KEY>
RQQIRMLGKSPXSE-UQPICLANSA-N

> <FORMULA>
C12H24O22P4

> <MOLECULAR_WEIGHT>
644.2008

> <EXACT_MASS>
643.9709685

> <JCHEM_ACCEPTOR_COUNT>
15

> <JCHEM_AVERAGE_POLARIZABILITY>
47.5068388936121

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
9

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
{[(1S,2S,3S,4S,5R,6S)-3-({[2,2-bis(acetyloxy)ethoxy](hydroxy)phosphoryl}oxy)-2,4-dihydroxy-5,6-bis(phosphonooxy)cyclohexyl]oxy}phosphonic acid

> <ALOGPS_LOGP>
-0.20

> <JCHEM_LOGP>
-4.070388187666666

> <ALOGPS_LOGS>
-1.65

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-7

> <JCHEM_PKA>
0.8749172009244854

> <JCHEM_PKA_STRONGEST_ACIDIC>
0.3804049912223664

> <JCHEM_PKA_STRONGEST_BASIC>
-3.689092103968366

> <JCHEM_POLAR_SURFACE_AREA>
349.09999999999997

> <JCHEM_REFRACTIVITY>
109.37409999999996

> <JCHEM_ROTATABLE_BOND_COUNT>
15

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.44e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
[(1S,2S,3S,4S,5R,6S)-3-{[2,2-bis(acetyloxy)ethoxy(hydroxy)phosphoryl]oxy}-2,4-dihydroxy-5,6-bis(phosphonooxy)cyclohexyl]oxyphosphonic acid

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

HMDB0004249
     RDKit          3D
Phosphatidylinositol-3,4,5-trisphosphate
 62 62  0  0  0  0  0  0  0  0999 V2000
    6.7918    1.3938   -2.9077 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9325    0.3116   -2.3522 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6679   -0.6580   -3.1040 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4277    0.3371   -1.0668 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6220   -0.7263   -0.6164 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2418   -0.2062   -0.2069 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3646    0.7294    0.8208 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8930    1.3394    1.3177 P   0  0  0  0  0  5  0  0  0  0  0  0
    2.0560    2.7432    1.9063 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3475    0.3652    2.6141 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7532    1.4466    0.1000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4829    0.9090    0.4580 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8883   -0.2027   -0.4331 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.3460    0.0629   -1.7136 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3119   -0.5201   -0.5444 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.6191   -0.8204   -1.8739 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2005   -2.3699   -2.0913 P   0  0  0  0  0  5  0  0  0  0  0  0
   -3.3607   -3.0860   -0.7715 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7333   -2.2594   -2.8180 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1708   -3.2483   -3.1345 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2845    0.5185   -0.0875 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.5279   -0.0242    0.2391 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7818    0.6092   -0.6630 P   0  0  0  0  0  5  0  0  0  0  0  0
   -6.7607   -0.5311   -0.9494 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2685    1.2684   -2.1329 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6527    1.7879    0.1730 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7596    1.2828    1.1172 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.6762    2.1625    1.6145 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0279    1.8381    3.2375 P   0  0  0  0  0  5  0  0  0  0  0  0
   -4.9033    2.9402    3.8073 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6047    1.6672    4.1445 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8297    0.3383    3.3033 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5271    2.0092    0.5553 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.1454    2.9703    1.4476 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2733   -1.2861    0.5133 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7198   -2.5851    0.5683 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3877   -3.0552    1.8083 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5503   -3.3329   -0.4282 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2985    1.8731   -2.0677 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4995    1.0344   -3.6666 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1507    2.1525   -3.4013 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5219   -1.4615   -1.4355 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7384    0.1986   -1.0919 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7101   -1.0811    0.2215 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0956    0.1261    3.1867 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3521    0.5374    1.5176 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3322   -1.1258   -0.0905 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5166   -0.6892   -2.3297 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5599   -1.4642    0.0250 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4359   -2.6910   -2.2833 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3995   -4.2062   -3.1261 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4151    1.2692   -0.8947 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9927    1.1390   -2.8239 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1099    2.5901    0.3699 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4401    0.5418    1.8809 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2219    0.7828    3.9521 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1356   -0.3629    3.1972 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7444    2.3963   -0.4709 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2489    3.8724    1.0713 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4993   -3.0706    1.6890 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0664   -4.0911    2.0725 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1591   -2.3890    2.6474 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  8 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  2  0
 17 19  1  0
 17 20  1  0
 15 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 23 25  1  0
 23 26  1  0
 21 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  2  0
 29 31  1  0
 29 32  1  0
 27 33  1  0
 33 34  1  0
  5 35  1  0
 35 36  1  0
 36 37  1  0
 36 38  2  0
 33 12  1  0
  1 39  1  0
  1 40  1  0
  1 41  1  0
  5 42  1  0
  6 43  1  0
  6 44  1  0
 10 45  1  0
 12 46  1  1
 13 47  1  1
 14 48  1  0
 15 49  1  1
 19 50  1  0
 20 51  1  0
 21 52  1  6
 25 53  1  0
 26 54  1  0
 27 55  1  1
 31 56  1  0
 32 57  1  0
 33 58  1  6
 34 59  1  0
 37 60  1  0
 37 61  1  0
 37 62  1  0
M  END
Download

