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Record Information

Version

5.0

Status

Detected but not Quantified

Creation Date

2012-09-06 21:02:45 UTC

Update Date

2021-09-14 15:46:59 UTC

HMDB ID

HMDB0028852

Secondary Accession Numbers

HMDB28852

Metabolite Identification

Common Name

Glycyl-Tryptophan

Description

Glycyl-Tryptophan is a dipeptide composed of glycine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an 'Expected' metabolite.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0028852
     RDKit          3D
Glycyl-Tryptophan
 34 35  0  0  0  0  0  0  0  0999 V2000
   -3.3257    2.6388   -0.9997 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654    1.5176   -0.1310 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1848    0.5282   -0.6224 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6139    0.7789   -1.7253 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8953   -0.6520    0.1094 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9194   -1.6340   -0.3811 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1287   -1.8667    0.6970 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8524   -0.6219    1.0498 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6842    0.1556    2.1757 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5210    1.2023    2.1416 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2643    1.1503    0.9991 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2532    1.9496    0.4636 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7886    1.5696   -0.7470 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3861    0.4504   -1.4278 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4040   -0.3393   -0.8914 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8463    0.0169    0.3245 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6389   -2.9284   -0.5346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8628   -3.0700   -0.2712 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8613   -4.0066   -0.9993 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3098    2.7689   -1.2918 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9637    3.4839   -0.5276 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8883    1.8130    0.9148 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1567    1.0120   -0.0265 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3997   -0.7990    1.0093 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4862   -1.3219   -1.3289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4094   -2.2570    1.5777 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8362   -2.6616    0.3868 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0193   -0.0512    2.9670 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6103    1.9569    2.8672 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5880    2.8415    0.9857 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5729    2.1643   -1.2164 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8190    0.1576   -2.3899 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420   -1.2419   -1.3866 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4969   -4.7049   -0.3411 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
  6 17  1  0
 17 18  2  0
 17 19  1  0
 16  8  1  0
 16 11  1  0
  1 20  1  0
  1 21  1  0
  2 22  1  0
  2 23  1  0
  5 24  1  0
  6 25  1  0
  7 26  1  0
  7 27  1  0
  9 28  1  0
 10 29  1  0
 12 30  1  0
 13 31  1  0
 14 32  1  0
 15 33  1  0
 19 34  1  0
M  END

  Mrv1652304062013432D          

 19 20  0  0  0  0            999 V2000
    1.3946   -0.8522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6100   -0.5972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4385    0.2097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0516    0.7618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8362    0.5068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0077   -0.3001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3211    1.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8362    1.8417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0516    1.5868    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1461    1.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5586    1.8888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1461    2.6032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3211    2.6032    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5586    3.3177    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3836    1.8888    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7961    2.6032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3836    3.3177    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6211    2.6032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0336    3.3177    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0028852

> <DATABASE_NAME>
hmdb

> <SMILES>
NCC(=O)NC(CC1=CNC2=CC=CC=C12)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C13H15N3O3/c14-6-12(17)16-11(13(18)19)5-8-7-15-10-4-2-1-3-9(8)10/h1-4,7,11,15H,5-6,14H2,(H,16,17)(H,18,19)

> <INCHI_KEY>
AJHCSUXXECOXOY-UHFFFAOYSA-N

> <FORMULA>
C13H15N3O3

> <MOLECULAR_WEIGHT>
261.2765

> <EXACT_MASS>
261.111341361

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
34

> <JCHEM_AVERAGE_POLARIZABILITY>
26.630689749599117

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-(2-aminoacetamido)-3-(1H-indol-3-yl)propanoic acid

