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Showing Protein Tripartite motif-containing protein 5 (HMDBP09321)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 5 metabolites
Identification
HMDB Protein ID HMDBP09321
Secondary Accession Numbers
  • 15155
Name Tripartite motif-containing protein 5
Synonyms
  1. RING finger protein 88
Gene Name TRIM5
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding
Cellular Location
  1. Cytoplasm
  2. P-body
Gene Properties
Chromosome Location Chromosome:1
Locus 11p15
SNPs TRIM5
Gene Sequence 
>1482 bp
ATGGCTTCTGGAATCCTGGTTAATGTAAAGGAGGAGGTGACCTGCCCCATCTGCCTGGAA
CTCCTGACACAACCCCTGAGCCTGGACTGCGGCCACAGCTTCTGCCAAGCATGCCTCACT
GCAAACCACAAGAAGTCCATGCTAGACAAAGGAGAGAGTAGCTGCCCTGTGTGCCGGATC
AGTTACCAGCCTGAGAACATACGGCCTAATCGGCATGTAGCCAACATAGTGGAGAAGCTC
AGGGAGGTCAAGTTGAGCCCAGAGGGGCAGAAAGTTGATCATTGTGCACGCCATGGAGAG
AAACTTCTACTCTTCTGTCAGGAGGACGGGAAGGTCATTTGCTGGCTTTGTGAGCGGTCT
CAGGAGCACCGTGGTCACCACACGTTCCTCACAGAGGAGGTTGCCCGGGAGTACCAAGTG
AAGCTCCAGGCAGCTCTGGAGATGCTGAGGCAGAAGCAGCAGGAAGCTGAAGAGTTAGAA
GCTGACATCAGAGAAGAGAAAGCTTCCTGGAAGACTCAAATACAGTATGACAAAACCAAC
GTCTTGGCAGATTTTGAGCAACTGAGAGACATCCTGGACTGGGAGGAGAGCAATGAGCTG
CAAAACCTGGAGAAGGAGGAGGAAGACATTCTGAAAAGCCTTACGAACTCTGAAACTGAG
ATGGTGCAGCAGACCCAGTCCCTGAGAGAGCTCATCTCAGATCTGGAGCATCGGCTGCAG
GGGTCAGTGATGGAGCTGCTTCAGGGTGTGGATGGCGTCATAAAAAGGACGGAGAACGTG
ACCTTGAAGAAGCCAGAAACTTTTCCAAAAAATCAAAGGAGAGTGTTTCGAGCTCCTGAT
CTGAAAGGAATGCTAGAAGTGTTTAGAGAGCTGACAGATGTCCGACGCTACTGGGTTGAT
GTGACAGTGGCTCCAAACAACATTTCATGTGCTGTCATTTCTGAAGATAAGAGACAAGTG
AGCTCTCCGAAACCACAGATAATATATGGGGCACGAGGGACAAGATACCAGACATTTGTG
AATTTCAATTATTGTACTGGCATCCTGGGCTCTCAAAGTATCACATCAGGGAAACATTAC
TGGGAGGTAGACGTGTCCAAGAAAACTGCTTGGATCCTGGGGGTATGTGCTGGCTTCCAA
CCTGATGCAATGTGTAATATTGAAAAAAATGAAAATTATCAACCTAAATACGGCTACTGG
GTTATAGGGTTAGAGGAAGGAGTTAAATGTAGTGCTTTCCAGGATAGTTCCTTCCATACT
CCTTCTGTTCCTTTCATTGTGCCCCTCTCTGTGATTATTTGTCCTGATCGTGTTGGAGTT
TTCCTAGACTATGAGGCTTGCACTGTCTCATTCTTCAATATCACAAACCATGGATTTCTC
ATCTATAAGTTTTCTCACTGTTCTTTTTCTCAGCCTGTATTTCCATATTTAAATCCTAGA
AAATGTGGAGTCCCCATGACTCTGTGCTCACCAAGCTCTTGA
Protein Properties
Number of Residues 493
Molecular Weight 56337.9
Theoretical pI 5.94
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Tripartite motif-containing protein 5
MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI
SYQPENIRPNRHVANIVEKLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERS
QEHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTN
VLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQ
GSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGMLEVFRELTDVRRYWVD
VTVAPNNISCAVISEDKRQVSSPKPQIIYGARGTRYQTFVNFNYCTGILGSQSITSGKHY
WEVDVSKKTAWILGVCAGFQPDAMCNIEKNENYQPKYGYWVIGLEEGVKCSAFQDSSFHT
PSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFSHCSFSQPVFPYLNPR
KCGVPMTLCSPSS
GenBank ID Protein 283046694
UniProtKB/Swiss-Prot ID Q9C035
UniProtKB/Swiss-Prot Entry Name TRIM5_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_033034.2
GeneCard ID TRIM5
GenAtlas ID TRIM5
HGNC ID HGNC:16276
References
General References
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  3. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
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  6. Yap MW, Nisole S, Lynch C, Stoye JP: Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10786-91. Epub 2004 Jul 12. [PubMed:15249690 ]
  7. Sawyer SL, Wu LI, Akey JM, Emerman M, Malik HS: High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. Curr Biol. 2006 Jan 10;16(1):95-100. [PubMed:16401428 ]
  8. Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S, Meroni G, Jensen JP, Weissman AM, D'Arpa P: BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Exp Cell Res. 2003 Aug 1;288(1):84-93. [PubMed:12878161 ]
  9. Mische CC, Javanbakht H, Song B, Diaz-Griffero F, Stremlau M, Strack B, Si Z, Sodroski J: Retroviral restriction factor TRIM5alpha is a trimer. J Virol. 2005 Nov;79(22):14446-50. [PubMed:16254380 ]
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  13. Stremlau M, Song B, Javanbakht H, Perron M, Sodroski J: Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1. Virology. 2006 Jul 20;351(1):112-20. Epub 2006 Apr 27. [PubMed:16643975 ]
  14. Luban J: Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. J Virol. 2007 Feb;81(3):1054-61. Epub 2006 Sep 6. [PubMed:16956947 ]