after absorption, it is metabolized in the liver to the intermediate 5’-deoxy-5-fluorouridine, which is subsequently converted into 5-fluorouracil (5-fu) by intracellular thymidine phosphorylase. 5-fu exerts cytotoxic effects on the cell by direct incorporation into dna and rna as well as by inhibiting thymidylate synthase.
Parent Term
Biochemical pathway
Parent Definition
A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Metabolites Mapped to 'Capecitabine Action Pathway'