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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2022-03-07 02:51:51 UTC
HMDB IDHMDB0015084
Secondary Accession Numbers
  • HMDB15084
Metabolite Identification
Common NameFelbamate
DescriptionFelbamate, also known as felbamatum or felbatol, belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. Felbamate is a drug which is used for use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use. Felbamate is a very weakly acidic compound (based on its pKa). Within humans, felbamate participates in a number of enzymatic reactions. In particular, felbamate can be converted into 2-hydroxyfelbamate; which is mediated by the enzymes cytochrome P450 2E1 and cytochrome P450 3A4. In addition, felbamate can be converted into p-hydroxyfelbamate; which is mediated by the enzymes cytochrome P450 3A4 and cytochrome P450 2E1. In humans, felbamate is involved in felbamate metabolism pathway. Felbamate is a potentially toxic compound. The bis(carbamate ester) of 2-phenylpropane-1,3-diol.
Structure
Data?1582753256
Synonyms
ValueSource
2-Phenyl-1,3-propanediol dicarbamateChEBI
Carbamic acid 2-phenyltrimethylene esterChEBI
Carbamic acid 3-carbamoyloxy-2-phenyl-propyl esterChEBI
FelbamatoChEBI
FelbamatumChEBI
FelbatolKegg
2-Phenyl-1,3-propanediol dicarbamic acidGenerator
Carbamate 2-phenyltrimethylene esterGenerator
Carbamate 3-carbamoyloxy-2-phenyl-propyl esterGenerator
Felbamic acidGenerator
FelbamylHMDB
Wallace brand 1 OF felbamateHMDB
TaloxaHMDB
Wallace brand 2 OF felbamateHMDB
(3-Carbamoyloxy-2-phenyl-propyl) carbamateHMDB
2 Phenyl 1,3 propanediol dicarbamateHMDB
Chemical FormulaC11H14N2O4
Average Molecular Weight238.2399
Monoisotopic Molecular Weight238.095356946
IUPAC Name3-(carbamoyloxy)-2-phenylpropyl carbamate
Traditional Namefelbamate
CAS Registry Number25451-15-4
SMILES
NC(=O)OCC(COC(N)=O)C1=CC=CC=C1
InChI Identifier
InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)
InChI KeyWKGXYQFOCVYPAC-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassNot Available
Direct ParentBenzene and substituted derivatives
Alternative Parents
Substituents
  • Monocyclic benzene moiety
  • Carbamic acid ester
  • Carbonic acid derivative
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Not AvailableNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point151.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.74 g/LNot Available
LogP0.3Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.74 g/LALOGPS
logP0.56ALOGPS
logP0.68ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)14.98ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area104.64 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity59.59 m³·mol⁻¹ChemAxon
Polarizability23.52 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+154.84231661259
DarkChem[M-H]-147.49231661259
DeepCCS[M+H]+157.9230932474
DeepCCS[M-H]-155.53630932474
DeepCCS[M-2H]-189.00130932474
DeepCCS[M+Na]+163.98730932474
AllCCS[M+H]+151.832859911
AllCCS[M+H-H2O]+148.132859911
AllCCS[M+NH4]+155.232859911
AllCCS[M+Na]+156.232859911
AllCCS[M-H]-152.032859911
AllCCS[M+Na-2H]-152.332859911
AllCCS[M+HCOO]-152.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
FelbamateNC(=O)OCC(COC(N)=O)C1=CC=CC=C13284.0Standard polar33892256
FelbamateNC(=O)OCC(COC(N)=O)C1=CC=CC=C12035.4Standard non polar33892256
FelbamateNC(=O)OCC(COC(N)=O)C1=CC=CC=C12198.0Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Felbamate,1TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(N)=O)C1=CC=CC=C12173.1Semi standard non polar33892256
Felbamate,1TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(N)=O)C1=CC=CC=C12111.9Standard non polar33892256
Felbamate,1TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(N)=O)C1=CC=CC=C13361.7Standard polar33892256
Felbamate,2TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(=O)N[Si](C)(C)C)C1=CC=CC=C12295.8Semi standard non polar33892256
Felbamate,2TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(=O)N[Si](C)(C)C)C1=CC=CC=C12236.0Standard non polar33892256
Felbamate,2TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(=O)N[Si](C)(C)C)C1=CC=CC=C12882.2Standard polar33892256
Felbamate,2TMS,isomer #2C[Si](C)(C)N(C(=O)OCC(COC(N)=O)C1=CC=CC=C1)[Si](C)(C)C2229.4Semi standard non polar33892256
Felbamate,2TMS,isomer #2C[Si](C)(C)N(C(=O)OCC(COC(N)=O)C1=CC=CC=C1)[Si](C)(C)C2230.7Standard non polar33892256
Felbamate,2TMS,isomer #2C[Si](C)(C)N(C(=O)OCC(COC(N)=O)C1=CC=CC=C1)[Si](C)(C)C3219.0Standard polar33892256
Felbamate,3TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C12308.0Semi standard non polar33892256
Felbamate,3TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C12327.3Standard non polar33892256
Felbamate,3TMS,isomer #1C[Si](C)(C)NC(=O)OCC(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C12721.4Standard polar33892256
Felbamate,4TMS,isomer #1C[Si](C)(C)N(C(=O)OCC(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C1)[Si](C)(C)C2405.7Semi standard non polar33892256
Felbamate,4TMS,isomer #1C[Si](C)(C)N(C(=O)OCC(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C1)[Si](C)(C)C2440.9Standard non polar33892256
Felbamate,4TMS,isomer #1C[Si](C)(C)N(C(=O)OCC(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)C1=CC=CC=C1)[Si](C)(C)C2585.6Standard polar33892256
Felbamate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(N)=O)C1=CC=CC=C12382.5Semi standard non polar33892256
Felbamate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(N)=O)C1=CC=CC=C12320.7Standard non polar33892256
Felbamate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(N)=O)C1=CC=CC=C13389.5Standard polar33892256
Felbamate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(=O)N[Si](C)(C)C(C)(C)C)C1=CC=CC=C12717.5Semi standard non polar33892256
Felbamate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(=O)N[Si](C)(C)C(C)(C)C)C1=CC=CC=C12585.7Standard non polar33892256
Felbamate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(=O)N[Si](C)(C)C(C)(C)C)C1=CC=CC=C13023.1Standard polar33892256
