Hmdb loader
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:49 UTC
Update Date2022-03-07 02:51:39 UTC
HMDB IDHMDB0014557
Secondary Accession Numbers
  • HMDB14557
Metabolite Identification
Common NamePramipexole
DescriptionPramipexole is a medication indicated for treating Parkinson's disease and restless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache or to counteract the problems with low libido experienced by some users of SSRI antidepressant drugs. Pramipexole has shown robust effects on pilot studies in bipolar disorder. Pramipexole is classified as a non-ergoline dopamine agonist.
Structure
Data?1582753193
Synonyms
ValueSource
(-)-PramipexoleChEBI
PramipexolChEBI
PramipexolumChEBI
2-Amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazoleHMDB
MirapexHMDB
SND 919CL2XHMDB
DexpramipexoleHMDB
Pramipexol, (+-)-isomerHMDB
SifroleHMDB
2-Amino-6-propylaminotetrahydrobenzothiazoleHMDB
SND-919HMDB
Pramipexol dihydrobromide, (+-)-isomerHMDB
Pramipexol dihydrochloride, (S)-isomerHMDB
4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazole-diamineHMDB
6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine dihydrochloride monohydrateHMDB
SND-919CL2XHMDB
SND919CL2XHMDB
Pramipexol, (R)-isomerHMDB
Pramipexole dihydrochlorideHMDB
Pramipexole dihydrochloride anhydrousHMDB
2 Amino 6 propylaminotetrahydrobenzothiazoleHMDB
Pramipexole hydrochloride monohydrateHMDB
SifrolHMDB
SND 919HMDB
Chemical FormulaC10H17N3S
Average Molecular Weight211.327
Monoisotopic Molecular Weight211.114318249
IUPAC Name(6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
Traditional Namepramipexole
CAS Registry Number104632-26-0
SMILES
CCCN[C@H]1CCC2=C(C1)SC(N)=N2
InChI Identifier
InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1
InChI KeyFASDKYOPVNHBLU-ZETCQYMHSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct ParentAralkylamines
Alternative Parents
Substituents
  • Aralkylamine
  • Heteroaromatic compound
  • Thiazole
  • Azole
  • Isothiourea
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Secondary aliphatic amine
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.14 g/LNot Available
LogP0.4Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.14 g/LALOGPS
logP2.18ALOGPS
logP1.76ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)17.66ChemAxon
pKa (Strongest Basic)10.31ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area50.94 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity59.77 m³·mol⁻¹ChemAxon
Polarizability24.47 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+150.10531661259
DarkChem[M-H]-145.90931661259
DeepCCS[M+H]+159.18630932474
DeepCCS[M-H]-156.82830932474
DeepCCS[M-2H]-191.31330932474
DeepCCS[M+Na]+167.05330932474
AllCCS[M+H]+149.432859911
AllCCS[M+H-H2O]+145.732859911
AllCCS[M+NH4]+152.932859911
AllCCS[M+Na]+153.932859911
AllCCS[M-H]-150.732859911
AllCCS[M+Na-2H]-151.432859911
AllCCS[M+HCOO]-152.332859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PramipexoleCCCN[C@H]1CCC2=C(C1)SC(N)=N23113.6Standard polar33892256
PramipexoleCCCN[C@H]1CCC2=C(C1)SC(N)=N21843.4Standard non polar33892256
PramipexoleCCCN[C@H]1CCC2=C(C1)SC(N)=N21959.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Pramipexole,1TMS,isomer #1CCCN[C@H]1CCC2=C(C1)SC(N[Si](C)(C)C)=N22127.2Semi standard non polar33892256
Pramipexole,1TMS,isomer #1CCCN[C@H]1CCC2=C(C1)SC(N[Si](C)(C)C)=N21952.2Standard non polar33892256
Pramipexole,1TMS,isomer #1CCCN[C@H]1CCC2=C(C1)SC(N[Si](C)(C)C)=N23005.0Standard polar33892256
Pramipexole,1TMS,isomer #2CCCN([C@H]1CCC2=C(C1)SC(N)=N2)[Si](C)(C)C2160.0Semi standard non polar33892256
Pramipexole,1TMS,isomer #2CCCN([C@H]1CCC2=C(C1)SC(N)=N2)[Si](C)(C)C2057.8Standard non polar33892256
Pramipexole,1TMS,isomer #2CCCN([C@H]1CCC2=C(C1)SC(N)=N2)[Si](C)(C)C3031.7Standard polar33892256
Pramipexole,2TMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N[Si](C)(C)C)=N2)[Si](C)(C)C2195.4Semi standard non polar33892256
Pramipexole,2TMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N[Si](C)(C)C)=N2)[Si](C)(C)C2121.0Standard non polar33892256
Pramipexole,2TMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N[Si](C)(C)C)=N2)[Si](C)(C)C2911.6Standard polar33892256
Pramipexole,2TMS,isomer #2CCCN[C@H]1CCC2=C(C1)SC(N([Si](C)(C)C)[Si](C)(C)C)=N22118.0Semi standard non polar33892256
Pramipexole,2TMS,isomer #2CCCN[C@H]1CCC2=C(C1)SC(N([Si](C)(C)C)[Si](C)(C)C)=N22163.6Standard non polar33892256
Pramipexole,2TMS,isomer #2CCCN[C@H]1CCC2=C(C1)SC(N([Si](C)(C)C)[Si](C)(C)C)=N22700.1Standard polar33892256
Pramipexole,3TMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N([Si](C)(C)C)[Si](C)(C)C)=N2)[Si](C)(C)C2190.4Semi standard non polar33892256
