the major metabolic route of doxorubicin metabolism is two-electron reduction to doxorubicinol. a second route is one-electron reduction resulting in a doxorubicin-semiquinone, which can be undertaken by nadh dehydrogenases in the sarcoplasmic reticulum or mitochondrion, or nitric oxide synthases, nadph dehydrogenase, or xanthine oxidase.
Parent Term
Biochemical pathway
Parent Definition
A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Metabolites Mapped to 'Doxorubicin Metabolism Pathway'