PDB for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  P   UNK     0      21.885 -10.830   0.000  0.00  0.00           P+0
HETATM    2  P   UNK     0      23.425 -18.832   0.000  0.00  0.00           P+0
HETATM    3  P   UNK     0      19.575 -17.499   0.000  0.00  0.00           P+0
HETATM    4  P   UNK     0      26.505 -16.165   0.000  0.00  0.00           P+0
HETATM    5  O   UNK     0      21.115 -12.164   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0      24.195 -17.499   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0      21.115 -17.499   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0      25.735 -14.831   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0      19.575 -14.831   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0      24.195 -12.164   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0      22.655  -9.496   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      20.551 -10.060   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0      22.091 -18.062   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0      24.759 -19.602   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0      19.575 -15.959   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0      19.575 -19.039   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0      25.171 -16.935   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0      27.839 -15.395   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0      23.219 -11.600   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0      22.655 -20.166   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0      18.035 -17.499   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0      27.275 -17.499   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0      24.195  -4.162   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      26.505  -5.495   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      23.425 -16.165   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      21.885 -16.165   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      24.195 -14.831   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      21.885 -13.497   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      21.115 -14.831   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      23.425 -13.497   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      24.195  -9.496   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      24.965  -8.163   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      24.195  -6.829   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0      24.965  -5.495   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0      26.505  -8.163   0.000  0.00  0.00           O+0
HETATM   36  C   UNK     0      28.815  -9.496   0.000  0.00  0.00           C+0
HETATM   37  O   UNK     0      26.505 -10.830   0.000  0.00  0.00           O+0
HETATM   38  C   UNK     0      27.275  -9.496   0.000  0.00  0.00           C+0
CONECT    1    5   11   12   19                                             
CONECT    2    6   13   14   20                                             
CONECT    3    7   15   16   21                                             
CONECT    4    8   17   18   22                                             
CONECT    5    1   28                                                       
CONECT    6    2   25                                                       
CONECT    7    3   26                                                       
CONECT    8    4   27                                                       
CONECT    9   29                                                            
CONECT   10   30                                                            
CONECT   11    1   31                                                       
CONECT   12    1                                                            
CONECT   13    2                                                            
CONECT   14    2                                                            
CONECT   15    3                                                            
CONECT   16    3                                                            
CONECT   17    4                                                            
CONECT   18    4                                                            
CONECT   19    1                                                            
CONECT   20    2                                                            
CONECT   21    3                                                            
CONECT   22    4                                                            
CONECT   23   34                                                            
CONECT   24   34                                                            
CONECT   25    6   26   27                                                  
CONECT   26    7   25   29                                                  
CONECT   27    8   25   30                                                  
CONECT   28    5   29   30                                                  
CONECT   29    9   26   28                                                  
CONECT   30   10   27   28                                                  
CONECT   31   11   32                                                       
CONECT   32   31   33   35                                                  
CONECT   33   32   34                                                       
CONECT   34   23   24   33                                                  
CONECT   35   32   38                                                       
CONECT   36   38                                                            
CONECT   37   38                                                            
CONECT   38   36   37   35                                                  
MASTER        0    0    0    0    0    0    0    0   38    0   76    0
END
Download