Pramipexole,3TMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N([Si](C)(C)C)[Si](C)(C)C)=N2)[Si](C)(C)C2316.4Standard non polar33892256
Pramipexole,3TMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N([Si](C)(C)C)[Si](C)(C)C)=N2)[Si](C)(C)C2571.1Standard polar33892256
Pramipexole,1TBDMS,isomer #1CCCN[C@H]1CCC2=C(C1)SC(N[Si](C)(C)C(C)(C)C)=N22330.3Semi standard non polar33892256
Pramipexole,1TBDMS,isomer #1CCCN[C@H]1CCC2=C(C1)SC(N[Si](C)(C)C(C)(C)C)=N22249.7Standard non polar33892256
Pramipexole,1TBDMS,isomer #1CCCN[C@H]1CCC2=C(C1)SC(N[Si](C)(C)C(C)(C)C)=N23031.0Standard polar33892256
Pramipexole,1TBDMS,isomer #2CCCN([C@H]1CCC2=C(C1)SC(N)=N2)[Si](C)(C)C(C)(C)C2370.9Semi standard non polar33892256
Pramipexole,1TBDMS,isomer #2CCCN([C@H]1CCC2=C(C1)SC(N)=N2)[Si](C)(C)C(C)(C)C2328.3Standard non polar33892256
Pramipexole,1TBDMS,isomer #2CCCN([C@H]1CCC2=C(C1)SC(N)=N2)[Si](C)(C)C(C)(C)C3072.6Standard polar33892256
Pramipexole,2TBDMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N[Si](C)(C)C(C)(C)C)=N2)[Si](C)(C)C(C)(C)C2588.1Semi standard non polar33892256
Pramipexole,2TBDMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N[Si](C)(C)C(C)(C)C)=N2)[Si](C)(C)C(C)(C)C2650.5Standard non polar33892256
Pramipexole,2TBDMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N[Si](C)(C)C(C)(C)C)=N2)[Si](C)(C)C(C)(C)C2982.3Standard polar33892256
Pramipexole,2TBDMS,isomer #2CCCN[C@H]1CCC2=C(C1)SC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=N22509.4Semi standard non polar33892256
Pramipexole,2TBDMS,isomer #2CCCN[C@H]1CCC2=C(C1)SC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=N22678.8Standard non polar33892256
Pramipexole,2TBDMS,isomer #2CCCN[C@H]1CCC2=C(C1)SC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=N22786.1Standard polar33892256
Pramipexole,3TBDMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=N2)[Si](C)(C)C(C)(C)C2767.2Semi standard non polar33892256
Pramipexole,3TBDMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=N2)[Si](C)(C)C(C)(C)C2995.6Standard non polar33892256
Pramipexole,3TBDMS,isomer #1CCCN([C@H]1CCC2=C(C1)SC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=N2)[Si](C)(C)C(C)(C)C2809.3Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Pramipexole GC-MS (Non-derivatized) - 70eV, Positivesplash10-0f89-5900000000-2f0a391f30cf7118b5c52017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Pramipexole GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Pramipexole GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Pramipexole 35V, Positive-QTOFsplash10-0udi-1900000000-c299b6c1b06ed6f2a7092021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 10V, Positive-QTOFsplash10-03di-1290000000-bc573dbf2f8ee5b710962016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 20V, Positive-QTOFsplash10-0gvo-9730000000-fd8c10c012fd8fe62c742016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 40V, Positive-QTOFsplash10-0006-8900000000-605ed0f5393829cb2bf32016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 10V, Negative-QTOFsplash10-03di-0090000000-4cbc9934fb61d87728262016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 20V, Negative-QTOFsplash10-03di-5490000000-7c5237ecb4da60355c972016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 40V, Negative-QTOFsplash10-0006-9100000000-ecd3da1b2e6cddd7b6392016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 10V, Positive-QTOFsplash10-03di-0090000000-d53b4114529d172c63152021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 20V, Positive-QTOFsplash10-03di-0090000000-05098f8885ac070a5c362021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 40V, Positive-QTOFsplash10-01tc-4900000000-1efa3719885d8a194bab2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 10V, Negative-QTOFsplash10-03di-0090000000-8370021700e32bab5e812021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 20V, Negative-QTOFsplash10-03di-0090000000-8f12c031e88379040ad02021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pramipexole 40V, Negative-QTOFsplash10-0f79-2900000000-89ca482dc7e68f54ab382021-09-22Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00413 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00413 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00413
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID106770
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkPramipexole
METLIN IDNot Available
PubChem Compound119570
PDB IDNot Available
ChEBI ID8356
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Mierau J, Schneider FJ, Ensinger HA, Chio CL, Lajiness ME, Huff RM: Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36. [PubMed:7664822 ]

