HMDB0000051 (Ammonia) HMDB0000538 (Adenosine triphosphate) HMDB0000547 (Magnesium) HMDB0001341 (ADP) HMDB0002111 (Water) HMDB0012943 (Fe3+) HMDB0014584 (Gemcitabine) HMDB0015532 (Zinc) HMDB0060638 (Gemcitabine triphosphate) HMDB0060639 (Gemcitabine diphosphate)
- HMDB0002111 (Water)
- Gemcitabine Action Pathway
- gemcitabine enters the cell via sodium nucleoside co-transporters (slc29a1, slc28a1, and slc28a3), where it acts through multiple mechanisms to produce a cytotoxic effect. gemcitabine is phosphorylated into gemcitabine monophosphate by deoxycytidine kinase, which is then subsequently phosphorylated into the diphosphate and triphosphate nucleotides by ump-cmp kinase and nucleoside diphosphate kinase respectively.
- Parent Term
- Biochemical pathway
- Parent Definition
- A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
- Other Metabolites Mapped to 'Gemcitabine Action Pathway'