Hmdb loader
Identification
HMDB Protein ID HMDBP04991
Secondary Accession Numbers
  • 10586
Name 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
Synonyms
  1. 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1
  2. Endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  3. er-cHL
Gene Name HMGCLL1
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
Pathways
  • (S)-3-hydroxy-3-methylglutaryl-CoA degradation
Reactions
3-Hydroxy-3-methylglutaryl-CoA → Acetyl-CoA + Acetoacetic acid details
GO Classification
Biological Process
ketone body biosynthetic process
Cellular Component
endoplasmic reticulum membrane
cytosol
endoplasmic reticulum
perinuclear region of cytoplasm
membrane
Function
catalytic activity
Molecular Function
metal ion binding
hydroxymethylglutaryl-CoA lyase activity
Process
metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location 6
Locus 6p12.1
SNPs HMGCLL1
Gene Sequence
>1113 bp
ATGGGGAATGTGCCATCCGCGGTGAAGCACTGCCTCAGCTACCAGCAGCTTCTCCGGGAG
CATCTCTGGATCGGGGATTCAGTGGCAGGGGCGCTCGACCCCGCGCAGACTTCTCTTCTA
ACAAACCTTCACTGCTTTCAGCCCGATGTCTCTGGCTTCTCAGTCTCCTTGGCAGGCACG
GTGGCTTGTATCCACTGGGAAACATCCCAGTTATCTGGACTCCCTGAGTTTGTTAAAATA
GTAGAAGTTGGGCCTAGGGATGGATTGCAGAATGAAAAGGTTATAGTTCCTACAGATATA
AAAATTGAATTTATCAATCGACTTTCCCAAACTGGCTTGTCTGTAATAGAAGTGACTAGC
TTTGTGTCTTCCAGATGGGTACCACAGATGGCTGATCACACTGAAGTAATGAAAGGCATT
CATCAATATCCAGGAGTTCGCTATCCTGTCCTTACTCCTAATCTTCAGGGTTTTCACCAT
GCTGTTGCTGCTGGAGCTACTGAGATATCAGTTTTTGGAGCTGCATCTGAATCCTTTAGC
AAGAAGAATATTAACTGTTCCATTGAAGAAAGTATGGGAAAATTTGAGGAGGTTGTTAAG
TCTGCAAGACACATGAATATTCCAGCACGAGGGTATGTGTCTTGTGCTCTGGGCTGTCCA
TATGAAGGAAGTATTACACCGCAAAAAGTGACAGAAGTGTCTAAGAGATTGTACGGCATG
GGTTGTTATGAGATCTCTCTAGGAGACACAATTGGAGTGGGAACTCCAGGAAGTATGAAA
AGAATGTTGGAAAGTGTGATGAAAGAAATCCCACCAGGTGCTCTTGCTGTTCACTGTCAT
GACACATACGGACAAGCCTTAGCAAATATCCTTACGGCCCTTCAGATGGGAATTAATGTG
GTGGACTCCGCAGTATCCGGATTAGGTGGCTGCCCTTATGCAAAAGGTGCTTCTGGGAAT
GTAGCCACTGAGGATTTGATATATATGCTTAATGGCCTGGGGCTCAATACAGGTGTGAAT
CTATACAAAGTGATGGAAGCTGGTGACTTTATTTGCAAAGCTGTGAATAAAACCACAAAC
TCTAAAGTAGCACAAGCCTCCTTCAATGCTTGA
Protein Properties
Number of Residues 370
Molecular Weight 36327.465
Theoretical pI 6.605
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGT
VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS
FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS
KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM
GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV
VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN
SKVAQASFNA
GenBank ID Protein 109150427
UniProtKB/Swiss-Prot ID Q8TB92
UniProtKB/Swiss-Prot Entry Name HMGC2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_019036.2
GeneCard ID HMGCLL1
GenAtlas ID HMGCLL1
HGNC ID HGNC:21359
References
General References
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