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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2009-11-30 15:51:15 UTC
Update Date2020-04-30 16:28:36 UTC
HMDB IDHMDB0013223
Secondary Accession Numbers
  • HMDB13223
Metabolite Identification
Common NameButyrylcholine
DescriptionButyrylcholine belongs to the class of organic compounds known as acyl cholines. These are acylated derivatives of choline. Butyrylcholine is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Butyrylcholine is a synthetic compound and does not occur in the body naturally. It is used as a tool to distinguish between acetyl- and butyrylcholinesterase. Butyrylcholine is an acetylcholine-like molecule, with activation of some of the same receptors as acetylcholine. It is hydrolyzed by acetylcholinesterase and butyrylcholinesterase (also known as pseudocholinesterase), with butyrylcholinesterase being more efficient than acetylcholinesterase. Butyrylcholine is a nicotinic receptor agonist and mimics the action of acetylcholine (ACh) at both enteric and epithelial nicotinic acetylcholine receptors (nAChRs). Additionally, butyrylcholine is also able to stimulate muscarinic acetylcholine receptors (mAChRs) (PMID: 6481626 , 27423041 ).
Structure
Thumb
Synonyms
ValueSource
(2-Butyryloxy-ethyl)-trimethyl-ammoniumHMDB
N,N,N-Trimethyl-2-(1-oxobutoxy)ethanaminiumHMDB
ButyrylcholineHMDB
Chemical FormulaC9H20NO2
Average Molecular Weight174.2606
Monoisotopic Molecular Weight174.149403889
IUPAC Name[2-(butanoyloxy)ethyl]trimethylazanium
Traditional Namebutyrylcholine
CAS Registry Number3922-86-9
SMILES
CCCC(=O)OCC[N+](C)(C)C
InChI Identifier
InChI=1S/C9H20NO2/c1-5-6-9(11)12-8-7-10(2,3)4/h5-8H2,1-4H3/q+1
InChI KeyYRIBGSCJIMXMPJ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as acyl cholines. These are acylated derivatives of choline. Choline or 2-Hydroxy-N,N,N-trimethylethanaminium is a quaternary ammonium salt with the chemical formula (CH3)3N+(CH2)2OH.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassQuaternary ammonium salts
Direct ParentAcyl cholines
Alternative Parents
Substituents
  • Acyl choline
  • Fatty acid ester
  • Fatty acyl
  • Tetraalkylammonium salt
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Monocarboxylic acid or derivatives
  • Organic oxygen compound
  • Amine
  • Organooxygen compound
  • Organic salt
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Carbonyl group
  • Organic cation
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB029342
KNApSAcK IDNot Available
Chemspider ID16312
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkButyrylcholine
METLIN IDNot Available
PubChem Compound17233
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Andreev AA, Veprintsev BN, Vulfius CA: Two-component desensitization of nicotinic receptors induced by acetylcholine agonists in Lymnaea stagnalis neurones. J Physiol. 1984 Aug;353:375-91. doi: 10.1113/jphysiol.1984.sp015341. [PubMed:6481626 ]
  2. Moreno S, Gerbig S, Schulz S, Spengler B, Diener M, Bader S: Epithelial propionyl- and butyrylcholine as novel regulators of colonic ion transport. Br J Pharmacol. 2016 Sep;173(18):2766-79. doi: 10.1111/bph.13555. Epub 2016 Aug 10. [PubMed:27423041 ]