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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2007-04-12 21:04:35 UTC
Update Date2023-02-21 17:17:14 UTC
HMDB IDHMDB0006044
Secondary Accession Numbers
  • HMDB06044
Metabolite Identification
Common NameNorsalsolinol
DescriptionNorsalsolinol is a putative metabolic neuromodulators that hs been found to be present in both rat and human brains. It modulates dopaminergic transmission and have been shown to be associated with neurotoxicity within cells and diseases such as alcoholism and Parkinsonism. Norsalsolinol can be synthesized in vivo non-enzymatically by condensation of dopamine with formaldehyde, the oxidized metabolite of methanol.
Structure
Thumb
Synonyms
ValueSource
Norsalsolinol hydrobromideMeSH
Norsalsolinol hydrochlorideMeSH
Norsalsolinol, 3H-labeled CPDMeSH
1,2,3,4-tetrahydro-6,7-IsoquinolinediolHMDB
6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinolineHMDB
6,7-DihydroxytetrahydroisoquinolineHMDB
tetrahydro-6,7-IsoquinolinediolHMDB
NorsalsolinolMeSH
Chemical FormulaC9H11NO2
Average Molecular Weight165.1891
Monoisotopic Molecular Weight165.078978601
IUPAC Name1,2,3,4-tetrahydroisoquinoline-6,7-diol
Traditional Namenorsalsolinol
CAS Registry Number34827-33-3
SMILES
OC1=C(O)C=C2CNCCC2=C1
InChI Identifier
InChI=1S/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2
InChI KeyMBFUSGLXKQWVDW-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as tetrahydroisoquinolines. These are tetrahydrogenated isoquinoline derivatives.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassTetrahydroisoquinolines
Sub ClassNot Available
Direct ParentTetrahydroisoquinolines
Alternative Parents
Substituents
  • Tetrahydroisoquinoline
  • 1-hydroxy-2-unsubstituted benzenoid
  • Aralkylamine
  • Benzenoid
  • Azacycle
  • Secondary amine
  • Secondary aliphatic amine
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023817
KNApSAcK IDNot Available
Chemspider ID33891
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNorsalsolinol
METLIN IDNot Available
PubChem Compound36937
PDB IDNot Available
ChEBI ID110006
Food Biomarker OntologyNot Available
VMH IDCE2172
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available