Felbamate,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(C(=O)OCC(COC(N)=O)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C2669.4Semi standard non polar33892256
Felbamate,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(C(=O)OCC(COC(N)=O)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C2618.8Standard non polar33892256
Felbamate,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(C(=O)OCC(COC(N)=O)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C3244.5Standard polar33892256
Felbamate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C12933.9Semi standard non polar33892256
Felbamate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C12860.2Standard non polar33892256
Felbamate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC(=O)OCC(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C12990.2Standard polar33892256
Felbamate,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C(=O)OCC(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C3173.7Semi standard non polar33892256
Felbamate,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C(=O)OCC(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C3129.2Standard non polar33892256
Felbamate,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C(=O)OCC(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C1=CC=CC=C1)[Si](C)(C)C(C)(C)C2924.7Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Felbamate GC-MS (Non-derivatized) - 70eV, Positivesplash10-0fdo-6900000000-0f546bad5ba921f66b402017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Felbamate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Felbamate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-0udi-5900000000-673caaab3dded596924c2014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Felbamate LC-ESI-qTof , Positive-QTOFsplash10-014i-2900000000-880b1fb1822a512a352c2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Felbamate LC-ESI-qTof , Positive-QTOFsplash10-016r-1900000000-f04127a0f39b9e0b001f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Felbamate , positive-QTOFsplash10-014i-2900000000-880b1fb1822a512a352c2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Felbamate , positive-QTOFsplash10-016r-1900000000-f04127a0f39b9e0b001f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Felbamate 35V, Positive-QTOFsplash10-014i-0900000000-edb979350df20b03f9952021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 10V, Positive-QTOFsplash10-000i-2390000000-02895c4e844f089545e62016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 20V, Positive-QTOFsplash10-004i-3920000000-e7c2dfe58df4e1e34dcc2016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 40V, Positive-QTOFsplash10-004l-9500000000-e824587a3374313f7cc42016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 10V, Negative-QTOFsplash10-0006-9010000000-b6e0a295dcbb7a9c52662016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 20V, Negative-QTOFsplash10-0006-9000000000-d549b5cb79133b3aa46e2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 40V, Negative-QTOFsplash10-0006-9000000000-6a77d5d551bb1bd0c3a62016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 10V, Positive-QTOFsplash10-014i-0900000000-de230d778fe1524d89772021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 20V, Positive-QTOFsplash10-014i-0900000000-12a693a2773960f72de02021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 40V, Positive-QTOFsplash10-014l-4900000000-bf2fec3e77955586472e2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 10V, Negative-QTOFsplash10-0udi-3900000000-3ae60a2a1bad9c4de09b2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 20V, Negative-QTOFsplash10-0006-9000000000-0ce4d922671bd2797d222021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Felbamate 40V, Negative-QTOFsplash10-0006-9000000000-94bb7174b97d6eefb9922021-10-11Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00949 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00949 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00949
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3214
KEGG Compound IDC07501
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkFelbamate
METLIN IDNot Available
PubChem Compound3331
PDB IDNot Available
ChEBI ID4995
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Leppik IE, Dreifuss FE, Pledger GW, Graves NM, Santilli N, Drury I, Tsay JY, Jacobs MP, Bertram E, Cereghino JJ, et al.: Felbamate for partial seizures: results of a controlled clinical trial. Neurology. 1991 Nov;41(11):1785-9. [PubMed:1944909 ]

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in ionotropic glutamate receptor activity
Specific function:
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits
Gene Name:
GRIN2A
Uniprot ID:
Q12879
Molecular weight:
165281.2
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
General function:
Involved in ionotropic glutamate receptor activity
Specific function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine
Gene Name:
GRIN2B
Uniprot ID:
Q13224
Molecular weight:
166365.9
References
  1. Kleckner NW, Glazewski JC, Chen CC, Moscrip TD: Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action. J Pharmacol Exp Ther. 1999 May;289(2):886-94. [PubMed:10215667 ]
  2. Harty TP, Rogawski MA: Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39(1):47-55. [PubMed:10690753 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  4. Chang HR, Kuo CC: Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor. J Med Chem. 2008 Mar 27;51(6):1534-45. doi: 10.1021/jm0706618. Epub 2008 Feb 27. [PubMed:18311896 ]
  5. Luszczki JJ, Danysz W, Czuczwar SJ: Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model. Pharmacology. 2008;81(3):259-65. doi: 10.1159/000114870. Epub 2008 Feb 4. [PubMed:18253065 ]
General function:
Involved in ionotropic glutamate receptor activity
Specific function:
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism
Gene Name:
GRIN3A
Uniprot ID:
Q8TCU5
Molecular weight:
125464.1
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]