Hmdb loader

Showing metabocard for Questiomycin A (HMDB0030483)

Jump To Section:
IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesXML
Show more...Show more...Show more...Show more...
Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2012-09-11 17:37:04 UTC
Update Date2022-03-07 02:52:34 UTC
HMDB IDHMDB0030483
Secondary Accession Numbers
  • HMDB30483
Metabolite Identification
Common NameQuestiomycin A
DescriptionQuestiomycin A, also known as isophenoxazine or 2-aminophenoxazon, belongs to the class of organic compounds known as phenoxazines. These are polycyclic aromatic compounds containing a phenoxazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a 1,4-oxazine ring. Questiomycin A is a primary metabolite. Primary metabolites are metabolically or physiologically essential metabolites. They are directly involved in an organism’s growth, development or reproduction. Based on a literature review very few articles have been published on Questiomycin A.
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0030483 (Questiomycin A)

  Mrv1652306051918202D          

 16 18  0  0  0  0            999 V2000
    0.3572    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
Download

3D MOL for HMDB0030483 (Questiomycin A)

HMDB0030483
     RDKit          3D
Questiomycin A
 24 26  0  0  0  0  0  0  0  0999 V2000
   -4.2758   -0.1956   -1.4697 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0936   -0.1547   -0.6811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8511   -0.0567   -1.2857 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6797   -0.0140   -0.5584 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5399    0.0809   -1.1190 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6394    0.1168   -0.3279 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810    0.2139   -0.9106 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0336    0.2541   -0.1496 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9860    0.1984    1.2287 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7332    0.1008    1.8044 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5693    0.0597    1.0486 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3842   -0.0335    1.6195 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7209   -0.0726    0.9030 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9752   -0.1701    1.4756 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1118   -0.2086    0.6972 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2627   -0.2989    1.2433 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5858    0.5745   -2.0988 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8797   -1.0442   -1.4250 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8074   -0.0124   -2.3710 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9264    0.2586   -2.0054 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9956    0.3305   -0.6311 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8914    0.2301    1.8218 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6956    0.0573    2.8803 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0318   -0.2146    2.5491 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 15  2  1  0
 13  4  1  0
 11  6  1  0
  1 17  1  0
  1 18  1  0
  3 19  1  0
  7 20  1  0
  8 21  1  0
  9 22  1  0
 10 23  1  0
 14 24  1  0
M  END
Download

3D SDF for HMDB0030483 (Questiomycin A)

  Mrv1652306051918202D          

 16 18  0  0  0  0            999 V2000
    0.3572    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3572   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3572   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0717   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7862   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7862   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5006   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5006   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0030483

> <DATABASE_NAME>
hmdb

> <SMILES>
NC1=CC2=NC3=CC=CC=C3OC2=CC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2

> <INCHI_KEY>
RDJXPXHQENRCNG-UHFFFAOYSA-N

> <FORMULA>
C12H8N2O2

> <MOLECULAR_WEIGHT>
212.2041

> <EXACT_MASS>
212.05857751

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
24

> <JCHEM_AVERAGE_POLARIZABILITY>
21.363998240399344

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2-amino-3H-phenoxazin-3-one

> <ALOGPS_LOGP>
1.06

> <JCHEM_LOGP>
1.193749461

> <ALOGPS_LOGS>
-3.04

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.951691158998358

> <JCHEM_PKA_STRONGEST_BASIC>
-0.29320707843769134

> <JCHEM_POLAR_SURFACE_AREA>
64.67999999999999

> <JCHEM_REFRACTIVITY>
63.56860000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.93e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-aminophenoxazin-3-one

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0030483 (Questiomycin A)

