Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2012-09-06 15:16:49 UTC |
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Update Date | 2022-03-07 02:51:40 UTC |
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HMDB ID | HMDB0014561 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Penicillin V |
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Description | Penicillin V is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions. |
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Structure | [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)COC1=CC=CC=C1)C(O)=O InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1 |
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Synonyms | Value | Source |
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(2S,5R,6R)-3,3-DIMETHYL-7-oxo-6-(2-phenoxyacetamido)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylIC ACID | ChEBI | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | ChEBI | 6-Phenoxyacetamidopenicillanic acid | ChEBI | Fenospen | ChEBI | Fenoximetilpenicilina | ChEBI | Oracillin | ChEBI | Penicillin phenoxymethyl | ChEBI | Phenoxomethylpenicillin | ChEBI | Phenoxymethylenepenicillinic acid | ChEBI | Phenoxymethylpenicilline | ChEBI | Phenoxymethylpenicillinum | ChEBI | PV | ChEBI | V-Cillin | ChEBI | Phenoxymethylpenicillin | Kegg | (2S,5R,6R)-3,3-DIMETHYL-7-oxo-6-(2-phenoxyacetamido)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylate | Generator | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | Generator | 6-Phenoxyacetamidopenicillanate | Generator | Phenoxymethylenepenicillinate | Generator | PCV | HMDB | Fenossimetilpenicillina | HMDB | Penicillin V potassium | HMDB | Phenoximethylpenicillinum | HMDB | Phenoxymethyl penicillin | HMDB | Phenoxymethylpenicillin potassium | HMDB | Phenoxymethylpenicillinic acid | HMDB | Phenoxymethylpenicillinic acid potassium salt | HMDB | Berromycin, penicillin | HMDB | Penicillin, phenoxymethyl | HMDB | V Cillin K | HMDB | Vegacillin | HMDB | Beromycin | HMDB | V-Cillin K | HMDB | VCillin K | HMDB | Apocillin | HMDB | Beromycin, penicillin | HMDB | Fenoxymethylpenicillin | HMDB | Pen VK | HMDB | Potassium, penicillin V | HMDB | V Sodium, penicillin | HMDB | Betapen | HMDB | Penicillin beromycin | HMDB | Penicillin berromycin | HMDB | Penicillin V sodium | HMDB | Penicillin VK | HMDB | Sodium, penicillin V | HMDB | Penicillin V | ChEBI |
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Chemical Formula | C16H18N2O5S |
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Average Molecular Weight | 350.39 |
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Monoisotopic Molecular Weight | 350.093642386 |
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IUPAC Name | (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
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Traditional Name | penicillin V |
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CAS Registry Number | 87-08-1 |
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SMILES | [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)COC1=CC=CC=C1)C(O)=O |
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InChI Identifier | InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1 |
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InChI Key | BPLBGHOLXOTWMN-MBNYWOFBSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Carboxylic acids and derivatives |
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Sub Class | Amino acids, peptides, and analogues |
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Direct Parent | Dipeptides |
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Alternative Parents | |
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Substituents | - Alpha-dipeptide
- Penicillin
- N-acyl-alpha amino acid or derivatives
- Alpha-amino acid or derivatives
- Phenoxy compound
- Phenol ether
- Penam
- Alkyl aryl ether
- Monocyclic benzene moiety
- Benzenoid
- Beta-lactam
- Tertiary carboxylic acid amide
- Thiazolidine
- Lactam
- Carboxamide group
- Secondary carboxylic acid amide
- Azetidine
- Azacycle
- Carboxylic acid
- Ether
- Organoheterocyclic compound
- Monocarboxylic acid or derivatives
- Dialkylthioether
- Hemithioaminal
- Thioether
- Organic oxygen compound
- Organopnictogen compound
- Organic oxide
- Hydrocarbon derivative
- Organonitrogen compound
- Organooxygen compound
- Carbonyl group
- Organic nitrogen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | Not Available |
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Role | Not Available |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 120 - 128 °C | Not Available | Boiling Point | 289.00 to 291.00 °C. @ 760.00 mm Hg (est) | The Good Scents Company Information System | Water Solubility | 0.45 g/L | Not Available | LogP | 1.4 | Not Available |
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Experimental Chromatographic Properties | Experimental Collision Cross Sections |
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Predicted Molecular Properties | | Show more...