3D PDB for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

COMPND    HMDB0004249
HETATM    1  C1  UNL     1       6.792   1.394  -2.908  1.00  0.00           C  
HETATM    2  C2  UNL     1       5.932   0.312  -2.352  1.00  0.00           C  
HETATM    3  O1  UNL     1       5.668  -0.658  -3.104  1.00  0.00           O  
HETATM    4  O2  UNL     1       5.428   0.337  -1.067  1.00  0.00           O  
HETATM    5  C3  UNL     1       4.622  -0.726  -0.616  1.00  0.00           C  
HETATM    6  C4  UNL     1       3.242  -0.206  -0.207  1.00  0.00           C  
HETATM    7  O3  UNL     1       3.365   0.729   0.821  1.00  0.00           O  
HETATM    8  P1  UNL     1       1.893   1.339   1.318  1.00  0.00           P  
HETATM    9  O4  UNL     1       2.056   2.743   1.906  1.00  0.00           O  
HETATM   10  O5  UNL     1       1.348   0.365   2.614  1.00  0.00           O  
HETATM   11  O6  UNL     1       0.753   1.447   0.100  1.00  0.00           O  
HETATM   12  C5  UNL     1      -0.483   0.909   0.458  1.00  0.00           C  
HETATM   13  C6  UNL     1      -0.888  -0.203  -0.433  1.00  0.00           C  
HETATM   14  O7  UNL     1      -0.346   0.063  -1.714  1.00  0.00           O  
HETATM   15  C7  UNL     1      -2.312  -0.520  -0.544  1.00  0.00           C  
HETATM   16  O8  UNL     1      -2.619  -0.820  -1.874  1.00  0.00           O  
HETATM   17  P2  UNL     1      -3.201  -2.370  -2.091  1.00  0.00           P  
HETATM   18  O9  UNL     1      -3.361  -3.086  -0.771  1.00  0.00           O  
HETATM   19  O10 UNL     1      -4.733  -2.259  -2.818  1.00  0.00           O  
HETATM   20  O11 UNL     1      -2.171  -3.248  -3.135  1.00  0.00           O  
HETATM   21  C8  UNL     1      -3.285   0.519  -0.088  1.00  0.00           C  
HETATM   22  O12 UNL     1      -4.528  -0.024   0.239  1.00  0.00           O  
HETATM   23  P3  UNL     1      -5.782   0.609  -0.663  1.00  0.00           P  
HETATM   24  O13 UNL     1      -6.761  -0.531  -0.949  1.00  0.00           O  
HETATM   25  O14 UNL     1      -5.268   1.268  -2.133  1.00  0.00           O  
HETATM   26  O15 UNL     1      -6.653   1.788   0.173  1.00  0.00           O  
HETATM   27  C9  UNL     1      -2.760   1.283   1.117  1.00  0.00           C  
HETATM   28  O16 UNL     1      -3.676   2.162   1.615  1.00  0.00           O  
HETATM   29  P4  UNL     1      -4.028   1.838   3.238  1.00  0.00           P  
HETATM   30  O17 UNL     1      -4.903   2.940   3.807  1.00  0.00           O  
HETATM   31  O18 UNL     1      -2.605   1.667   4.144  1.00  0.00           O  
HETATM   32  O19 UNL     1      -4.830   0.338   3.303  1.00  0.00           O  
HETATM   33  C10 UNL     1      -1.527   2.009   0.555  1.00  0.00           C  
HETATM   34  O20 UNL     1      -1.145   2.970   1.448  1.00  0.00           O  
HETATM   35  O21 UNL     1       5.273  -1.286   0.513  1.00  0.00           O  
HETATM   36  C11 UNL     1       5.720  -2.585   0.568  1.00  0.00           C  