> <ALOGPS_LOGP>
-1.23

> <JCHEM_LOGP>
-2.1930502369128337

> <ALOGPS_LOGS>
-2.34

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.70113814862232

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.8161279857206654

> <JCHEM_PKA_STRONGEST_BASIC>
8.139572536240388

> <JCHEM_POLAR_SURFACE_AREA>
108.21

> <JCHEM_REFRACTIVITY>
69.00630000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.19e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-(2-aminoacetamido)-3-(1H-indol-3-yl)propanoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0028852
     RDKit          3D
Glycyl-Tryptophan
 34 35  0  0  0  0  0  0  0  0999 V2000
   -3.3257    2.6388   -0.9997 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654    1.5176   -0.1310 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1848    0.5282   -0.6224 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6139    0.7789   -1.7253 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8953   -0.6520    0.1094 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9194   -1.6340   -0.3811 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1287   -1.8667    0.6970 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8524   -0.6219    1.0498 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6842    0.1556    2.1757 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5210    1.2023    2.1416 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2643    1.1503    0.9991 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2532    1.9496    0.4636 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7886    1.5696   -0.7470 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3861    0.4504   -1.4278 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4040   -0.3393   -0.8914 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8463    0.0169    0.3245 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6389   -2.9284   -0.5346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8628   -3.0700   -0.2712 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8613   -4.0066   -0.9993 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3098    2.7689   -1.2918 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9637    3.4839   -0.5276 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8883    1.8130    0.9148 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1567    1.0120   -0.0265 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3997   -0.7990    1.0093 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4862   -1.3219   -1.3289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4094   -2.2570    1.5777 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8362   -2.6616    0.3868 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0193   -0.0512    2.9670 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6103    1.9569    2.8672 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5880    2.8415    0.9857 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5729    2.1643   -1.2164 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8190    0.1576   -2.3899 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420   -1.2419   -1.3866 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4969   -4.7049   -0.3411 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
  6 17  1  0
 17 18  2  0
 17 19  1  0
 16  8  1  0
 16 11  1  0
  1 20  1  0
  1 21  1  0
  2 22  1  0
  2 23  1  0
  5 24  1  0
  6 25  1  0
  7 26  1  0
  7 27  1  0
  9 28  1  0
 10 29  1  0
 12 30  1  0
 13 31  1  0
 14 32  1  0
 15 33  1  0
 19 34  1  0
M  END

HEADER    PROTEIN                                 06-APR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-APR-20         0                                  
HETATM    1  C   UNK     0       2.603  -1.591   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.139  -1.115   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.819   0.391   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.963   1.422   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.428   0.946   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.748  -0.560   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.333   2.192   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.428   3.438   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0       1.963   2.962   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0       5.873   2.192   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.643   3.526   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.873   4.859   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       4.333   4.859   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       6.643   6.193   0.000  0.00  0.00           O+0
HETATM   15  N   UNK     0       8.183   3.526   0.000  0.00  0.00           N+0
HETATM   16  C   UNK     0       8.953   4.859   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       8.183   6.193   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0      10.493   4.859   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0      11.263   6.193   0.000  0.00  0.00           N+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5    9                                                  
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5    8   10                                                  
CONECT    8    7    9                                                       
CONECT    9    8    4                                                       
CONECT   10    7   11                                                       
CONECT   11   10   12   15                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12                                                            
CONECT   15   11   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19                                                       
CONECT   19   18                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   40    0
END