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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Penicillin V,1TMS,isomer #1 | CC1(C)S[C@@H]2[C@H](NC(=O)COC3=CC=CC=C3)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C | 2775.5 | Semi standard non polar | 33892256 | Penicillin V,1TMS,isomer #2 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C)C(=O)N2[C@H]1C(=O)O | 2722.3 | Semi standard non polar | 33892256 | Penicillin V,2TMS,isomer #1 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C | 2702.0 | Semi standard non polar | 33892256 | Penicillin V,2TMS,isomer #1 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C | 2709.5 | Standard non polar | 33892256 | Penicillin V,2TMS,isomer #1 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C | 3361.4 | Standard polar | 33892256 | Penicillin V,1TBDMS,isomer #1 | CC1(C)S[C@@H]2[C@H](NC(=O)COC3=CC=CC=C3)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C(C)(C)C | 3004.2 | Semi standard non polar | 33892256 | Penicillin V,1TBDMS,isomer #2 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C(C)(C)C)C(=O)N2[C@H]1C(=O)O | 2943.1 | Semi standard non polar | 33892256 | Penicillin V,2TBDMS,isomer #1 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C(C)(C)C)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C(C)(C)C | 3132.9 | Semi standard non polar | 33892256 | Penicillin V,2TBDMS,isomer #1 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C(C)(C)C)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C(C)(C)C | 3181.7 | Standard non polar | 33892256 | Penicillin V,2TBDMS,isomer #1 | CC1(C)S[C@@H]2[C@H](N(C(=O)COC3=CC=CC=C3)[Si](C)(C)C(C)(C)C)C(=O)N2[C@H]1C(=O)O[Si](C)(C)C(C)(C)C | 3548.0 | Standard polar | 33892256 |
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Spectra |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - Penicillin V GC-MS (Non-derivatized) - 70eV, Positive | splash10-0006-9322000000-4de191c98a42f568cb80 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Penicillin V GC-MS (1 TMS) - 70eV, Positive | splash10-00dl-9120000000-a1d43b6f7b36c99253c8 | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Penicillin V GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 10V, Negative-QTOF | splash10-0a4i-0291000000-38115fcb2144512aafd8 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 20V, Negative-QTOF | splash10-0a4l-4391000000-14c84175bfebc1ce80fe | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 40V, Negative-QTOF | splash10-0006-9210000000-f2936b57e120f47f39dc | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 10V, Negative-QTOF | splash10-0002-1109000000-319f4d6a2a700a6ed3b9 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 20V, Negative-QTOF | splash10-0a4m-9512000000-0f48145338e3fec3b861 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 40V, Negative-QTOF | splash10-0006-9000000000-a450a07a0a44f54cace0 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 10V, Positive-QTOF | splash10-03dl-2923000000-d226fb5017278afb5e95 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 20V, Positive-QTOF | splash10-03dl-3910000000-48ee65139c72804d81c8 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 40V, Positive-QTOF | splash10-0a4i-9500000000-90eba449715f7273e81a | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 10V, Positive-QTOF | splash10-0udi-0109000000-3f8cdfcceea1602d0a07 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 20V, Positive-QTOF | splash10-0w2c-1933000000-090201c465f23ad0611a | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Penicillin V 40V, Positive-QTOF | splash10-004i-8901000000-04830724f7ecfdc9d13f | 2021-09-25 | Wishart Lab | View Spectrum |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | |
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Tissue Locations | Not Available |
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Pathways | |
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Normal Concentrations |
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Blood | Expected but not Quantified | Not Quantified | Not Available | Not Available | Taking drug identified by DrugBank entry DB00417 | | details | Urine | Expected but not Quantified | Not Quantified | Not Available | Not Available | Taking drug identified by DrugBank entry DB00417 | | details |
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Abnormal Concentrations |
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| Not Available |
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Associated Disorders and Diseases |
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Disease References | None |
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Associated OMIM IDs | None |
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External Links |
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DrugBank ID | DB00417 |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | Not Available |
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KNApSAcK ID | Not Available |
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Chemspider ID | 6607 |
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KEGG Compound ID | C08126 |
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BioCyc ID | Not Available |
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BiGG ID | Not Available |
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Wikipedia Link | Phenoxymethylpenicillin |
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METLIN ID | Not Available |
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PubChem Compound | 6869 |
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PDB ID | PNV |
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ChEBI ID | 27446 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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MarkerDB ID | Not Available |
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Good Scents ID | rw1018181 |
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References |
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Synthesis Reference | Not Available |
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Material Safety Data Sheet (MSDS) | Not Available |
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General References | - Authors unspecified: Inadvertent use of Bicillin C-R to treat syphilis infection--Los Angeles, California, 1999-2004. MMWR Morb Mortal Wkly Rep. 2005 Mar 11;54(9):217-9. [PubMed:15758893 ]
- Gruchalla RS, Pirmohamed M: Clinical practice. Antibiotic allergy. N Engl J Med. 2006 Feb 9;354(6):601-9. [PubMed:16467547 ]
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