HETATM   37  C12 UNL     1       6.388  -3.055   1.808  1.00  0.00           C  
HETATM   38  O22 UNL     1       5.550  -3.333  -0.428  1.00  0.00           O  
HETATM   39  H1  UNL     1       7.299   1.873  -2.068  1.00  0.00           H  
HETATM   40  H2  UNL     1       7.499   1.034  -3.667  1.00  0.00           H  
HETATM   41  H3  UNL     1       6.151   2.153  -3.401  1.00  0.00           H  
HETATM   42  H4  UNL     1       4.522  -1.462  -1.436  1.00  0.00           H  
HETATM   43  H5  UNL     1       2.738   0.199  -1.092  1.00  0.00           H  
HETATM   44  H6  UNL     1       2.710  -1.081   0.222  1.00  0.00           H  
HETATM   45  H7  UNL     1       2.096   0.126   3.187  1.00  0.00           H  
HETATM   46  H8  UNL     1      -0.352   0.537   1.518  1.00  0.00           H  
HETATM   47  H9  UNL     1      -0.332  -1.126  -0.091  1.00  0.00           H  
HETATM   48  H10 UNL     1      -0.517  -0.689  -2.330  1.00  0.00           H  
HETATM   49  H11 UNL     1      -2.560  -1.464   0.025  1.00  0.00           H  
HETATM   50  H12 UNL     1      -5.436  -2.691  -2.283  1.00  0.00           H  
HETATM   51  H13 UNL     1      -2.400  -4.206  -3.126  1.00  0.00           H  
HETATM   52  H14 UNL     1      -3.415   1.269  -0.895  1.00  0.00           H  
HETATM   53  H15 UNL     1      -5.993   1.139  -2.824  1.00  0.00           H  
HETATM   54  H16 UNL     1      -6.110   2.590   0.370  1.00  0.00           H  
HETATM   55  H17 UNL     1      -2.440   0.542   1.881  1.00  0.00           H  
HETATM   56  H18 UNL     1      -2.222   0.783   3.952  1.00  0.00           H  
HETATM   57  H19 UNL     1      -4.136  -0.363   3.197  1.00  0.00           H  
HETATM   58  H20 UNL     1      -1.744   2.396  -0.471  1.00  0.00           H  
HETATM   59  H21 UNL     1      -1.249   3.872   1.071  1.00  0.00           H  
HETATM   60  H22 UNL     1       7.499  -3.071   1.689  1.00  0.00           H  
HETATM   61  H23 UNL     1       6.066  -4.091   2.072  1.00  0.00           H  
HETATM   62  H24 UNL     1       6.159  -2.389   2.647  1.00  0.00           H  
CONECT    1    2   39   40   41
CONECT    2    3    3    4
CONECT    4    5
CONECT    5    6   35   42
CONECT    6    7   43   44
CONECT    7    8
CONECT    8    9    9   10   11
CONECT   10   45
CONECT   11   12
CONECT   12   13   33   46
CONECT   13   14   15   47
CONECT   14   48
CONECT   15   16   21   49
CONECT   16   17
CONECT   17   18   18   19   20
CONECT   19   50
CONECT   20   51
CONECT   21   22   27   52
CONECT   22   23
CONECT   23   24   24   25   26
CONECT   25   53
CONECT   26   54
CONECT   27   28   33   55
CONECT   28   29
CONECT   29   30   30   31   32
CONECT   31   56
CONECT   32   57
CONECT   33   34   58
CONECT   34   59
CONECT   35   36
CONECT   36   37   38   38
CONECT   37   60   61   62
END
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SMILES for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