COMPND    HMDB0028852
HETATM    1  N1  UNL     1      -3.326   2.639  -1.000  1.00  0.00           N  
HETATM    2  C1  UNL     1      -3.165   1.518  -0.131  1.00  0.00           C  
HETATM    3  C2  UNL     1      -2.185   0.528  -0.622  1.00  0.00           C  
HETATM    4  O1  UNL     1      -1.614   0.779  -1.725  1.00  0.00           O  
HETATM    5  N2  UNL     1      -1.895  -0.652   0.109  1.00  0.00           N  
HETATM    6  C3  UNL     1      -0.919  -1.634  -0.381  1.00  0.00           C  
HETATM    7  C4  UNL     1       0.129  -1.867   0.697  1.00  0.00           C  
HETATM    8  C5  UNL     1       0.852  -0.622   1.050  1.00  0.00           C  
HETATM    9  C6  UNL     1       0.684   0.156   2.176  1.00  0.00           C  
HETATM   10  N3  UNL     1       1.521   1.202   2.142  1.00  0.00           N  
HETATM   11  C7  UNL     1       2.264   1.150   0.999  1.00  0.00           C  
HETATM   12  C8  UNL     1       3.253   1.950   0.464  1.00  0.00           C  
HETATM   13  C9  UNL     1       3.789   1.570  -0.747  1.00  0.00           C  
HETATM   14  C10 UNL     1       3.386   0.450  -1.428  1.00  0.00           C  
HETATM   15  C11 UNL     1       2.404  -0.339  -0.891  1.00  0.00           C  
HETATM   16  C12 UNL     1       1.846   0.017   0.324  1.00  0.00           C  
HETATM   17  C13 UNL     1      -1.639  -2.928  -0.535  1.00  0.00           C  
HETATM   18  O2  UNL     1      -2.863  -3.070  -0.271  1.00  0.00           O  
HETATM   19  O3  UNL     1      -0.861  -4.007  -0.999  1.00  0.00           O  
HETATM   20  H1  UNL     1      -4.310   2.769  -1.292  1.00  0.00           H  
HETATM   21  H2  UNL     1      -2.964   3.484  -0.528  1.00  0.00           H  
HETATM   22  H3  UNL     1      -2.888   1.813   0.915  1.00  0.00           H  
HETATM   23  H4  UNL     1      -4.157   1.012  -0.026  1.00  0.00           H  
HETATM   24  H5  UNL     1      -2.400  -0.799   1.009  1.00  0.00           H  
HETATM   25  H6  UNL     1      -0.486  -1.322  -1.329  1.00  0.00           H  
HETATM   26  H7  UNL     1      -0.409  -2.257   1.578  1.00  0.00           H  
HETATM   27  H8  UNL     1       0.836  -2.662   0.387  1.00  0.00           H  
HETATM   28  H9  UNL     1      -0.019  -0.051   2.967  1.00  0.00           H  
HETATM   29  H10 UNL     1       1.610   1.957   2.867  1.00  0.00           H  
HETATM   30  H11 UNL     1       3.588   2.842   0.986  1.00  0.00           H  
HETATM   31  H12 UNL     1       4.573   2.164  -1.216  1.00  0.00           H  
HETATM   32  H13 UNL     1       3.819   0.158  -2.390  1.00  0.00           H  
HETATM   33  H14 UNL     1       2.042  -1.242  -1.387  1.00  0.00           H  
HETATM   34  H15 UNL     1      -0.497  -4.705  -0.341  1.00  0.00           H  
CONECT    1    2   20   21
CONECT    2    3   22   23
CONECT    3    4    4    5
CONECT    5    6   24
CONECT    6    7   17   25
CONECT    7    8   26   27
CONECT    8    9    9   16
CONECT    9   10   28
CONECT   10   11   29
CONECT   11   12   12   16
CONECT   12   13   30
CONECT   13   14   14   31
CONECT   14   15   32
CONECT   15   16   16   33
CONECT   17   18   18   19
CONECT   19   34
END

HMDB0028852
     RDKit          3D
Glycyl-Tryptophan
 34 35  0  0  0  0  0  0  0  0999 V2000
   -3.3257    2.6388   -0.9997 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654    1.5176   -0.1310 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1848    0.5282   -0.6224 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6139    0.7789   -1.7253 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8953   -0.6520    0.1094 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9194   -1.6340   -0.3811 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1287   -1.8667    0.6970 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8524   -0.6219    1.0498 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6842    0.1556    2.1757 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5210    1.2023    2.1416 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2643    1.1503    0.9991 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2532    1.9496    0.4636 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7886    1.5696   -0.7470 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3861    0.4504   -1.4278 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4040   -0.3393   -0.8914 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8463    0.0169    0.3245 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6389   -2.9284   -0.5346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8628   -3.0700   -0.2712 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8613   -4.0066   -0.9993 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3098    2.7689   -1.2918 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9637    3.4839   -0.5276 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8883    1.8130    0.9148 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1567    1.0120   -0.0265 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3997   -0.7990    1.0093 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4862   -1.3219   -1.3289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4094   -2.2570    1.5777 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8362   -2.6616    0.3868 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0193   -0.0512    2.9670 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6103    1.9569    2.8672 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5880    2.8415    0.9857 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5729    2.1643   -1.2164 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8190    0.1576   -2.3899 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420   -1.2419   -1.3866 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4969   -4.7049   -0.3411 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
  6 17  1  0
 17 18  2  0
 17 19  1  0
 16  8  1  0
 16 11  1  0
  1 20  1  0
  1 21  1  0
  2 22  1  0
  2 23  1  0
  5 24  1  0
  6 25  1  0
  7 26  1  0
  7 27  1  0
  9 28  1  0
 10 29  1  0
 12 30  1  0
 13 31  1  0
 14 32  1  0
 15 33  1  0
 19 34  1  0
M  END

