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Showing metabocard for Methimazole (HMDB0014901)

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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2023-02-21 17:18:18 UTC
HMDB IDHMDB0014901
Secondary Accession Numbers
  • HMDB14901
Metabolite Identification
Common NameMethimazole
DescriptionMethimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is an extremely weak basic (essentially neutral) compound (based on its pKa). Methimazole exists in all living organisms, ranging from bacteria to humans. Those who developed significant side effects may also have problems with propylthiouracil. The drug may also be taken before thyroid surgery to lower thyroid hormone levels and minimize the effects of thyroid manipulation. It is available as a generic medication. The boiling point is 280 °C (decomposition). Galenic preparations are injectable solutions and tablets.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0014901 (Methimazole)

763
  Mrv0541 02231214592D          

  7  7  0  0  0  0            999 V2000
    3.7697   -0.1992    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3176   -0.4292    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7301    0.8404    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9850    0.0558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6501    0.0558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3176   -1.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9050    0.8404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  2  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  4  1  0  0  0  0
  3  7  1  0  0  0  0
  5  7  2  0  0  0  0
M  END
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3D MOL for HMDB0014901 (Methimazole)

HMDB0014901
     RDKit          3D
Methimazole
 13 13  0  0  0  0  0  0  0  0999 V2000
   -1.8905   -0.1200   -0.0367 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4322   -0.0554   -0.0086 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4292   -1.0772    0.1055 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7353   -0.6356    0.0954 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6441    0.6965   -0.0293 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3525    1.0510   -0.0921 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2447    2.5777   -0.2465 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1738   -1.1810   -0.1144 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3241    0.3434    0.8974 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3158    0.4555   -0.8710 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1314   -2.1271    0.1952 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6293   -1.2660    0.1743 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4592    1.3380   -0.0693 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  2  1  0
  1  8  1  0
  1  9  1  0
  1 10  1  0
  3 11  1  0
  4 12  1  0
  5 13  1  0
M  END
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3D SDF for HMDB0014901 (Methimazole)

763
  Mrv0541 02231214592D          

  7  7  0  0  0  0            999 V2000
    3.7697   -0.1992    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3176   -0.4292    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7301    0.8404    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9850    0.0558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6501    0.0558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3176   -1.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9050    0.8404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  2  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  4  1  0  0  0  0
  3  7  1  0  0  0  0
  5  7  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0014901

> <DATABASE_NAME>
hmdb

> <SMILES>
CN1C=CNC1=S

> <INCHI_IDENTIFIER>
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

> <INCHI_KEY>
PMRYVIKBURPHAH-UHFFFAOYSA-N

> <FORMULA>
C4H6N2S

> <MOLECULAR_WEIGHT>
114.169

> <EXACT_MASS>
114.025168892

> <JCHEM_ACCEPTOR_COUNT>
0

> <JCHEM_AVERAGE_POLARIZABILITY>
11.63833435680311

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
1-methyl-2,3-dihydro-1H-imidazole-2-thione

> <ALOGPS_LOGP>
-0.38

> <JCHEM_LOGP>
0.7456704696666666

> <ALOGPS_LOGS>
-1.00

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.411967101924702

> <JCHEM_PKA_STRONGEST_BASIC>
-3.000000002357205

> <JCHEM_POLAR_SURFACE_AREA>
15.27

> <JCHEM_REFRACTIVITY>
33.2322

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.13e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methimazole

> <JCHEM_VEBER_RULE>
1

$$$$
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3D-SDF for HMDB0014901 (Methimazole)

HMDB0014901
     RDKit          3D
Methimazole
 13 13  0  0  0  0  0  0  0  0999 V2000
   -1.8905   -0.1200   -0.0367 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4322   -0.0554   -0.0086 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4292   -1.0772    0.1055 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7353   -0.6356    0.0954 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6441    0.6965   -0.0293 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3525    1.0510   -0.0921 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2447    2.5777   -0.2465 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1738   -1.1810   -0.1144 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3241    0.3434    0.8974 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3158    0.4555   -0.8710 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1314   -2.1271    0.1952 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6293   -1.2660    0.1743 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4592    1.3380   -0.0693 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  6  2  1  0
  1  8  1  0
  1  9  1  0
  1 10  1  0
  3 11  1  0
  4 12  1  0
  5 13  1  0
M  END
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PDB for HMDB0014901 (Methimazole)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 763                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  S   UNK     0       7.037  -0.372   0.000  0.00  0.00           S+0
HETATM    2  N   UNK     0       4.326  -0.801   0.000  0.00  0.00           N+0
HETATM    3  N   UNK     0       5.096   1.569   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0       5.572   0.104   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.080   0.104   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       4.326  -2.341   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.556   1.569   0.000  0.00  0.00           C+0
CONECT    1    4                                                            
CONECT    2    4    5    6                                                  
CONECT    3    4    7                                                       
CONECT    4    1    2    3                                                  
CONECT    5    2    7                                                       
CONECT    6    2                                                            
CONECT    7    3    5                                                       
MASTER        0    0    0    0    0    0    0    0    7    0   14    0
END
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3D PDB for HMDB0014901 (Methimazole)