CC(=O)OC(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(C)=O
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INCHI for HMDB0004249 (Phosphatidylinositol-3,4,5-trisphosphate)

InChI=1S/C12H24O22P4/c1-4(13)29-6(30-5(2)14)3-28-38(26,27)34-9-7(15)10(31-35(17,18)19)12(33-37(23,24)25)11(8(9)16)32-36(20,21)22/h6-12,15-16H,3H2,1-2H3,(H,26,27)(H2,17,18,19)(H2,20,21,22)(H2,23,24,25)/t7-,8-,9-,10+,11-,12-/m0/s1
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
Phosphatidylinositol-3,4,5-trisphosphoric acidGenerator
1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)HMDB
1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphateHMDB
Chemical FormulaC12H24O22P4
Average Molecular Weight644.2008
Monoisotopic Molecular Weight643.9709685
IUPAC Name{[(1S,2S,3S,4S,5R,6S)-3-({[2,2-bis(acetyloxy)ethoxy](hydroxy)phosphoryl}oxy)-2,4-dihydroxy-5,6-bis(phosphonooxy)cyclohexyl]oxy}phosphonic acid
Traditional Name[(1S,2S,3S,4S,5R,6S)-3-{[2,2-bis(acetyloxy)ethoxy(hydroxy)phosphoryl]oxy}-2,4-dihydroxy-5,6-bis(phosphonooxy)cyclohexyl]oxyphosphonic acid
CAS Registry NumberNot Available
SMILES
CC(=O)OC(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(C)=O
InChI Identifier
InChI=1S/C12H24O22P4/c1-4(13)29-6(30-5(2)14)3-28-38(26,27)34-9-7(15)10(31-35(17,18)19)12(33-37(23,24)25)11(8(9)16)32-36(20,21)22/h6-12,15-16H,3H2,1-2H3,(H,26,27)(H2,17,18,19)(H2,20,21,22)(H2,23,24,25)/t7-,8-,9-,10+,11-,12-/m0/s1
InChI KeyRQQIRMLGKSPXSE-UQPICLANSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassAlcohols and polyols
Direct ParentInositol phosphates
Alternative Parents
Substituents
  • Inositol phosphate
  • Cyclohexanol
  • Acylal
  • Dialkyl phosphate
  • Monoalkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Carboxylic acid ester
  • Secondary alcohol
  • Acetal
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Aliphatic homomonocyclic compound
Molecular FrameworkAliphatic homomonocyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-7.965Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023351
KNApSAcK IDNot Available
Chemspider ID34980938
KEGG Compound IDC05981
BioCyc IDPHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT
BiGG ID47125
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID16618
Food Biomarker OntologyNot Available
VMH IDPAIL345P_HS
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD, Prescott M, Whisstock JC, Mitchell CA: Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem. 2003 Mar 28;278(13):11376-85. Epub 2003 Jan 20. [PubMed:12536145 ]
  2. Liu Q, Dumont DJ: Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program. Genomics. 1997 Jan 1;39(1):109-12. [PubMed:9027494 ]
  3. Ijuin T, Takenawa T: SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. Mol Cell Biol. 2003 Feb;23(4):1209-20. [PubMed:12556481 ]
  4. Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM: PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol. 2003 Sep;23(17):6139-49. [PubMed:12917336 ]
  5. Maxwell MJ, Yuan Y, Anderson KE, Hibbs ML, Salem HH, Jackson SP: SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem. 2004 Jul 30;279(31):32196-204. Epub 2004 May 27. [PubMed:15166241 ]

Only showing the first 10 proteins. There are 80 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
General function:
Involved in calcium ion binding
Specific function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene Name:
PLCB1
Uniprot ID:
Q9NQ66
Molecular weight:
138565.805
Enzyme Details
2. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
General function:
Involved in calcium ion binding
Specific function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
Gene Name:
PLCB4
Uniprot ID:
Q15147
Molecular weight:
136105.065
Enzyme Details
3. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
General function:
Involved in calcium ion binding
Specific function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene Name:
PLCB2
Uniprot ID:
Q00722
Molecular weight:
134023.21
Enzyme Details
4. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
General function:
Involved in calcium ion binding
Specific function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene Name:
PLCB3
Uniprot ID:
Q01970
Molecular weight:
138797.725
Enzyme Details
5. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
General function:
Involved in phosphoinositide phospholipase C activity
Specific function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Gene Name:
PLCG2
Uniprot ID:
P16885
Molecular weight:
147868.67
Enzyme Details
6. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
General function:
Involved in calcium ion binding
Specific function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Gene Name:
PLCG1
Uniprot ID:
P19174
Molecular weight:
148658.92
Enzyme Details
7. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
General function:
Involved in calcium ion binding
Specific function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
Gene Name:
PLCD1
Uniprot ID:
P51178
Molecular weight:
88134.23
Enzyme Details
8. N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
General function:
Involved in N-acetylglucosaminylphosphatidylinositol de
Specific function:
Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Gene Name:
PIGL
Uniprot ID:
Q9Y2B2
Molecular weight:
28530.965
Enzyme Details
9. Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
General function:
Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity
Specific function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:
PIGQ
Uniprot ID:
Q9BRB3
Molecular weight:
65343.25
Enzyme Details
10. Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
General function:
Involved in biosynthetic process
Specific function:
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Gene Name:
PIGA
Uniprot ID:
P37287
Molecular weight:
54126.065

Only showing the first 10 proteins. There are 80 proteins in total.

Show all enzymes and transporters