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
g-W Dipeptide	HMDB
Gly-TRP	HMDB
Glycine tryptophan dipeptide	HMDB
Glycine-tryptophan dipeptide	HMDB
Glycyltryptophan	HMDB
GW Dipeptide	HMDB
L-Glycyl-L-tryptophan	HMDB
Glycyl-L-tryptophan	HMDB
Glycyltryptophan, (DL)-isomer	HMDB
2-[(2-Amino-1-hydroxyethylidene)amino]-3-(1H-indol-3-yl)propanoate	HMDB

Chemical Formula

C₁₃H₁₅N₃O₃

Average Molecular Weight

261.2765

Monoisotopic Molecular Weight

261.111341361

IUPAC Name

2-(2-aminoacetamido)-3-(1H-indol-3-yl)propanoic acid

Traditional Name

2-(2-aminoacetamido)-3-(1H-indol-3-yl)propanoic acid

CAS Registry Number

Not Available

SMILES

NCC(=O)NC(CC1=CNC2=CC=CC=C12)C(O)=O

InChI Identifier

InChI=1S/C13H15N3O3/c14-6-12(17)16-11(13(18)19)5-8-7-15-10-4-2-1-3-9(8)10/h1-4,7,11,15H,5-6,14H2,(H,16,17)(H,18,19)

InChI Key

AJHCSUXXECOXOY-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Dipeptides

Alternative Parents

Substituents

Alpha-dipeptide
N-acyl-alpha amino acid or derivatives
N-acyl-alpha-amino acid
Alpha-amino acid amide
Indolyl carboxylic acid derivative
Alpha-amino acid or derivatives
3-alkylindole
Indole
Indole or derivatives
Substituted pyrrole
Benzenoid
Pyrrole
Heteroaromatic compound
Amino acid
Amino acid or derivatives
Secondary carboxylic acid amide
Carboxamide group
Carboxylic acid
Azacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Primary aliphatic amine
Amine
Organic oxygen compound
Hydrocarbon derivative
Organic nitrogen compound
Organic oxide
Carbonyl group
Organopnictogen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Ontology

Not Available

Feces (PMID: 27275383)

Source

Endogenous

Endogenous (HMDB: HMDB0028852)