COMPND    HMDB0014901
HETATM    1  C1  UNL     1      -1.891  -0.120  -0.037  1.00  0.00           C  
HETATM    2  N1  UNL     1      -0.432  -0.055  -0.009  1.00  0.00           N  
HETATM    3  C2  UNL     1       0.429  -1.077   0.106  1.00  0.00           C  
HETATM    4  C3  UNL     1       1.735  -0.636   0.095  1.00  0.00           C  
HETATM    5  N2  UNL     1       1.644   0.697  -0.029  1.00  0.00           N  
HETATM    6  C4  UNL     1       0.352   1.051  -0.092  1.00  0.00           C  
HETATM    7  S1  UNL     1      -0.245   2.578  -0.247  1.00  0.00           S  
HETATM    8  H1  UNL     1      -2.174  -1.181  -0.114  1.00  0.00           H  
HETATM    9  H2  UNL     1      -2.324   0.343   0.897  1.00  0.00           H  
HETATM   10  H3  UNL     1      -2.316   0.455  -0.871  1.00  0.00           H  
HETATM   11  H4  UNL     1       0.131  -2.127   0.195  1.00  0.00           H  
HETATM   12  H5  UNL     1       2.629  -1.266   0.174  1.00  0.00           H  
HETATM   13  H6  UNL     1       2.459   1.338  -0.069  1.00  0.00           H  
CONECT    1    2    8    9   10
CONECT    2    3    6
CONECT    3    4    4   11
CONECT    4    5   12
CONECT    5    6   13
CONECT    6    7    7
END
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SMILES for HMDB0014901 (Methimazole)

CN1C=CNC1=S
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INCHI for HMDB0014901 (Methimazole)

InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC4H6N2S
Average Molecular Weight114.169
Monoisotopic Molecular Weight114.025168892
IUPAC Name1-methyl-2,3-dihydro-1H-imidazole-2-thione
Traditional Namemethimazole
CAS Registry Number60-56-0
SMILES
CN1C=CNC1=S
InChI Identifier
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChI KeyPMRYVIKBURPHAH-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzolines
Sub ClassImidazolines
Direct ParentImidazolethiones
Alternative Parents
Substituents
  • N-substituted imidazole
  • Imidazole-2-thione
  • Heteroaromatic compound
  • Imidazole
  • Azole
  • Thiourea
  • Azacycle
  • Organic nitrogen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point146 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility11.3 g/LNot Available
LogP-0.2Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available117.162http://allccs.zhulab.cn/database/detail?ID=AllCCS00000926
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00763 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00763 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00763
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID1131173
KEGG Compound IDC07190
BioCyc IDCPD-11282
BiGG IDNot Available
Wikipedia LinkMethimazole
METLIN IDNot Available
PubChem Compound1349907
PDB IDMMZ
ChEBI ID50673
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Thyroid peroxidase
General function:
Involved in calcium ion binding
Specific function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Gene Name:
TPO
Uniprot ID:
P07202
Molecular weight:
102961.63
References
  1. Sugawara M, Sugawara Y, Wen K: Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles. Thyroid. 1999 May;9(5):513-8. [PubMed:10365684 ]
  2. Manzon RG, Holmes JA, Youson JH: Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus). J Exp Zool. 2001 Apr 15;289(5):290-303. [PubMed:11241400 ]
  3. Ferreira AC, de Carvalho Cardoso L, Rosenthal D, de Carvalho DP: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole. Eur J Biochem. 2003 Jun;270(11):2363-8. [PubMed:12755690 ]
  4. Magnusson RP, Yu B, Brennan V: Effect of serum thyrotropin levels on the concentration of messenger RNA for thyroid peroxidase in the rat. Acta Endocrinol (Copenh). 1992 May;126(5):460-6. [PubMed:1320313 ]
  5. Chiovato L, Pinchera A: The microsomal/peroxidase antigen: modulation of its expression in thyroid cells. Autoimmunity. 1991;10(4):319-31. [PubMed:1663395 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Enzyme Details
2. Cytochrome P450 3A4
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
3. Cytochrome P450 2C9
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
4. Cytochrome P450 2C19
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
5. Cytochrome P450 2E1
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
6. Cytochrome P450 2D6
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55768.94
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
7. Cytochrome P450 2B6
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
8. Cytochrome P450 1A2
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular weight:
58406.915
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
9. Cytochrome P450 2A6
General function:
Involved in monooxygenase activity
Specific function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular weight:
56517.005
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]