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Showing Protein Platelet-derived growth factor receptor alpha (HMDBP12102)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12102
Secondary Accession Numbers None
Name Platelet-derived growth factor receptor alpha
Synonyms
  1. PDGF-R-alpha
  2. PDGFR-alpha
  3. Alpha platelet-derived growth factor receptor
  4. Alpha-type platelet-derived growth factor receptor
  5. CD140 antigen-like family member A
  6. Platelet-derived growth factor alpha receptor
Gene Name PDGFRA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity).
Pathways
  • Calcium signaling pathway
  • Central carbon metabolism in cancer
  • Choline metabolism in cancer
  • EGFR tyrosine kinase inhibitor resistance
  • Endocytosis
  • Focal adhesion
  • Gap junction
  • Glioma
  • Human cytomegalovirus infection
  • JAK-STAT signaling pathway
  • MAPK signaling pathway
  • Melanoma
  • MicroRNAs in cancer
  • Phospholipase D signaling pathway
  • PI3K-Akt signaling pathway
  • Prostate cancer
  • Rap1 signaling pathway
  • Ras signaling pathway
  • Regulation of actin cytoskeleton
Reactions Not Available
GO Classification
Biological Process
estrogen metabolic process
multicellular organismal development
response to inorganic substance
wound healing
organ morphogenesis
elevation of cytosolic calcium ion concentration
positive regulation of cell migration
extracellular matrix organization
positive regulation of cell proliferation
cardiac myofibril assembly
positive regulation of fibroblast proliferation
cell chemotaxis
response to hormone stimulus
embryonic digestive tract morphogenesis
lung growth
metanephric glomerular capillary formation
cellular response to fibroblast growth factor stimulus
platelet aggregation
platelet-derived growth factor receptor-alpha signaling pathway
positive regulation of branching involved in lung morphogenesis
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
positive regulation of kinase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of phospholipase C activity
Leydig cell differentiation
regulation of chemotaxis
regulation of mesenchymal stem cell differentiation
response to formaldehyde
signal transduction involved in regulation of gene expression
face morphogenesis
cell migration
palate development
adrenal gland development
in utero embryonic development
cellular response to amino acid stimulus
anatomical structure morphogenesis
white fat cell differentiation
response to organic substance
skeletal system morphogenesis
cellular response to interleukin-1
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
hematopoietic progenitor cell differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
brain development
embryonic skeletal system morphogenesis
cellular response to reactive oxygen species
male gonad development
female gonad development
platelet-derived growth factor receptor signaling pathway
embryonic cranial skeleton morphogenesis
odontogenesis of dentin-containing tooth
inner ear development
male genitalia development
phosphatidylinositol-mediated signaling
luteinization
aging
lung development
negative regulation of platelet activation
protein autophosphorylation
response to cytokine stimulus
response to estradiol stimulus
response to hyperoxia
response to estrogen stimulus
Cellular Component
cilium
cell surface
intrinsic component of plasma membrane
protein-containing complex
receptor complex
cytoplasm
plasma membrane
Golgi apparatus
nucleus
microvillus
external side of plasma membrane
axon
integral to plasma membrane
Molecular Function
growth factor binding
phosphatidylinositol 3-kinase binding
platelet-derived growth factor alpha-receptor activity
platelet-derived growth factor binding
protein-containing complex binding
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor binding
vascular endothelial growth factor-activated receptor activity
platelet-derived growth factor receptor binding
ATP binding
protein homodimerization activity
protein kinase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1088
Molecular Weight 122641.125
Theoretical pI 5.167
Pfam Domain Function
Signals
  • 1-23;
Transmembrane Regions
  • 528-548;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P20786
UniProtKB/Swiss-Prot Entry Name PGFRA_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Lee KH, Bowen-Pope DF, Reed RR: Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium. Mol Cell Biol. 1990 May;10(5):2237-46. doi: 10.1128/mcb.10.5.2237-2246.1990. [PubMed:2157969 ]
  2. Herren B, Weyer KA, Rouge M, Lotscher P, Pech M: Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Biochim Biophys Acta. 1993 Jun 25;1173(3):294-302. doi: 10.1016/0167-4781(93)90127-y. [PubMed:8318539 ]