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Process

Not Available

Role

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	-2.19	Extrapolated

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	1.19 g/L	ALOGPS
logP	-1.2	ALOGPS
logP	-2.2	ChemAxon
logS	-2.3	ALOGPS
pKa (Strongest Acidic)	3.82	ChemAxon
pKa (Strongest Basic)	8.14	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	108.21 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	69.01 m³·mol⁻¹	ChemAxon
Polarizability	26.63 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	160.307	31661259
DarkChem	[M-H]-	159.429	31661259
DeepCCS	[M-2H]-	185.111	30932474
DeepCCS	[M+Na]+	160.599	30932474
AllCCS	[M+H]+	159.7	32859911
AllCCS	[M+H-H2O]+	156.2	32859911
AllCCS	[M+NH4]+	163.0	32859911
AllCCS	[M+Na]+	164.0	32859911
AllCCS	[M-H]-	161.3	32859911
AllCCS	[M+Na-2H]-	161.2	32859911
AllCCS	[M+HCOO]-	161.2	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Glycyl-Tryptophan	NCC(=O)NC(CC1=CNC2=CC=CC=C12)C(O)=O	3834.6	Standard polar	33892256
Glycyl-Tryptophan	NCC(=O)NC(CC1=CNC2=CC=CC=C12)C(O)=O	2368.9	Standard non polar	33892256
Glycyl-Tryptophan	NCC(=O)NC(CC1=CNC2=CC=CC=C12)C(O)=O	2832.8	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
Glycyl-Tryptophan,1TMS,isomer #1	C[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)CN	2665.9	Semi standard non polar	33892256
Glycyl-Tryptophan,1TMS,isomer #2	C[Si](C)(C)NCC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O	2734.9	Semi standard non polar	33892256
Glycyl-Tryptophan,1TMS,isomer #3	C[Si](C)(C)N(C(=O)CN)C(CC1=C[NH]C2=CC=CC=C12)C(=O)O	2693.0	Semi standard non polar	33892256
Glycyl-Tryptophan,1TMS,isomer #4	C[Si](C)(C)N1C=C(CC(NC(=O)CN)C(=O)O)C2=CC=CC=C21	2693.4	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #1	C[Si](C)(C)NCC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C	2725.0	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #1	C[Si](C)(C)NCC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C	2536.0	Standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #2	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)NC(=O)CN	2655.6	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #2	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)NC(=O)CN	2453.6	Standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #3	C[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C	2660.0	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #3	C[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C	2547.0	Standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #4	C[Si](C)(C)N(CC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2887.9	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #4	C[Si](C)(C)N(CC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2719.8	Standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #5	C[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2752.7	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #5	C[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2666.3	Standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #6	C[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O	2760.6	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #6	C[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O	2643.5	Standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #7	C[Si](C)(C)N(C(=O)CN)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O	2684.7	Semi standard non polar	33892256
Glycyl-Tryptophan,2TMS,isomer #7	C[Si](C)(C)N(C(=O)CN)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O	2605.9	Standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #1	C[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C)[Si](C)(C)C	2855.1	Semi standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #1	C[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C)[Si](C)(C)C	2728.4	Standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #2	C[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2702.2	Semi standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #2	C[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2679.1	Standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #3	C[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C	2720.3	Semi standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #3	C[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C	2591.4	Standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #4	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C	2642.4	Semi standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #4	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C	2598.6	Standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #5	C[Si](C)(C)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)C(CC1=C[NH]C2=CC=CC=C12)C(=O)O	2890.4	Semi standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #5	C[Si](C)(C)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)C(CC1=C[NH]C2=CC=CC=C12)C(=O)O	2820.5	Standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #6	C[Si](C)(C)N(CC(=O)NC(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2897.2	Semi standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #6	C[Si](C)(C)N(CC(=O)NC(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2817.7	Standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #7	C[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2726.6	Semi standard non polar	33892256
Glycyl-Tryptophan,3TMS,isomer #7	C[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C	2740.5	Standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #1	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C)[Si](C)(C)C	2844.7	Semi standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #1	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C)[Si](C)(C)C	2768.2	Standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #2	C[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2879.1	Semi standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #2	C[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2821.5	Standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #3	C[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2710.3	Semi standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #3	C[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2714.4	Standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #4	C[Si](C)(C)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O	2914.1	Semi standard non polar	33892256
Glycyl-Tryptophan,4TMS,isomer #4	C[Si](C)(C)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)C(=O)O	2883.7	Standard non polar	33892256
Glycyl-Tryptophan,5TMS,isomer #1	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2917.1	Semi standard non polar	33892256
Glycyl-Tryptophan,5TMS,isomer #1	C[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C)C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2859.6	Standard non polar	33892256
Glycyl-Tryptophan,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)CN	2963.0	Semi standard non polar	33892256
