Hmdb loader
Identification
HMDB Protein ID HMDBP01133
Secondary Accession Numbers
  • 6429
Name Serine/threonine-protein kinase RIO2
Synonyms
  1. RIO kinase 2
Gene Name RIOK2
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function ATP + a protein = ADP + a phosphoprotein
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:5
Locus 5q15
SNPs RIOK2
Gene Sequence
>1659 bp
ATGGGGAAAGTGAATGTGGCCAAGTTGCGTTACATGAGCCGAGATGACTTCAGGGTCTTG
ACCGCGGTTGAAATGGGCATGAAGAACCATGAAATTGTTCCCGGCAGTTTGATTGCTTCT
ATAGCCAGCCTTAAACATGGTGGCTGTAATAAAGTTTTAAGAGAATTAGTGAAACATAAA
CTCATAGCTTGGGAGCGTACCAAAACTGTCCAGGGCTATCGGTTGACAAATGCAGGATAT
GATTACCTAGCTTTGAAAACACTTTCTTCTAGGCAAGTAGTTGAGTCTGTTGGAAACCAG
ATGGGTGTTGGCAAAGAATCAGATATTTACATTGTTGCAAATGAAGAAGGACAACAATTT
GCATTAAAGCTTCACAGACTAGGAAGAACCTCGTTTCGAAATTTGAAAAACAAACGCGAT
TATCATAAACATAGGCACAATGTGTCTTGGCTTTATTTATCTCGTCTCTCTGCCATGAAG
GAATTTGCCTATATGAAGGCATTGTATGAGAGGAAATTTCCAGTTCCAAAGCCAATTGAT
TACAATCGTCATGCAGTGGTCATGGAACTCATAAATGGTTATCCACTATGTCAGATACAC
CATGTTGAAGATCCTGCATCAGTATATGATGAAGCTATGGAACTAATTGTCAAACTTGCA
AATCATGGGCTGATTCATGGAGATTTTAATGAATTTAATCTCATTTTGGATGAAAGTGAC
CATATCACCATGATTGATTTTCCACAGATGGTTTCAACTTCTCATCCCAATGCTGAGTGG
TATTTTGACAGAGATGTTAAATGCATTAAAGATTTCTTTATGAAACGTTTCAGCTACGAA
AGTGAGCTTTTTCCAACTTTTAAGGATATCAGGAGAGAAGACACTCTTGATGTGGAGGTT
TCTGCCAGTGGCTACACAAAGGAAATGCAGGCAGATGATGAACTGCTTCATCCATTAGGT
CCAGATGATAAAAATATTGAAACAAAAGAGGGATCTGAATTCTCATTTTCAGATGGAGAA
GTGGCAGAAAAAGCAGAGGTTTACAGGTCAGAAAATGAAAGTGAACGGAACTGTCTAGAA
GAATCAGAGGGCTGCTATTGCAGATCATCTGGAGACCCTGAACAAATAAAGGAAGACAGT
TTATCAGAAGAGAGTGCTGATGCACGGAGTTTTGAAATGACTGAATTCAATCAAGCTTTA
GAAGAAATAAAAGGGCAGGTTGTTGAAAACAACTCTGTAACTGAATTTTCTGAGGAGAAA
AACAGAACTGAAAATTACAACAGGCAAGATGGTCAGAGAGTTCAAGGAGGAGTCCCTGCT
GGCTCTGACGAGTATGAAGATGAATGCCCTCATCTAATTGCCTTGTCGTCATTAAATAGA
GAATTCAGGCCTTTCAGAGATGAAGAAAATGTGGGAGCTATGAATCAGTATAGAACAAGA
ACTCTGAGTATCACTTCTTCAGGCAGTGCTGTAAGCTGTTCAACAATTCCTCCAGAACTG
GTGAAACAGAAGGTGAAACGTCAGTTGACAAAACAGCAAAAATCAGCTGTCAGACGTCGA
TTGCAGAAAGGAGAAGCAAATATATTTACCAAGCAACGTAGGGAAAACATGCAAAATATC
AAATCAAGTTTGGAAGCAGCTAGCTTTTGGGGAGAATAA
Protein Properties
Number of Residues 552
Molecular Weight 63282.6
Theoretical pI 5.78
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Serine/threonine-protein kinase RIO2
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHK
LIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQF
ALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID
YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESD
HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEV
SASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLE
ESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEK
NRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTR
TLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNI
KSSLEAASFWGE
GenBank ID Protein 7023651
UniProtKB/Swiss-Prot ID Q9BVS4
UniProtKB/Swiss-Prot Entry Name RIOK2_HUMAN
PDB IDs Not Available
GenBank Gene ID AK002021
GeneCard ID RIOK2
GenAtlas ID RIOK2
HGNC ID HGNC:18999
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
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  8. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  9. Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. [PubMed:18220336 ]
  10. Wang B, Malik R, Nigg EA, Korner R: Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. Anal Chem. 2008 Dec 15;80(24):9526-33. doi: 10.1021/ac801708p. [PubMed:19007248 ]
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