Human Metabolome Database: Showing Protein Translation initiation factor IF-2, mitochondrial (HMDBP08453)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08453

Secondary Accession Numbers

14165

Name

Translation initiation factor IF-2, mitochondrial

Synonyms

IF-2(Mt)
IF-2Mt
IF2(mt)

Gene Name

MTIF2

Protein Type

Unknown

Biological Properties

General Function

Involved in GTPase activity

Specific Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
intracellular
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
translation initiation factor activity
gtpase activity
nucleic acid binding
translation factor activity, nucleic acid binding
nucleoside-triphosphatase activity
rna binding
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Process
translational initiation
cellular process

Cellular Location

Mitochondrion

Gene Properties

Chromosome Location

Chromosome:2

Locus

2p16.1

SNPs

MTIF2

Gene Sequence

>2184 bp
ATGAACCAGAAGCTACTGAAGTTGGAGAACTTGCTACGATTTCACACTATTTATAGGCAA
CTGCACAGTCTGTGTCAAAGAAGAGCATTAAGACAGTGGAGGCATGGGTTTTCATCTGCT
TACCCTGTGTGGACAGCTCAACTGTGTGCCTGGCCCTGGCCAACAGATGTGCTCACTGGG
GCTGCTTTATCTCAGTATAGGCTTCTAGTAACAAAAAAGGAAGAAGGACCATGGAAATCT
CAGTTATCTTCAACAAAATCTAAAAAGGTGGTAGAAGTATGGATTGGAATGACTATTGAG
GAACTGGCCAGGGCAATGGAAAAAAACACAGATTATGTATATGAAGCTTTATTGAACACT
GATATTGACATAGATTCACTGGAAGCAGACTCACATTTAGATGAAGTCTGGATCAAAGAA
GTGATAACGAAGGCAGGGATGAAGTTAAAGTGGAGTAAATTAAAACAGGACAAAGTCAGA
AAAAATAAAGATGCTGTAAGAAGGCCCCAGGCAGATCCAGCTTTATTAACCCCAAGGTCC
CCAGTTGTTACTATAATGGGCCATGTTGATCACGGGAAAACGACATTACTTGACAAATTT
CGAAAAACTCAAGTGGCAGCAGTGGAAACTGGAGGCATCACTCAGCACATTGGTGCCTTT
CTTGTCTCTCTGCCTTCTGGGGAAAAGATAACTTTTCTTGATACTCCAGGACATGCTGCT
TTCTCAGCAATGAGAGCCAGAGGTGCTCAGGTCACTGACATTGTCGTATTGGTTGTAGCT
GCAGATGATGGAGTGATGAAACAAACTGTAGAATCTATTCAGCATGCCAAAGATGCACAG
GTTCCTATTATCCTTGCCGTAAATAAATGTGACAAAGCTGAGGCTGATCCTGAGAAAGTG
AAAAAAGAGCTGCTGGCTTACGATGTGGTATGTGAAGATTATGGAGGTGATGTTCAAGCA
GTGCCTGTCTCCGCACTTACGGGCGATAATCTGATGGCTTTGGCAGAAGCAACAGTTGCT
CTTGCAGAAATGTTAGAATTGAAAGCAGATCCCAATGGTCCAGTGGAAGGAACAGTAATA
GAGTCTTTCACAGACAAAGGAAGAGGTCTTGTTACTACAGCTATAATTCAAAGAGGAACT
TTAAGAAAAGGCTCTGTTCTGGTTGCTGGAAAATGTTGGGCAAAAGTACGCTTAATGTTT
GATGAAAATGGAAAAACAATTGATGAGGCCTATCCCAGCATGCCAGTGGGAATTACAGGC
TGGAGAGACCTTCCTTCTGCAGGAGAAGAAATTCTTGAAGTAGAATCTGAGCCAAGGGCA
CGTGAAGTTGTTGACTGGAGGAAATATGAACAAGAACAGGAGAAAGGTCAGGAGGATCTG
AAAATAATAGAAGAAAAGCGAAAGGAACACAAAGAAGCACATCAGAAAGCCCGTGAGAAG
TATGGCCATCTACTGTGGAAGAAGAGATCAATTCTACGGTTTTTAGAAAGAAAAGAACAA
ATACCCTTAAAGCCAAAAGAGAAAAGGGAAAGAGATTCAAATGTACTTTCTGTGATTATT
AAAGGTGATGTTGATGGTTCTGTTGAGGCCATTTTGAACATTATAGATACCTATGATGCT
TCACACGAGTGTGAACTAGAATTAGTACATTTTGGAGTGGGTGATGTAAGTGCAAATGAT
GTTAACCTTGCTGAAACATTTGATGGTGTTATATATGGCTTTAATGTGAATGCAGGCAAT
GTTATCCAACAGTCAGCTGCAAAAAAAGGAGTAAAAATTAAACTTCACAAAATAATTTAC
CGTCTTGTTGAAGATTTGCAAGAGGAACTGAGCAGCAGATTACCCTGTGCTGTGGAAGAG
CACCCAGTAGGTGAGGCATCTATACTAGCTACCTTCTCTGTAACAGAAGGGAAGAAAAAA
GTTCCTGTGGCTGGCTGCAGAGTCCAAAAGGGACAGTTAGAAAAACAAAAAAAATTTAAA
CTAACCCGTAATGGACATGTAATTTGGAAGGGCTCATTAACCTCATTGAAACACCATAAA
GATGACATTTCAATTGTCAAAACGGGAATGGATTGTGGTCTCAGTTTAGATGAAGACAAT
ATGGAATTTCAAGTGGGAGACAGAATTGTTTGTTATGAAGAAAAGCAAATTCAAGCCAAG
ACTTCTTGGGATCCAGGATTTTAA

Protein Properties

Number of Residues

727

Molecular Weight

81316.8

Theoretical pI

7.16

Pfam Domain Function

GTP_EFTU (PF00009 )
GTP_EFTU_D2 (PF03144 )
IF-2 (PF11987 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Translation initiation factor IF-2, mitochondrial
MNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTG
AALSQYRLLVTKKEEGPWKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTDYVYEALLNT
DIDIDSLEADSHLDEVWIKEVITKAGMKLKWSKLKQDKVRKNKDAVRRPQADPALLTPRS
PVVTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGEKITFLDTPGHAA
FSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKV
KKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLELKADPNGPVEGTVI
ESFTDKGRGLVTTAIIQRGTLRKGSVLVAGKCWAKVRLMFDENGKTIDEAYPSMPVGITG
WRDLPSAGEEILEVESEPRAREVVDWRKYEQEQEKGQEDLKIIEEKRKEHKEAHQKAREK
YGHLLWKKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDA
SHECELELVHFGVGDVSANDVNLAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIY
RLVEDLQEELSSRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCRVQKGQLEKQKKFK
LTRNGHVIWKGSLTSLKHHKDDISIVKTGMDCGLSLDEDNMEFQVGDRIVCYEEKQIQAK
TSWDPGF

External Links

GenBank ID Protein

53729339

UniProtKB/Swiss-Prot ID

P46199

UniProtKB/Swiss-Prot Entry Name

IF2M_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
Ma L, Spremulli LL: Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA. J Biol Chem. 1995 Jan 27;270(4):1859-65. [PubMed:7829522 ]
Overman RG Jr, Enderle PJ, Farrow JM 3rd, Wiley JE, Farwell MA: The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. Biochim Biophys Acta. 2003 Aug 25;1628(3):195-205. [PubMed:12932832 ]