Glycyl-Tryptophan,1TBDMS,isomer #2	CC(C)(C)[Si](C)(C)NCC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O	2982.6	Semi standard non polar	33892256
Glycyl-Tryptophan,1TBDMS,isomer #3	CC(C)(C)[Si](C)(C)N(C(=O)CN)C(CC1=C[NH]C2=CC=CC=C12)C(=O)O	2982.4	Semi standard non polar	33892256
Glycyl-Tryptophan,1TBDMS,isomer #4	CC(C)(C)[Si](C)(C)N1C=C(CC(NC(=O)CN)C(=O)O)C2=CC=CC=C21	2957.0	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)NCC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C	3225.4	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)NCC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C	2986.0	Standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)NC(=O)CN	3158.5	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)NC(=O)CN	2897.6	Standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C(C)(C)C	3198.3	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #3	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C(C)(C)C	2985.8	Standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)N(CC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3385.7	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #4	CC(C)(C)[Si](C)(C)N(CC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3106.5	Standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #5	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3256.1	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #5	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3073.5	Standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #6	CC(C)(C)[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O	3215.0	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #6	CC(C)(C)[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O	3042.3	Standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #7	CC(C)(C)[Si](C)(C)N(C(=O)CN)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O	3205.9	Semi standard non polar	33892256
Glycyl-Tryptophan,2TBDMS,isomer #7	CC(C)(C)[Si](C)(C)N(C(=O)CN)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O	2976.0	Standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3573.1	Semi standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3312.5	Standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3457.5	Semi standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #2	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=C[NH]C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3285.0	Standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C	3361.0	Semi standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #3	CC(C)(C)[Si](C)(C)NCC(=O)NC(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C	3216.2	Standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C(C)(C)C	3354.6	Semi standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #4	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)N(C(=O)CN)[Si](C)(C)C(C)(C)C	3168.5	Standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #5	CC(C)(C)[Si](C)(C)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(CC1=C[NH]C2=CC=CC=C12)C(=O)O	3605.3	Semi standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #5	CC(C)(C)[Si](C)(C)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(CC1=C[NH]C2=CC=CC=C12)C(=O)O	3372.8	Standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #6	CC(C)(C)[Si](C)(C)N(CC(=O)NC(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3581.0	Semi standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #6	CC(C)(C)[Si](C)(C)N(CC(=O)NC(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3339.3	Standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #7	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3439.0	Semi standard non polar	33892256
Glycyl-Tryptophan,3TBDMS,isomer #7	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O)[Si](C)(C)C(C)(C)C	3287.0	Standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3691.4	Semi standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)NC(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3485.5	Standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3777.6	Semi standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #2	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3547.0	Standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #3	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3549.0	Semi standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #3	CC(C)(C)[Si](C)(C)NCC(=O)N(C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3449.7	Standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #4	CC(C)(C)[Si](C)(C)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O	3771.0	Semi standard non polar	33892256
Glycyl-Tryptophan,4TBDMS,isomer #4	CC(C)(C)[Si](C)(C)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)C(=O)O	3523.1	Standard non polar	33892256
Glycyl-Tryptophan,5TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3916.2	Semi standard non polar	33892256
Glycyl-Tryptophan,5TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OC(=O)C(CC1=CN([Si](C)(C)C(C)(C)C)C2=CC=CC=C12)N(C(=O)CN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3686.0	Standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - Glycyl-Tryptophan GC-MS (Non-derivatized) - 70eV, Positive	splash10-053r-9530000000-641adea5b5bd8c5b1b86	2017-09-01	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Glycyl-Tryptophan GC-MS (1 TMS) - 70eV, Positive	splash10-05ai-9310000000-25a82050e786866e464f	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Glycyl-Tryptophan GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 10V, Positive-QTOF	splash10-01qc-4190000000-a1d5225f41faeefa88e5	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 20V, Positive-QTOF	splash10-053r-9430000000-4db47620b8d9e5d99c80	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 40V, Positive-QTOF	splash10-001i-3900000000-08b7953f817ffc28aca8	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 10V, Negative-QTOF	splash10-03di-0190000000-d7f8689a0c0b62fb8942	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 20V, Negative-QTOF	splash10-0jc0-4690000000-c355a939326dd8fe5a16	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 40V, Negative-QTOF	splash10-006x-9600000000-b513f0d8bcb4ca7b36fd	2017-09-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 10V, Positive-QTOF	splash10-06ri-0970000000-3dd29b27823e7c9ebedd	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 20V, Positive-QTOF	splash10-000i-0900000000-40692a2998702b910397	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 40V, Positive-QTOF	splash10-05o3-2900000000-c2f94b822153e489f5b7	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 10V, Negative-QTOF	splash10-0zfr-1960000000-1341d80adb499fa09e2f	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 20V, Negative-QTOF	splash10-00xr-9720000000-9b3f0adc7aefc92a0b5b	2021-09-25	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Glycyl-Tryptophan 40V, Negative-QTOF	splash10-014l-5900000000-d7adc70a2504f012d0f1	2021-09-25	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Feces