Only showing the first 10 proteins. There are 16 proteins in total.

Enzymes

General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular weight:
48956.3
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular weight:
49953.1
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular weight:
50618.9
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  3. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Gene Name:
HTR2B
Uniprot ID:
P41595
Molecular weight:
54297.4
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity
Gene Name:
HTR1B
Uniprot ID:
P28222
Molecular weight:
43567.5
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
Gene Name:
DRD4
Uniprot ID:
P21917
Molecular weight:
48359.9
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity
Gene Name:
HTR1A
Uniprot ID:
P08908
Molecular weight:
46106.3
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular weight:
52602.6
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Gene Name:
HTR2C
Uniprot ID:
P28335
Molecular weight:
51820.7
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity
Gene Name:
HTR1D
Uniprot ID:
P28221
Molecular weight:
41906.4
References
  1. Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. [PubMed:18691132 ]
  2. Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. [PubMed:10641988 ]

Transporters

General function:
Involved in ion transmembrane transporter activity
Specific function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular weight:
61187.4
References
  1. Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. [PubMed:15640376 ]
General function:
Involved in ion transmembrane transporter activity
Specific function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular weight:
62564.0
References
  1. Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. [PubMed:15640376 ]

Only showing the first 10 proteins. There are 16 proteins in total.