HMDB0030483
     RDKit          3D
Questiomycin A
 24 26  0  0  0  0  0  0  0  0999 V2000
   -4.2758   -0.1956   -1.4697 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0936   -0.1547   -0.6811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8511   -0.0567   -1.2857 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6797   -0.0140   -0.5584 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5399    0.0809   -1.1190 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6394    0.1168   -0.3279 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810    0.2139   -0.9106 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0336    0.2541   -0.1496 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9860    0.1984    1.2287 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7332    0.1008    1.8044 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5693    0.0597    1.0486 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3842   -0.0335    1.6195 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7209   -0.0726    0.9030 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9752   -0.1701    1.4756 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1118   -0.2086    0.6972 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2627   -0.2989    1.2433 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5858    0.5745   -2.0988 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8797   -1.0442   -1.4250 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8074   -0.0124   -2.3710 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9264    0.2586   -2.0054 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9956    0.3305   -0.6311 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8914    0.2301    1.8218 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6956    0.0573    2.8803 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0318   -0.2146    2.5491 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 15  2  1  0
 13  4  1  0
 11  6  1  0
  1 17  1  0
  1 18  1  0
  3 19  1  0
  7 20  1  0
  8 21  1  0
  9 22  1  0
 10 23  1  0
 14 24  1  0
M  END
Download

PDB for HMDB0030483 (Questiomycin A)

HEADER    PROTEIN                                 05-JUN-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   05-JUN-19         0                                  
HETATM    1  C   UNK     0       0.667   0.770   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.667  -0.770   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0      -0.667   1.540   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0       2.001   1.540   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      -0.667  -1.540   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       2.001  -1.540   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -2.001   0.770   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.334   0.770   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -2.001  -0.770   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.334  -0.770   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -3.334   1.540   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       4.668   1.540   0.000  0.00  0.00           N+0
HETATM   13  C   UNK     0      -3.334  -1.540   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       4.668  -1.540   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0      -4.668   0.770   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -4.668  -0.770   0.000  0.00  0.00           C+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5    6                                                  
CONECT    3    1    7                                                       
CONECT    4    1    8                                                       
CONECT    5    2    9                                                       
CONECT    6    2   10                                                       
CONECT    7    3   11    9                                                  
CONECT    8    4   12   10                                                  
CONECT    9    5   13    7                                                  
CONECT   10    6   14    8                                                  
CONECT   11    7   15                                                       
CONECT   12    8                                                            
CONECT   13    9   16                                                       
CONECT   14   10                                                            
CONECT   15   11   16                                                       
CONECT   16   13   15                                                       
MASTER        0    0    0    0    0    0    0    0   16    0   36    0
END
Download

3D PDB for HMDB0030483 (Questiomycin A)

COMPND    HMDB0030483
HETATM    1  N1  UNL     1      -4.276  -0.196  -1.470  1.00  0.00           N  
HETATM    2  C1  UNL     1      -3.094  -0.155  -0.681  1.00  0.00           C  
HETATM    3  C2  UNL     1      -1.851  -0.057  -1.286  1.00  0.00           C  
HETATM    4  C3  UNL     1      -0.680  -0.014  -0.558  1.00  0.00           C  
HETATM    5  N2  UNL     1       0.540   0.081  -1.119  1.00  0.00           N  
HETATM    6  C4  UNL     1       1.639   0.117  -0.328  1.00  0.00           C  
HETATM    7  C5  UNL     1       2.881   0.214  -0.911  1.00  0.00           C  
HETATM    8  C6  UNL     1       4.034   0.254  -0.150  1.00  0.00           C  
HETATM    9  C7  UNL     1       3.986   0.198   1.229  1.00  0.00           C  
HETATM   10  C8  UNL     1       2.733   0.101   1.804  1.00  0.00           C  
HETATM   11  C9  UNL     1       1.569   0.060   1.049  1.00  0.00           C  
HETATM   12  O1  UNL     1       0.384  -0.034   1.619  1.00  0.00           O  
HETATM   13  C10 UNL     1      -0.721  -0.073   0.903  1.00  0.00           C  
HETATM   14  C11 UNL     1      -1.975  -0.170   1.476  1.00  0.00           C  
HETATM   15  C12 UNL     1      -3.112  -0.209   0.697  1.00  0.00           C  
HETATM   16  O2  UNL     1      -4.263  -0.299   1.243  1.00  0.00           O  
HETATM   17  H1  UNL     1      -4.586   0.575  -2.099  1.00  0.00           H  
HETATM   18  H2  UNL     1      -4.880  -1.044  -1.425  1.00  0.00           H  
HETATM   19  H3  UNL     1      -1.807  -0.012  -2.371  1.00  0.00           H  
HETATM   20  H4  UNL     1       2.926   0.259  -2.005  1.00  0.00           H  
HETATM   21  H5  UNL     1       4.996   0.330  -0.631  1.00  0.00           H  
HETATM   22  H6  UNL     1       4.891   0.230   1.822  1.00  0.00           H  
HETATM   23  H7  UNL     1       2.696   0.057   2.880  1.00  0.00           H  
HETATM   24  H8  UNL     1      -2.032  -0.215   2.549  1.00  0.00           H  
CONECT    1    2   17   18
CONECT    2    3    3   15
CONECT    3    4   19
CONECT    4    5    5   13
CONECT    5    6
CONECT    6    7    7   11
CONECT    7    8   20
CONECT    8    9    9   21
CONECT    9   10   22
CONECT   10   11   11   23
CONECT   11   12
CONECT   12   13
CONECT   13   14   14
CONECT   14   15   24
CONECT   15   16   16
END
Download

SMILES for HMDB0030483 (Questiomycin A)

NC1=CC2=NC3=CC=CC=C3OC2=CC1=O
Download

INCHI for HMDB0030483 (Questiomycin A)

InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2
Download
View in JSmolView Stereo Labels
Synonyms
Chemical FormulaC12H8N2O2
Average Molecular Weight212.2041
Monoisotopic Molecular Weight212.05857751
IUPAC Name2-amino-3H-phenoxazin-3-one
Traditional Name2-aminophenoxazin-3-one
CAS Registry Number1916-59-2
SMILES
NC1=CC2=NC3=CC=CC=C3OC2=CC1=O
InChI Identifier
InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2
InChI KeyRDJXPXHQENRCNG-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phenoxazines. These are polycyclic aromatic compounds containing a phenoxazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a 1,4-oxazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzoxazines
Sub ClassPhenoxazines
Direct ParentPhenoxazines
Alternative Parents
Substituents
  • Phenoxazine
  • Benzenoid
  • Heteroaromatic compound
  • Cyclic ketone
  • Azacycle
  • Oxacycle
  • Amine
  • Organopnictogen compound
  • Organic oxygen compound
  • Primary amine
  • Organic nitrogen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationRoute of exposureSource
ProcessNot Available
RoleNot Available
Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility40350 mg/L @ 25 °C (est)The Good Scents Company Information System
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB002352
KNApSAcK IDC00018683
Chemspider ID65565
KEGG Compound IDC02161
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkQuestiomycin A
METLIN IDNot Available
PubChem Compound72725
PDB IDNot Available
ChEBI ID17293
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1820341
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Adhikari KB, Laerke HN, Mortensen AG, Fomsgaard IS: Plasma and urine concentrations of bioactive dietary benzoxazinoids and their glucuronidated conjugates in rats fed a rye bread-based diet. J Agric Food Chem. 2012 Nov 21;60(46):11518-24. doi: 10.1021/jf301737n. Epub 2012 Nov 12. [PubMed:23113707 ]
  2. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .
  3. Koistinen VM (2019). Effects of Food Processing and Gut Microbial Metabolism on Whole Grain Phytochemicals: A Metabolomics Approach. In Publications of the University of Eastern Finland. Dissertations in Health Sciences., no 510 (pp. 26-58). University of Eastern Finland. [ISBN:978-952-61-3088-0 ]