Tissue Locations

Not Available

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	25037050	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal Cancer	27275383	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal cancer	25037050	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal cancer	27015276	details

Associated Disorders and Diseases

Disease References

Colorectal cancer

Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ]
Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]

Associated OMIM IDs

114500 (Colorectal cancer)

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB111884

KNApSAcK ID

Not Available

Chemspider ID

92825

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102763

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Kano K, Hasegawa H, Miyamura M: Chiral recognition of dipeptide methyl esters by an anionic beta-cyclodextrin. Chirality. 2001 Aug;13(8):474-82. [PubMed:11466771 ]
Jean PA, Reed DJ: In vitro dipeptide, nucleoside, and glutathione alkylation by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)-L-cysteine. Chem Res Toxicol. 1989 Nov-Dec;2(6):455-60. [PubMed:2519737 ]
Lozovskaia EL, Makareeva EN, Makedonov IU: [Photosensitization and photoprotection by some drugs, metabolites and other compounds]. Biofizika. 1997 May-Jun;42(3):549-57. [PubMed:9296615 ]
Eisenberg AS, Juszczak LJ: Correlation of TrpGly and GlyTrp Rotamer Structure with W7 and W10 UV Resonance Raman Modes and Fluorescence Emission Shifts. J Amino Acids. 2012;2012:735076. doi: 10.1155/2012/735076. Epub 2012 Jul 22. [PubMed:22888404 ]
Babizhayev MA, Lozovskaya EL, Makareyeva EN, Lul'kin YA, Sapezhinskii II: Photoprotector and antioxidant properties of histamine-containing peptidomimetics in the photooxidation of glycyltryptophan. Biochemistry (Mosc). 1998 May;63(5):523-8. [PubMed:9632886 ]
Lozovskaia EL, Sapezhinskii II: [Comparative effectiveness of some medicinal substances as acceptors of superoxide radicals]. Biofizika. 1993 Jan-Feb;38(1):31-6. [PubMed:8386002 ]
Viell B, Weidler B, Krause B, Vestweber KH: Analysis of tryptophan, tyrosine and related dipeptides in mouse brain by isocratic high-performance liquid chromatography with switchable wavelength fluorescence detection. J Pharm Biomed Anal. 1988;6(6-8):933-8. [PubMed:16867364 ]
Turoverov KK, Kuznetsova IM: What causes the depolarization of trypsin and trypsinogen fluorescence. Intramolecular mobility or non-radiative energy transfer? Biophys Chem. 1986 Dec 31;25(3):315-23. [PubMed:3828470 ]
Lozovskaia EL, Kaplunskii GD, Sapezhinskii II: [Superoxide dismutase activity and photosensitizing properties of 2,5-dihydroxybenzolsulfonate]. Biofizika. 1990 Nov-Dec;35(6):912-6. [PubMed:1965686 ]
Norberg A, Sillard R, Carlquist M, Jornvall H, Mutt V: Chemical detection of natural peptides by specific structures. Isolation of chicken galanin by monitoring for its N-terminal dipeptide, and determination of the amino acid sequence. FEBS Lett. 1991 Aug 19;288(1-2):151-3. [PubMed:1715289 ]
Drozdz R, Naskalski JW, Sznajd J: Oxidation of amino acids and peptides in reaction with myeloperoxidase, chloride and hydrogen peroxide. Biochim Biophys Acta. 1988 Nov 2;957(1):47-52. [PubMed:2846070 ]
Lozovskaya EL, Vartanyan LS: Superoxide dismutase: determination of activity by inhibition of photosensitized chemiluminescence of glycyltryptophan. Biochemistry (Mosc). 2000 May;65(5):599-603. [PubMed:10851038 ]
Kaplunskii GD, Sapezhinskii II: [Protection and latent and patent sensitization by nucleotides of radiation-induced transformations of gylcyltryptophan and serum albumin]. Radiobiologiia. 1988 Jul-Aug;28(4):549-53. [PubMed:3420231 ]
Popova TV, Reinbolt J, Ehresmann B, Shakirov MM, Serebriakova MV, Gerassimova YV, Knorre DG, Godovikova TS: Why do p-nitro-substituted aryl azides provide unintended dark reactions with proteins? J Photochem Photobiol B. 2010 Jul 2;100(1):19-29. doi: 10.1016/j.jphotobiol.2010.04.004. Epub 2010 Apr 14. [PubMed:20570168 ]

Showing metabocard for Glycyl-Tryptophan (HMDB0028852)

MOL for HMDB0028852 (Glycyl-Tryptophan)

3D MOL for HMDB0028852 (Glycyl-Tryptophan)

3D SDF for HMDB0028852 (Glycyl-Tryptophan)

3D-SDF for HMDB0028852 (Glycyl-Tryptophan)

PDB for HMDB0028852 (Glycyl-Tryptophan)

3D PDB for HMDB0028852 (Glycyl-Tryptophan)

SMILES for HMDB0028852 (Glycyl-Tryptophan)

INCHI for HMDB0028852 (Glycyl-Tryptophan)

Structure for HMDB0028852 (Glycyl-Tryptophan)

3D Structure for HMDB0028852 (Glycyl-Tryptophan)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra